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A statistical approach to enhance the productivity of streptomyces baarensis mh-133 for bioactive compounds

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synthetic and systems Biotechnology 2024年第2期9卷 196-208页

作者： mohamed h.Kalaba Gamal m.El-sherbiny Osama m.darwesh saad A.moghannem Botany and microbiology department Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt Agricultural microbiology department National Research CentreDokkiCairoEgypt

The goal of this study was to use statistical optimization to change the nutritional and environmental conditions so that streptomyces baarensis mh-133 could make more active *** trials were used to screen for critical variables influencing productivity using the placket-Burman design *** mh-133 is significantly influenced by elicitation,yeast extract,inoculum size,and incubation period in terms of antibacterial activity.A total of 27 experimental trials with various combinations of these factors were used to carry out the response surface technique using the Box-Behnken *** analyses revealed that the model was highly significant(ph a lack-of-fit of 0.212 and a coefficient determination(R2)of ***,the model predicted that the response as inhibition zone diameter would reach a value of 27 *** optimal conditions,*** mh-133 produced 18.0 g of crude extract to each 35L and was purified with column *** active fraction exhibiting antibacterial activity was characterized using spectroscopic *** mIC and mBC values varied between 37.5 and 300μg/ml and 75 and 300μg/ml,*** conclusion,the biostatistical optimization of the active fraction critical variables,including environmental and nutritional conditions,enhances the production of bioactive molecules by streptomyces species.

关键词： s.baarensis mh-133 placket-Burman designBox-Behnken design EsKApE Antibacterial activity

Battery health management-a perspective of design,optimization,manufacturing,fault detection,and recycling

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Energy storage and saving 2024年第3期3卷 190-208页

作者： pavel m.Roy harsh h.sawant pratik p.shelar prashil U.sarode s.h.Gawande Industrial Tribology Laboratory Department of Mechanical EngineeringM.E.S.College of EngineeringSavitribai Phule Pune UniversityPune411007India

This paper explores the key aspects of battery technology,focusing on lithium-ion,lead-acid,and nickel metal hydride(Nimh)*** delves into manufacturing processes and highlighting their significance in optimizing battery *** addition,the study investigates battery fault detection,emphasizing the importance of early diagnosis using artificial intellignece(AI)and machine learning(mL)*** paper also addresses battery recycling techniques,discussing methods such as pyrometallurgy,hydrometallurgy,mechanical separation,and electrodialysis,considering their environmental *** comprehensive analysis sheds light on the evolution of battery technology and its role in sustainable energy systems.

关键词： Battery health manufacturing Fault detection Recycling

Unequal distribution of Innovation Efforts for Neglected Tropical diseases: The Role of Funding Evaluation Criteria

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health 2024年第5期16卷 490-520页

作者： Anne m. G. Neevel Kenneth d. s. Fernald Linda h. m. van de Burgwal Athena Institute Faculty of Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Background: International research and innovation efforts for neglected tropical diseases have increased in recent decades due to disparities in overall health research funding in relation to global burden of disease. however, within the field of neglected tropical diseases some seem far more neglected than others. In this research the aim is to investigate the distribution of resources and efforts, as well as the mechanisms that underpin funding allocation for neglected tropical diseases. methodology: A systematic literature review was conducted to establish a comprehensive overview of known indicators for innovation efforts related to a wide range of neglected tropical diseases. Articles were selected based on a subjective evaluation of their relevance, the presence of original data, and the breadth of their scope. This was followed by thirteen in-depth open-ended interviews with representatives of private, public and philanthropic funding organizations, concerning evaluation criteria for funding research proposals. Results: The findings reveal a large difference in the extent to which the individual diseases are neglected with notable differences between absolute and relative efforts. Criteria used in the evaluation of research proposals relate to potential impact, the probability of success and strategic fit. private organizations prioritize strategic fit and economic impact;philanthropic organizations prioritize short-term societal impact;and public generally prioritize the probability of success by accounting for follow-up funding and involvement of industry. Funding decisions of different types of organizations are highly interrelated. Conclusions: This study shows that the evaluation of funding proposals introduces and retains unequal funding distribution, reinforcing the relative neglect of diseases. societal impact is the primary rationale for funding but application of it as a funding criterion is associated with significant challenges. Furthermore, curre

关键词： Neglected Tropical diseases Funding decision Evaluation Criteria health Research Funding Research Impact

In vivo and in vitro study of resorbable magnesium wires for medical implants:mg purity,surface quality,Zn alloying and polymer coating

