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Protecting lithium metal anode in all-solid-state batteries with a composite electrolyte

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Rare Metals 2021年第2期40卷 409-416页

作者： Wen-Qing Wei Bing-Qiang Liu Yi-Qiang Gan hai-Jian Ma Da-Wei Cui School of Mechanical-electronic and Vehicle Engineering Weifang UniversityWeifang261061China department of Chemical and Materials Engineering the University of AucklandAuckland1142New Zealand College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao266590China

The volume of the metallic lithium anode in allsolid-state Li metal batteries increases significantly due to the lithium dendrite formation during the battery cycling,and the rough surface of lithium metal also reduces Li-ion transport in Li/electrolyte *** this work,we developed a solid polymer composite by adding the lowcost Si_(3)N_(4)particles to protect the lithium anode in allsolid-state *** Fourier transform infrared spectroscopy(FTIR)data show that the surface of 10 wt%Si_(3)N_(4)particles interacts with the polyethylene oxide(PEO)and lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)salt;the interaction restricts the anion mobility and improves the ionic conductivity(1×10^(-4)S·cm^(-1))and lithium-ion transference number(0.28)of the composite *** lithium metal anode is well protected by the composite electrolyte in all-solid-state cells,including symmetric and Li/LiFePO_(4)*** lithium dendrite growth suppression by this composite electrolyte indicates the possible application of these low-cost composite electrolytes for lithium metal protection.

关键词： Lithium metal anode Lithium dendrite growth Composite electrolyte Symmetric cell

Efficacy and safety of intravitreal ranibizumab with panretinal photocoagulation followed by trabeculectomy compared with Ahmed glaucoma valve implantation in neovascular glaucoma

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 400-405页

作者： Jin-Tao Sun hai-Jing Liang Meng An Da-Bo Wang qingdao university Qingdao 266000 Shandong Province China department of Ophthalmology Qingdao Economic and Technological Development Area First People's Hospital Qingdao 266555 Shandong Province China department of Ophthalmology Laixi People's Hospital Qingdao 266600 Shandong Province China department of Ophthalmology Qingdao Traditional Chinese Medical Hospital of Huangdao District Qingdao 266500 Shandong Province China department of Ophthalmology the Affiliated Hospital of Qingdao University Qingdao 266000 Shandong Province China

AIM：To evaluate the efficacy and safety of intravitreal ranibizumab（IVR）with panretinal photocoagulation（PRP）followed by trabeculectomy compared with Ahmed glaucoma valve（AGV）implantation in neovascular glaucoma（NVG）.METHODS：This was a retrospective comparative *** reviewed the cases of a total of 45 eyes from 45 NVG patients among which 23 eyes underwent AGV implantation and the other 22 underwent trabeculectomy. The causes of neovascular glaucoma included：diabetic retinopathy（25 eyes）,and retinal vein occlusion（20 eyes）.All patients received preoperative IVR combined with postoperative PRP. The mean best-corrected visual acuities（BCVA）were converted to the logarithms of the minimum angle of resolution（log MAR）for the statisitical *** pressure（IOP）,the log MAR BCVA and surgical complications were evaluated before and after *** follow-up period was 12 ***：A total of 39 cases showed complete regression of iris neovascularization at 7d after injection,and 6 cases showed a small amount of residual iris neovascularization. The success rates were 81.8% and 82.6% at 12 mo after trabeculectomy and AGV implantation,respectively. In the trabeculectomy group,the log MAR BCVA improved at the last follow-up in 14 eyes,remained stable in 6 eyes and decreased in 2 eyes. In 4 cases,slight hyphemas developed after trabeculectomy. A shallow anterior chamber developed in 2 cases and 2 vitreous hemorrhages. In the AGV group,the log MAR BCVA improved in 14 eyes,remained stable in 5 eyes and decreased in 4 eyes. Slight hyphemas developed in 3 cases,and a shallow anterior chamber in 3 cases. The mean postoperative IOP was significantly lower in both groups after surgery（F=545.468,P〈0.05）,and the mean postoperative log MAR BCVA was also significantly improved（F=10.964,P〈0.05）with no significant difference between two ***：It is safe and effective to treat NVG with this combined procedure,and we found similar results after IVR＋AGV implantat

关键词： neovascular glaucoma trabeculectomy Ahmed drainage valve implantation ranibizumab panretinal photocoagulation

Management of ductal spasm in a neonate with pulmonary atresia and an intact ventricular septum during cardiac catheterization:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13015-13021页

作者： Xu Zhang Ning Zhang hai-Cheng Song Yue-Yi Ren department of Heart Center Qingdao Women's and Children's Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina department of Medical Technology Qingdao Women's and Children's Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina

