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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cellular & molecular Immunology 2024年第2期21卷 103-118页

作者： s.Cankat m.U.Demael L.swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of sARs-CoV-2,mERs-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKU1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation sARs-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection Universal

The role of Down syndrome cell adhesion molecule in Down syndrome

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medical Review 2024年第1期4卷 31-41页

作者： ty Hergenreder Tao Yang Bing Ye Life sciences Institute and Department of Cell and Developmental Biology University of MichiganAnn ArborMIUSA Life sciences Institute and Department of Cell and Developmental Biology University of Michigan210 Washtenaw AvenueRoom 5403Ann ArborMI48109USA

Down syndrome(Ds)is caused by the presence of an extra copy of the entire or a portion of human chromosome 21(HsA21).This genomic alteration leads to elevated expression of numerous HsA21 genes,resulting in a variety of health issues in individuals with *** the genes located in the Ds“critical region”of HsA21,Down syndrome cell adhesion molecule(DsCAm)plays an important role in neuronal *** is a growing body of evidence underscoring DsCAm’s involvement in various Ds-related *** review aims to provide a concise overview of the established functions of DsCAm,with a particular focus on its implications in *** delve into the roles that DsCAm plays in Ds-associated *** the concluding section of this review,we explore prospective avenues for future research to further unravel DsCAm’s role in Ds and opportunities for therapeutic treatments.

关键词： Down syndrome DsCAm neuron axon GABAergic synapse

Factors influencing farmers’adoption of solar water-pumping systems in Gujarat

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Clean Energy 2024年第3期8卷 157-165页

作者： m sathish Kumar Y.A.Lad R.s.Pundir International Agribusiness management Institute Anand Agricultural UniversityAnand388110GujaratIndia Department of HRD&Pm International Agribusiness Management InstituteAnand Agricultural UniversityAnand388110GujaratIndia Department of Agribusiness Economics and Policies International Agribusiness Management InstituteAnand Agricultural UniversityAnand388110GujaratIndia

Agriculture has played an important role in the growth of the Indian *** and electricity are essential inputs for agriculture *** produces the third-largest amount of electricity in the world,behind China and the *** an incentive to increase production,most states provide free electricity to *** electricity has decreased groundwater levels and increased electricity *** objective of this study was to find out the factors that influenced farmers to adopt a solar water-pumping system in *** samples were randomly *** study examined the entire state of *** hundred and fifty farmers who adopted solar water-pumping systems were interviewed,including 50 banana farmers,50 cotton farmers and 50 groundnut *** data were collected through an *** adoption of solar water-pumping systems by farmers was identified using factor *** software was used to analyse the data *** this study,only two factors contributed to the variance of 59.469%.The adoption of solar water pumps by farmers was influenced by government policy and economic *** economic benefit variance of 33.20%was found,while a government policy variance was 26.27%.A solar water-pumping system has low initial costs,flexible credit policies motivate adoption,solar water-pumping systems can save electricity,and maintenance and repair costs are *** policy that includes solar water-pumping systems is motivated by awareness,subsidies for adoption and a fair price to sell energy *** are recommended to adopt a solar water-pumping system in conjunction with a drip irrigation system to receive additional *** successful scheme will be recommended to other states in India for implementation.

关键词： solar water-pumping system factor analysis banana cotton groundnut famers

Tribological behavior of lubricant-impregnated porous polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.WONG school of mechanical Engineering and mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different densities were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is released under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of released oil increases with increasing PPI *** moduli,E*,estimated based on the actual contact size show that trapped oil in iPPIs contributes to load *** higher speeds,tribological rehydration of the contact occurs in low density iPPI,with that E*rises with *** high density PPIs,high speeds give a constantly high E*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughness of the PPI *** low-and medium-density(highly porous,high roughness)PPIs,large amount of oil is released,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high density(low porosity)PPI,with lower roughness,hydrodynamic lubrication is achieved which gives the lowest *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughness,stiffness,oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication

Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.sardar m.D.Hossain m.s.sikder m.N.I.Khan m.R.Rahman Physics Discipline Khulna UniversityKhulna9208Bangladesh Department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh Department ofComputer science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh material science Division Atomic Energy CentreDhaka1000Bangladesh

spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FEsEm),energy dispersive X-ray(EDX),vibrating sample magnetometer(Vsm),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRD patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FEsEm images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EDX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EDX Resistivity