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Journal of magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar J.Luňácková m.Jex m.Žaloudková R.Vrbová m.Bartoš p.Klein L.Vištejnová J.dušková E.Filová Z.sucharda m.steinerová s.habr K.Balík A.singh department of materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of dental medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic department of physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic department of Composites and Carbon materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic department of pathological physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic department of histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for structural materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and h_(2)generation limit the potential of mg-based *** low-alloyed mg-Zn wires can strongly reduce problems with large h_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure mg,commercially pure mg,mg-0.15Zn,mg-0.4Zn and mg-1Zn was ***,mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed mg-induced osteogenesis,polymer-coated mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： magnesium Resorbable mg wire mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation

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Large magnetocaloric effect and magnetic properties of EuRhO3

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Journal of Rare Earths 2024年第9期42卷 1724-1729页

作者： m.Lassri m.sajieddine A.Elouafi A.El hachmi s.El Ouahbi R.moubah Laboratory of Energy and materials Engineering (LGEm) University of Sultan Moulay SlimaneFaculty of Science and Technology (FST) Institute of Applied physics (IAp)-school of Industrial management (EmINEs) Mohammed Ⅵ Polytechnic University National school of Applied sciences (ENsA) University of Sultan Moulay Slimane Laboratory of mechanics Production and Industrial Engineering (LMPGI)Higher School of Technology of Casablanca (ESTC)University of Hassan Ⅱ Casablanca Laboratory of Radiation on matter and Instrumentation (LRmI) Faculty of Science and Technology (FST) SettatHassan Ⅰ University Laboatory of physics of Advanced materials and Thermic (LpmAT) Faculty of Science Ain Chock (FSAC)University of Hassan Ⅱ Casablanca

We report on the structural,magnetic,and magnetocaloric properties of *** oxidation states of Eu and Rh ions were studied using X-ray photoelectron spectroscopy（Xps）.It is found that the Eu ions are mainly in the divalent oxidation state while the Rh ions have+4 ***3powders are found to be antiferromagnetic with a second order magnetic transition at Neel temperature（TN=2.9 K）.Analysis of the magnetic susceptibility versus temperature data in terms of the Curie=Weiss law:(χ=C/（T-θW）) for T>TN,yields θW=-3.1 K and effective magne tic moment ■,which is close to the theoretical value ■.The magnetic entropy change(-Δsm),was determined by em ploying the thermodynam ic maxwell's *** μ0h=5 T and near TN,■ and relative cooling power（RCp） exhibit large values of 33.7 J/（kg·K） and 238 J/kg,*** large magnitude of-Δsmand RCp show that the EuRhO3compound could be a potential candidate to be used in cryogenic magnetic refrigeration.

关键词： Cryogenic magnetic refrigeration magnetic properties magnetocaloric effect Rare earths X-ray photoelectron spectroscopy

The dorsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen martínez-padilla Lourdes sánchez-salido Anne Baron-Van Evercooren Beatriz García-díaz Instituto de Investigación Biomédica de málaga y plataforma en Nanomedicina(IBImA plataforma BIONANd) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain departamento de Biología molecular y Bioquímica Universidad de MálagaSpain sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe and chronic condition widely found in the general *** reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in *** the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical ***,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells(satellite glial cells and inflammatory cells)and factors(cytokines,neurotrophic factors and genetic factors)that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic *** importantly,we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines dorsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies satellite glial cells sensory neurons

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Improving the Transmission security of Vein Images Using a Bezier Curve and Long short-Term memory

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Computers, materials & Continua 2024年第6期79卷 4825-4844页

作者： Ahmed h.Alhadethi Ikram smaoui Ahmed Fakhfakh saad m.darwish Computer science and school of Electronics and Telecommunications University of SfaxSfax3029Tunisia LETI Laboratory University of SfaxSfax3029Tunisia digital Research Center of sfax Technopark of SfaxSfax3029Tunisia department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt

The act of transmitting photos via the Internet has become a routine and significant *** the security measures to safeguard these images from counterfeiting and modifications is a critical domain that can still be further *** study presents a system that employs a range of approaches and algorithms to ensure the security of transmitted venous *** main goal of this work is to create a very effective system for compressing individual biometrics in order to improve the overall accuracy and security of digital photographs by means of image *** paper introduces a content-based image authentication mechanism that is suitable for usage across an untrusted network and resistant to data loss during *** employing scale attributes and a key-dependent parametric Long short-Term memory(LsTm),it is feasible to improve the resilience of digital signatures against image deterioration and strengthen their security against malicious ***,the successful implementation of transmitting biometric data in a compressed format over a wireless network has been *** applications involving the transmission and sharing of images across a *** suggested technique utilizes the scalability of a structural digital signature to attain a satisfactory equilibrium between security and picture *** effective adaptive compression strategy was created to lengthen the overall lifetime of the network by sharing the processing of *** scheme ensures a large reduction in computational and energy requirements while minimizing image quality *** approach employs multi-scale characteristics to improve the resistance of signatures against image *** proposed system attained a Gaussian noise value of 98%and a rotation accuracy surpassing 99%.

