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人参皂苷 Rg3激活线粒体功能改善慢性疼痛的机制

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中国药理学通报 2025年第1期41卷 94-100页

作者：张培根朱海丽高卉湖北科技学院医学部药学院湖北咸宁437100

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参... 详细信息

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参皂苷Rg3给药;记录小鼠痛觉行为变化;HE染色、尼氏染色、免疫印迹及免疫组化检测各组PFC脑组织神经和线粒体损伤情况;分子对接探究人参皂苷Rg3的作用靶点;Mito-Tracker检测线粒体膜电位;ATP试剂盒分析ATP含量。结果与假手术组相比,模型组小鼠表现为痛觉过敏和运动能力受损;PFC内神经及线粒体损伤(P<0.05)。与模型组相比,人参皂苷Rg3给药可增加小鼠机械痛阈值、热缩足潜伏期和转棒停留时间;同时降低PFC内炎性细胞、尼氏小体及Dnm1l阳性细胞数,下调c-Fos、IL-1β和Dnm1l蛋白表达水平(P<0.05)。分子对接显示人参皂苷Rg3可结合Dnm1l。在细胞水平,人参皂苷Rg3给药可升高线粒体膜电位和ATP含量(P<0.05)。结论人参皂苷Rg3可通过调控降低PFC内炎症因子和线粒相关蛋白表达,改善线粒体功能,缓解CCI小鼠痛觉过敏。

关键词：人参皂苷Rg3 慢性神经性疼痛线粒体前额叶皮层 CCI PFC

Hot versus cold subduction initiation

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National Science Review 2024年第2期11卷 101-102页

作者： Zhong-hai li Key Laboratory of Computational Geodynamics College of Earth and Planetary SciencesUniversity of Chinese Academy of Sciences

In the framework of plate tectonics, subduction initiation(SI) indicates the birth of a plate convergent boundary, which is a key point of plate tectonics and Wilson's cycle; however, its dynamic process is not well c...

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Possible ground states and parallel magnetic-field-driven phase transitions of collinear antiferromagnets

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npj Computational Materials 2016年第1期2卷 36-43页

作者： hai-Feng li Institute of Applied Physics and Materials Engineering Faculty of Science and TechnologyUniversity of MacaoAvenida da UniversidadeTaipaMacaoChina

Understanding the nature of all possible ground states and especially magnetic-field-driven phase transitions of antiferromagnets represents a major step towards unravelling the real nature of interesting phenomena such as superconductivity,multiferroicity or magnetoresistance in condensed-matter *** a consistent mean-field calculation endowed with antiferromagnetic(AFM)exchange interaction(J),easy axis anisotropy(γ),uniaxial single-ion anisotropy(D)and Zeeman coupling to a magnetic field parallel to the AFM easy axis consistently unifies the AFM state,spin-flop(SFO)and spin-flip *** reveal some mathematically allowed exotic spin states and fluctuations depending on the relative coupling strength of(J,γand D).We build the three-dimensional(J,γand D)and two-dimensional(γand D)phase diagrams clearly displaying the equilibrium phase conditions and discuss the origins of various magnetic states as well as their transitions in different *** the traditional first-order type one,we unambiguously confirm an existence of a second-order type SFO *** study provides an integrated theoretical model for the magnetic states of collinear antiferromagnets with two interpenetrating sublattices and offers a practical approach as an alternative to the estimation of magnetic exchange parameters(J,γand D),and the results may shed light on nontrivial magnetism-related properties of bulks,thin films and nanostructures of correlated electron systems.

关键词： transitions magnetic phase

Prospects for rare and forbidden hyperon decays at BESⅢ

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Frontiers of physics 2017年第5期12卷 1-10页

作者： hai-Bo li Institute of High Energy Physics Beijing 100049 China University of Chinese Academy of Sciences Beijing 100049 China

The study of hyperon decays at the Beijing Electron Spectrometer Ⅲ （BESⅢ） is proposed to investigate the events of J/φ decay into hyperon pairs, which provide a pristine experimental environment at the Beijing Electron-Positron Collider Ⅱ. About 10^6-10^8 hyperons, i.e., ∧, ∑, ∈, and Ω, will be produced in the J/φ and φ（2S） decays with the proposed data samples at BESⅢ. Based on these samples, the measurement sensitivity of the branching fractions of the hyperon decays is in the range of 10^-5-10^-8. In addition, with the known center-of-mass energy and ＂tag technique＂, rare decays and decays with invisible final states can be probed.

