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Detection and Local Staging of Prostate Cancer by 68Ga-PSMA-PET/CT, Comparison with mpMRI and histopathology

Advances in Molecular Imaging 2020年第3期10卷 15-29页

作者： F. Intema A. Kooistra M. C. Vermeulen R. M. hoeben A. M. van de Berk A. Lont W. Dingemans L. M. andrews G. K. Lammers J. M. h. de Klerk Department of Radiology and Nuclear Medicine Meander Medical Centre Amersfoort The Netherlands Department of Urology Meander Medical Centre Amersfoort The Netherlands Department of Pathology Meander Medical Centre Amersfoort The Netherlands hospital Pharmacy Meander Medical Centre Amersfoort The Netherlands

Introduction: 68Ga-PSMA-PET/CT has proven its value in prostate cancer with high positive predictive value for lymph node metastasis and superior detection of distant metastasis. There is growing evidence that 68Ga-PS... 详细信息

ong>Introduction:ong> 68Ga-PSMA-PET/CT has proven its value in prostate cancer with high positive predictive value for lymph node metastasis and superior detection of distant metastasis. There is growing evidence that 68Ga-PSMA- PET/CT has high sensitivity for detection of tumor lesions in the prostate as well. Studies thus far have mainly been performed in patients prior to prostatectomy. Aim of this study is to evaluate diagnostic accuracy in a mixed population of men with increased risk of prostate cancer and evaluate diagnostic possibilities with respect to extra-capsular extension and seminal vesicle invasion. ong>Methods:ong> The population consisted of a retrospectively included sequential cohort of 69 patients with 68Ga-PSMA-PET/CT and mpMRI available. 68Ga-PSMA-PET/CT was re-evaluated by two readers blinded for mpMRI and clinical information. Likelihood of tumour presence, extra-prostatic extension and seminal vesicle invasion was scored on 5-point Likert scale and localized schematically. Results were compared with mpMRI. Available pathological outcome served as gold standard. SUVmax of index lesions was measured and correlated to index tumor Gleason grade. ong>Results:ong> Clinically significant prostate cancer (Gleason ≥ 3 + 4) was detected in 57 (83%) of 69 patients. Diagnostic accuracy was 89% for PET reader 1, 93% for PET reader 2 and 86% for mpMRI. Lesion concordance of 68Ga-PSMA-PET/CT and mpMRI was 97%. SUVmax of the index lesion correlated to Gleason grade. Sensitivity for extracapsular extension in the prostatectomy group was 62% for PET reader 1, 33% for PET reader 2 and 50% for mpMRI. Specificity was 62% for PET reader 1, 100% for PET reader 2 and 69% for mpMRI. ong>Conclusion:ong> Ga68-PSMA-PET shows high accuracy in the detection of tumor lesions in the prostate. Results on evaluating extra-capsular extension and seminal vesicle invasion are comparable to mpMRI. This study adds to the increasing evidence th

关键词： Prostate Cancer Detection Local Staging 68-Gallium-Prostate Specific Membrane Antigen-Positron Emission Tomography Multiparametric Magnetic Resonance Imaging

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环氧树脂和玻璃粘合的研究

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高等学校化学学报 1984年第5期5卷 740-745页

作者：何平笙 E.h.安德鲁斯 C.符拉柯斯中国科学技术大学应用化学系伦敦大学玛丽皇后学院材料系

以断裂力学方法研究了环氧树脂与玻璃的粘合及添加偶联剂的影响.测定了该粘合在80℃水中不同浸泡时间、不同偶联剂、不同偶联剂浓度和不同ph值的断裂能.利用andrews普适断裂力学理论求得了破坏单位截面积界面上原子键合的界面能θ_(o)... 详细信息

以断裂力学方法研究了环氧树脂与玻璃的粘合及添加偶联剂的影响.测定了该粘合在80℃水中不同浸泡时间、不同偶联剂、不同偶联剂浓度和不同ph值的断裂能.利用andrews普适断裂力学理论求得了破坏单位截面积界面上原子键合的界面能θ_(o)及水对θ_(o)的影响符合一级反应规律.比较了θ_(o)值与界面范得华相互作用能.推算出环氧树脂-玻璃粘合中至少有部分是主价键合.

