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Transcranial photobiomodulation with near-infrared light:a promising therapeutic modality for Alzheimer's disease

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Neural Regeneration Research 2023年第9期18卷 1944-1945页

作者： hanli Liu Damir Nizamutdinov Jason h.huang Bioengineering Department the University of Texas at ArlingtonArlingtonTXUSA Neurosurgery Neuroscience InstituteBaylor Scott and White HealthTempleTXUSA Neurosurgery College of MedicineTexas A&M UniversityTempleTXUSA

Transcranial photobiomodulation(tPBM) is a noninvasive neuromodulation technique that delivers near-infrared(NIR) light with low irradiance(i.e.,power density in mW/cm2) in the wavelength range of 800-1070 *** recently published books or collected literature(hamblin,2019;GonzalezLima,2021) and papers(Nizamutdinov et al. 2022)offer comprehensive reviews of the mechanism of action and potential clinical translations of tPBM for the treatment of a variety of diseases,including neurodegenerative diseases(Alzheimer’s disease(AD),and Parkinson’s disease),traumatic brain injury.

关键词： Alzheimer diseases

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason h.huang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University School of Medicine TempleTXUSA Texas A&M University School of Pharmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s *** astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in *** on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical *** findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways shows promise for treating sleep disorders and arousal *** research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness

An update–tissue engineered nerve grafts for the repair of peripheral nerve injuries

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Neural Regeneration Research 2018年第5期13卷 764-774页

作者： Nitesh P.Patel Kristopher A.Lyon Jason h.huang Texas A&M College of Medicine Temple TX USA Department of Neurosurgery Baylor Scott & White Healthcare Temple TX USA

Peripheral nerve injuries（PNI） are caused by a range of etiologies and result in a broad spectrum of disability. While nerve autografts are the current gold standard for the reconstruction of extensive nerve damage, the limited supply of autologous nerve and complications associated with harvesting nerve from a second surgical site has driven groups from multiple disciplines, including biomedical engineering, neurosurgery, plastic surgery, and orthopedic surgery, to develop a suitable or superior alternative to autografting. Over the last couple of decades, various types of scaffolds, such as acellular nerve grafts（ANGs）, nerve guidance conduits, and non-nervous tissues, have been filled with Schwann cells, stem cells, and/or neurotrophic factors to develop tissue engineered nerve grafts（TENGs）. Although these have shown promising effects on peripheral nerve regeneration in experimental models, the autograft has remained the gold standard for large nerve gaps. This review provides a discussion of recent advances in the development of TENGs and their efficacy in experimental models. Specifically, TENGs have been enhanced via incorporation of genetically engineered cells, methods to improve stem cell survival and differentiation, optimized delivery of neurotrophic factors via drug delivery systems（DDS）, co-administration of platelet-rich plasma（PRP）, and pretreatment with chondroitinase ABC（Ch-ABC）. Other notable advancements include conduits that have been bioengineered to mimic native nerve structure via cell-derived extracellular matrix（ECM） deposition, and the development of transplantable living nervous tissue constructs from rat and human dorsal root ganglia（DRG） neurons. Grafts composed of non-nervous tissues, such as vein, artery, and muscle, will be briefly discussed.

关键词： peripheral nerve injury peripheral nerve repair tissue engineered nerve graft nerve conduit stem cells Schwann cells dorsal root ganglia neurons axon stretch-growth autologous tissue graft

Pazopanib in advanced soft tissue sarcomas

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Signal Transduction and Targeted Therapy 2019年第1期4卷 538-547页

作者： Alex T.J.Lee Robin L.Jones Paul h.huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in STS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with STS of various *** efficacy of pazopanib in specific STS subtypes has been further described in real-world-based case series in both mixed and subtype-specific STS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced STS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in STS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

Grown-in Defects of InSb Crystals:Models and Computation

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Communications in Computational Physics 2006年第3期1卷 511-527页

作者： N.Vaidya h.huang D.Liang Department of Mathematics and Statistics York UniversityToronto M3J 1P3Canada

In this paper,we present a model for grown-in point defects inside indium antimonide crystals grown by the Czochralski(CZ)*** model is similar to the ones used for silicon crystal,which includes the Fickian diffusion and a recombina-tion *** type of models is used for the first time to analyze grown-in point defects in indium antimonide *** temperature solution and the advance of the melt-crystal interface,which determines the time-dependent domain of the model,are based on a recently derived perturbation *** propose a finite difference method which takes into account the moving *** study the effect of thermal flux on the point defect patterns during and at the end of the growth *** results show that the concentration of excessive point defects is positively correlated to the heat flux in the system.

关键词： Crystal growth Czochralski technique point defects recombination thermal flux finite difference method

Numerical Study of heat and Moisture Transfer in Textile Materials by a Finite Volume Method

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Communications in Computational Physics 2008年第9期4卷 929-948页

作者： C.Ye h.huang J.Fan W.Sun Department of Mathematics City University of Hong KongKowloonHong Kong. Department of Mathematics&Statistics York UniversityTorontoOntario M3J 1P3Canada. Institute of Textiles and Clothing Hong Kong Polytechnic UniversityHong Kong

This paper focuses on the numerical study of heat and moisture transfer in clothing assemblies,based on a multi-component and multiphase flow model which includes heat/moisture convection and conduction/diffusion as well as phase change.A splitting semi-implicit finite volume method is proposed for solving a set of nonlinear convection-diffusion-reaction equations,in which the calculation of liquid water content absorbed by fiber is decoupled from the rest of the *** method maintains the conservation of air,vapor and heat flux(energy).Four types of clothing assemblies are investigated and comparison with experimental measurements are also presented.

