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Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

The Application of Cross-Cultural Education Strategies in International Schools and Their Role in Cultivating Students’Global Awareness

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Education and Teaching Research

Education and Teaching Research 2024年第3期 4-8页

作者： han na Faculty of Arts Xinyang collegeChina

This paper presents a comprehensive examination of the application of cross-cultural education strategies within international schools and their critical role in fostering students’global *** international schools serve as a melting pot of diverse cultures,the research delves into the importance of cross-cultural education in preparing students to become global *** study outlines the theoretical underpinnings of cross-cultural education,emphasizing the need for an inclusive curriculum that addresses cultural sensitivity and promotes international *** case studies,such as interdisciplinary projects and Model United nations activities,are analyzed to understand their impact on students’engagement and cross-cultural *** faced by schools,including resource limitations and cultural sensitivity,are discussed alongside potential solutions like enhanced teacher training and the use of *** paper also explores the assessment of students’global awareness and the future development of cross-cultural education,considering the influence of educational policies and technological *** research concludes with policy implications and practical guidance for educators,advocating for a personalized approach to cross-cultural education that aligns with the needs of the globalized era.

关键词： Cross-cultural education International schools Global awareness Curriculum integration Teacher training Technology application Student engagement Cultural sensitivity Educational policy Personalized learni

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

Shexiang Tongxin Dropping Pill Promotes Angiogenesis through VEGF/eNOS Signaling Pathway on Diabetic Coronary Microcirculation Dysfunction

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Chinese Journal of Integrative Medicine 2024年第10期30卷 886-895页

作者： CUI Xin-yu LIU Tian-hua BAI Ya-li ZhanG Meng-di LI Guo-dong ZhanG Yu-ting YUAN Yue-ying ZhanG Ya-wen YU Li-shuang han Li-na WU Yan School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Key Laboratory of Traditional Chinese Medicine Syndrome and Formula Ministry of Education Beijing University of Chinese MedicineBeijing100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective:To study the effect of Shexiang Tongxin Dropping Pill(STDP)on angiogenesis in diabetic cardiomyopathy mice with coronary microcirculation dysfunction(CMD).Methods:According to a random number table,6 of 36 SPF male C57BL/6 mice were randomly selected as the control group,and the remaining 30 mice were injected with streptozotocin intraperitoneally to replicate the type 1 diabetes *** successfully copied the diabetes model were randomly divided into the model group,STDP low-dose group[15 mg/(kg·d)],medium-dose group[30 mg/(kg·d)],high-dose group[60 mg/(kg·d)],and nicorandil group[15 mg/(kg·d)],6 in each *** drug was given by continuous gavage for 12 *** cardiac function of mice in each group was detected at the end of the experiment,and coronary flow reserve(CFR)was detected by chest Doppler *** changes of myocardium were observed by hematoxylin-eosin staining,collagen fiber deposition was detected by masson staining,the number of myocardial capillaries was detected by platelet endothelial cell adhesion molecule-1 staining,and the degree of myocardial hypertrophy was detected by wheat germ agglutinin *** expression of the vascular endothlial growth factor(VEGF)/endothelial nitric oxide synthase(eNOS)signaling pathway-related proteins in myocardial tissue was detected by Western ***:Compared with the model group,medium-and high-dose STDP significantly increased the left ventricular ejection fraction and left ventricular fraction shortening(Pnase,protein kinase B,and eNOS(P<0.05 or P<0.01).Conclusion:STDP has a definite therapeuti

关键词： Shexiang Tongxin Dropping Pill type 1 diabetes diabetic cardiomyopathy coronary microcirculation dysfunction angiogenesis

数字时代的认知域安全:理论解构、风险生成及治理路径

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国际安全研究 2024年第3期42卷 55-75,158,159页

作者：韩娜董小宇中国人民公安大学网络空间国际治理研究基地中国人民公安大学国家安全学院北京100038

“认知域”是大国博弈的关键领域,在数字时代认知域安全已成为影响全球安全的重要议题。认知域安全研究经历了科学化、军事化、战略化再到国家安全化的四重演进,其理念被逐渐重塑。国家安全视角下的认知域安全,是指国家内部和外部的意... 详细信息

