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Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-Seq approach

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Animal models and Experimental medicine 2024年第1期7卷 36-47页

作者： Roa'a h.S.Yosief Iqbal m.Lone Aharon Nachshon heinz h.m.elbauer Irit Gat-Viks Fuad A.Iraqi Department of Clinical microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael School of molecular Cell Biology and Biotechnology George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Computational Biology Department of BiotechnologyUniversity of Natural Resources and Life SciencesMuthgasse 181190 ViennaAustria

Background:Aspergillus fumigatus(Af)is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic *** aim of this study was to search for candidate genes associated with host susceptibility to Aspergillus fumigatus(Af)using an RNAseq approach in CC lines and hepatic gene ***:We studied 31 male mice from 25 CC lines at 8 weeks old;the mice were infected with *** tissues were extracted from these mice 5 days post-infection,and next-generation RNA-sequencing(RNAseq)was *** GENE-E analysis platform was used to generate a clustered heat map ***:Significant variation in body weight changes between CC lines was *** gene expression revealed 12 top prioritized candidate genes differ-entially expressed in resistant versus susceptible mice based on body weight ***,three candidate genes are located within genomic intervals of the previ-ously mapped quantitative trait loci(QTL),including Gm16270 and Stox1 on chromo-some 10 and Gm11033 on chromosome ***:Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards *** a next step,eQTL analysis will be performed for our RNA-Seq *** candidate genes from our study will be further assessed with a h.m.n cohort with aspergillosis.

关键词： aspergillus fumigatus infection collaborative cross(CC)mice gene expression profile gene-network host susceptibility quantitative trait loci(QTL)mapping RNA-Seq

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mitigating Urban heat Island Effects: A Review of Innovative Pavement Technologies and Integrated Solutions

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Structural Durability & health.m.nitoring 2024年第5期18卷 525-551页

作者： S.F.Ismael A.h.Alias N.A.haron B.B.Zaidan Abdulrahman m.Abdulghani Department of Civil Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdang43400Malaysia Central Region Heavy Civil DivisionGranite ConstructionWoodlandsTexas77381USA SP Jain School of Global management LidcombeSydneyNSW2141Australia Department of Communication Technology and Network Faculty of Computer Science and Information TechnologyUniversiti Putra MalaysiaSerdang43400Malaysia

In this review paper,we present a thorough investigation into the role of pavement technologies in advancing urban *** analysis traverses the historical evolution of these technologies,meticulously evaluating their socio-economic and environmental impacts,with a particular emphasis on their role in mitigating the urban heat island *** evaluation of pavement types and variables inﬂuencing pavement performance to be used in the multi-criteria decision-making(mCDm)framework to choose the optimal pavement application are at the heart of our *** serves to assess a spectrum of pavement options,revealing insights into the most effective and sustainable *** highlighting both the existing challenges and potential innovative solutions within theﬁeld,this paper aims to offer a directional compass for future urban planning and infrastructural *** review not only synthesizes the current state of knowledge but also aims to chart a course for future exploration,emphasizing the critical need for innovative and environmentally sensitive pavement tech-nologies in the creation of resilient and sustainable urban environments.

关键词： Pavement sustainability urban heat island environmental impact of pavements innovative pavement solutions economic and social implications sustainable development in urban areas

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The impact of ch.m.therapy-naïve open radical cystectomy delay and perioperative transfusion on the recurrence-free survival: A perioperative parameters-based nomogram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： Ahmed m.harraz Ahmed Elkarta moh.m.d h.Zahran Ahmed mosbah Atallah A.Shaaban hassan Abol-Enein Urology and Nephrology Center Mansoura UniversityEgypt

Objective: To develop and internally validate a nomogram to predict recurrence-free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (n=948) and validating (n=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nomogram. Discrimination, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On multivariate analysis, independent predictors were TTC (hazards ratio [hR] 1.07, 95% confidence interval [CI] 1.05-1.08, phR 1.40, 95% CI 1.03-1.90, p=0.03;two or more units: hR 1.72, 95% CI 1.29-2.29, phydronephrosis (hR 1.54, 95% CI 1.21-1.97, pmous cell carcinoma (hR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (hR 1.77, 95% CI 1.41-2.22, pmph node status (hR 1.53, 95% CI 1.21-1.95, pmphovascular invasion (hR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nomogram with good discrimination, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectomy Blood transfusion Time to radical cystectomy Survival Nomogram

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Systematic study of rotational energy formulae for superdeformed bands in La and Ce isotopes

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Chinese Physics C 2017年第12期41卷 55-66页

作者： honey Sharma h.m. mittal Dr. B.R. Ambedkar National Institute of Technology Jalandhar 144011 India

The experimental rotational spectra of superdeformed（SD） bands of 130La, 131Ce（1,2）, 132Ce（1,2,3） and133 Ce（1,2,3） in the A～130 mass region are systematically analyzed with the four parameter formula, power index formula, nuclear softness formula, and VmI model. It is observed that out of all the formulae, the four parameter formula suits best for the study of the 130La, 131Ce（1,2）, 132Ce（2,3） and 133Ce（1,2,3） SD bands. The four parameter formula works efficiently in determining the band head spin of the 130La, 131Ce（1,2） 132Ce（2,3） and 133Ce（1,2,3） SD bands. Good agreement is seen between the calculated and observed transition energies whenever the accurate spin is assigned. In 132Ce（1）, the power index formula is found to work better than the other three formulae. The dynamic moment of inertia is also calculated for all the formulae and its variation with the rotational frequency is investigated.