BACKGROUND Ductal spasm is a rare but life-threatening complication of cardiac catheterization in neonates with pulmonary atresia and an intact ventricular *** patients with ductal-dependent pulmonary blood flow,ductal spasm may lead to refractory hypoxemia and severe hemodynamic instability,which need to be treated in perfect *** SUMMARY We present a male infant with a gestational age of 39 wk,and his fetal echocardiography showed pulmonary *** 28 d of age,transcatheter pulmonary valvuloplasty with balloon dilatation was *** hours after the operation,the patient's pulse oxygen saturation continued to *** patient was then transferred to receive cardiac *** catheterization,the invasive blood pressure and pulse oxygen saturation suddenly decreased,and repeated aortography revealed partial occlusion of the ductus *** no longer changed when pulse oxygen saturation rose to 51%after approximately 20 min of maintenance ***,a ductal stent was used for *** and hypoxemia were *** We should know that ductal spasm may occur during pulmonary atresia and intact ventricular septum cardiac *** the pathophysiology of ductal-dependent pulmonary blood flow and make comprehensive perioperative preparations essential to deal with hemodynamic disorders caused by ductal spasm.

关键词： Cardiac catheterization Ductus arteriosus Ductal stent Ductal spasm Intact ventricular septum Pulmonary atresia Case report

Integrated analysis of single-cell and bulk RNA-seq establishes a novel signature for prediction in gastric cancer

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1215-1226页

作者： Fei Wen Xin Guan hai-Xia Qu Xiang-Jun Jiang qingdao university Medical CollegeQingdao 266000Shandong ProvinceChina department of Gastroenterology Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina

BACKGROUND Single-cell sequencing technology provides the capability to analyze changes in specific cell types during the progression of ***,previous single-cell sequencing studies on gastric cancer(GC)have largely focused on immune cells and stromal cells,and further elucidation is required regarding the alterations that occur in gastric epithelial cells during the development of *** To create a GC prediction model based on single-cell and bulk RNA sequencing(bulk RNA-seq)*** In this study,we conducted a comprehensive analysis by integrating three singlecell RNA sequencing(scRNA-seq)datasets and ten bulk RNA-seq *** analysis mainly focused on determining cell proportions and identifying differentially expressed genes(DEGs).Specifically,we performed differential expression analysis among epithelial cells in GC tissues and normal gastric tissues(NAGs)and utilized both single-cell and bulk RNA-seq data to establish a prediction model for *** further validated the accuracy of the GC prediction model in bulk RNA-seq *** also used Kaplan–Meier plots to verify the correlation between genes in the prediction model and the prognosis of *** By analyzing scRNA-seq data from a total of 70707 cells from GC tissue,NAG,and chronic gastric tissue,10 cell types were identified,and DEGs in GC and normal epithelial cells were *** determining the DEGs in GC and normal gastric samples identified by bulk RNA-seq data,a GC predictive classifier was constructed using the Least absolute shrinkage and selection operator(LASSO)and random forest *** LASSO classifier showed good performance in both validation and model verification using The Cancer Genome Atlas and Genotype-Tissue Expression(GTEx)datasets[area under the curve(AUC)_min=0.988,AUC_1se=0.994],and the random forest model also achieved good results with the validation set(AUC=0.92).Genes TIMP1,PLOD3,CKS2,TYMP,TNFRSF10B,CPNE1,GDF15,BCAP31,and CLDN7 were identified to ha

关键词： Gastric cancer Single-cell RNA sequencing Prediction model Least absolute shrinkage and selection operator Random forest

Coupled Modified Korteweg-de Vries Lattice in （2＋1） Dimensions and Soliton Solutions

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Communications in Theoretical Physics 2006年第4期45卷 581-586页

作者： YANG Hong-Xiang LI Xiu-Zhen XU Xi-Xiang DING hai-Yong department of Information Science and Technology Taishan College Taian 271021 China department of Radiology Taishan Medical University Talan 271000 China College of Science Shandong University of Science and Technology Qingdao 266510 China College of Information Science and Engineering Shandong Agricultural University Taian 271018 China

The coupled semi-discrete modified Korteweg-de Vries equation in （2＋1）-dimensions is proposed, it is shown that it, can be decomposed into two （1＋1）-dimensional differential-difference equations belonging to mKdV lattice hierarchy by considering a discrete isospeetral problem. A Darboux transformation is set up for the resulting （2＋1）- dimensional lattice soliton equation with the help of gauge transformations of Lax pairs. As an illustration by example, the soliton solutions of the mKdV lartice equation in （2＋1）-dimensions are explicitly given,

