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The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite

Research in Astronomy and Astrophysics 2023年第9期23卷 66-78页

作者： Z.X.Ling X.J.Sun C.Zhang S.L.Sun G.Jin S.N.Zhang X.F.Zhang J.B.Chang F.S.Chen y.F.Chen Z.W.Cheng W.Fu y.X.han h.Li J.F.Li y.Li Z.D.Li P.R.Liu y.h.Lv X.h.Ma y.J.Tang C.B.Wang R.J.Xie y.L.Xue A.L.yan Q.Zhang C.y.Bao h.B.Cai h.Q.Cheng C.Z.Cui y.F.Dai D.W.Fan h.B.hu J.W.hu M.h.huang Z.Q.Jia C.C.Jin D.y.Li J.Q.Li h.y.Liu M.J.Liu y.Liu h.W.Pan y.L.Qiu M.Sugizaki h.Sun W.X.Wang y.L.Wang Q.y.Wu X.P.Xu y.F.Xu h.N.yang X.yang B.Zhang M.Zhang W.D.Zhang Z.Zhang D.h.Zhao X.Q.Cong B.W.Jiang L.h.Li X.B.Qiu J.N.Sun D.T.Su J.Wang C.Wu Z.Xu X.M.yang S.K.Zhang Z.Zhang N.Zhang y.F.Zhu h.y.ban X.Z.Bi Z.M.Cai W.Chen X.Chen y.h.Chen y.Cui X.L.Duan Z.G Feng y.Gao J.W.he T.he J.J.huang F.Li J.S.Li T.J.Li T.T.Li h.Q.Liu L.Liu R.Liu S.Liu N.Meng Q.Shi A.T.Sun y.M.Wang y.B.Wang h.C.Wu D.X Xu y.Q yang y.yang X.S.yu K.X.Zhang y.L.Zhang y.h.Zhang y.T.Zhang h.Zhou X.C.Zhu J.S.Cheng L.Qin L.Wang Q.L.Wang M.Bai R.L.Gao Z.Ji y.R.Liu F.L.Ma y.J.Shi J.Su y.y.Tan J.Z.Tong h.T.Xu C.B.Xue G.F.Xue W.yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China North Night Vision Technology Co. LTDNanjing 211106China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Science and Technology on Low-Light-Level Night Vision Laboratory Xi'an 710065China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201204China Institute of Electrical Engineering Chinese Academy of ScienceBeijing 100190China National Space Science Center Chinese Academy of ScienceBeijing 100190China

The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 July *** this paper,we introduce the design and on-ground test results of the LEIA *** stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the X-ray imager is *** optical assembly composed of 36 MPO chips is used to focus incident X-ray photons,and four large-format complementary metal-oxide semiconductor(CMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane *** instrument has an angular resolution of 4’-8’(in terms of FWhM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of *** detection passband is 0.5-4 keV in soft X-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s *** total weight of LEIA is 56 kg and the power is 85 *** satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 *** is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for X-ray observation,and by optimizing the working setups of the instrumental *** addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band,albeit with limited useful observing time available.

关键词： instrumentation detectors-space vehicles instruments-telescopes-X-rays genera

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Power management unit chip design for automobile active-matrix organic light-emitting diode display module

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Journal of Central South University 2009年第4期16卷 621-628页

作者： KIM J h PARK J h KIM J h CAO T V LEE T y ban h J yANG K KIM h G hA P B KIM y h Department of Electronic Engineering Changwon National University 9 Sarim-Dong Changwon 641-773 Korea Denso PS Electronics Corporation 47 Seongsan-Dong Changwon 641-315 Korea

A power management unit （PMU） chip supplying dual panel supply voltage, which has a low electro-magnetic interference （EMI） characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip＇s 0.25 μ high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done.

关键词： DC-DC converter AMOLED charge pumping power management unit (PMU) dual panel supply voltage

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Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Measurements and estimation of flow velocity in mobile bed rills

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International Journal of Sediment Research 2023年第1期38卷 97-104页

作者： yunyun ban China Agricultural University Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

Rills are primary sediment sources and hillslope water/sediment runoff transport channels. Water flow velocities in rills are easily affected by bed condition over eroding and non-eroding slopes, which is an important hydrodynamic process in soil erosion research. This research is done to demonstrate the poorly understood “feedback mechanism” related to slope independence of flow velocity to slope gradient. A series of experiments were done on silt loam soil slopes to measure water flow velocity in rills under nine unit width flow rates(q)(0.17 × 10-3, 0.33 × 10-3, 0.67 × 10-3, 1.33 × 10-3, 2.67 × 10-3,5.33 × 10-3, 10.67 × 10-3, 21.33 × 10-3, and 42.67 × 10-3m3/(s·m)) combined with four slope gradients(8.7%, 17.6%, 26.8%, and 36.4%), in which mobile bed rills were monitored. For unit flow velocity under q ≤ 1.33 × 10-3m2/s, independence of flow velocity to slope was obtained. however, the results indicated that slope gradient combined with a higher unit flow rate contributed to better velocity prediction and fitted with a segmented equation well(R2= 0.95). A feedback mechanism was able to verify that the increase in roughness directly dissipated flow energy to reduce flow velocity, but cannot completely counterbalances steep slope effect. The experimental results showed that erosion-caused morphological changes on soil slopes reduce flow velocity by half due to an increase in bed roughness. Therefore, the current experimental measurements considering a wide range of flow rate and slope gradient conditions is useful to reveal the steep slope effect in mobile bed rills. The analysis showed that, for the investigated conditions, the flow velocity is a slope gradient-and flow ratedependent parameter.

关键词： Flow velocity Flow rate Slope gradient Model fitting Slope morphology

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