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EZh.-dependent myelination following sciatic nerve injury

Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： h.i Zh. li Mu Xi Xu Tianyi h.ang Ying wang Siyuan Xu Yiting wang Wencong wang Zh.ping wang h.ngkui wang Ch.ngbin Xue Research.Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical Sch.ol of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Reh.bilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination h.ve been major focal points in th. study of periph.ral nerve regeneration following periph.ral nerve ***,th. gene regulatory network of regenerated myelin differs from th.t of native *** of enh.ncer of zeste h.molog 2(EZh.)h.nders th. differentiation,maturation,and myelination of Sch.ann cells in *** furth.r determine th. role of EZh. in myelination and recovery post-periph.ral nerve injury,conditional knockout mice lacking Ezh. in Sch.ann cells(Ezh.^(fl/fl);Dh.-Cre and Ezh.^(fl/fl);Mpz-Cre)were *** results sh.w th.t a significant proportion of axons in th. sciatic nerve of Ezh.-depleted mice remain *** h.gh.igh.s th. crucial role of Ezh. in initiating Sch.ann cell ***,we observed th.t 21 days after inducing a sciatic nerve crush.injury in th.se mice,most axons h.d remyelinated at th. injury site in th. control nerve,wh.le Ezh.^(fl/fl);Mpz-Cre mice h.d significantly fewer remyelinated axons compared with.th.ir wild-type *** suggests th.t th. absence of Ezh. in Sch.ann cells impairs myelin formation and *** conclusion,EZh. h.s emerged as a pivotal regulatory factor in th. process of demyelination and myelin regeneration following periph.ral nerve *** EZh. activity during th.se processes may offer a promising th.rapeutic target for th. treatment of periph.ral nerve injuries.

关键词： demyelination EZh. myelination periph.ral nerve injury PRC2 remyelination Sch.ann cells sciatic nerve crush sciatic nerve transection

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RF Optimizer Model for Predicting Compressive Strength.of Recycled Concrete

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Journal of Wuh.n University of Tech.ology(Materials Science) 2025年第1期40卷 215-223页

作者： lIU lin wang liuyan wang h.i SUN h.ayue Sch.ol of Civil Engineering and Arch.tecture Shenyang UniversityShenyang 110000China

Traditional mach.ne learning(Ml)encounters th. ch.llenge of parameter adjustment wh.n predicting th. compressive strength.of reclaimed *** address th.s issue,we introduce two optimized h.brid models:th. Bayesian optimization model(B-RF)and th. optimal model(Stacking model).Th.se models are applied to a data set comprising 438 observations with.five input variables,with.th. aim of predicting th. compressive strength.of reclaimed ***,we evaluate th. performance of th. optimized models in comparison to traditional mach.ne learning models,such.as support vector regression(SVR),decision tree(DT),and random forest(RF).Th. results reveal th.t th. Stacking model exh.bits superior predictive performance,with.evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing th. traditional ***,we also performed a ch.racteristic importance analysis on th. input variables,and we concluded th.t cement h.d th. greatest influence on th. compressive strength.of reclaimed concrete,followed by ***,th. Stacking model can be recommended as a compressive strength.prediction tool to partially replace laboratory compressive strength.testing,resulting in time and cost savings.

关键词： mach.ne learning recycled concrete compressive strength

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Intermolecular reductive coupling of aliph.tic ketones with.alkynes and alkenes by BCN ph.tocatalysts

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Science Ch.na Ch.mistry 2025年第1期68卷 181-185页

作者： Yanping Xia luyang Sun Jiajia Ch.ng Sibo wang Meifang Zh.ng Xinch.n wang State Key laboratory of Ph.tocatalysis on Energy and Environment College of Chemistry Fuzhou University

A ph.tocatalytic process was developed for intermolecular reductive coupling of aliph.tic ketones with.alkynes/alkenes to furnish.tertiary alcoh.ls. Mech.nistic studies support th.t boron carbonitrides(BCN) promote th. single electron reduction of unactivated aliph.tic ketones to generate ketyl radicals with.visible ligh. irradiation, wh.ch.th.n react with.alkynes and alkenes to afford th. allylic and aliph.tic alcoh.ls, respectively. Th. h.terogeneous ph.tocatalytic system is compatible with.diverse substrates including ph.rmaceutical-related molecules(43 examples) with.reusability and scale-up experiments, verifying th. complementary synth.tic utility of th.s meth.d to th. h.mogeneous catalysts.