关键词： Fibrous porous medium multi-component flow clothing assemblies finite volume method condensation/evaporation.

Acute effects of human protein S administration after traumatic brain injury in mice

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Neural Regeneration Research 2020年第11期15卷 2073-2081页

作者： Xiaowei Wang Jing Tong Xiaodi han Xiaoming Qi Jun Zhang Erxi Wu Jason h.huang Center for Translational Neuromedicine University of RochesterRochesterNYUSA Department of Neurosurgery 4th Affiliated Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery Tiantan HospitalBeijingChina Department of Neurosurgery Baylor Scott&White HealthTempleTXUSA Department of Neurosurgery PLA General HospitalBeijingChina College of Medicine Texas A&M Health Science CenterTempleTXUSA

Despite years of effort,no effective acute phase treatment has been discovered for traumatic brain *** impediment to successful drug development is entangled secondary injury *** we show that protein S,a natural multifunctional protein that regulates coagulation,inflammation,and apoptosis,is able to reduce the extent of multiple secondary injuries in traumatic brain injury,and therefore improve *** subjected to controlled cortical impact were treated acutely(10–15 minutes post-injury)with a single dose of either protein S(1 mg/kg)or vehicle phosphate buffered saline via intravenous *** 24 hours post-injury,compared to the non-treated group,the protein S treated group showed substantial improvement of edema and fine motor coordination,as well as mitigation of progressive tissue *** and western blot targeting caspase-3,B-cell lymphoma 2(Bcl-2)along with terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay revealed that apoptosis was suppressed in treated *** targeting CD11 b showed limited leukocyte infiltration in the protein S-treated ***,protein S treatment increased the ipsilesional expression of aquaporin-4,which may be the underlying mechanism of its function in reducing *** results indicate that immediate intravenous protein S treatment after controlled cortical impact is beneficial to traumatic brain injury *** Use Protocols(AUPs)were approved by the University Committee on Animal Resources(UCAR)of University of Rochester Medical Center(approval ***-2008-102 R)on November 12,2013.

关键词： apoptosis aquaporin-4 controlled cortical impact edema inflammation protein S TBI therapy traumatic brain injury

Nano Brazing of Pt-Ag Nanoparticles under Femtosecond Laser Irradiation

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Nano-Micro Letters 2013年第2期5卷 88-92页

作者： L.Liu h.huang A.hu G.Zou L.Quintino Y.Zhou Department of Mechanical Engineering Tsinghua University Department of Mechanical & Mechatronics Engineering University of Waterloo Technical University of Lisbon

Nano brazing of Pt-Ag nanoparticles with nano Ag filler metal is reported in this letter, which presents an effective way to join nanoobjects by femtosecond laser irradiation. The nano brazed interface between Pt-Ag and Ag showed good lattice matching along(111)_(Ag) //(111)_(Ag-Pt). Lattice mismatch can hardly be observed at the interface between the filler metal and Pt-Ag nanoparticle, which is important for the joint strength and normally does not occur during joining. The very low mismatch also suggested that melting and solidification occurred during nano brazing by femtosecond laser. The role of Brownian motion on the nano joining process is also discussed in this paper.

关键词： Femtosecond laser Nanojoining Nanoparticles

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一种新的快速特征选择和数据分类方法

计算机研究与发展 2012年第4期49卷 735-745页

作者：陈铁明马继霞 Samuel h.huang 蔡家楣浙江工业大学计算机科学与技术学院杭州310023 软件开发环境国家重点实验室(北京航空航天大学) 北京100191 辛辛那提大学智能系统实验室美国辛辛那提45221

针对数据分类问题提出一种新型高效的特征选择和规则提取方法.首先通过减少初始区间数量改进Chi-Merge离散化方法,再采用改进的Chi-Merge离散化连续型特征变量;特征离散化后,统计样本数据在每个特征子集划分下的频数表,并根据频数表计... 详细信息

针对数据分类问题提出一种新型高效的特征选择和规则提取方法.首先通过减少初始区间数量改进Chi-Merge离散化方法,再采用改进的Chi-Merge离散化连续型特征变量;特征离散化后,统计样本数据在每个特征子集划分下的频数表,并根据频数表计算数据不一致率,再利用顺序前向最优搜索的方法,快速确定特征数量由小到大的每一个最优特征子集;根据特征子集对应的数据不一致率差异最小化原则,完成特征个数最小化的最优特征子集筛选;根据最优特征子集的数据频数表,可直接提取数据分类规则.实验表明,快速提取的规则可获得较好的分类效果.基于该特征选择方法,提出一种面向分布式同构数据的快速分类模型,不但具有良好的分类效果,还支持对样本数据内容的隐私保护.

关键词：离散化频数表特征选择规则提取数据分类隐私保护