关键词：环氧树脂偶联剂界面能断裂力学方法断裂力学理论粘合反应规律截面积

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Thermo-optically induced transparency on a photonic chip

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Light(Science & Applications) 2021年第12期10卷 2482-2491页

作者： Marco Clementi Simone Iadanza Sebastian A.Schulz Giulia Urbinati Dario Gerace Liam o’Faloain Matteo Galli Dipartimento di Fisica Universitàdi PaviaVia A.Bassi 627100 PaviaItaly Centre for Advanced Photonics and Process Analysis Munster Technological UniversityRossa Ave BishopstownCorkT12 P928Ireland Tyndall National Institute Lee Maltings Complex Dyke ParadeCorkT12 R5CPIreland SUPA School of Physics and AstronomyUniversity of St.AndrewsFifeKY169SSUK Present address:École Polytechnique Fédérale de Lausanne Photonic Systems Laboratory(PHOSL)STI-IELStation 11Lausanne1015Switzerland

Controlling the optical response of a medium through suitably tuned coherent electromagnetic fields is highly relevant in a number of potential applications,from all-optical modulators to optical storage *** particular,electromagnetically induced transparency(EIT)is an established phenomenon in which destructive quantum interference creates a transparency window over a narrow spectral range around an absorption line,which,in turn,allows to slow and ultimately stop light due to the anomalous refractive index *** we report on the observation of a new form of both induced transparency and amplification of a weak probe beam in a strongly driven silicon photonic crystal resonator at room *** effect is based on the oscillating temperature field induced in a nonlinear optical cavity,and it reproduces many of the key features of EIT while being independent of either atomic or mechanical *** thermo-optically induced transparency will allow a versatile implementation of EIT-analogs in an integrated photonic platform,at almost arbitrary wavelength of interest,room temperature and in a practical,low cost,and scalable system.

关键词： temperature transparency oscillating

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Emission from quantum-dot high-β microcavities: transition from spontaneous emission to lasing and the effects of superradiant emitter coupling

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Light(Science & Applications) 2017年第1期6卷 638-645页

作者： Sören Kreinberg Weng W Chow Janik Wolters Christian Schneider Christopher Gies Frank Jahnke Sven höfling Martin Kamp Stephan Reitzenstein 无 Institut für Festkörperphysik Technische Universität BerlinBerlin 10623Germany Sandia National Laboratories AlbuquerqueNM 87185-1086USA Lehrstuhl für Technische Physik Universität WürzburgWürzburg 97074Germany School of Physics and Astronomy University of St AndrewsSt Andrews KY169SSUK Institute for Theoretical Physics University of BremenBremen 28334Germany

Measured and calculated results are presented for the emission properties of a new class of emitters operating in the cavity quantum electrodynamics *** structures are based on high-finesse GaAs/AlAs micropillar cavities,each with an active medium consisting of a layer of InGaAs quantum dots(QDs)and the distinguishing feature of having a substantial fraction of spontaneous emission channeled into one cavity mode(highβ-factor).This paper demonstrates that the usual criterion for lasing with a conventional(lowβ-factor)cavity,that is,a sharp non-linearity in the input–output curve accompanied by noticeable linewidth narrowing,has to be reinforced by the equal-time second-order photon autocorrelation function to confirm *** paper also shows that the equal-time second-order photon autocorrelation function is useful for recognizing superradiance,a manifestation of the correlations possible in high-βmicrocavities operating with *** terms of consolidating the collected data and identifying the physics underlying laser action,both theory and experiment suggest a sole dependence on intracavity photon *** for this assertion comes from all our measured and calculated data on emission coherence and fluctuation,for devices ranging from light-emitting diodes(LEDs)and cavity-enhanced LEDs to lasers,lying on the same two curves:one for linewidth narrowing versus intracavity photon number and the other for g(2)(0)versus intracavity photon number.

