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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong fei luan Juanjuan Yang feng Miao Peifeng Wei College of Pharmacy and first Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MfSD2A) transcytosis

On the relationship between imprint and reliability in hf_(0.5)Zr_(0.5)O_(2) based ferroelectric random access memory

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Journal of Semiconductors 2024年第4期45卷 42-47页

作者： Peng Yuan Yuting Chen Liguo Chai Zhengying Jiao Qingjie luan Yongqing Shen Ying Zhang Jibin Leng Xueli Ma Jinjuan Xiang Guilei Wang Chao Zhao Beijing Superstring Academy of Memory Technology Beijing 100176China

The detrimental effect of imprint,which can cause misreading problem,has hindered the application of ferroelectric hfO_(2).In this work,we present results of a comprehensive reliability evaluation of hf_(0.5)Zr_(0.5)O_(2)-based ferroelectric random access *** influence of imprint on the retention and endurance is ***,a solution in circuity is pro-posed to effectively solve the misreading problem caused by imprint.

关键词： feRAM hZO imprint reliability

TcPO_(2)changes are more pronounced than SpO_(2)changes during simulated altitude changes in a hypobaric oxygen chamber:a nonrandomized controlled trial

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Emergency and Critical Care Medicine 2024年第3期4卷 105-110页

作者： Yang Li Liang Chen Ziyu fu Zhiwei Wang Shijun Sun Xiaorong luan Dedong Ma Tianliang hu School of Nursing and Rehabilitation Shandong UniversityJinanShandongChina Department of Emergency and Critical Care Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Emergency Management Center of State Grid Shandong Electric Power Company JinanShandongChina School of Nursing and Rehabilitation Cheeloo College of MedicineUniversity of ShandongDepartment of Infection ControlQilu Hospital of Shandong UniversityJinanShandongChina School of Mechanical Engineering Shandong UniversityKey Laboratory of the Ministry of Education for Efficient and Clean Machinery ManufacturingNational Experimental Teaching Demonstration Center for Mechanical EngineeringJinanShandongChina

Background:hypoxia is a significant risk factor of ***,no studies have used transcutaneous tissue partial pressure of oxygen(TcPO_(2))and partial pressure of carbon dioxide(TcPCO_(2))monitors to measure the respective partial pressures in healthy *** saturation(SpO_(2))is often used for traditional monitoring of vital *** study investigated the changes in TcPO_(2)and SpO_(2)values during rapid changes in *** trial was registered at ***(registration ***06076057).Methods:healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber,which ascended from 0 m to 2500 m at a uniform speed within 10 *** Danish Radiometer TCM4 was used to measure TcPO_(2)and TcPCO_(2)with the ventral side of the upper arm as the measurement *** Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO_(2),with values recorded once every 500 ***:Altogether,49 healthy volunteers were recruited between March 2023 and August *** increasing altitude,TcPO_(2)and SpO_(2)decreased significantly(Phe ascent from 0 m,TcPO_(2)began to change statistically at 500 m(Phereas SpO_(2)began to change statistically at 1000 m(Phe same altitude,the difference in TcPO_(2)was greater than the difference in SpO_(2).At 1000 m,there were statistically significant changes in TcPO_(2)and SpO_(2)(P500 m,statistical significance was identified between TcPO_(2)in both sexes(Pficance in TcPCO_(2)and heart rate was observed at the different elevations(Phanging low-pressure hypoxic environments,TcPO_(2)changed more dramatically than SpO_(2).

关键词： Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen

failure to Rescue as a Quality Metric in Congenital heart Surgeries in a high-Complexity Service Provider Institution Located in a Middle-Income Country

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Congenital heart Disease 2024年第2期19卷 207-218页

作者： Gustavo Cruz Santiago Pedroza Juan f.Vélez Jessica Largo Juan f.Tejada Jorge h.Mejía-Mantilla Departamento de Anestesiología Fundación Valle del LiliCali760032Colombia Centro de Investigaciones Clínicas Fundación Valle del LiliCali760032Colombia Departamento de Cardiología Pediátrica Fundación Valle del LiliCali760032Colombia facultad de Medicina Universidad IcesiCali760031Colombia Unidad de Cuidado Intensivo Fundación Valle del LiliCali760032Colombia

