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α1-cOP modulates plasmodesmata function through sphingolipid enzyme regulation

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Journal of Integrative Plant Biology 2024年第8期66卷 1639-1657页

作者： arya Bagus Boedi Iswanto Minh huy Vu Jong cheol Shon Ritesh Kumar Shuwei Wu hobin Kang Da-Ran Kim Geon hui Son Woe Yoen Kim Youn-Sig Kwak Kwang hyeon Liu Sang hee Kim Jae-Yean Kim Division of Applied Life Science(BK21 FOUR Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea college of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 702-701Korea Departement of Plant Medicine Gyeongsang National UniversityJinju 52828Korea Division of Life Science Gyeongsang National UniversityJinju 52828Korea

callose,aβ-1,3-glucan plant cell wall polymer,regulates symplasmic channel size at plasmodesmata(PD)and plays a crucial role in a variety of plant ***,elucidating the molecular mechanism of PD callose homeostasis is *** screened and identified an Arabidopsis mutant plant with excessive callose deposition at PD and found that the mutated gene wasα1-cOP,a member of the coat protein I(cOPI)coatomer *** report that loss of function ofα1-cOP elevates the callose accumulation at PD by affecting subcellular protein localization of callose degradation enzyme Pd *** process is linked to the functions of ERh1,an inositol phosphoryl ceramide synthase,and glucosylceramide synthase through physical interactions with theα1-cOP ***,the loss of function ofα1-cOP alters the subcellular localization of ERh1 and GcS proteins,resulting in a reduction of Glc cers and Glc hcers molecules,which are key sphingolipid(SL)species for lipid raft *** findings suggest thatα1-cOP protein,together with SL modifiers controlling lipid raft compositions,regulates the subcellular localization of GPI-anchored PDBG2 proteins,and hence the callose turnover at PD and symplasmic movement of *** findings provide the first key clue to link the cOPI-mediated intracellular trafficking pathway to the callose-mediated intercellular signaling pathway through PD.

关键词： callose coatomer proteins membrane-bound vesicle plasmodesmata sphingolipid enzymes

Free vibration and buckling analysis of polymeric composite beams reinforced by functionally graded bamboo fbers

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 543-562页

作者： h.M.FEIZABAD M.h.YAS Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent *** fibers are renowned for their good mechanical properties,abundance,and short cycle *** beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRc)beams on the elastic *** different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the *** elastic properties of the composite are determined with the law of *** hamilton’s principle,the governing equations of motion are *** generalized differential quadrature method(GDQM)is then applied to the equations to obtain the *** achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(Bcs)and slenderness ratio of the beam ***,a comparative study is conducted between the derived analysis outcomes for BFRc and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber ***,the obtained analysis results of BFRc beams are also compared with those for carbon nanotube reinforced composite(cNTRc)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRc beams are lower than those of cNTRc beams.

关键词： bamboo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature method(GDQM)

SARS-coV-2 variants are associated with different clinical courses in children with MIS-c

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto helen harvey Adriana h.Tremoulet Jane c.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑coV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-c).SARS‑coV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-c at Rady children’s hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-c waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to c,20G,21c(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22c).MIS-c presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PIcU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-coV-2 triggered MIS-c with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： complications cOVID-19 MIS-c SARS-coV-2 variants

Trial characteristics and treatment effect estimates in randomized controlled trials of chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty h.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu claire c.W.Zhong Mary Y.Jiang chen Mao Xiao-bo Yang Vincent c.h.chung Irene X.Y.Wu Jockey club School of Public health and Primary care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public health Central South UniversityChangsha 410006Hunan ProvinceChina School of chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of clinical Research on Traditional chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina hunan Provincial Key Laboratory of clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RcTs).Nevertheless,it remains unclear if similar associations exist in RcTs on chinese herbal medicine(chM).Further,chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on chM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on chM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RcTs of chM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RcTs using the cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (cI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RcTs were *** binary outcomes,RcTs incorporated with syndrome differentiation (ROR:1.23;95%cI:[1.07,1.39]),adopting chinese medicine formula (ROR:1.19;95%cI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%cI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%cI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%cI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RcTs with chinese medicine diagnostic criteria (dSMD:0.23;95%cI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%cI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

Empirical model for fusion cross sections of ca-induced reactions

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chinese Physics c 2024年第3期48卷 126-132页