关键词： coherence laser physics microlasers nanolasers optoelectronics photon statistics quantum dots quantum optics

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出生前被诊断为先天性心脏病的早产儿的转归

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 40-41页

作者： andrews R. E. Simpson J. M. Sharland G. K. 王一飞(译) - J. PEDIATR. 2006 148/2(213 -216) 不详

objective:To determine outcome of delivery before 36 weeks gestation in babie s diagnosed antenatally with serious congenital heart disease(ChD).Study desig n:A retrospective database review at 2 tertiary care fetal cardiology *** of neonatal course and outcome were obtained for those antenatally diagn osed with serious ChD who were live born before 36 weeks ***:Bet ween January 1998 and December 2002,9918 women were referred for fetal echocard *** ChD was diagnosed in 1191 fetuses(12%),of which 46(4%)de livered *** gestation was 33(range 24-35)weeks,and median bi rth weight 1.56(0.50-3.59)***/karyotypic anomalies occurred in 23(50%).Twenty-six babies(57%)underwent neonatal surgery:16 a cardiac pr ocedure,5 a general surgical procedure,and 5 *** died during or after operation(31%).Two babies underwent interventional heart catheterization;bot h *** overall mortality rate was 72%.Extracardiac/karyotypic anomalies i ncreased the relative risk of death by a factor of *** hospital stay for those surviving to initial discharge was 46(2-137)***:There is a very high morbidity and mortality rate in this group,particularly for those with extracardiac/karyotypic *** should be reflected in decisions ov er elective preterm delivery and when counseling parents.

关键词：先天性心脏病出生前早产儿诊断转归平均出生体重胎儿心脏病心脏超声检查回顾性分析新生儿期

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A DIURNAL EVALUATIoN oF IoP IN PA-TIENTS TREATED WITh TRAVATAN oR XALATAN

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国际眼科杂志 2003年第1期3卷 115-115页

作者： h.DuBiner M.Ratliff T.Landry F.Turner S.M.Robertson R.M.andrews A.L.Weiner J.Pryzdryga Clayton Eye Center Clayton Eye CenterClayton Eye CenterAlcon Research Ltd.Alcon Research Ltd.Alcon Research Ltd.Alcon Research Ltd.Alcon Laboratories Inc. USA

Purpose: To determine the IoP over a 44 hour following discontinuation of daily Travatan or Xalatan, thus simulating the duration of action of a missed dose. Methods: This was a double-masked, randomized parallel study conducted at a single site. 35 patients with elevated IoP (24-36mmhg at 0800) were washed off prior medications and baseline pressures were measured every 4 hours for 24 hours. Patients then received

关键词：曲福前列素拉坦前列素治疗 IoP 昼夜变化

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Sharpening emitter localization in front of a tuned mirror

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Light(Science & Applications) 2018年第1期7卷 71-78页

作者： hannah S.heil Benjamin Schreiber Ralph Götz Monika Emmerling Marie-Christine Dabauvalle Georg Krohne Sven höfling Martin Kamp Markus Sauer Katrin G.heinze Rudolf Virchow Center Research Center for Experimental BiomedicineUniversity of WürzburgJosef-Schneider-Str.297080 WürzburgGermany Department of Biotechnology and Biophysics BiozentrumUniversity of WürzburgAm Hubland97074 WürzburgGermany Technische Physik Physikalisches Institut and Wilhelm Conrad Röntgen-Center for Complex Material SystemsUniversity of WürzburgAm Hubland97074 WürzburgGermany Division of Electron Microscopy BiozentrumUniversity of WürzburgAm Hubland97074 WürzburgGermany SUPA School of Physics and AstronomyUniversity of St AndrewsSt Andrews KY169SSUK

Single-molecule localization microscopy(SMLM)aims for maximized precision and a high signal-to-noise *** features can be provided by placing the emitter in front of a metal-dielectric nanocoating that acts as a tuned mirror2–***,we demonstrate that a higher photon yield at a lower background on biocompatible metal-dielectric nanocoatings substantially improves SMLM performance and increases the localization precision by up to a factor of *** resolution improvement relies solely on easy-to-fabricate nanocoatings on standard glass coverslips and is spectrally and spatially tunable by the layer design and wavelength,as experimentally demonstrated for dual-color SMLM in cells.

关键词： emitter mirror tunable

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对设计过程中结构化技术设计的引导

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工程设计学报 1999年第3期6卷 12-18页

作者： h.Rⅹper 黄靖远福特有限公司 John-Andrews开发中心清华大学精仪系 100084

本文说明，设计者怎样在技术设计过程中减少所需的迭代步数和时间的花费。对此，文章为设计元素之间的相互关系建立了图表，由此图表并借助于适当的算法导出了一种有利的各个步骤的顺序。

关键词：设计过程结构化技术设计技术系统

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