Background:failure to rescue has been an effective quality metric in congenital heart ***,mor-bidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality *** aim to measure the complications,mortality,and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar ***:A retrospective observational study was conducted in a high-complexity service provider institution,in Cali,*** pediatric patients undergoing any congenital heart surgery between 2019 and 2022 were *** main outcomes evaluated in the study were complication,mortality,and failure to rescue *** and multivariate logistic regression analysis was performed with mortality as the outcome ***:We evaluated 308 congenital heart *** the outcomes,201(65%)complications occurred,23(7.5%)patients died,and the fTR of the entire cohort was 11.4%.The presence of a postoperative complication(OR 14.88,CI 3.06–268.37,p=0.009),age(OR 0.79,CI 0.57–0.96,p=0.068),and urgent/emergent surgery(OR 8.14,CI 2.97–28.66,phe most significant variables in predicting ***:failure to rescue is an effective and comparable quality measure in healthcare institutions and is the major contributor to postoperative mortality in congenital heart *** our higher mortality and complication rate,we obtained a comparable failure to rescue rate to high-income countries’health institutions.

关键词： Congenital heart surgery complication mortality failure to rescue quality metric

Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei luan fei Zeng Xuyuan Wang Shurong Qin Qianglan Lu Guanzhong he Yanfeng Gao Xiaolian Sun Xin han Bangshun he Yujun Song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/h_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COf) is synthesized to coat a-ZIf-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIf-8@COf to activate GOx,which amplifies intracellular h^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/h_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate hybridmaterial hypoxia Gene editing Precise nanomedicine Multimodal therapy

Overexpression of the transcription factor MdWRKY115 improves drought and osmotic stress tolerance by directly binding to the MdRD22 promoter in apple

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horticultural Plant Journal 2024年第3期10卷 629-640页

作者： Qinglong Dong Yi Tian Xuemei Zhang Dingyue Duan he Zhang Kaiyu Yang Peng Jia haoan luan Suping Guo Guohui Qi Ke Mao fengwang Ma College of forestry Hebei Agricultural UniversityBaodingHebei 071001China National Engineering Research Center for Agriculture in Northern Mountainous Areas Agricultural Technology Innovation Center in Mountainous Areas of Hebei ProvinceHebei Agricultural UniversityBaodingHebei 071001China State Key Laboratory of Crop Stress Biology for Arid Areas Shaanxi Key Laboratory of AppleCollege of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China College of horticulture Hebei Agricultural UniversityBaodingHebei 071001China

Abiotic stress reduces plant yield and *** transcription factors play key roles in abiotic stress responses in plants,but the molecular mechanisms by which WRKY transcription factors mediate responses to drought and osmotic stresses in apple(Malus×domestica Borkh.)remain ***,we functionally characterized the apple GroupⅢWRKY gene ***-PCR analysis showed that MdWRKY115 expression was up-regulated by drought and osmotic *** activity analysis revealed that the promoter activity of MdWRKY115 was enhanced under osmotic *** localization and transactivation assays indicated that MdWRKY115 was localized to the nucleus and had a transcriptional activity domain at the N-terminal *** analysis revealed that the overexpression of MdWRKY115 in Arabidopsis plants and in apple callus markedly enhanced their tolerance to drought and osmotic *** affinity purification sequencing showed that MdWRKY115 binds to the promoter of the stress-related gene *** binding was further verified by an electrophoretic mobility shift ***,these findings suggest that MdWRKY115 is an important regulator of osmotic and drought stress tolerance in apple.