“认知域”是大国博弈的关键领域,在数字时代认知域安全已成为影响全球安全的重要议题。认知域安全研究经历了科学化、军事化、战略化再到国家安全化的四重演进,其理念被逐渐重塑。国家安全视角下的认知域安全,是指国家内部和外部的意识形态、思想文化、战略决策、价值观念、思维方式等不被内外势力操纵和改造,从而使认知的过程及其结果保持稳定有序的状态,并持续保障这种安全状态的能力。在要素特征方面,数字时代认知域安全呈现出主体多元、对象精准、智能驱动、战略隐蔽和全局领域的特点;在风险生成方面,内外势力往往通过观察-导向-决策-行动(OODA)循环模型进行精准操控,涵盖观察阶段的精准识别、导向阶段的信息加工、决策阶段的信息集成、行动阶段的主体协同以及评估阶段的信息反馈,形成了一个完整的操控链条,对认知域安全构成了严重威胁。中国必须双管齐下,积极有效应对认知域的安全风险。在顶层战略层面,国家需要制定全面而前瞻的战略政策框架;在务实策略层面,需在风险识别、风险评估、风险防控、风险应对等方面开展协同创新治理,进一步有效降低认知域操纵带来的安全风险。

关键词：国家安全认知域安全认知域操纵国家安全治理

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电化学二电子氧还原制备过氧化氢研究进展

物理化学学报 2024年第2期40卷 1-11页

作者：文兆宇韩娜李彦光苏州大学功能纳米与软物质研究院江苏苏州215123 澳门科技大学材料科学与工程研究院中国澳门氹仔岛999078

利用电化学二电子氧还原(2e-Oxygen Reduction Reaction,2e-ORR)方法实现过氧化氢(H_(2)O_(2))的分散式制备,被认为是具有广阔发展前景的技术之一。为实现高的氧还原活性和理想的H_(2)O_(2)选择性,设计高性能2e-ORR电催化剂是该技术的... 详细信息

利用电化学二电子氧还原(2e-Oxygen Reduction Reaction,2e-ORR)方法实现过氧化氢(H_(2)O_(2))的分散式制备,被认为是具有广阔发展前景的技术之一。为实现高的氧还原活性和理想的H_(2)O_(2)选择性,设计高性能2e-ORR电催化剂是该技术的核心关键。尽管现阶段发展的2e-ORR催化剂已经取得了显著进展,但距离规模化应用仍存在很大的差距。基于此,本文综述了电化学二电子氧还原制备H_(2)O_(2)的最新研究进展,首先简要介绍了反应机理和评价方法,并根据机理分析了影响电催化性能的关键因素。随后围绕贵金属催化剂、碳基催化剂、单原子及分子催化剂的最新研究进展,阐述了提升催化剂活性与H_(2)O_(2)选择性的主要策略。最后,针对电化学二电子氧还原制备H_(2)O_(2)体系面临的关键问题和挑战,对该领域未来的发展趋势进行了展望。

关键词：电化学二电子氧还原反应过氧化氢催化剂选择性

TonEBP expression is essential in the IL-1β–induced migration and invasion of human A549 lung cancer cells

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Oncology Research 2024年第1期32卷 151-161页

作者： HEE JU SONG TAEHEE KIM han na CHOI SOO JIN KIM SANG DO LEE Department of Physiology School of MedicineChungnam National UniversityDaejeon35015Korea

Lung cancer has the highest mortality rate among all cancers,in part because it readily *** tumor microenvironment,comprising blood vessels,fibroblasts,immune cells,and macrophages[including tumor-associated macrophages(TAMs)],is closely related to cancer cell growth,migration,and *** secrete several cytokines,including interleukin(IL)-1β,which participate in cancer migration and invasion.p21-activated kinase 1(PAK1),an important signaling molecule,induces cell migration and invasion in several ***responsive enhancer-binding protein(TonEBP)is also known to participate in cancer cell growth,migration,and ***,the mechanisms by which it increases lung cancer migration remain ***,in this study,we aimed to elucidate the mechanisms by which IL-1βand TonEBP affect lung cancer cell migration and *** found that A549 cocultured-MΦ-secreted IL-1βinduced A549 cell migration and invasion via the PAK1 *** deficiency reduced A549 cell migration and invasion and increased responsiveness to IL-1β–induced migration and ***1 phosphorylation,which was promoted by IL-1β,was reduced when TonEBP was *** results suggest that TonEBP plays an important role in IL-1βinduction and invasiveness of A549 cells via the PAK1 *** findings could be valuable in identifying potential targets for lung cancer treatment.