关键词： modified Korteweg-de Vries lattice Darboux transformation soliton solutions

Effect of Human Cytomegalovirus Infection on Nerve Growth Factor Expression in Human Glioma U251 Cells

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Biomedical and Environmental Sciences 2009年第4期22卷 354-358页

作者： hai-TAO WANG BIN WANG ZHI-JUN LIU ZHI-QIANG BAI LING LI hai-YAN LIU DONG-MENG QIAN ZHI-YONG YAN XU-XIA SONG department of Microbiology Qingdao Medical College and Key Laboratory of Medicine and Biotechnology of Qingdao Qingdao University Medical College Qingdao 266071 Shandong China qingdao Center for Disease Control and Prevention Qingdao 266033 Shandong China LRB 270E University of Massachusetts Medical School Worcester MA. 01605 USA

Objective To explore the change of endogenic nerve growth factor （NGF） expression in human glioma cells infected with human cytomegalovirus （HCMV）. Methods U251 cells were cultured in RPMI 1640 culture medium and infected with HCMV AD 169 strain in vitro to establish a cell model of viral infection. Morphologic changes of U251 cells were observed under inverted microscope before and after infection with HCMV. Expression of NGF gene and protein of cells was detected by RT-PCR and Western blotting before and after infection with HCMV. Results The cytopathic effects of HCMV-infected cells appeared on day 5 after infection. However, differential NGF expression was evident on day 7. NGF expression was decreased significantly in U251 cells on day 7 after infection in comparison with control group （P〈0.05）. Conclusion HCMV can down-regulate endogenous NGF levels in human glioma cell line U251.

关键词： Human cytomegalovirus U251 cells Nerve growth factor

Feasibility and clinical benefits of the double-ProGlide technique for hemostasis after cryoballoon atrial fibrillation ablation with uninterrupted oral anticoagulants

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Journal of Geriatric Cardiology 2023年第4期20卷 268-275页

作者： Jia-Yin SUN Chang-Bo XUAN hai-Liang YU hai-Yang WANG Hong-Ya HAN Zhi-Ming ZHOU De-An JIA Dong-Mei SHI Yu-Jie ZHOU Shi-Wei YANG department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel Diseasethe Key Laboratory of Remodeling-Related Cardiovascular DiseaseMinistry of EducationBeijingChina department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina department of Cardiology Tangshan Fengrun District Second People’s HospitalHebeiChina department of Cardiology Qingdao Municipal HospitalQingdaoChina

OBJECTIVE To access the efficacy and safety of the double-ProGlide technique for the femoral vein access-site closure in cryoballoon ablation with uninterrupted oral anticoagulants(OAC),and its impact on the electrophysiology laboratory time as well as hospital stay after the procedure in this observational *** Patients with atrial fibrillation undergoing cryoballoon ablation with uninterrupted OAC at department of Cardiology,Beijing Anzhen Hospital,Capital Medical university,Beijing,china from May 2019 to May 2021 were enrolled in this *** October 2020,double-ProGlide technique was consistently used for hemostasis(ProGlide group),and before that conventional manual compression was utilized(manual compression group).The occurrence of vascular and groin complications was accessed during the hospital stay and until the three-month *** A total of 140 participants(69.30%of male,mean age:59.21±10.29 years)were evaluated,70 participants being in each *** hemostasis was achieved in all the patients with ProGlide *** major vascular complications were found in the ProGlide group while two major vascular complications were occurred in the manual compression *** incidence of any groin complication was obviously higher in subjects with manual compression than patients with ProGlide devices(15.71%vs.2.86%,P=0.009).In addition,compared with the manual compression group,the ProGlide group was associated with significantly shorter total time in the electrophysiology laboratory[112.0(93.3–128.8)min vs.123.5(107.3–158.3)min,P=0.006],time from sheath removal until venous site hemostasis[3.8(3.4–4.2)min vs.8.0(7.6–8.5)min,P<0.001],bed rest time[8.0(7.6–8.0)h vs.14.1(12.0–17.6)h,P<0.001]and hospital stay after the procedure[13.8(12.5–17.8)h vs.38.0(21.5–41.0)h,P<0.001].CONCLUSIONS Utilization of the double-ProGlide technique for hemostasis after cryoballoon ablation with uninterrupted OAC is feasible and safe,which has the clinical

关键词： balloon interrupted closure

肾恶性肿瘤患者行肾部分切除术后急性肾损伤分级的影响因素分析

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新医学 2024年第8期55卷 601-607页

作者：焦鹏张博文祝海侯四川山东第二医科大学临床医学院山东潍坊261000 青岛市胶州中心医院泌尿外科山东青岛266000 青岛市市立医院泌尿外科山东青岛266000