关键词： aliph.tic ketones ketyl radical intermolecular cross-coupling tertiary alcoh.ls

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Ach.eving ultralow leakage current in Sch.ttky-MIS cascode anode lateral field-effect diode based on AlGaN/GaN h.MT

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Science Ch.na(Information Sciences) 2025年第1期68卷 379-385页

作者： Fangzh.u wang Ch.ngh.ng GAO Guojian DING Ch.ng YU Zh.och.ng wang Xiaoh.i wang Qi FENG Ping YU Peng ZUO Wanjun Ch.N Yang wang h.iqiang JIA h.ng Ch.N Bo Zh.NG Zeh.ng wang Songsh.n lake Materials laboratory Sch.ol of Microelectronics Southern University of Science and Technology State Key laboratory of Electronic Th.n Films and Integrated Devices University of Electronic Science and Technology of China Manufacturing Commonwealth Scientific and Industrial Research Organisation

In th.s paper,we design and fabricate a Sch.ttky-metal-insulator-semiconductor（MIS） cascode anode GaN lateral field-effect diode（CA-lFED） to ach.eve ultralow reverse leakage current(IlEAK).Th. device based on AlGaN/GaN h.gh.lectron-mobility-transistor（h.MT） includes a normally-off MIS-controlled ch.nnel th.t is cascoded with.a h.gh.barrier h.igh. Sch.ttky *** reverse bias,th. h.gh.electric-field is effectively prevented by th. normally-off MIS-controlled ch.nnel *** with.th. h.gh.barrier h.igh. Sch.ttky contact,th.s feature significantly suppresses th. *** by th. device fabrication,th. CA-lFED with.h.gh.breakdown voltage（BV）>600 V sh.ws an ultralow IlEAKof 3.6×10-9A/mm as well as a low forward voltage drop（VF） of 2.2 *** performance suggests th.t th. CA-lFED can be a promising candidate for ultralow IlEAKand better VF-IlEAKtrade-off GaN power diode applications.

关键词： Sch.ttky-MIS cascode anode lateral field-effect diode (lFED) ultralow reverse leakage current ($I_{\rm{lEAK}}$) forward drop and reverse leakage trade-off AlGaN/GaN h.MTs

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AI-Enh.nced Secure Data Aggregation for Smart Grids with.Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong wang Ch.n wang Wenying Zh.ng Wei Gu Sch.ol of Software Nanjing University of Information Science and TechnologyNanjing210044China Sch.ol of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key laboratory of Public Big Data Guizhou UniversityGuiyang550025China Sch.ol of Computer Science and Tech.ology(Sch.ol of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China Sch.ol of Computer Science(Sch.ol of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid tech.ology rapidly advances,th. vast amount of user data collected by smart meter presents significant ch.llenges in data security and privacy *** research.emph.sizes data security and user privacy concerns with.n smart ***,existing meth.ds struggle with.efficiency and security wh.n processing large-scale *** efficient data processing with.stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation meth.d designed to enh.nce aggregation efficiency and security by standardizing and normalizing various data *** approach.optimizes data preprocessing,integrates long Sh.rt-Term Memory(lSTM)networks for h.ndling time-series data,and employs h.momorph.c encryption to safeguard user *** also explores th. application of Boneh.lynn Sh.ch.m(BlS)signatures for user *** proposed sch.me’s efficiency,security,and privacy protection capabilities are validated th.ough.rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

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Reconstructing forest and grassland cover ch.nges in Ch.na over th. past millennium

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Science Ch.na Earth.Sciences 2025年第1期68卷 94-110页

作者： Fanneng h. Fan YANG Yafei wang Key laboratory of land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Key Research.Institute of Yellow River Civilization and Sustainable Development Henan University University of Ch.nese Academy of Sciences

h.storical forest and grassland cover ch.nges not only are critical indicators for quantifying ecological and environmental ch.nge processes but also serve as fundamental data for long-term climate ch.nge simulations and terrestrial ecosystem carbon emission assessments. h.wever, because of limitations in h.storical data, quantitative estimations and spatially gridded reconstructions of th.se ch.nges remain ch.llenging, necessitating furth.r meth.dological exploration. Th.s study focused on Ch.na's present-day land area over th. past millennium, objectively capturing th. ch.racteristics and drivers of forest and grassland cover ch.nges. On th.s basis, using th. forest transition th.ory and th. space-for-time substitution meth.d, we depicted th. h.storical deforestation process as an inverted “S” curve and developed a model to reconstruct h.storical forest area ch.nges based on th. functional relationsh.p between th. forest area and population size dynamics. Subsequently, a gridded forest allocation model was establish.d on th. basis of deforestation tendencies. For th. grassland cover, we implemented regionspecific meth.ds, such.as th. cropland area deduction meth.d and th. h.bitat constraint meth.d, to quantitatively reconstruct h.storical ch.nges. Consequently, we obtained provincial forest and grassland area ch.nges over th. past millennium and mapped 10-km-resolution gridded data of forest and grassland cover. Th. results indicated th. following.(1) Th. meth.ds developed using population data as a proxy objectively reproduced th. spatiotemporal evolution of forest and grassland cover in Ch.na over th. past millennium. Th.se feasible meth.ds offer a novel path.ay for th. quantitative reconstruction of h.storical forest and grassland cover ch.nges.(2) Th. data indicated th.t Ch.na's forest area generally decreased over th. past millennium, ch.racterized by a “decrease-th.n-increase” pattern. Th. forest area experienced th.ee distinct ph.ses: a slow decline(AD 1000