关键词： superdeformed bands four parameter formula power index formula nuclear softness formula VmI model

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microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with different prestrain levels

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Journal of materials Science & Technology 2024年第4期171卷 80-93页

作者： Y.h.Zhang h.Li Z.W.Yang X.Liu Q.F.Gu State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of high-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape memory alloy(SmA)is a promising material in the aerospace field due to its wide transformation *** application of shape memory effect depends on multistep thermomechan-ical loading,viz.,low-temperature deformation and subsequent heating to ***-temperature deformation prestrain plays a pivotal role in shape memory properties tailoring of SmA ***,microstructure evolution and deformation mechanisms of Ni_(47)Ti_(44)Nb_(9)SmA subjected to vari-ous prestrain levels are still *** this end,microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with prestrain levels of 8%-16%at-28℃(m_(s)+30℃)were *** results demonstrate that the stress-strain curve of the specimen exhibits four distinct stages at a maximal prestrain of 16%.Whereas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,the stress-induced martensitic transformation is accompanied by the dislocation slip of the NiTi matrix andβ-Nb *** stageⅢ,in addition to the higher density of dislocations and further growth of stress-induced martensite variants(SImVs),(001)compound twins are introduced as a result of the(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and heating,a higher density of{114}austenite twins form in the specimen with a larger prestrain of 16%.With increasing prestrain from 8%to 16%,the recoverable strainε_(re)^(T)upon heating increases first and then ***ε_(re)^(T)obtains a maximum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to the formation of new SImVs,the further growth of existing SImVs,and the recoverable(001)compound *** the decrease ofε_(re)^(T)is mainly associated with the irrecoverable strain by{20−1}martensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)shape memory alloy Wide transformation hysteresis Thermomechanical loading microstructure evolution Shape memory behaviors Stress-induced martensitic transformation Deformation twinning

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Fish-on-Chips:unveiling neural processing of ch.m.cals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel K.h.Sy ho Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Shing Institute of health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina margaret K.L.Cheung Research Center for management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise ch.m.cal cue presentation alongside advanced brainwide imaging techniques is important to the study of ch.m.sensory processing in ***,the dynamic nature of ch.m.cal-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled ch.m.cal flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

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Band head spin determination of triaxial superdeformed bands in ^163,164,165Lu through two-parameter formulae

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Chinese Physics C 2018年第11期42卷 72-77页

作者： honey Sharma h.m. mittal Dr. B.R. Ambedkar National Institute of Technology Jalandhar 144011 India

The two-parameter formulae, i.e. the nuclear softness formula and the power index formula, have been used to obtain the band head spin （I0） of the triaxial superdeformed （SD） bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3）, in the A - 160 mass region. The least squares fitting approach is used. The values of the root mean square （RmS） deviation among the computed and the measured experimental transition energies are obtained by calculating the model parameters. Whenever accurate spins are available, superb agreement is shown between the determined and the measured experimental transition energies. In comparison to the power index formula, the values of band head spin （I0） of the triaxial SD bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3） obtained by the nuclear softness formula are closer to the experimental data. The lowest RmS deviation is also achieved by the nuclear softness formula. hence, the nuclear softness formula works well for obtaining the band head spin （I0） for the triaxial SD bands in ^163Lu（1,2,3,4）, ^164Lu（1,2,3） and ^165Lu（1,2,3） in the A-160 mass region. The dynamic moment of inertia against hω is also studied.

关键词： band head spin nuclear softness formula power index formula triaxial superdeformed bands

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Sustainable Resource Use in Enhancing Agricultural Development in China

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Engineering 2018年第5期4卷 588-589页

作者： Jianbo Shen Fusuo Zhang Kadambot h.m. Siddique National Academy of Agriculture Green Development Center for Resources Environment and Food Security College of Resources and Environmental SciencesChina Agricultural University Beijing 100193 China hackett Professor and Director of the UWA Institute of Agriculture The University of Western Australia Perth WA 6001 Australia

1. IntroductionChina is entering an impressive era of grain production since its reform and opening up in 1978. At present, China feeds 22% of the world population with only 9% of the world＇s arable land [1]. Thus, China has become a leader in the global fight against hunger[2] . Grain production has increased dramatically, from about 3 × 10^8t in 1978 to 6.21 × 10^8t in 2016, which is an annual increase rate of 9% [3].

关键词：改革开放中国粮食安全农业

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R & D ACTIVITIES ON AEROSPACE mATERIALS IN KOREA

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Acta metallurgica Sinica(English Letters) 1996年第6期9卷 417-421页

作者： h.m. Kim(Korea Institute of machinery and materials,Korea ) Korea Inst of machinery and Materials South Korea

This paper briefly reviews research and development programs in Korean aerospace industry,with an emphasis on aircraft materials technology. International collaborations in these areas are outlined and the R & D activities are highlighted against the background of the national *** is shown that the investment from government agencies and large enterprises has led to healthy development of aerospace materials industries in Korea.

关键词： R & D aerospace materials international collaboration Korea

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid h.A.L-hash.m.Salah O.Bashir Amal F.Dawood moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz m.Al-Garni moh.m.d D.morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the morris Water maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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