作者： Reddi Rani.L N.Sowmya K.N Sridhar h c.Manjunatha M.M.Armstrong Arasu Department of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Department of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Department of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Department of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new empirical formula for the astrophysical S-factor has been suggested as a function of the coulomb interaction parameter,center of mass energy,and barrier *** 22 fusion reactions with ^(40,48)ca as projectiles were considered for different targets,leading to compound nuclei with atomic and mass numbers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion cross-sections have been estimated using the geometric factor,the Gamow-Sommerfield factor,and the empirical formula for the *** study's findings showed better agreement with those of available experiments when compared to Wong's *** present work leads to a smaller standard deviation value than Wong's formula when used to correlate the experimental data of calcium-induced fusion ***'s formula provides a good approximation of fusion cross-sections when the center of mass energy is below the fusion barrier when compared to above the fusion barrier.

关键词： fusion cross-sections Wong formula Gamow-Sommerfield-factor Geometric-factor S-factor

Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor

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Food Science and human Wellness 2024年第3期13卷 1608-1616页

作者： hyo-Geun Lee h.h.A.c.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.Liyanage Kyung-Mo Song Yun-Sang choi Seung-hong Lee You-Jin Jeon Min-cheol Kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Department of Pharmoceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a *** studies proved that there is a potential to use marine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAc)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(hFD)-induced obese mice were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplementation with STAc significantly declined gain in body weight and fat weight,and serum lipid contents in an hFD-induced obesity mouse *** and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial ***,these results indicate that STAc and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum thunbergii Fucoidan Anti-obesity Anti-steatosis

cellulose synthesis in land plants

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Molecular Plant 2024年第2期17卷 359-361页

作者： Gustav B.Pedersen Leonard Blaschek Kristian E.h.Frandsen Lise c.Noack Staffan Persson 不详

After the original publication of the above article,we and/or attentive readers identified several instances of unclear or erroneous writing that needed correcting,as *** are added for emphasis.

关键词： synthesis instance identif

convexification of hybrid Ac-Dc Optimal Power Flow with Line-commutated converters

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cSEE Journal of Power and Energy Systems 2024年第2期10卷 617-628页

作者： hongyuan Liang Zhigang Li J.h.Zheng Q.h.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

Line-commutated converter (Lcc)-based high-voltage Dc (hVDc) systems have been integrated with bulk Ac power grids for interregional transmission of renewable power. The nonlinear Lcc model brings additional nonconvexity to optimal power flow (OPF) of hybrid Ac-Dc power grids. A convexification method for the Lcc station model could address such nonconvexity but has rarely been discussed. We devise an equivalent reformulation for classical Lcc station models that facilitates second-order cone convex relaxation for the OPF of Lcc-based Ac-Dc power grids. We also propose sufficient conditions for exactness of convex relaxation with its proof. Equivalence of the proposed Lcc station models and properties, exactness, and effectiveness of convex relaxation are verified using four numerical simulations. Simulation results demonstrate a globally optimal solution of the original OPF can be efficiently obtained from relaxed model.

关键词： Ac-Dc power system convex relaxation linecommutated converter optimal power flow second-order cone programming

Shell-model representations of the microscopic version of the Bohr-Mottelson collective model

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communications in Theoretical Physics 2024年第8期76卷 79-90页

作者： h G Ganev Joint Institute for Nuclear Research DubnaRussia Institute of Mechanics Bulgarian Academy of SciencesSofiaBulgaria

The structure of the irreducible collective spaces of the group Sp(12,R),which many-particle nuclear states are classified according to the chain Sp(12,R)⊃U(6)⊃SO(6)⊃SU_(pn)(3)⊗SO(2)⊃SO(3)of the proton-neutron symplectic model(PNSM),is considered in *** chain of the PNSM was recently shown to correspond to a microscopic shell-model version of the Bohr-Mottelson collective *** construction of the relevant shell-model representations of the Sp(12,R)group along this chain is considered for three nuclei with varying collective properties and from different mass *** is shown that the SU_(pn)(3)basis states of the Sp(12,R)representations belonging to the SO(6)irreps with seniorityυ≥υ0,withυ0 denoting the maximal seniority SO(6)irrep contained in the Sp(12,R)bandhead,are always Pauli allowed,but organized in a different way into different SO(6)*** is in contrast to the case of filling the levels of the standard three-dimensional harmonic oscillator and using the plethysm *** the SU_(pn)(3)multiplets withinυcard *** results obtained in the present work are important for the practical application of the microscopic version of the Bohr-Mottelson collective model.

关键词： microscopic shell-model version of the Bohr-Mottelson model proton-neutron symplectic model Sp(12,R)dynamical algebra shell-model representations