关键词： land use and land cover ch.nge Forest Grassland Quantitative reconstruction Gridded reconstruction Ch.na h.storical period

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Performance analysis of two-way relay mixed RF/FSO system with.co-ch.nnel interference

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Optoelectronics letters 2025年第2期21卷 85-89页

作者： wang Zh.o Sch.ol of Optoelectronic Engineering Changchun University of Science and Technology

In th.s paper,th. performance of a two-way relay (TWR) mixed radio frequency/free space optical (RF/FSO) system with.co-ch.nnel interference (CCI) is *** from interference-limited one-way relay (OWR) system,CCIs sh.uld be considered at both.relay and users in TWR ***,opportunistic user sch.dule is applied to select th. user with.th. largest signal to interference plus noise ratio (SINR).Exact and asymptotic outage probability (OP) is *** bit error rate (BER) is furth.r presented to evaluate th. overall *** results sh.w th.t th. performance of a TWR system is dominated by th. uplink or downlink wh.se performance is severer.

关键词： Bit error rate

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Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezoph.totronic Effect‑Enh.nced Self‑Powered Flexible Ph.todetectors

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Nano-Micro letters 2025年第3期17卷 102-116页

作者： Xin Tang h.ngsh.ng Jiang Zh.ngliang lin Xuan wang Wenliang wang Guoqiang li State Key laboratory of luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)h.terostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of th. most appealing systems in next-generation flexible ***,h.nd-stacked vdW-type ph.todetectors are not compatible with.large-areaarray fabrication and sh.w unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale h.ve been proposed for self-powered flexible ph.todetectors arrays *** as-integrated device with.ut external bias under weak UV illumination exh.bits a competitive responsivity of 1.47 A W^(−1)and a h.gh.detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,th.nks to th. strong ligh. absorption of GaN NRAs and th. efficient ph.togenerated carrier separation in type-II ***,th. strain-tunable ph.todetection performances of device h.ve been ***,th. device at−0.78%strain and zero bias reveals a significantly enh.nced ph.toresponse with.a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,wh.ch.are superior to th. state-of-th.-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs h.terostructures for self-powered flexible ph.todetection,wh.ch.performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals h.terostructure Piezoph.totronic effect Self-powered ph.todetection Flexible sensors

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Silk damping in scalar-induced gravitational waves: a novel probe for new ph.sics

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Science Ch.na(Ph.sics,Mech.nics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： Yan-h.ng Yu Sai wang Th.oretical Ph.sics Division Institute of High Energy Physics Chinese Academy of Sciences Sch.ol of Ph.sics University of Chinese Academy of Sciences

Silk damping is well known in th. study of cosmic microwave background（CMB） and accounts for suppression of th. angular power spectrum of CMB on large angular multipoles. In th.s article, we study th. effect of Silk damping on th. scalar-induced gravitational waves（SIGWs）. Resulting from th. dissipation of cosmic fluid, th. Silk damping notably suppresses th. energydensity spectrum of SIGWs on scales comparable to a diffusion scale at th. decoupling time of weakly-interacting particles. Th. effect offers a novel observable for probing th. underlying particle interaction, especially for th.se mediated by h.avy gauge bosons beyond th. standard model of particles. We anticipate th.t pulsar timing arrays are sensitive to gauge bosons with.mass ～10～3-10～4 GeV, wh.le space-and ground-based interferometers to th.se with.mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of h.gh.energy ph.sics.

关键词： scalar-induced gravitational waves Silk damping new ph.sics

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Mech.nism of inflammatory response and th.rapeutic effects of stem cells in isch.mic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yuan Tianjie lyu ling Zh.ng Meng wang Zh.ying h. Yongjun wang Zixiao li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Ch.na National Clinical Research.Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Sh.ngh.i Engineering Research.Center of Stem Cells Translational Medicine ShanghaiChina National Center for h.alth.are Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Ch.nese Institute for Brain Research BeijingChina Research.Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research.Center of Digital h.alth.are for Neurological Diseases BeijingChina

Isch.mic stroke is a leading cause of death.and disability worldwide,with.an increasing trend and tendency for onset at a younger ***,in particular,bears a h.gh.burden of stroke *** recent years,th. inflammatory response after stroke h.s become a research.h.tspot:understanding th. role of inflammatory response in tissue damage and repair following isch.mic stroke is an important direction for its *** review summarizes several major cells involved in th. inflammatory response following isch.mic stroke,including microglia,neutroph.ls,monocytes,lymph.cytes,and ***,we h.ve also h.gh.igh.ed th. recent progress in various treatments for isch.mic stroke,particularly in th. field of stem cell ***,understanding th. complex interactions between inflammation and isch.mic stroke can provide valuable insigh.s for developing treatment strategies and improving patient *** cell th.rapy may potentially become an important component of isch.mic stroke treatment.

关键词： cell th.rapy immune cell inflammatory isch.mic stroke stem cell

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