关键词： Image transmission image compression text hiding Bezier curve histogram of Oriented Gradients(hOG) LsTm image enhancement Gaussian noise rotation

Broadband nonreciprocal thermal emissivity and absorptivity

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Light(science & Applications) 2024年第9期13卷 1820-1827页

作者： Komron J.shayegan Jae s.hwang Bo Zhao Aaswath p.Raman harry A.Atwater Thomas J.Watson Laboratory of Applied physics California Institute of TechnologyPasadenaCAUSA department of Electrical Engineering California Institute of TechnologyPasadenaCAUSA department of materials science and Engineering University of CaliforniaLos AngelesLos AngelesCAUSA department of mechanical Engineering University of HoustonHoustonTXUSA

A body that violates Kirchhoff’s law of thermal radiation exhibits an inequality in its spectral directional absorptivity and *** such an inequality is of fundamental interest as well as a prerequisite for achieving thermodynamic limits in photonic energy conversion1 and radiative *** far,inequalities in the spectral directional emissivity and absorptivity have been limited to narrow spectral resonances3,or wavelengths well beyond the infrared *** the gap from basic demonstrations to practical applications requires control over a broad spectral range of the unequal spectral directional absorptivity and *** this work,we demonstrate broadband nonreciprocal thermal emissivity and absorptivity by measuring the thermal emissivity and absorptivity of gradient epsilon-near-zero InAs layers of subwavelength thicknesses(50 nm and 150 nm)with an external magnetic *** effect occurs in a spectral range(12.5–16μm)that overlaps with the infrared transparency window and is observed at moderate(1 T)magnetic fields.

关键词： field. reciprocal thermal

New Antenna Array Beamforming Techniques Based on hybrid Convolution/Genetic Algorithm for 5G and Beyond Communications

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Computer modeling in Engineering & sciences 2024年第3期138卷 2749-2767页

作者： shimaa m.Amer Ashraf A.m.Khalaf Amr h.hussein salman A.Alqahtani mostafa h.dahshan hossam m.Kassem Electronics and Communications Engineering department Higher Institute of Engineering and TechnologyKafr ElsheikhEgypt Electronics and Electrical Communications Engineering department Faculty of EngineeringMinia UniversityMiniaEgypt Electronics and Electrical Communications Engineering department Faculty of EngineeringTanta UniversityTantaEgypt Electronics and Electrical Communications Engineering department Faculty of EngineeringHorus University EgyptNew DamiettaEgypt department of Computer Engineering College of computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia school of Computing Mathematics and EngineeringCharles Sturt UniversityBathurstNSW2795Australia

side lobe level reduction(sLL)of antenna arrays significantly enhances the signal-to-interference ratio and improves the quality of service(QOs)in recent and future wireless communication systems starting from 5G up to ***,it improves the array gain and directivity,increasing the detection range and angular resolution of radar *** study proposes two highly efficient sLL reduction *** techniques are based on the hybridization between either the single convolution or the double convolution algorithms and the genetic algorithm(GA)to develop the Conv/GA anddConv/GA,*** convolution process determines the element’s excitations while the GA optimizes the element *** m elements linear antenna array(LAA),the convolution of the excitation coefficients vector by itself provides a new vector of excitations of length N=(2m−1).This new vector is divided into three different sets of excitations including the odd excitations,even excitations,and middle excitations of lengths m,m−1,andm,*** the same element spacing as the original LAA is used,it is noticed that the odd and even excitations provide a much lower sLL than that of the LAA but with amuch wider half-power beamwidth(hpBW).While the middle excitations give the same hpBWas the original LAA with a relatively higher *** the increased hpBWof the odd and even excitations,the element spacing is optimized using the ***,the synthesized arrays have the same hpBW as the original LAA with a two-fold reduction in the ***,for extreme sLL reduction,the dConv/GA is *** this technique,the same procedure of the aforementioned Conv/GA technique is performed on the resultant even and odd excitation *** provides a relatively wider hpBWthan the original LAA with about quad-fold reduction in the sLL.

关键词： Array synthesis convolution process genetic algorithm(GA) half power beamwidth(hpBW) linear antenna array(LAA) side lobe level(sLL) quality of service(QOs)