关键词： Lung cancer TonEBP Tumor microenvironment Tumor-associated macrophage IL-1β

美国对华网络空间安全政策:动因、举措及影响

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国家安全论坛 2024年第4期 44-52,91页

作者：韩娜中国人民公安大学国家安全学院中国人民公安大学网络空间国际治理研究基地

网络空间是大国战略竞争的核心领域之一。美国通过强化国家网络空间实力、打造网络空间联盟合作、对华网络空间实施“污名化”三方面政策举措,试图巩固其网络空间安全治理规则主导权,其在网络空间安全治理过程中采取的对华竞争政策进一... 详细信息

网络空间是大国战略竞争的核心领域之一。美国通过强化国家网络空间实力、打造网络空间联盟合作、对华网络空间实施“污名化”三方面政策举措,试图巩固其网络空间安全治理规则主导权,其在网络空间安全治理过程中采取的对华竞争政策进一步加深了中美两国之间的“信任鸿沟”。由于美国两党对华角色认知的一致性、强化盟伴合作网络的黏合性以及升级话语叙事空间的主导性,对中国网络空间安全产生了严重影响,促使中国在强化技术支撑、完善规则体系、升级话语叙事等方面坚定不移地推行“网络空间命运共同体”理念,丰富拓展相关实践,以期为下步制定全球网络空间安全治理规则和未来继续深化该领域改革贡献中国智慧和中国方案。

关键词：美国网络空间安全网络空间安全治理竞争政策大国竞争

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新疆哈密恐龙骨骼化石风化原因分析

光谱学与光谱分析 2024年第4期44卷 1106-1111页

作者：韩向娜代黎洋蒋顺兴汪筱林北京科技大学科技史与文化遗产研究院北京100083 中国科学院古脊椎动物与古人类研究所脊椎动物演化与人类起源重点实验室北京100044 中国科学院大学地球与行星科学学院北京100049

新疆早白垩世哈密翼龙动物群中恐龙化石的发现,增加了动物群的多样性,也为恐龙的系统演化提供了新的信息,具有重要的科学意义。然而,哈密恐龙化石在脱离原始埋藏环境在异地保存时,由于保存环境的改变,化石出现严重的风化现象。为了使哈... 详细信息

新疆早白垩世哈密翼龙动物群中恐龙化石的发现,增加了动物群的多样性,也为恐龙的系统演化提供了新的信息,具有重要的科学意义。然而,哈密恐龙化石在脱离原始埋藏环境在异地保存时,由于保存环境的改变,化石出现严重的风化现象。为了使哈密恐龙化石能够得到更好的保存、研究和展陈,采用多种分析技术方法,对产生明显风化现象的哈密恐龙骨骼化石进行检测,分析导致化石风化破碎的原因。X射线衍射(XRD)结果显示,哈密恐龙骨骼化石风化严重区域是骨松质部分,其主要矿物成分为石英和方解石,含有较少磷灰石、长石和黏土矿物等。其中石英和长石是充填骨松质孔隙中的外来碎屑颗粒,方解石是后期成岩或化石风化过程中形成的胶结物,而少量的磷灰石则主要来自骨骼。离子色谱(IC)、傅里叶变换红外光谱(FTIR)、拉曼光谱(Raman)以及扫描电子显微镜能谱仪(SEM-EDS)的结果表明,哈密恐龙骨骼化石风化区域的可溶盐以naCl、CaCl_(2)和Ca(NO_(3))_(2)·4H_(2)O为主,以及少量CaSO 4,可溶盐含量高达2.63%,初步判断高可溶盐含量是造成化石出现严重风化现象的主要原因。压汞(MIP)测试结果表明,哈密恐龙骨骼化石风化区域的孔隙率为21.2722%,与未风化区域16.4206%的孔隙率相比显著增大。另外,恐龙骨骼化石风化区域存在两种孔径分布的孔隙,尺寸分别为0.005~0.04和17.3~283.2μm,相较于未风化区域,风化区域产生较多微裂隙,大孔径孔隙数量急剧增多。结论认为化石中含有大量以CaCl_(2)和Ca(NO_(3))_(2)·4H_(2)O为代表的潮解盐,易受北京四季温湿度变化的影响,潮解盐具有巨大破坏作用,从而使哈密恐龙骨骼化石风化区域孔隙率升高,孔隙增大,并且其内部充填物结构酥松且不均一,最终导致哈密恐龙骨骼化石酥粉破碎。该研究工作对哈密恐龙化石的异地保存及保护具有一定的科学指导意义。

关键词：哈密翼龙动物群恐龙骨骼化石风化机理潮解盐新疆哈密