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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di Wu Yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and human health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

NiO-Doped Fe_(2)O_(3)/MgO Properties for the Chemical Looping Oxidative Dehydrogenation of Ethane

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 27-33页

作者： Liang hao Chen Junjie sun Jie sun hui Shenyang Ligong University Shenyang 110159China Fushun Ecology Environment Bureau Qingyuan County Branch Fushun 113399China

Ethane chemical looping oxidative dehydrogenation(CL-ODh)to ethylene is a new technology for ethylene ***_(2)O_(3)/MgO oxygen carrier was prepared using the co-precipitation *** influence of added NiO and its different loadings on Fe_(2)O_(3)/MgO were ***,a series of oxygen carriers were applied in the CL-ODh of the ethane cycle ***-Emmett-Teller(BET),x-ray diffractometry(xRD),x-ray photoelection spectroscopy(xPS),and h2-temperature programmed reduction(TPR)were used to characterize the physicochemical properties of these oxygen *** was confirmed that an interaction between NiO and Fe_(2)O_(3) occurred based on the xPS and h2-TPR *** on the CL-ODh activity performance tests conducted in a fixed-bed reactor,it was revealed that ethylene selectivity was significantly improved after NiO ***_(2)O_(3)-10%NiO/MgO showed the best activity performance with 93%ethane conversion and 50%ethylene selectivity at a reaction temperature of 650℃,atmospheric pressure,and space velocity of 7500 mL/(g·h).

关键词： chemical looping oxidative dehydrogenation oxygen carrier Fe_(2)O_(3)/MgO NiO

Catalyst design and structure control for photocatalytic refineries of cellulosic biomass to fuels and chemicals

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Journal of Energy Chemistry 2024年第7期94卷 102-127页

作者： Lulu sun Nengchao Luo State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Lignocellulosic biomass is the largest renewable hydrocarbon resource on *** cellulose,one of the major components of lignocellulose,powered by solar energy is a promising way of providing lowcarbon-footprint energy chemicals such as h_(2),hCOOh,CO,and transportation ***-of-the-art biorefineries target the full use of biomass feedstocks as they have a maximum collection radius of 75-100 km,requesting efficient and selective photocatalysts that significantly influence the outcome of photocatalytic ***-performed photocatalysts can harvest a broad solar spectrum and are active in breaking the chemical bonds of cellulose,decreasing the capital investments of ***,photocatalysts should control the selectivity of cellulose conversion,originating target products to level down separation *** separation in photocatalysts and interfacial charge transfer between photocatalysts and cellulose affect the activity and selectivity of cellulose refineries to h2 and carbonaceous *** account for the challenges above,this review summarizes photocatalysts for the refineries of cellulose and downstream platform molecules based on the types of products,with the structure features of different types of photocatalysts discussed in relation to the targets of either improving the activity or product *** addition,this review also sheds light on the methods for designing and regulating photocatalyst structures to facilitate photocatalytic refineries of cellulose and platform molecules,meanwhile summarizing proposed future research challenges and opportunities for designing efficient photocatalysts.

关键词： Photocatalysts Biorefineries Cellulose Fuels hydrogen

Blindness-free beam scanning antenna with array of array architecture: principle,design,and experiment

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Science China(Information Sciences) 2024年第3期67卷 209-224页

作者： Jianxu sun Yujian ChENG School of Electronic Science and Engineering University of Electronic Science and Technology of China