目的探讨肾恶性肿瘤患者行肾部分切除术后急性肾损伤(AKI)分级的影响因素。方法收集2013年1月至2023年1月在青岛市市立医院因恶性肾肿瘤行肾部分切除术的患者一般信息、手术及治疗相关数据、临床分期和病理分级、实验室检查结果、手... 详细信息

目的探讨肾恶性肿瘤患者行肾部分切除术后急性肾损伤(AKI)分级的影响因素。方法收集2013年1月至2023年1月在青岛市市立医院因恶性肾肿瘤行肾部分切除术的患者一般信息、手术及治疗相关数据、临床分期和病理分级、实验室检查结果、手术记录等临床资料,根据患者术后是否出现AKI及AKI程度分为非AKI组、AKI1期组和AKI 2期组,应用Logistic回归分析AKI的影响因素,受试者操作特征(ROC)曲线分析血清肌酐对肾恶性肿瘤患者行肾部分切除术后发生AKI的预测效能。结果共纳入503例肾恶性肿瘤行肾部分切除术患者,其中非AKI378例(75.1%),AKI 1期83例(16.5%),AKI 2期42例(8.3%)。AKI 1期组中高血压患者比例、糖尿病患者比例、术前48 h内血清肌酐变化值、肿瘤体积、热缺血时间、体质量指数与非AKI组比较差异均有统计学意义(P均<0.05);AKI 2期组中性别构成、高血压患者比例、糖尿病患者比例、R.E.N.A.L.评分、术前48 h内血清肌酐变化值、肿瘤体积、热缺血时间、BMI与AKI 1期组比较差异均有统计学意义(P均<0.05)。Logistic回归分析显示,肾部分切除术后发生AKI的影响因素包括BMI、高血压、糖尿病、术前48 h内血清肌酐变化值、肿瘤体积、热缺血时间,发生AKI2期的影响因素还包括性别和R.E.N.A.L.评分(P均<0.05)。血清肌酐对AKI和AKI 2期的诊断截断值分别为23.29、39.88 mmol/L,灵敏度分别为98.1%、99.8%,特异度分别为81.3%、89.6%,ROC曲线下面积分别为0.969、0.974。结论恶性肾肿瘤患者行肾部分切除术后发生AKI的影响因素有高血压、糖尿病、术前48 h内血清肌酐变化值、肿瘤体积、热缺血时间、BMI,AKI 2期的影响因素还有性别和R.E.N.A.L.评分,临床医师应早期识别这些影响因素并采取积极干预,以降低术后AKI发生率及减轻损伤程度。

关键词：肾恶性肿瘤肾部分切除术急性肾损伤影响因素高血压糖尿病血清肌酐

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Immunoglobulin G4-related lymph node disease with an orbital mass mimicking Castleman disease:A case report

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World Journal of Clinical Cases 2021年第35期9卷 10999-11006页

作者： Feng-Yun Hao Feng-Xia Yang hai-Yan Bian Xia Zhao department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina department of Abdominal Ultrasound The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina department of Hematology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Immunoglobulin(Ig)G4-associated diseases are a group of systemic diseases involving multiple organs and are also known as IgG4-associated sclerosing ***4-associated lymphadenopathy occurring in the lymph nodes is characterized by a lack of specificity due to its clinicopathological characteristics and must be differentiated from a variety of lesions,such as Castleman disease,lymphatic follicular reactive hyperplasia,and *** SUMMARY A 65-year-old male patient,with Guillain-Barre syndrome for 5 years,presented to our hospital complaining of bilateral orbital mass for 2 *** hospitalization,the results of the patient’s laboratory tests showed that immunoglobulin subgroup IgG4 was 33.90 g/L and IgG was 30.30 g/L,but serum interleukin-6 was *** pathological morphology of orbital mass and cervical lymph node were consistent,which showed that a large number of plasma cells and eosinophils were observed in the lymphatic follicles,and the interstitial fibrous tissue was *** showed that CD20(B cells)(+),CD3(T cells)(+),CD38(+),IgG(+),IgG4 positive cells>100/high powered field,and IgG4/IgG>40%.Combined with clinical and immunohistochemical results,lymphadenopathy was consistent with Castleman disease-like IgG4-associated sclerosing *** acetate treatment was given at 40 mg/*** 2 wk,the superficial lymph nodes and orbital masses shrank,and the IgG4 level *** prednisone acetate was regularly used at a reduced dosage,no recurrence of the disease has been *** This case suggested that it is necessary to proceed cautiously in clinical practice with such patients,and immunoglobulin,complement,interleukin-6,C-reactive protein,and other examinations should be performed to confirm the diagnosis.

关键词： IgG4-associated disease Castleman disease Lymphadenopathy Orbital neoplasm Pathological morphology Case report