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NADPh oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice

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World Journal of Gastroenterology 2016年第46期22卷 10158-10165页

作者： Fong-Fong Chu R Steven Esworthy James h Doroshow Binghui Shen Department of Gastroenterology and hepatology The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of Hope Center for Cancer Research and Division of Cancer Treatment and Diagnosis National Cancer Institute

AIM To test whether Nox1 plays a role in typhlitis induced by Salmonella enterica serovar Typhimurium(S. Tm) in a mouse *** Eight-week-old male wild-type(WT) and Nox1 knockout(KO) C57BL6/J(B6) mice were administered metronidazole water for 4 d to make them susceptible to S. Tm infection by the oral route. The mice were given plain water and administered with 4 different doses of S. Tm by oral gavage. The mice were followed for another 4 d. From the time of the metronidazole application, the mice were observed twice daily and weighed daily. The ileum, cecum and colon were removed for sampling at the fourth day post-inoculation. Portions of all three tissues were fixed for histology and placed in RNAlater for m RNA/c DNA preparation and quantitative real-time PCR. The contents of the cecum were recovered for estimation of S. Tm *** We found Nox1-knockout(Nox1-KO) mice were not more sensitive to S. Tm colonization and infection than WT B6 mice. This conclusion is based on the following observations:(1) S. Tm-infection induced similar weight loss in Nox1-KO mice compared to WT mice;(2) the same S. Tm CFU was recovered from the cecal content of Nox1-KO and WT mice regardless of the inoculation dose, except the lowest inoculation dose(2 × 106 CFU) for which the Nox1-KO had one-log lower CFU than WT mice;(3) there is no difference in cecal pathology between WT and Nox1-KO groups; and(4) there are no S. Tm infection-induced changes in gene expression levels(IL-1b, TNF-α, and Duox2) between WT and Nox1-KO groups. The Alpi gene expression was more suppressed by S. Tm treatment in WT than the Nox1-KO cecum. CONCLUSION Nox1 does not protect mice from S. Tm colonization. Nox1-KO provides a very minor protective effect against S. Tm infection. Using NOX1-specific inhibitors for colitis therapy should not increase risks in bacterial infection.

关键词：猛烈老鼠 NADPh Oxidase-1 沙门氏菌 typhimurium 离脚玻璃杯或瓷杯房间反应的氧种类

The Credit-Risk Decision Mechanism on Fixed Loan Interest Rate with Imperfect Information

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Journal of Systems Engineering and Electronics 2001年第3期12卷 20-24页

作者： Pang, S. Liu, Y. Wang, Y. Yao, h. Department of Mathematics Jinan University Guangzhou 510632 China

In this paper, decision mechanism of credit-risk for banks is studied when the loan interest rate is fixed with asymmetry information in credit market. We give out the designs of rationing and non-rationing on credit risky decision mechanism when collateral value provided by an entrepreneur is not less than the minimum demands of the bank. It shows that under the action of the mechanism, banks could efficiently identify the risk size of the project. Finally, the condition of the project investigation of bank is given over again.

关键词： Classification (of information) Financial data processing Risk assessment

Analysis of Chlorogenic Acid in herbal Medicines by Capillary Electrophoresis

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Chinese Chemical Letters 1998年第10期9卷 941-944页

作者： Long, h Yang, JJ Liu, hW Wang, TS huang, AJ Sun, YL Peking Univ Dept Chem Beijing 100871 Peoples R China

A simple, rapid and accurate capillary zone electrophoresis method was developed for the determination of chlorogenic acid as a marker in traditional Chinese medicines. The buffer solution comprised of 10 mmol/L sodium phosphate and 20 mmol/L boric acid containing 5% ethanol with the ph value adjusted to 7.00. The contents of chlorogenic acid in Flos Lonicerae and Flos Lonicerae containing herbal preparations were determined within 15 min.

关键词： chlorogenic acid quantitation herbal medicines capillary zone electrophoresis

CLASSIFICATION OF CUBIC PARAMETERIZED hOMOGENEOUS VECTOR FIELDS

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Journal of Systems Science & Complexity 2002年第2期15卷 125-138页

作者： Kamal h Yasir Tang Yun Department of Mathematical Science Tsinghua University 北京 100084

Abstract. In this paper the cubic homogeneous parameterized vector fields aJre *** classification of the phase portrait near the critical point is presented. This classifica- tion is an extension of the result given b... 详细信息

关键词：二次微分方程各向同性矢量场矢量场分类

NUMERICAL SIMULATION STUDY ON DEFORMATION UNIFORMITY OF EQUAL CROSS SECTION LATERAL EXTRUSION

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Acta Metallurgica Sinica(English Letters) 2004年第1期17卷 61-63页

作者： Z.L.Chang J.L.Song N.h.hao Department of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 China

Equal cross section lateral extrusion (ECSLE) is an effective method realizing pure shear deformation. The influence of friction factor on the deformation uniformity of ECSLE was investigated with rigid plastic finite element method. The result shows that the non-uniform deformation in extrusion is caused mainly by the friction between workpiece and die. The higher the friction factor is, the more uneven plastic deformation resulted in extruded workpiece. The relation curve of deformation uniformity vs. friction factor was drawn based on the analysis result. The curve can be used as a basis of ECSLE process design.