This paper presents a 66–76-Ghz sparsely-excited phased array antenna with the array of array(Ao A) architecture for eliminating the blindness and suppressing the grating lobe when scanning. For the array antennas printed on the thick dielectric layers with high relative permittivity, scanning blindness appears and seriously impacts the radiation performance. To address this issue, the Ao A topology is developed first. It finds that the scanning blindness appears due to the coupling of the radiating Floquet modes to the non-radiating surface wave(SW) modes. Therefore, the array is divided into two types of domino *** inner-phase distributions are introduced into the domino subarrays to break the one-to-one relationship between the Floquet mode and the SW mode. Then, the blindness inside ±60° scanning volume is eliminated by the aperiodic subarrays. Meanwhile, the aperiodic inner-phase distributions enhance the aperiodicity of the array and contribute to suppressing the grating lobe when scanning. Next, the meta-surface-based dipole with the shorted post is chosen as the unit cell for the proposed aperiodic array. Based on these methods,the array achieves the wide-scanning performance of ±60° in the E-plane and ±30° in the h-plane, without the blindness and the grating lobe. Finally, the 16×16 array is built and simulated with the dimension of32 mm × 32 mm. At the highest operating frequency, the simulated gains are 28.42, 25.17, and 24.01 d Bi when scanning to the broadside, 50° in the E-plane, and 30° in the h-plane, respectively. Compared to the ideal gain, it shows that the simulated radiation efficiency is about 84.13%, 62.08%, and 35.23% when scanning to the broadside, 50° in the E-plane, and 30° in the h-plane, respectively. The worst transmission coefficient, i.e., the worst isolation, is-11.97 d B between the central element and its two adjacent elements in the E-plane. The array prototypes are fabricated, and the experiments are carried out to ver

关键词： 6G communication systems phased array AoA aperiodic subarray wideband wide-scanning surface-wave scanning blindness grating lobe

Self-Aligning Multi-Modal Transformer for Oropharyngeal Swab Point Localization

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Tsinghua Science and Technology 2024年第4期29卷 1082-1091页

作者： Tianyu Liu Fuchun sun Department of Computer Science and Technology Tsinghua UniversityBeijing 100083China

The oropharyngeal swabbing is a pre-diagnostic procedure used to test various respiratory diseases, including COVID and Influenza A (h1N1). To improve the testing efficiency of testing, a real-time, accurate, and robust sampling point localization algorithm is needed for robots. however, current solutions rely heavily on visual input, which is not reliable enough for large-scale deployment. The transformer has significantly improved the performance of image-related tasks and challenged the dominance of traditional convolutional neural networks (CNNs) in the image field. Inspired by its success, we propose a novel self-aligning multi-modal transformer (SAMMT) to dynamically attend to different parts of unaligned feature maps, preventing information loss caused by perspective disparity and simplifying overall implementation. Unlike preexisting multi-modal transformers, our attention mechanism works in image space instead of embedding space, rendering the need for the sensor registration process obsolete. To facilitate the multi-modal task, we collected and annotate an oropharynx localization/segmentation dataset by trained medical personnel. This dataset is open-sourced and can be used for future multi-modal research. Our experiments show that our model improves the performance of the localization task by 4.2% compared to the pure visual model, and reduces the pixel-wise error rate of the segmentation task by 16.7% compared to the CNN baseline.

关键词： segmentation localization transformer multi-modal perception robotic perception

Effect of nourishing Yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： sun Yanyan xUE Yuanyuan sun Wen WANG Yonghong YU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJECTIVE:To elucidate the mechanism of the nourishing Yin and purging fire Chinese herbal mixture(NYPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were randomly assigned to normal group(N),long light exposure group(L),NYPF and normal saline group(NS).Rats in the L,NYPF and NS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the N group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the NYPF group or NS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-E1),and on the day when the second estrous interphase occurred in rats of L group(L-E2),***:On day 34,all rats in the L group,80%of rats in the NS group,40%of rats in the N group,and 20%of rats in the NYPF group showed complete opening of the *** P28,m RNA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the N group(Phe rats in the L and NS groups had significantly lower hypothalamic argininephenylalanine-amide(RFamide)-related peptide 3(RFRP-3)m RNA levels than those in the N group(Phereas RFRP-3 m RNA level was significantly higher in the NYPF group than that in the L group(Phe ovarian index of the L and NS groups was significantly higher than that of the N group(Phe NYPF group was significantly lower than that of the N and NS groups(Phypothalamic Kiss-1 m RNA level in the L and NS groups was significantly higher than that in the N and NYPF groups(Phereas hypothalamic RFRP-3 m RNA level in the L,NYPF,and NS groups was significantly lower than that in the N group(Phe L and NS groups was significantly higher than that of the N group(Pher

关键词： light puberty precocious kisspeptins RFRP-3 melatonin Nourishing Yin and Purging Fire

In situ biosynthesis of bacterial cellulose hydrogel spheroids with tunable dimensions

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Journal of Bioresources and Bioproducts 2024年第1期9卷 90-101页

作者： Bianjing sun Ping Wang Jingang Zhang Jianbin Lin Lingling sun xiaokun Wang Chuntao Chen Dongping sun Institute of Chemicobiology and Functional Materials School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China Zhonghao Chenguang Chemical Research Institute Co. Ltd.Zigong 643201China

Bacterial cellulose(BC)hydrogel spheroid plays a significant role in diverse fields due to its spatial 3D structure and *** the present work,a series of BC spheroids with controllable size and shape was obtained via an in situ *** factors for fabricating BC spheroid in-cluding inoculum concentration of 1.35×10^(3)CFU/mL,shaking speeds at 100 r/min,and 48-96 h incubation time during the biosynthetic process,were comprehensively *** operable mechanism model for tuning the size of BC spheroids from 0.4 to 5.0 mm was proposed with a fresh feeding medium strategy of dynamic *** resulting BC spheroids exhibit an inter-active 3D network of nanofibers,a crystallinity index of 72.3%,a specific surface area of 91.2 m^(2)/g,and good *** study reinforces the understanding of BC spheroid forma-tion and explores new horizons for the design of BC spheroids-derived functional matrix materials for medical care.

关键词： In situ biosynthesis Bacterial cellulose hydrogel Spheroid Tunable dimension

Neddylation Regulation of Immune Responses

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Research 2024年第3期2023卷 545-559页

作者： hongmei Mao xin Lin Yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for Immunology School of MedicineTsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Cancer Center of Zhejiang University Hangzhou 310029China Zhejiang Provincial Clinical Research Center for Cancer HangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences HangzhouZhejiang ProvinceChina Research Center for Life Science and human health Binjiang Institute of Zhejiang UniversityHangzhou 310053China.

Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关键词： activation thereby initiating

Tetraethylenepentamine-functionalized magnetic mesoporous composites as a novel adsorbent for the removal Cr(Ⅲ)-ethylenediaminetetraacetic acid in complex solution

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Chinese Journal of Chemical Engineering 2024年第4期68卷 16-26页

作者： Zhi hu Jiahong Wang Tongtong sun School of Environmental Science and Engineering Shaanxi University of Science&TechnologyXi'an 710021China Shaanxi Key Laboratory of Green Preparation and Functionalization of Inorganic Materials Xi'an 710021China

A novel tetraethylenepentamine(TEPA) functionalized magnetic mesoporous silica adsorbent(FNMs/TEPA) was prepared for the adsorption of Cr(Ⅲ)-ethylenediaminetetraacetic acid(EDTA)from wastewater. The characterization of the prepared adsorbent certified that TEPA was modified onto the magnetic mesoporous silicon(FNMs), while FNMs/TEPA maintained the ordered mesoporous and pristine magnetic properties. The batch adsorption experiments demonstrated that TEPA significantly enhanced the removal capacity of the adsorbent for Cr(Ⅲ)-EDTA. FNMs/TEPA exhibited an excellent adsorption property(13.84 mg·g-1) at p h 4.0. Even in the presence of high concentrations of coexisting ions and organic acids, the adsorption performance of FNMs/TEPA was stable. Experimental characterization and DFT demonstrated that the adsorption of Cr(Ⅲ)-EDTA was ascribed to the electrostatic interaction, hydrogen bonding, and complexation between Cr(Ⅲ)-EDTA and amino groups on the adsorbent surface. The analysis of the independent gradient model(IGM) shows that electrostatic interaction is the main mode of action in the adsorption process. Moreover, FNMs/TEPA demonstrated remarkable reusability in three regeneration cycles. These findings indicated that FNMs/TEPA possessed excellent application prospects in the disposal of wastewater containing Cr(Ⅲ)-EDTA.

关键词： TEPA functionalized magnetic mesoporous silicon Adsorption Cr(III)-EDTA Density functional theory calculations