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Immunological Exploration of h.licobacter pylori Serotype O_(2) O-Antigen by Using a Synth.tic Glycan Library

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Ch.nese Journal of Ch.mistry 2024年第3期42卷 243-251页

作者： Ming Zh.o Guangzong Tian Ch.njun Qin Xiaopeng Zou Peter h. Seeberger Jing h. Jian Yin Key Laboratory of Carboh.drate Ch.mistry and Biotech.ology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi Sch.ol of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

h.licobacter pylori(***)infection is a th.eat to h.man *** lipopolysacch.ride(LPS)O-antigen h.lds promise for developing *** is meaningful to explore th. immunological activity of oligosacch.rides with.different length. and framesh.fts for antigen ***,a glycan library of *** O2 O-antigen containing eigh. fragments is *** screening with.*** O2 LPS sera and patients’sera by glycan microarray,th. disacch.ride h.O2G-2b and trisacch.ride h.O2G-3a sh.w strong antigenicity and th.n are separately conjugated with.carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-h.O2G-3a IgG antibodies possess a much.stronger binding affinity with.th. LPS and bacteria of *** O2 th.n th. anti-h.O2G-2b IgG *** is no cross-reaction between both.sera IgG antibodies with.LPS and bacteria of *** O1,O6,and *** results demonstrate th. trisacch.ride h.O2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates h.licobacter pylori Immunology Microarrays O-antigen Oligosacch.rides

Research.onManeuver Decision-Making ofMulti-Agent Adversarial Game in a Random Interference Environment

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Computers, Materials and Continua 2024年第1期81卷 1879-1903页

作者： h. S. Ru L. Lu B. Wang Z. Zh.o X. Wang W. Xi h. Equipment Management and UAV Engineering College Air Force Engineering University Xi'an 710051 China National Key Laboratory of Unmanned Aerial Veh.cle Tech.ology Xi'an 710051 China College of Information Tech.ology Nanjing Police University Nanjing 210023 China

Th. strategy evolution process of game players is h.gh.y uncertain due to random emergent situations and oth.r external disturbances. Th.s paper investigates th. issue of strategy interaction and beh.vioral decision-making among game players in simulated confrontation scenarios with.n a random interference environment. It considers th. possible risks th.t random disturbances may pose to th. autonomous decision-making of game players, as well as th. impact of participants' manipulative beh.viors on th. state ch.nges of th. players. A nonlinear math.matical model is establish.d to describe th. strategy decision-making process of th. participants in th.s scenario. Subsequently, th. strategy selection interaction relationsh.p, strategy evolution stability, and dynamic decision-making process of th. game players are investigated and verified by simulation experiments. Th. results sh.w th.t maneuver-related parameters and random environmental interference factors h.ve different effects on th. selection and evolutionary speed of th. agent's strategies. Especially in a h.gh.y uncertain environment, even small information asymmetry or miscalculation may h.ve a significant impact on decision-making. Th.s also confirms th. feasibility and effectiveness of th. meth.d proposed in th. paper, wh.ch.can better explain th. beh.vioral decision-making process of th. agent in th. interaction process. Th.s study provides feasibility analysis ideas and th.oretical references for improving multi-agent interactive decision-making and th. interpretability of th. game system model. © 2024 Th. Auth.rs. Publish.d by Tech.Science Press.

关键词： Beh.vior decision-making maneuver multi-agent nonlinear math.matical modeling stoch.stic evolutionary game

Optimization of ch.mistry and process parameters for control of intermetallic formation in Mg sludges

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Journal of Magnesium and Alloys 2024年第4期12卷 1431-1448页

作者： Y.Fu G.G.Wang A.h. Y.Li K.B.Th.cker J.P.Weiler h.h. Department of Mech.nical Automotive and Materials EngineeringUniversity of Windsor401 Sunset AveWindsorOntario N9B 3P4Canada Global Tech.ology Centre Meridian Lightweight Technologies25 MacNab AveStrathroyOntario N7G 4H6Canada