Acceleration of solar wind particles due to inertial Alfvén waves

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Communications in Theoretical Physics 2024年第6期76卷 137-141页

作者： Kiran Batool Imran A Khan m shamir Abdul Kabir s Ayaz Theoretical Physics Department National Centre for PhysicsIslamabad 44000Pakistan Department of space sciences Institute of Space TechnologyIslamabad 44000Pakistan space and Astrophysics Research Lab(sARL) National Center of GIS and Space Applications(NCGSA)Islamabad 44000Pakistan salam Chair Department of PhysicsGC University LahoreKatchery RoadLahorePunjab 54000Pakistan Department of space science and CsPAR University of Alabama in HuntsvilleHuntsvilleAL 35899United States of America

Gaining an understanding of the effects and dynamics of the solar wind is crucial for the study of space weather,Earth's magnetosphere,spacecraft protection,the dynamics of the solar system,and various other *** show that Alfvén waves effectively transfer energy to resonant *** study demonstrates how inertial Alfvén waves deliver their energy to resonant plasma particles in different solar environments under certain *** analysis shows that inertial Alfvén waves experience more rapid damping with increasing parallel wavenumber,ambient magnetic field strength,and particle number density,coupled with a decrease in *** rate of energy transfer to resonant particles intensifies with higher temperatures and reduced parallel wavenumber and particle number *** with higher initial velocities actively participate in Landau damping,especially in regions with a stronger ambient magnetic field.

关键词： solar wind inertial Alfven waves resonant particles

multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

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Communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef Alvaro H salas B m Alotaibi s A El-Tantawy Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of mathematics and statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(msm)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** msm first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order msm approximations are compared to the fourth-order Runge-Kutta(RK4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the msm,compared to the numerical approximations obtained by the RK4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(msm)and He-msm to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

Provenance and depositional setting of the Late miocenePleistocene clastic sediments in the eastern Arabian Peninsula and western Iraq using rare earth elements geochemistry

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Acta Geochimica 2024年第2期43卷 399-410页

作者： salih m.Awadh Zinah s.Al-Ankaz mohanad R.A.Al-Owaidi John s.Armstrong-Altrin Department of Geology College of ScienceUniversity of BaghdadBaghdadIraq Department of Geology College of ScienceUniversity of WasitWasit 52011Iraq Department of Applied Geology College of ScienceUniversity of BabylonBabylon 51001Iraq Unidad de Procesos Oceanicos y Costeros Instituto de Ciencias del Mar y LimnologíaUniversidad Nacional Autonoma de MexicoCiudad Universitaria04510 Mexico CityCDMXMexico Department of marine sciences Bharathidasan UniversityTiruchirapalliTamil Nadu 620024India

The sandstones of the Late miocene–Pliocene Dibdibba Formation in the Najaf–Karbala Plateau and Basra were examined to determine their source rocks and origin. The rare earth elements(REE) and trace elements(sc, Co, V, and Th) concentrations in these sandstones revealed that they likely derived from a single source. The steep light rare earth elements(LREE) and flat, heavy rare earth element(HREE) patterns, negative Eu anomaly, and high ΣREE contents in sandstones suggest its derivation from a suggests that a passive continental margin environment and originated from felsic source rocks. The average concentration of ΣREE is 93.5 ppm, which is lower than that of the average crustal compositions like Upper Continental Crust and Post Archean Australian shale. The higher proportion of LREE compared to HREE implies that these sandstones were recycled and derived from a distal source. The Th/Co, Th/sc, La/sc, La/Co, Eu/Eu*and(La/Lu)cn elemental ratios indicated that these Late miocene–Pliocene sandstones were derived from felsic rocks located in the marginal region of the Arabian shield.

关键词： REE Dibdibba formation Clastic sediments Passive continental margin

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： morten s.Hansen Kaja madsen maria Price Kent søe Yasunori Omata mario m.Zaiss Caroline m.Gorvin morten Frost Alexander Rauch molecular Endocrinology Laboratory(KmEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of metabolism and systems Research(ImsR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for membrane Proteins and Receptors(COmPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of molecular medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density sNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(ssTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating ssTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif