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Zinc-doped hydroxyapatite-zeolite/polycaprolactone composites coating on magnesium substrate for enhancing in-vitro corrosion and antibacterial performance

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Transactions of Nonferrous Metals Society of China 2020年第1期30卷 123-133页

作者： Nida IQBAL Saman IQBAL Tanveer IQBAL h.R.BAKhShEShI-RAD Ahmed ALSAKKAF Ahmad KAMIL Mohammed Rafiq ABDUL KADIR Mohd hasbullah IDRIS h.balaji raghav Biomedical Engineering Centre University of Engineering and TechnologyKala Shah Kaku(KSK)CampusLahorePakistan Department of Physics University of the PunjabQuaid-e-Azam CampusLaborePakistan Department of Chemical Polymer&Composite Material Engineering University of Engineering and TechnologyKala Shah Kaku(KSK)New CampusLahorePakistan Advanced Materials Research Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran School of Mechanical Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaJohorMalaysia Kulliyyah of Science International Islamic University MalaysiaBandar Indera Mahkota CampusJalan Sultan Ahmad Shah25200 KuantanPahang Darul MakmurMalaysia School of Biomedical Engineering and health Sciences Faculty of EngineeringUniversiti Teknologi MalaysiaJohorMalaysia Tissue Engineering Group(TEG) National Orthopaedic Centre of Excellence in Research and Learning(NOCERAL)Department of Orthopaedic SurgeryFaculty of MedicineUniversity of Malaya50603 Lembah PantaiKuala LumpurMalaysia

This work is focused on developing zinc-doped hydroxyapatite-zeolite(Zn hA-Zeo)and polycaprolactone(PCL)composite coatings on magnesium(Mg)substrate to improve the corrosion resistance and antimicrobial ***-coating technique was used to coat Zn hA-Zeo/PCL on the Mg substrate at room *** samples were subjected to field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Fourier transform infrared(FTIR),energy dispersive X-ray spectroscopy(EDX)and antimicrobial *** demonstrated that composite coatings consist of hA,scholzite,zeolite,and PCL *** spectra indicated the presence of calcium(Ca),silicon(Si),aluminum(Al),zinc(Zn),phosphorus(P)and oxygen(O).The composite surface appeared in spherical-like microstructure on coating with thickness ranging 226-260μ***-doped hA-Zeo composite coating had a high corrosion resistance and provided sufficient protection to the Mg surface against galvanic *** Zn hA-Zeo coating samples exhibited superior disc inhibition by confirming antimicrobial activity against the *** as compared to hA-Zeo *** these results showed that the Zn hA-Zeo coatings not only improved the corrosion resistance,but also enhanced the antimicrobial property and hence they can be used as suitable candidates for implant applications.

关键词： biodegradable magnesium bioceramics coating corrosion resistance antimicrobial activity

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Effect of tool tilt angle on strength and microstructural characteristics of friction stir welded lap joints of AA2014-T6 aluminum alloy

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Transactions of Nonferrous Metals Society of China 2019年第9期29卷 1824-1835页

作者： C.RAJENDRAN K.SRINIVASAN V.BALASUBRAMANIAN h.balaji P.SELVARAJ Department of Mechanical Engineering Sri Krishna College of Engineering and TechnologyCoimbatore Tamil Nadu 641008India Center for Materials Joining and Research(CEMAJOR) Annamalai UniversityTamil Nadu 608002India Aeronautical Development Agency BangaloreKarnataka 560017India

Friction stir welding(FSW)has been extensively adopted to fabricate aluminium alloy joints by incorporating various welding parameters that include welding speed,rotational speed,diameters of shoulder and pin and tool tilt *** parameters significantly affect the weld *** tilt angle is one of the significant process parameters among the weld *** present study focused on the effect of tool tilt angle on strength of friction stir lap welding of AA2014-T6 aluminium *** tool tilt angle was varied between 0°and 4°with an equal increment of 1°.Other process parameters were kept *** and microstructure analysis,microhardness measurement,scanning electron micrograph,transmission electron micrograph and energy dispersive spectroscopy analysis were performed to evaluate the lap shear strength of friction stir lap welded *** proved that,defect-free weld joint was obtained while using a tool tilt angle of 1°to 3°.however,sound joints were welded using a tool tilt angle of 2°,which had the maximum lap shear strength of 14.42 kN and microhardness of hV *** joints welded using tool tilt angles of 1°and 3°yielded inferior lap shear strength due to unbalanced material flow in the weld region during FSW.

关键词： AA2014 aluminium alloy friction stir lap welding tool tilt angle lap shear strength microstructure

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Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: Role of drug metabolizing microsomal enzyme system, tumor necrosis factor-a and fate of liver cell structural integrity

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World Journal of Gastroenterology 2006年第24期12卷 3829-3834页

作者： h.balaji raghavendran A Sathivel T Devaki Department of Biochemistry University of Madras Guindy campusChennai-25India

AIM： To assess the defensive nature of Sargassum polycystum （S. polycystum）（Brown alga） against acetaminophen （AAP）-induced changes in drug metabolizing microsomal enzyme system, tumor necrosis factor （TNF-α） and fine structural features of the liver during toxic hepatitis in rats. METhODS： Male albino Wistar strain rats used for the study were randomly categorized into 4 groups. Group Ⅰ consisted of normal control rats fed with standard diet. Group II rats were administered with acetaminophen （800 mg/kg body weight, intraperitoneally）. Group Ⅲ rats were pre-treated with S. polycystum extract alone. Group IV rats were orally pre-treated with S. polycystum extract （200 mg/kg body weight for 21 d） prior to acetaminophen induction （800 mg/kg body weight, intraperitoneally）. Serum separated and liver was excised and microsomal fraction was isolated for assaying cytochrome P450, NADPh Cyt P450 reductase and bs. Serum TNF-α was detected using ELISA. Fine structural features of liver were examined by transmission electron microscopy. RESULTS： Rats intoxicated with acetaminophen showed considerable impairment in the activities of drug metabolizing microsomal enzymes, such as cytochrome P450, NADPh Cyt P450 reductase and bs when compared with the control rats. The rats intoxicated with acetaminophen also significantly triggered serum TNF-a when compared with the control rats. These severe alterations in the drug metabolizing enzymes were appreciably pretreated with S. polycystum. prevented in the rats The rats pretreated withS. polycystum showed considerable inhibition in the elevation of TNF-α compared to the rats intoxicated with acetaminophen. The electron microscopic observation showed considerable loss of structural integrity of the endoplasmic reticulum, lipid infiltration and ballooning of mitochondria in the acetaminophen-intoxicated rats, whereas the rats treated with S. polycystum showed considerable protection against acetaminophen-induced alterations in structur

关键词： Sargassum polycystum Acetaminophen Toxic hepatitis NAPQI Free radical

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Development of a GIS-based failure investigation system for highway soil slopes

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Frontiers of Earth Science 2015年第2期9卷 165-178页

作者： raghav RAMANAThAN Ahmet h. AYDILEK Burak F. TANYU Paul C. Rizzo Associates Inc. 500 Penn Center Blvd. Pittsburgh PA 15235 USA Department of Civil and Environmental Engineering University of Maryland MD 20742 USA Department of Civil Environmental and Infrastructure Engineenng George Mason University Fairfax VA 22030 USA

A framework for preparation of an early warning system was developed for Maryland, using a GIS database and a collective overlay of maps that highlight highway slopes susceptible to soil slides or slope failures in advance through spatial and statistical analysis. Data for existing soil slope failures was collected from geotechnical reports and field visits. A total of 48 slope failures were recorded and analyzed. Six factors, including event precipitation, geological formation, land cover, slope history, slope angle, and elevation were considered to affect highway soil siope stability. The observed trends indicate that precipitation and poor surface or subsurface drainage conditions are principal factors causing slope failures. 96% of the failed slopes have an open drainage section. A majority of the failed slopes lie in regions with relatively high event precipitation （P 〉 200 mm）. 90% of the existing failures are surficial erosion type failures, and only 1 out of the 42 slope failures is deep rotational type failure. More than half of the analyzed slope failures have occurred in regions having low density land cover. 46% of failures are on slopes with slope angles between 20~ and 30~. Influx of more data relating to failed slopes should give rise to more trends, and thus the developed slope management system will aid the state highway engineers in prudential budget allocation and prioritizing different remediation projects based on the literature reviewed on the principles, concepts, techniques, and methodology for slope instability evaluation （Lesh- chinsky et al., 2015）.

关键词： soil slope slope management system geo-graphic information system hazard mapping

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Ionic liquid mediated morphologically improved lanthanum oxide nanoparticles by Andrographis paniculata leaves extract and its biomedical applications

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Journal of Rare Earths 2020年第3期38卷 281-291页

作者： Muthulakshmi Veerasingam balaji Murugesan Sundrarajan Mahalingam Advanced Green Chemistry Lab Department of Industrial ChemistrySchool of Chemical SciencesAlagappa UniversityKaraikudi03Tamil NaduIndia

Greener synthesis of ionic liquid(IL) assisted lanthanum oxide(La2O3) nanoparticles(NPs) was followed using Andrographis paniculata leaves extract by hydrothermal method at low temperature,The IL assisted La2O3(La2O3-IL) NPs were characterized by various properties such as structural,spectral,optical,morphological,and biological *** X-ray diffraction studies confirm that La2O3-IL NPs crystallize in the form of body-centered cubic structure and average crystalline size is shown-43 *** and Laser Raman spectroscopy confirm the La-O,O-h and various functional *** La-O stretching vibration band attributes at 639 *** optical property of La2O3-IL NPs was characterized by UV-Vis and photo luminesce nce *** sharp and intense absorbance peak observed in the UV region at 288 nm can be *** the PL spectrum,we observe two different emission bands like blue and green *** morphological and particle size determination were investigated by SEM with EDX spectra and TEM *** agglomerated particles of hexagonal,spherical,and parallelogram shape are observed in the TEM *** chemical elements,binding energies as well as La metal states on the surface of these synthesized NPs were determined using ***2O3 NPs for good biological activities regarding antibacterial and anti-inflammatory potentials could be utilized in different biological applications to the food and biomedical ***2O3-IL has a high percentage of inhibitions than La2O3 and standard diclofenac.

关键词： La2O3 nanoparticles Ionic liquid X-ray diffraction X-ray photoelectron spectroscopy Antibacterial Anti-inflammatory

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h.264/SVC Mode Decision Based on Mode Correlation and Desired Mode List

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International Journal of Automation and computing 2014年第5期11卷 510-516页

作者： L.balaji K.K.Thyagharajan Faculty of Information and Communication Anna University RMD Engineering College

Design of video encoders involves implementation of fast mode decision(FMD) algorithm to reduce computation complexity while maintaining the performance of the coding. Although h.264/scalable video coding(SVC) achieves high scalability and coding efficiency, it also has high complexity in implementing its exhaustive computation. In this paper, a novel algorithm is proposed to reduce the redundant candidate modes by making use of the correlation among layers. A desired mode list is created based on the probability to be the best mode for each block in base layer and a candidate mode selection in the enhancement layer by the correlations of modes among reference frame and current frame. Our algorithm is implemented in joint scalable video model(JSVM)9.19.15 reference software and the performance is evaluated based on the average encoding time, peak signal to noise ration(PSNR)and bit rate. The experimental results show 41.89% improvement in encoding time with minimal loss of 0.02 dB in PSNR and 0.05%increase in bit rate.

关键词： h.264 scalable video coding mode decision mode correlation rate distortion cost

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Luciferase reporter phage phAE85 for rapid detection of rifampicin resistance in clinical isolates of Mycobacterium tuberculosis

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 728-731页

作者： Gomathi Sivaramakrishnan balaji Subramanyam Ponnuraja C Vanaja Kumar Department of Bacteriology National Institute for Research in Tuberculosis(Formerly Tuberculosis Research Centre)

Objective:To evaluate luciferase reporter phage(LRP)phAE85 in rapid detection of rifampicin resistance in a region where TB is ***:One hundred and ninety primary isolates on Lowenstein-Jensen medium were *** 7h9 complete medium with and without rifampicin at 2μg/mL was inoculated with standard inoculum from suspensions of the clinical *** incubation for 72 h,LRP was *** 4 h of further incubation,light output from both control and test was measured as relative light *** exhibiting a reduction of less than 50%relative light units in the drug containing vial compared to control were classified as *** were compared with the conventional minimum inhibitory concentration method(MIC)of drug susceptibility ***:The two methods showed high level of agreement of 97%(CI 0.94,0.99)and P value was 0.000 *** sensitivity and specificity of LRP assay for detection of rifampicin resistance were 91%h(CI 0.75,0.98)and 99ct(CI0.95,1.00)*** to detection of resistance by LRP assay was 3 d in comparison with 28 d by the minimum inhibitory concentration ***:LRP assay with phAE85 is 99%specific,91%sensitive and is highly *** the assay offers a simple procedure for drug sensitivity testing,within die scope of semi-automation.