Intermetallic formation in sludge during magnesium(Mg)melting,h.lding and h.gh.pressure die casting practices is a very important ***,very often it is overlooked by academia,original equipment manufacturers(OEM),metal ingot producers and even die *** aim of th.s study was to minimize th. intermetallic formation in Mg sludge via th. optimization of th. ch.mistry and process *** Al8Mn5 intermetallic particles were identified by th. microstructure analysis based on th. Al and Mn *** design of experiment(DOE)tech.ique,Taguch. meth.d,was employed to minimize th. intermetallic formation in th. sludge of Mg alloys with.various ch.mical compositions of Al,Mn,Fe,and different process parameters,h.lding temperature and h.lding *** sludge yield(SY)and intermetallic size(IS)was selected as two *** optimum combination of th. levels in terms of minimizing th. intermetallic formation were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,690℃ for th. h.lding temperature and h.lding at 30 mins for th. h.lding time,*** best combination for smallest intermetallic size were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,630℃ for th. h.lding temperature and h.lding at 60 mins for th. h.lding time,*** groups of sludge factors,Ch.mical Sludge(CSF),Ph.sical Sludge(PSF)and Compreh.nsive Sludge Factors(and CPSF)were establish.d for prediction of sludge yields and intermetallic sizes in Al-containing Mg *** CPSF with.five independent variables including both.ch.mical elements and process parameters gave h.gh.accuracy in prediction,as th. prediction of th. PSF with.only th. two processing parameters of th. melt h.lding temperature and time sh.wed a relatively large deviation from th. experimental *** Ch.mical Sludge Factor was primarily designed for small ingot producers and die casters with.a limited melting and h.lding capacity,of wh.ch.process parameters could be fixed *** Ph.sical Sludge Factor could be used f

关键词： Magnesium sludge Al-Mn intermetallic Optimization Taguch. meth.d Sludge factor Ch.mical composition Process parameter

Carbon dioxide enrich.ent affected flower numbers transiently and increased successful post-pollination development stably but with.ut altering final acorn production in mature pedunculate oak (Quercus robur L.)

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Journal of Forestry Research 2024年第4期35卷 1-12页

作者： Ryan McClory Rich.rd h.Ellis martin Lukac Jo Clark Carolina Mayoral Kris M.h.rt Andrew R.G.Plackett A.Rob MacKenzie Sch.ol of Agriculture Policy and DevelopmentUniversity of ReadingAgricultureEarley GateWhiteknights RoadPO Box 237Reading RG66EUUK Faculty of Forestry and Wood Sciences Czech University of Life Sciences PraguePrague 165000Czechia Future Trees Trust Harwell Innovation CentreBuilding 173Curie AvenueHarwellOxford OX110QGUK Birmingh.m Institute of Forest Research University of BirminghamEdgbastonBirmingham B152TTUK Sch.ol of Biosciences University of BirminghamEdgbastonBirmingham B152TTUK Sch.ol of Geograph. Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

Acorn production in oak(Quercus spp.)sh.ws considerable inter-annual variation,known as masting,wh.ch.provides a natural defence against seed predators but a h.gh.y-variable supply of acorns for uses such.as in commercial tree planting each.*** emissions of greenh.use gases h.ve been very widely reported to influence plant growth.and seed or fruit size and quantity via th.‘fertilisation effect’th.t leads to enh.nced *** examine if acorn production in mature woodland communities will be affected by furth.r increase in CO_(2),th. contents of litter traps from a Free Air Carbon Enrich.ent(FACE)experiment in deciduous woodland in central England were analysed for numbers of flowers and acorns of pedunculate oak(Quercus robur L.)at different stages of development and th.ir predation levels under ambient and elevated CO_(2) ***-annual variation in acorn numbers was considerable and cyclical between 2015 and 2021,with.th. greatest numbers of mature acorns in 2015,2017 and 2020 but almost none in *** numbers of flowers,enlarged cups,immature acorns,empty acorn cups,and galls in th. litter traps also varied amongst years;comparatively h.gh.numbers of enlarged cups were recorded in 2018,suggesting *** at th.s site is a fruit maturation masting species(i.e.,th. extent of abortion of pollinated flowers during acorn development affects mature acorn numbers greatly).Raising th. atmosph.ric CO_(2) concentration by 150μL L^(−1),from early 2017,increased th. numbers of immature acorns,and all acorn evidence(empty cups+immature acorns+mature acorns)detected in th. litter traps compared to ambient controls by 2021,but did not consistently affect th. numbers of flowers,enlarged cups,empty cups,or mature *** number of flowers in th. elevated CO_(2) plots’litter traps was greater in 2018 th.n 2017,one year after CO_(2) enrich.ent began,wh.reas numbers declined in ambient *** with.CO_(2) also increased th. number o

关键词： Quercus robur L. Acorns Masting Pedunculate oak Carbon dioxide

Antibodies elicited by Newcastle disease virus-vectored h.N9 avian influenza vaccine are functional in activating th. complement system

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Journal of Integrative Agriculture 2024年第6期23卷 2052-2064页

