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Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors

Bioactive Materials 2022年第5期7卷 107-117页

作者： A.Khodaei F.Jahanmard h.R.Madaah hosseini R.Bagheri A.Dabbagh h.weinans Amin Yavari Institute for nanoscience and nanotechnology sharif university of technologytehraniran department of orthopedics university medical center utrechtutrechtthe netherlands department of materials science and engineering sharif university of technologytehraniran school of medicine faculty of health and medical sciencestaylor’s universitysubang jayamalaysia regenerative medicine utrecht utrecht universityutrechtthe netherlands

Systemic chemotherapy has lost its position to treat cancer over the past years mainly due to drug resistance,side effects,and limited survival *** a plethora of local drug delivery systems to solve this issue,the combinatorial strategy of chemo-hyperthermia has recently received *** we developed a magneto-thermal nanocarrier consisted of superparamagnetic iron oxide nanoparticles(SPIONs)coated by a blend formulation of a three-block copolymer Pluronic F127 and F68 on the oleic acid(OA)in which Curcumin as a natural and chemical anti-cancer agent was *** subsequent nanocarrier SPION@OA-F127/F68-Cur was designed with a controlled gelation temperature of the shell,which could consequently control the release of *** release was systematically studied as a function of temperature and ph,via response surface methodology(RSM).The bone tumor killing efficacy of the released curcumin from the carrier in combination with the hyperthermia was studied on MG-63 osteosarcoma cells through Alamar blue assay,live-dead staining and apoptosis caspase 3/7 activation *** was found that the shrinkage of the F127/F68 layer stimulated by elevated temperature in an alternative magnetic field caused the curcumin *** the maximum release concentration and cell death took place at 45℃,treatment at 41℃ was chosen as the optimum condition due to considerable cell apoptosis and lower side effects of mild *** cell metabolic activity results confirmed the synergistic effects of curcumin and hyperthermia in killing MG-63 osteosarcoma cells.

关键词： Osteosarcoma Magnetic hyperthermia Curcumin MRI contrast agent

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