关键词： BESⅢ J/φ decay hyperon rare decay FCNC lepton flavor violation

Flow stress model considering the transformation-induced plasticity effect and the inelastic strain recovery behavior

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International Journal of Minerals,Metallurgy and Materials 2011年第2期18卷 185-191页

作者： hai-yan Yu li Bao School of Automotive Engineering Tongji University Shanghai 200092 China

On the basis of continuum mechanics and the Mori-Tanaka mean field theory, a micro-mechanical flow stress model that considered both the transformation-induced plasticity （TRIP） effect and the inelastic strain recovery behavior of TRIP multiphase steels was presented. The relation between the volume fraction of constituent phases and plastic strain was introduced to characterize the transformation-induced plasticity effect of TRIP steels. Loading-unloading-reloading uniaxial tension tests of TRIP600 steel were carried out and the strain recovery behavior after unloading was analyzed. From the experimental data, an empirical elastic modulus expression is extracted to characterize the inelastic strain recovery. A comparison of the predicted flow stress with the experimental data shows a good agreement. The mechanism of the transformation-induced plasticity effect and the inelastic recovery effect acting on the flow stress is also discussed in detail.

关键词： flow stress transformation-induced plasticity inelastic strain elastic modulus

Tf_2NH-catalyzed,highly regio-and stereo-selective synthesis of trisubstituted alkenes and indane derivatives from benzylic alcohols and alkenes

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Chinese Chemical Letters 2015年第3期26卷 320-322页

作者： hai-Hua li Department of Environmental and Chemical Engineering Tangshan College

A reaction of benzylic alcohols with alkenes has been developed in the presence of bis（trifluoromethane）sulfonimide for the synthesis of trisubstituted alkenes and indane derivatives with high *** general,benzylic alcohols react with 1,1-diaryl alkenes to afford trisubstituted alkenes,and the reaction with 1,2-disubstituted and trisubstituted alkenes affords indane derivatives through a [3 ＋ 2] annulation reaction.

关键词： alcohols catalyzed afford selectivity stereo Friedel react catalysis inexpensive stilbene

Injection of stored nucleotides from single-walled carbon nanotubes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 709-713页

作者： Zhen-hai li Wei YANG Applied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Beijing 100084 China University Office Zhejiang University Hangzhou 310058 China

We investigate the possibility of injection of a nucleotide via single-walled carbon nanotubes (SWNTs). The collapse process of an SWNT with a large radius may proceed like falling dominoes. The characteristics of a large radius SWNT are utilized to drive the nucleotide movement in the SWNT, or even to inject the stored nucleotide out of the SWNT. In this process, the lateral section of the collapsed SWNT resembles a dumbbell. Occasionally, the nucleotide in the SWNT will be inbreathed into one of the two dumbbell ends, leading to interference with the injection process. To investigate the random nature of the injection process, a series of simulations on SWNT with different lengths were carried out. It was found that the injection probability was not influenced by the tube length. Freezing the nucleotide at the beginning, or modifying the SWNT at the outlet, may serve to facilitate the injection process, as indicated by the rise in the injection probability.

关键词： Nano injection Single-walled carbon nanotube (SWNT) Nucleotide

Micro-angle tilt detection for the rotor of a novel rotational gyroscope with a 0.47″resolution

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Frontiers of Information Technology & Electronic Engineering 2017年第5期18卷 591-598页

作者： hai li Xiao-wei liU Rui WENG hai-feng ZHANG MEMS Center Harbin Institute of TechnologyHarbin 150001China MOE Key Laboratory of Micro-Systems and Micro-Structures Manufacturing Harbin 150001China

Differential capacitive detection has been widely used in the displacement measurement of the proof mass of vibratory gyroscopes, but it did not achieve high resolutions in angle detection of rotational gyroscopes due to restrictions in structure, theory, and interface circuitry. In this paper, a differential capacitive detection structure is presented to measure the tilt angle of the rotor of a novel rotational gyroscope. A mathematical model is built to study how the structure's capacitance changes with the rotor tilt angles. The relationship between differential capacitance and structural parameters is analyzed, and preliminarily optimized size parameters are adopted. A lownoise readout interface circuit is designed to convert differential capacitance changes to voltage signals. Rate table test results of the gyroscope show that the smallest resolvable tilt angle of the rotor is less than 0.47(0.00013?),and the nonlinearity of the angle detection structure is 0.33%, which can be further improved. The results indicate that the proposed detection structure and the circuitry are helpful for a high accuracy of the gyroscope.

关键词： Micro-angle detection Differential capacitive structure Rotational gyroscope Structure optimization

MATHEMATICAL MODEliNG OF OIL SPILL ON THE SEA AND APPliCATION OF THE MODEliNG IN DAYA BAY

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Journal of Hydrodynamics 2007年第3期19卷 282-291页

作者： CHEN hai-zhou li Da-ming li Xiao School of Civil Engineering Tianjin University Tianjin 300072

Through the study of the theory of oil spill model, a mathematical modeling of oil spill on the sea is developed which with the consideration of spread, diffusion, drifting and attenuation of oil slick is influenced by evaporation and emulsification factors. A model that under the effect of ocean dynamic condition of tide, wind and wave, using Monte Carlo method to simulate the movement of oil slick is established. The modeling is applied to calculate and predict pollution range of oil spill at oil quay and oil ship in Daya Bay. The prediction results have basically shown the pollution situation by emergency of oil spill on the sea.

关键词： oil spill on the sea spread of oil slick diffusion of oil slick Monte Carlo method bay contamination