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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Using coalgebras and the Giry monad for interpreting game logics a tutorial

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Frontiers of Computer Science 2017年第6期11卷 948-970页

作者： Ernst-erich DOBERKAT Math++ Software Bochum 44879 Germany

The stochastic interpretation of Parikh＇s game logic should not follow the usual pattern of Kripke models, which in turn are based on the Kleisli morphisms for the Giry monad, rather, a specific and more general approach to proba- bilistic nondeterminism is required. We outline this approach together with its probabilistic and measure theoretic basis, in- troducing in a leisurely pace the Giry monad and its Kleisli morphisms together with important techniques for manipu- lating them. Proof establishing specific techniques are given, and pointers to the extant literature are provided. After working through this tutorial, the reader should find it easier to follow the original literature in this and related areas, and it should be possible for her or him to appreciate measure theoretic arguments for original work in the areas of Markov transition systems, and stochastic effectivity func- tions.

关键词： coalgebras modal logics monads Giry monad,upper closed monad composition of monads game logics

Evaluation of factors influencing soluble microbial product in submerged MBR through hybrid ASM model

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Frontiers of Environmental Science & Engineering 2009年第2期3卷 226-235页

作者： Fangyue LI Joachim BEhRENDT Knut wichmann Ralf OTTERPOhL Institute of Water Resources and Water Supply Hamburg University of TechnologySchwarzenbergstr.95 ED-21073 HamburgGermany Department of Wastewater Management Hamburg University of TechnologyEissendorfer Strasse 42D-21073 HamburgGermany

In this study,a mathematical model was established to predict the formation of the soluble microbial product(SMP)in a submerged membrane *** developed model was calibrated under the reference *** results were in good agreement with the measured results under the reference *** calibrated model was then used in the scenario studies to evaluate the effect of three chosen operating parameters:hydraulic retention time(hRT),dissolved oxygen concentration,and sludge retention time(SRT).Simulation results revealed that the SMP dominated the soluble organic substances in the *** scenario studies also revealed that the hRT can be decreased to 1 h without deteriorating the effluent quality;dissolved oxygen concentration in the reactor can be kept at 2–3 mg/L to maintain the effluent quality,reduce the content of SMP,and minimize operating costs;the optimal SRT can be controlled to 10–15 d to achieve complete nitrification process,less membrane fouling potential,and acceptable organic removal efficiency.

关键词： hybrid activated sludge model(ASM) membrane bioreactor(MBR) soluble microbial product(SMP)

Plasma Spray Forming of Nanostructured Composite Coatings

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Journal of Materials Science & Technology 2002年第3期18卷 287-288页

作者： XianliangJIANG erich.Jordan 等 InstituteofSurfaceandCoatingsTechnology CentralSouthUniversityChangsha410083China InstituteofMatrialsScience UniversityofConnecticutStorrsCT06269USA

The nanostructure composite coating is obtained via plasma spraying of Al2O3-13 wt pct TiO2 powder. Brittle and hard lamella results from melted nanostructured powder. Ductile nanostructured matrix forms from unmelted nanostructured particles. Through the adjustment of constituent and nanostructure, hardness/strength and toughness/ductility are balanced and overall properties of the structure composite are achieved.

关键词： Plasma spray forming Nanostructured coating Mechanical Property

A NOTE ON PRESSURE APPROXIMATION OF FIRST AND hIGhER ORDER PROJECTION SChEMES FOR ThE NONSTATIONARY INCOMPRESSIBLE NAVIER-STOKES EQUATIONS

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Journal of Computational Mathematics 2009年第2期27卷 338-347页

作者： erich Carelli Andrcas Prohl Mathematisches Institut Universitt TübingenAuf der Morgenstelle 10D-72076 Tübingen

Projection methods are efficient operator-splitting schemes to approximate solutions of the incompressible Navier-Stokes equations. As a major drawback, they introduce spurious layers, both in space and time. In this work, we survey convergence results for higher order projection methods, in the presence of only strong solutions of the limiting problem; in particular, we highlight concomitant difficulties in the construction process of accurate higher order schemes, such as limited regularities of the limiting solution, and a lack of accurate initial data for the pressure. Computational experiments are included to compare the presented schemes, and illustrate the difficulties mentioned.

关键词： Incompressible Navier-Stokes equation Time discretization Projection method

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

A combined method to model grain crushing with DEM

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Geoscience Frontiers 2020年第2期11卷 451-459页

作者： Jia Lin erich Bauer WeiWu Institute of Geotechnical Engineering University of Natural Resources and Life SciencesViennaAustria Institute of Applied Mechanics Graz University of TechnologyGrazAustria

This paper presents a combined method to model grain crushing effects with discrete element *** method combines the two most commonly used concepts to model grain crushing in DEM,*** replacement method and the agglomerate method,so that it is both accurate and *** method can be easily *** performance is shown by several DEM simulations of biaxial *** with different crush-abilities are *** simulation results with and without grain crushing are compared and *** change of grain size distribution due to grain crushing is also investigated.

关键词： Grain crushing Discrete element method Granular material