关键词： equal cross section lateral extrusion strain finite element method

ThE CREEP AND FRACTURE BEhAVIOR OF TWO NICKEL-BASED SUPERALLOYS

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Acta Metallurgica Sinica(English Letters) 1998年第6期11卷 425-428页

作者： S.h.Ai Y.B.Xia J.F.Tian Inst of Metal Research Chinese Acad of Sciences Shenyang China

The creep and fracture behavior of the cast K417 and forged Gh4049 nickel-based superalloys were investigated in the temperature range of 700-900℃ C. Within the ranges of stress and temperature studied, the steady state creep rates exhibited a power law relationship with the applied stress and temperature. The time to rupture is inversely proportional to the steady state creep rate. Under all testing conditions, the creep fracture process was mainly controled by crack initiation and growth of the intergranular oxidation. Casting porosities, pores and carbides were also prefecentral locations of creep crack initiation in the cast K417 alloy. In addition, the intergranular fracture feature in the forged Gh4049 alloy was apparently associated with the formation and coalescence of the cavitations on the grain boundaries.

关键词： superalloy creep rate fracture

球囊压迫与射频治疗原发性三叉神经痛:一项随机对照研究

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中国疼痛医学杂志 2022年第2期28卷 86-88页

作者： Sterman-Neto h Fukuda CY Duarte KP 李泓锡(译) 丁远远(译) 不详中国医科大学附属盛京医院疼痛科

临床上有超过一半以上的三叉神经痛病人需要手术治疗,射频(radio frequency, RF)和球囊压迫(balloon compression, BC)等微创手术方法在临床上广泛应用。但关于两种手术方法的镇痛效果、并发症等方面的比较尚无正式的临床试验。该研究... 详细信息

临床上有超过一半以上的三叉神经痛病人需要手术治疗,射频(radio frequency, RF)和球囊压迫(balloon compression, BC)等微创手术方法在临床上广泛应用。但关于两种手术方法的镇痛效果、并发症等方面的比较尚无正式的临床试验。该研究采用随机、双盲、头对头试验方案,评估BC和RF手术方法治疗原发性三叉神经痛的效果。病人随机分为BC组和RF组,术前和术后全程对病人进行疼痛、心理和生活质量评估,主要结果是术后6个月内的疼痛评分(0~10分)及并发症情况。研究在完成一半预估样本后,进行了预先计划的中期分析。结果显示:两组病人疼痛评分无显著性差异;同时,并发症、疼痛对日常生活的影响、神经病理性疼痛症状、情绪评分、镇痛药物使用量和生活质量评分等观察指标两组间比较均无统计学差异。唯有术后30天时点,RF组病人的面部感觉异常症状多于BC组,其他时间点无明显差异。基于以上结果,BC与RF两种手术方法的治疗效果无明显差异,根据实验设计,终止进一步研究观察。

关键词：原发性三叉神经痛球囊压迫射频治疗神经病理性疼痛观察指标随机对照研究镇痛效果药物使用量

Smart computing approach for design and scale-up of conical spouted beds with open-sided draft tubes

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Particuology 2021年第2期19卷 179-190页

作者： M.Karimia B.Vaferi S.h.hosseini M.Olazar S.Rashidi Laboratory of Separation and Reaction Engineering(LSRE) Associate Laboratory(LSRE/LCM)Department of Chemical EngineeringFaculty of EngineeringUniversity of PortoRua Dr.Roberto FriasS/N4099-002 PortoPortugal Department of Advanced Calculations ChemicalPetroleumand Polymer Engineering Research CenterShiraz BranchIslamic Azad UniversityShirazIran Department of Chemical Engineering Ilam UniversityIlam 69315-516Iran Department of Chemical Engineering University of the Basque Country UPV/EHUP.O.Box 644E48080 BilbaoSpain Department of Petroleum Engineering Omidiyeh BranchIslamic Azad UniversityOmidiyehIran

Open-sided draft tubes provide an optimal gas distribution through a cross flow pattern between the spout and the annulus in conical spouted *** design,optimization,control,and scale-up of the spouted beds require precise information on operating and peak pressure *** this study,a multi-layer perceptron(MLP)neural network was employed for accurate prediction of these hydrodynamic characteristics.A relatively huge number of experiments were accomplished and the most influential dimensionless groups were extracted using the Buckingham-pi ***,the dimensionless groups were used for developing the MLP model for simultaneous estimation of operating and peak pressure *** iterative constructive technique confirmed that 4-14-2 is the best structure for the MLP model in terms of absolute average relative deviation(AARD%),mean square error(MSE),and regression coefficient(R^(2)).The developed MLP approach has an excellent capacity to predict the transformed operating(MSE=0.00039,AARD%=1.30,and R^(2)=0.76099)and peak(MSE=0.22933,AARD%=11.88,and R2=0.89867)pressure drops.

关键词： Conical spouted beds Open-sided draft tubes Operating pressure drops Peak pressure drop Smart modeling Design guidelines

Influence of plasma condition on carbon nanotube growth by rf-PECVD

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Nano-Micro Letters 2010年第1期2卷 37-41页

作者： Y.h.Man Z.C.Li Z.J.Zhang Advanced Materials Laboratory Department of Materials Science and Engineering Tsinghua University

Carbon nanotubes(CNTs)have been synthesized from Ar-Ch_4 mixtures using rf-plasma enhanced chemical vapor deposition(rf-PECVD)at *** gases such as h_2 and Nh_3 were found unnecessary for carbon nanotube formation compared to thermal *** relationship between the growth of CNTs and the plasma condition in PECVD has been investigated by in situ self bias *** conditions were controlled by changing the interelectrode distance,rf power and the applied substrate negative *** increasing the interelectrode distance and rf power,the spatial density of CNTs was on a rise as a result of the increase in ions density and self *** the applied substrate negative bias increased,the spatial density of CNTs decreased possibly due to the positive ions over bombarding effect.

关键词： Carbon nanotube Plasma enhanced CVD Plasma condition