作者： Zenglei h. Ya h.ang Jiao h. Xiaoquan Wang Sh.nlin h. Xiufan Liu Joint International Research.Laboratory of Agriculture and Agri-Product Safety of th. Ministry of Education of Ch.na Yangzhou UniversityYangzhou 225009China Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou 225009China

h.N9 subtype avian influenza virus poses a great ch.llenge for poultry *** disease virus(NDV)-vectored h.N9 avian influenza vaccines(NDV_(vec)h.N9)are effective in disease control because th.y are protective and allow mass *** note,th.se vaccines elicit undetectable h.N9-specific h.magglutination-inh.bition(h.)but h.gh.IgG antibodies in ***,th. molecular basis and protective mech.nism underlying th.s particular antibody immunity remain ***,immunization with.an NDV_(vec)h.N9 induced low anti-h.N9 h. and virus neutralization titers but h.gh.levels of h.magglutinin(h.)-binding IgG antibodies in *** residues(S150,G151 and S152)in h. of h.N9 virus were identified as th. dominant epitopes recognized by th. NDV_(vec)h.N9 immune *** transferred NDV_(vec)h.N9 immune serum conferred complete protection against h.N9 virus infection in *** NDV_(vec)h.N9 immune serum can mediate a potent lysis of h.-expressing and h.N9 virus-infected cells and significantly suppress h.N9 virus *** activities of th. serum were significantly impaired after h.at-inactivation or treatment with.complement inh.bitor,suggesting th. engagement of th. complement ***,mutations in th. 150-SGS-152 sites in h. resulted in significant reductions in cell lysis and virus neutralization mediated by th. NDV_(vec)h.N9 immune serum,indicating th. requirement of antibody-antigen binding for complement ***,antibodies induced by th. NDV_(vec)h.N9 can activate antibody-dependent complement-mediated lysis of h.N9 virus-infected cells and complement-mediated neutralization of h.N9 *** findings unveiled a novel role of th. complement in protection conferred by th. NDV_(vec)h.N9,h.gh.igh.ing a potential benefit of engaging th. complement system in h.N9 vaccine design.

关键词： h.N9 subtype avian influenza virus NDV vector vaccine antibody immunity complement protection

An improved pulse coupled neural networks model for semantic IoT

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Digital Communications and Networks 2024年第3期10卷 557-567页

作者： Rong Ma Zh.n Zh.ng Yide Ma Xiping h. Edith.C.h.Ngai Victor C.M.Leung Sch.ol of Information Science and Engineering Lanzhou UniversityLanzhou 730000China Sch.ol of Medical Tech.ology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and Computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,th. Internet of Th.ngs(IoT)h.s gradually developed applications such.as collecting sensory data and building intelligent services,wh.ch.h.s led to an explosion in mobile data ***,with.th. rapid development of artificial intelligence,semantic communication h.s attracted great attention as a new communication ***,for IoT devices,h.wever,processing image information efficiently in real time is an essential task for th. rapid transmission of semantic *** th. increase of model parameters in deep learning meth.ds,th. model inference time in sensor devices continues to *** contrast,th. Pulse Coupled Neural Network(PCNN)h.s fewer parameters,making it more suitable for processing real-time scene tasks such.as image segmentation,wh.ch.lays th. foundation for real-time,effective,and accurate image ***,th. parameters of PCNN are determined by trial and error,wh.ch.limits its *** overcome th.s limitation,an Improved Pulse Coupled Neural Networks(IPCNN)model is proposed in th.s *** IPCNN constructs th. connection between th. static properties of th. input image and th. dynamic properties of th. neurons,and all its parameters are set adaptively,wh.ch.avoids th. inconvenience of manual setting in traditional meth.ds and improves th. adaptability of parameters to different types of *** segmentation results demonstrate th. validity and efficiency of th. proposed self-adaptive parameter setting meth.d of IPCNN on th. gray images and natural images from th. Matlab and Berkeley Segmentation *** IPCNN meth.d ach.eves a better segmentation result with.ut training,providing a new solution for th. real-time transmission of image semantic information.

关键词： Internet of th.ngs(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

Rational design of AgGaS/ZnS/ZnS quantum dots with.a near-unity ph.toluminescence quantum yield via double sh.lling sch.me

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Journal of Materials Science & Tech.ology 2024年第2期169卷 235-242页

作者： h.X.Lu h.Liu Z.Z.Fu Y.Y.Ch.n h.Q.Dai Z.h. W.L.Zh.ng R.Q.Guo Institute for Electric Ligh. Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Ligh.ing Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Yiwu Research.Institute of Fudan University YiwuZhejiang 322000China Zh.ngsh.n-Fudan Joint Innovation Center Zhongshan 528437China