关键词： Apple MdWRKY115 Osmotic stress Drought stress function analysis

Application of novel constrained friction processing method to produce fine grained biomedical Mg-Zn-Ca alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 516-529页

作者： Ting Chen Banglong fu Junjun Shen Uceu f.h.R.Suhuddin Björn Wiese Yuanding huang Min Wang Jorge f.dos Santos Jean Pierre Bergmann Benjamin Klusemann Solid State Materials Processing Institute of Material MechanicsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany functional Magnesium Materials Institute of Metallic BiomaterialsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Shanghai Key Laboratory of Materials Laser Processing and Modification Shanghai Jiao Tong UniversityDongchuan Road 800Shanghai 200240China Applied Materials and Manufacturing Energy and Environment DivisionPacific Northwest National LaboratoryPO Box 999RichlandWA 99352USA Production Technology Group Technisiche Universität IlmenauGustav-Kirchhoff-Platz 2Ilmenau 98693Germany Institute for Production Technology and Systems Leuphana University of LüneburgUniversitätsallee 1Lüneburg 21335Germany

In order to obtain Mg alloys with fine microstructures and high mechanical performances,a novel friction-based processing method,name as“constrained friction processing(CfP)”,was *** CfP,defect-free Mg-Zn-Ca rods with greatly refined grains and high mechanical properties were *** to the previous as-cast microstructure,the grain size was reduced from more than 1 mm to around 4μm within 3 s by a single process *** compressive yield strength was increased by 350%while the ultimate compressive strength by 53%.According to the established material flow behaviors by“tracer material”,the plastic material was transported by shear *** the base material to the rod,the material experienced three stages,*** by the tool,upward flow with additional tilt,followed by upward *** microstructural evolution was revealed by“stop-action”*** microstructural development at regions adjacent to the rod is mainly controlled by twinning,dynamic recrystallization(DRX)as well as particle stimulated nucleation,while that within the rod is related to DRX combined with grain growth.

关键词： Constrained friction processing Magnesium alloys Microstructure Mechanical properties Grain refinement Plastic deformation

Cognition on oxidation behavior of Ni-based superalloy Gh4742 when exposed to water vapor

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Journal of Materials Science & Technology 2024年第7期174卷 15-22页

作者： h.Xu S.f.Yang E.h.Wang C.Y.Guo Y.S.Liu X.M.hou Y.L.Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The oxidation behavior of Ni-based superalloy Gh4742 exposed to water vapor was investigated at 900-1100℃for 50 h in Ar+20%h_(2)O,with Ar+20%O_(2)included for *** presence of h_(2)O is adverse to formation of continuous Cr_(2)O_(3)oxide layer but contributes to generation of big *** on this,Ni^(2+)and Co^(2+)are more easily to diffuse towards the outermost oxide layer(OOL),forming non-protective Ni-and Co-rich oxides with high *** leads to a higher weight gain in Ar+20%h_(2)O than that in Ar+20%O_(2).At elevated temperatures,the spallation of oxide scale occurs while the consumption of Cr is reduced in Ar+20%h_(2)O,and the contents of Ni-and Co-rich oxides at this moment are reduced in the *** oxidation mechanism was also discussed.

关键词： Gh4742 Superalloy h_(2)O Diffusion Oxidation Mechanism

Implementation of sub-100 nm vertical channel-all-around(CAA) thin-film transistor using thermal atomic layer deposited IGZO channel

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Journal of Semiconductors 2024年第7期45卷 40-44页

作者： Yuting Chen Xinlv Duan Xueli Ma Peng Yuan Zhengying Jiao Yongqing Shen Liguo Chai Qingjie luan Jinjuan Xiang Di Geng Guilei Wang Chao Zhao Beijing Superstring Academy of Memory Technology Beijing 100176China State Key Laboratory of fabrication Technologies for Integrated Circuits Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China

In-Ga-Zn-O(IGZO) channel based thin-film transistors(TfT), which exhibit high on-off current ratio and relatively high mobility, has been widely researched due to its back end of line(BEOL)-compatible potential for the next generation dynamic random access memory(DRAM) application. In this work, thermal atomic layer deposition(TALD) indium gallium zinc oxide(IGZO) technology was explored. It was found that the atomic composition and the physical properties of the IGZO films can be modulated by changing the sub-cycles number during atomic layer deposition(ALD) process. In addition, thin-film transistors(TfTs) with vertical channel-all-around(CAA) structure were realized to explore the influence of different IGZO films as channel layers on the performance of transistors. Our research demonstrates that TALD is crucial for high density integration technology, and the proposed vertical IGZO CAA-TfT provides a feasible path to break through the technical problems for the continuous scale of electronic equipment.

关键词： In-Ga-Zn-O(IGZO) thermal atomic layer deposition vertical channel thin-film transistor