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Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of clinical cases 2025年第6期13卷 30-34页

作者： cheng-Feng Fu Li-Fen Yang Lei Tian song Deng Qi Zhang Biao Yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BAcKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome cardiac pacemaker Adverse drug reaction case report

The normal directions and shape of the magnetopause

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Science china Earth Sciences 1998年第5期41卷 486-491页

作者：吕建永 J.K.chao J.h.Shue h.c.Fu P.song center for Space Science and Applied Research Beijing China Institute of Space Science National Ccntral University Taiwan China Space Physics Research Laboratory University of Michigan University Toyokawa Japan

The minimum variance and tangential discontinuity analyses are used to find the normal directions of the magnetopause using 550 crossings from ISEE 1 and 2, AMPTE/IRM, and IMP 8 satellites. Then, the average shape of the magnetopause is studied by using two\|region fit procedure. These studies show: (i) most of the crossings are reasonably characterized as tangential discontinuity; (ii) there does appear to be east\|west and north\|south asymmetry in the shape of the magnetopause; (iii) the magnetopause in the equatorial region is swept back from the vacuum location for both northward and southward IMF, which means that the simple single conic section used in previous fits may not be appropriate to the entire shape of the magnetopause, especially at the nightside.

关键词： mapetopause MV analysis TD analysis solar wind

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes c.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). however, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Boosting corticospinal system synaptic plasticity to recover motor functions

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Neural Regeneration Research 2023年第10期18卷 2182-2183页

作者： Weiguo song John h.Martin Feinstein Institutes for Medical Research ManhassetNYUSA Department of Molecular Cellularand Biomedical SciencesCenter for Discovery and Innovation Neuroscience Program Graduate Center of the City University of New YorkNew YorkNYUSA

An importa nt strategy to promote voluntary movements after motor system injury is to strengthen the connections between the motor cortex and muscles by taking advantage of the plasticity of the corticospinal motor *** neuromodulation approaches are directed to activate the spinal cord and peripheral axons to strengthen muscle *** discuss in this perspective that,the cortex and spinal cord should be ta rgeted together to enhance cortex-to-musclefunction(Amer and Martin,2022).

关键词： plasticity system activation

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： hauser sclerosis damage

Experimental Study and Numerical Simulation of the casting-Forging complex Near Net Forming of Alternator claw-pole

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上海交通大学学报 2004年第Z2期38卷 79-82页

作者： J.L.song D.J.hu Q.c.Wang h.Q.chen h.G.Guo School of Mechanical and Power Engineering Shanghai Jiaotong University Shanghai200030 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China School of Mechanical and Power Engineering Shanghai Jiaotong University Shanghai200030 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China Scool of Materials Science and Engineering Taiyuan Heavy Machinery Institute Taiyuan030024 China

As a newly developed precision technology, casting-forging complex near net forming process is utilized to produce complex components with a short lead time, low cost and high precision, thus to accelerate the response speed of the market and enhance the competitive power of products. In this paper, the casting-forging complex near net forming process of alternator claw pole was developed and investigated with a combination of experimental and numerical simulation method. Qualified near net workpiece was manufactured, mechanical parameter and relative field information during the forming process was also obtained. While the alternator claw-pole is processed with this technology, the forming force is small, the process is short and the quality of forgings is perfect. Therefore, the complex casting-forging near net forming process of claw-pole is an energy and material saving technology, which will have a vast developing and application prospect in the future.

关键词： alternator claw-pole casting-forging near net forming numerical simulation

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of clinical cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying Tang Qi Yang Tian-Tian Meng song Li Jing Zhang Stomatological hospital and college Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BAcKGROUND complicated crown–root fracture (cRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the cRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated cRF and an additional root fracture.

关键词： complicated crown-root fracture Multiple root fracture Spontaneous healing cone-beam computed tomography Long-term follow-up case report

Influence of Ti^(4+) doping on hyperfine field parameters of Mg_(0.95)Mn_(0.05)Fe_(2-2x)Ti_(2x)O_4(0≤x≤0.7)

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Journal of central South University 2010年第6期17卷 1139-1143页

作者： KUMAR S PRAKASh R ALIMUDDIN chOI h K KOO B h song J I chUNG h JEONG h LEE c G School of Nano and Advanced Materials Engineering Changwon National UniversityChangwon 641773Korea Department of Mechanical Engineering Changwon National UniversityChangwon 641773Korea Department of Applied Physics Aligarh Muslim UniversityAligarh 202002India Department of Precision & Mechanical Engineering and BK21 Eco-Friendly heat & cooling Energy Mechanical Research Team Gyeongsang National U niversityTongyeong 650160Korea

The mixed spinel ferrite system Mg0.95Mn0.05Fe2-2xTizxO4 （0 ≤x ≤ 0.7） was synthesized by the conventional solid-state reaction technique. The effect of Ti^4＋ doping was studied by using the Moessbauer spectroscopy measurements at room temperature. From the analysis of the Moessbauer spectra, it is observed that s-electron density, electric field gradient （EFG）, quadrupole coupling constant （Qcc） and the net hyperfine magnetic fields acting on the Moessbauer nuclei-FeA^3＋ and FeB^3＋ change with the increase of Ti^4＋ doping in Mg0.95Mn0.05Fe2O4. The hyperfine magnetic field decreases with the increase of Ti^4＋ doping.

关键词： spinel ferrite Moessbauer spectroscopy hyperfine magnetic field isomer shift Ti^4+ doping

Impedance spectroscopy study on Mn_(1+x)Fe_(2-2x)Ti_xO_4(0≤x≤0.5) ferrites

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Journal of central South University 2010年第6期17卷 1133-1138页

作者： KUMAR S BATOO K M PRAKASh R chOI h K KOO B h song J I chUNG h JEONG h LEE c G School of Nano and Advanced Materials Engineering Changwon National UniversityChangwon 641773Korea King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia Department of Mechanical Engineering Changwon National UniversityChangwon 641773Korea Department of Precision & Mechanical Engineering and BK21 Eco-Friendly heat & cold Energy Mechanical Research Team Gyeongsang National U niversityTongyeong 650160Korea

The complex impedance spectroscopy and surface morphology of Mn1+xFe2-2xTixO4(0≤x≤0.5) system,prepared using a conventional solid state reaction technique,were *** impedance spectroscopy measurements were carried out at room temperature in the frequency range of 42-5 *** electrical processes in the samples were modeled in the form of an equivalent circuit made up of a combination of two parallel Rc circuits attributed to grain and grain *** Dc conductivity obtained by extrapolation of Ac data using impedance spectroscopy and four-probe method increases at 10% doping of Ti *** energy-dispersive X-ray(EDX) pattern confirmed the homogeneous mixing of the Mn,Fe,Ti and O atoms in pure and doped ferrite samples.

关键词： spinel ferrite magnetic properties impedance spectroscopy Ti4+ ions doping