In th.s study,a two-step meth.d was used to synth.size h.gh.y luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In th. first step,an inner ZnS sh.ll was formed via a one-pot meth.d,wh.ch.resulted in a smaller lattice mismatch.between th. AgGaS core and th. outer ZnS sh.ll,th.reby facilitating th. formation of a th.ck outer *** th. two-step sh.lling process,th. synth.sized AgGaS/ZnS/ZnS QDs sh.wed an excellent ph.toluminescence quantum yield(PLQY)of 96.4%with.a peak wavelength.of 508 nm,repre-senting th. h.gh.st PLQY reported th.s far for AgGaS ***,th. effect of h.logen ions in Zn precursors on th. sh.lling process was *** was proposed th.t th. capacity of h.logen ions to coordinate with.th. QDs influenced th. balance between Zn cation diffusion and ZnS sh.lling ***,th. ZnS sh.lling reaction was dominant wh.n ZnCl_(2)was employed,wh.le Zn cation diffusion was th. dominant process under th. I^(−)-rich.*** work provides insigh.s into th. interfacial restructuring during th. ZnS sh.lling and offers a clear map for th. tailored synth.sis of core/sh.ll QDs.

关键词： AgGaS Quantum dots Ph.toluminescence Core/sh.ll Alloyed core/sh.ll interface

Genomic Mosaicism of th. Brain:Origin,Impact,and Utility

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Neuroscience Bulletin 2024年第6期40卷 759-776页

作者： Jared h.Grah.m Joh.nnes C.M.Sch.ach.tzki Xiaoxu Yang martin W.Breuss Department of Pediatrics Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of Cellular and Molecular Medicine University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of Neurosciences University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady Ch.ldren’s Institute for Genomic Medicine San Diego92123CAUSA

Genomic mosaicism describes th. ph.nomenon wh.re some but not all cells with.n a tissue h.rbor unique genetic ***,research.focused on th. impact of genomic mosaicism on clinical ph.notype—motivated by its involvement in cancers and overgrowth.*** recently,we increasingly sh.fted towards th. pleth.ra of neutral mosaic variants th.t can act as recorders of cellular lineage and environmental ***,we summarize th. current state of th. field of genomic mosaicism research.with.a special emph.sis on our current understanding of th.s ph.nomenon in brain development and *** th. field of genomic mosaicism h.s a rich.h.story,tech.ological advances in th. last decade h.ve ch.nged our approach.s and greatly improved our *** will provide current definitions and an overview of contemporary detection approach.s for genomic ***,we will discuss th. impact and utility of genomic mosaicism.

关键词： Genomics Brain development Brain h.meostasis Genomic mosaicism

Tetraeth.lenepentamine-functionalized magnetic mesoporous composites as a novel adsorbent for th. removal Cr(Ⅲ)-eth.lenediaminetetraacetic acid in complex solution

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Ch.nese Journal of Ch.mical Engineering 2024年第4期68卷 16-26页

作者： Zh. h. Jiah.ng Wang Tongtong Sun Sch.ol of Environmental Science and Engineering Shaanxi University of Science&TechnologyXi'an 710021China Sh.anxi Key Laboratory of Green Preparation and Functionalization of Inorganic Materials Xi'an 710021China

A novel tetraeth.lenepentamine(TEPA) functionalized magnetic mesoporous silica adsorbent(FNMs/TEPA) was prepared for th. adsorption of Cr(Ⅲ)-eth.lenediaminetetraacetic acid(EDTA)from wastewater. Th. ch.racterization of th. prepared adsorbent certified th.t TEPA was modified onto th. magnetic mesoporous silicon(FNMs), wh.le FNMs/TEPA maintained th. ordered mesoporous and pristine magnetic properties. Th. batch.adsorption experiments demonstrated th.t TEPA significantly enh.nced th. removal capacity of th. adsorbent for Cr(Ⅲ)-EDTA. FNMs/TEPA exh.bited an excellent adsorption property(13.84 mg·g-1) at p h.4.0. Even in th. presence of h.gh.concentrations of coexisting ions and organic acids, th. adsorption performance of FNMs/TEPA was stable. Experimental ch.racterization and DFT demonstrated th.t th. adsorption of Cr(Ⅲ)-EDTA was ascribed to th. electrostatic interaction, h.drogen bonding, and complexation between Cr(Ⅲ)-EDTA and amino groups on th. adsorbent surface. Th. analysis of th. independent gradient model(IGM) sh.ws th.t electrostatic interaction is th. main mode of action in th. adsorption process. Moreover, FNMs/TEPA demonstrated remarkable reusability in th.ee regeneration cycles. Th.se findings indicated th.t FNMs/TEPA possessed excellent application prospects in th. disposal of wastewater containing Cr(Ⅲ)-EDTA.

关键词： TEPA functionalized magnetic mesoporous silicon Adsorption Cr(III)-EDTA Density functional th.ory calculations