关键词： Mycobacterium tuberculosis Rifampicin resistance Rapid detection

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In vitro anti oxidant activity and acute oral toxicity of Terminalia paniculata bark ethanolic extract on Sprague Dawley rats

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 294-298页

作者： Ramgopal Mopuri balaji Meriga Department of Biochemistry Sri Venkateswara University

Objective:To ensure the safety and evaluate the anti oxidant activity of Terminalia paniculata(***)ethanolic extract in Sprague Dawley ***:The solvent extracts(hexane,ethyl acetate and ethanol)of *** were subjected to phytochemical analysis and their DPPh radical scavenging activity was *** oral acute toxicity was evaluated using ethanolic extract of ***:Ethyl acetate and elhanolic extracts showed more phytochemicals,whereas highest DPPh scavenging activity was found in ethanolic *** an acute toxicity study,*** ethanolic extract was orally administered(1000 mg/kg body weight)to rats and observed for72 h for any toxic symptoms and the dose was continued up to 14 *** the 15th day rats were sacrificed and blood samples were collected from control and test animals and analyzed for some biochemical *** did not observe any behavioral changes in test groups in comparison with their ***,there were no significant alterations in biochemical,hematological(hemoglobin content and blood cells count)and liver function parameters such as serum glutamate pyruvate transaminase,serum glutamate oxaloacetate transaminase,alkaline phosphatase,total proteins,albumin and bilirubin levels between *** ethanolic extract treated and normal control ***:Together our results demonstrated that *** ethanolic possessed potent antioxidant activity and it was safer and non toxic to rats even at higher doses and therefore could be well considered for further investigation for its medicinal and therapeutic efficacy.

关键词： Terminalia paniculata Acute toxicity 2,2-Diphenyl-1-picrylhydrazyl Biochemical activity hematological parameters

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Optimization of friction stir welding parameters for improved corrosion resistance of AA2219 aluminum alloy joints

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Defence Technology（防务技术） 2015年第4期11卷 330-337页

作者： G.RAMBABU D.balaji NAIK C.h.VENKATA RAO K.SRINIVASA RAO G.MADhUSUDAN REDDY Department of Mechanical Engineering Andhra University Department of Metallurgical Engineering Andhra University Defence Metallurgical Research Laboratory

The aluminium alloy AA2219(Al—Cu—Mg alloy) is widely used in the fabrication of lightweight structures with high strength-to-weight ratio and good corrosion *** is main fabrication method of AA2219 alloy for manufacturing various engineering *** stir welding(FSW) is a recently developed solid state welding process to overcome the problems encountered in fusion *** process uses a non-consumable tool to generate frictional heat on the abutting *** welding parameters,such as tool pin profile,rotational speed,welding speed and axial force,play major role in determining the microstructure and corrosion resistance of welded *** main objective of this work is to develop a mathematical model to predict the corrosion resistance of friction stir welded AA2219 aluminium alloy by incorporating FSW process *** this work a central composite design with four factors and five levels has been used to minimize the experimental *** polarization testing was carried out to determine critical pitting potential in millivolt,which is a criteria for measuring corrosion resistance and the data was used in *** the response surface method(RSM) was used to develop the *** developed mathematical model was optimized using the simulated annealing algorithm optimizing technique to maximize the corrosion resistance of the friction stir welded AA2219 aluminium alloy joints.

关键词： 2219铝合金耐腐蚀性能搅拌摩擦焊焊接接头参数优化数学模型摩擦搅拌焊接模拟退火算法

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Chemopreventive effect of apple and berry fruits against colon cancer

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World Journal of Gastroenterology 2014年第45期20卷 17029-17036页

作者： Saravana Kumar Jaganathan Muthu Vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto Dyah Ekashanti Octorina Dewi Aqilah Leela T Narayanan Arunpandian balaji Aruna Priyadarshini Subramanian Mustafa Yusof IJN-UTM Cardiovascular Engineering Centre Faculty of Bioscience and Medical Engineering Universiti Teknologi Malaysia Department of Research and Development PSNA College of Engineering and Technology Department of Pharmacology

Colon cancer arises due to the conversion of precancerous polyps(benign)found in the inner lining of the *** is better than cure,and this is very true with respect to colon *** epidemiologic studies have linked colorectal cancer with food *** and berry juices are widely consumed among various ethnicities because of their nutritious *** this review article,chemopreventive effects of these fruit juices against colon cancer are *** dealing with bioavailability,in vitro and in vivo effects of apple and berry juices are emphasized in this article.A thorough literature survey indicated that various phenolic phytochemicals present in these fruit juices have the innate potential to inhibit colon cancer cell *** review proposes the need for more preclinical evidence for the effects of fruit juices against different colon cancer cells,and also strives to facilitate clinical studies using these juices in humans in large *** conclusion of the review is that these apple and berry juices will be possible candidates in the campaign against colon cancer.

关键词： Apple Berry Chemoprevention Colon cancer Fruit juices Phytochemicals

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