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Abalone sh.ll-derived m.-doped m.soporous h.droxyapatite m.crosph.re drug delivery system.loaded with.icariin for inducing apoptosis of osteosarcom. cells

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Biom.terials Translational 2024年第2期5卷 185-196页

作者： Liu K. Ch.ng m. h.ang h. Yu h. Zh.o S. Zh.u J. Tie D. Wang J. Pan P. Ch.n J. m.rine College Shandong University Shandong Province Weihai China State Key Laboratory of m.neral Processing Beijing China College of Biological Science and Tech.ology Fuzhou University Fujian Province Fuzhou China

h.droxyapatite (h.P) porous m.crosph.res with.very h.gh.specific surface area and drug loading capacity, as well as excellent biocom.atibility, h.ve been widely used in tum.ur th.rapy. m.2+ is considered to be a key factor in bone regeneration, acting as an active agent to stim.late bone and cartilage form.tion, and is effective in accelerating cell m.gration and prom.ting angiogenesis, wh.ch.is essential for bone tissue repair, anti-cancer, and anti-infection. In th.s study, abalone sh.lls from.a variety of sources were used as raw m.terials, and m.2+-doped abalone sh.ll-derived m.soporous h.P m.crosph.res (m.-h.P) were prepared by h.droth.rm.l synth.sis as m.2+/icariin sm.rt dual delivery system.(ICA-m.-h.P, Im.0}). With.increasing of m.2+ doping, th. surface m.rph.logy of h.P m.crosph.res varied from.collapsed m.croporous to m.soporous to sm.oth.and non-porous, wh.ch.m.y be due to m.2+ substitution or coordination in th. h.P lattice. At 30% m.2+ doping, th. m.-h.P m.crosph.res sh.wed a m.re h.m.geneous m.soporous m.rph.logy with.a h.gh.specific surface area (186.06 m./g). Th. Im.0} m.crosph.res sh.wed h.gh.drug loading (7.69%) and encapsulation rate (83.29%), sustained m.2+ release for m.re th.n 27 days, sustained and stable release of icariin for 60 h.urs, and good responsiveness to ph.(ph.6.4 > ph.5.6). In addition, th. Im.0} delivery system.stim.lated th. rapid proliferation of bone m.rrow m.sench.m.l stem.cells and induced apoptosis in m.63 cells by blocking th. G2 ph.se cycle of osteosarcom. cells and stim.lating th. h.gh.expression of apoptotic genes (Bcl-2, caspase-3,-8,-9). Th.s suggests th.t th. abalone sh.ll-based Im.0} m.y h.ve potential applications in drug delivery and tum.ur th.rapy. © 2024, Ch.nese m.dical m.ltim.dia Press Co Ltd. All righ.s reserved.

关键词： abalone sh.ll drug delivery h.droxyapatite m.crosph.res m.gnesium.doping osteosarcom.

m.gnesium.oxide(m.O)nanoadsorbents in wastewater treatm.nt:A com.reh.nsive review

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Journal of m.gnesium.and Alloys 2024年第5期12卷 1709-1773页

作者： h.C.S.Perera V.Gurunanth.nan Anoop Singh.m.m.m.G.P.G.m.ntilaka G.Das Sandeep Arya Departm.nt of Ph.sics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of Science University of PeradeniyaPeradeniyaSri Lanka Departm.nt of h.m.nities and Sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India Centre for Global h.alth.Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia Departm.nt of Ph.sics University of JammuJammu and Kashmir180006India

Wastewater contam.nation by h.avy m.tals and synth.tic dyes presents a significant environm.ntal ch.llenge,necessitating effective and sustainable separation *** review article provides a detailed exam.nation of m.gnesium.oxide(m.O)nanoparticles as an innovative nanoadsorbent for wastewater treatm.nt,with.a specific focus on h.avy m.tal and dye *** review com.reh.nsively explores various aspects of m.O nanoparticles,including th.ir structural ch.racteristics and synth.sis *** article delves into th. m.rph.logy and crystallograph.c arrangem.nt of m.O nanoparticles,offering insigh.s into th.ir structural *** th. com.lexity of adsorption processes,th. review identifies and analyzes param.ters influencing th. adsorption efficiency of m.O nanoparticles,such.as tem.erature,ph.contact tim.,initial concentration,and co-existing *** interplay between th.se param.ters and th. adsorption capability of m.O nanoparticles em.h.sizes th. im.ortance of optim.zing operational ***,th. review assesses various synth.sis m.th.ds for m.O nanoparticles,including sol-gel,h.droth.rm.l,precipitation,green synth.sis,solvoth.rm.l,and tem.late-assisted *** discusses th. advantages,lim.tations,and resulting nanoparticle ch.racteristics of each.m.th.d,enabling readers to grasp th. im.lications of synth.sis processes on adsorption *** com.reh.nsive review consolidates current insigh.s into th. effectiveness of m.O nanoparticles as a potent nanoadsorbent for rem.ving h.avy m.tals and dyes from.wastewater covering a wide spectrum.of aspects related to m.O ***,th.re is a need to investigate th. use of m.O in th. treatm.nt of actual wastewater or river water,in order to leverage its cost-effectiveness and h.gh.efficiency for practical water treatm.nt applications in real-tim..

关键词： m.O nanoparticles Nanoadsorbent Wastewater treatm.nt h.avy m.tals Dye separation Adsorption Synth.sis m.th.ds

Im.unological Exploration of h.licobacter pylori Serotype O_(2) O-Antigen by Using a Synth.tic Glycan Library

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Ch.nese Journal of Ch.m.stry 2024年第3期42卷 243-251页

作者： m.ng Zh.o Guangzong Tian Ch.njun Qin Xiaopeng Zou Peter h. Seeberger Jing h. Jian Yin Key Laboratory of Carboh.drate Ch.m.stry and Biotech.ology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biom.lecular System. Departm.nt Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi Sch.ol of m.dicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

h.licobacter pylori(***)infection is a th.eat to h.m.n *** lipopolysacch.ride(LPS)O-antigen h.lds prom.se for developing *** is m.aningful to explore th. im.unological activity of oligosacch.rides with.different length. and fram.sh.fts for antigen ***,a glycan library of *** O2 O-antigen containing eigh. fragm.nts is *** screening with.*** O2 LPS sera and patients’sera by glycan m.croarray,th. disacch.ride h.O2G-2b and trisacch.ride h.O2G-3a sh.w strong antigenicity and th.n are separately conjugated with.carrier protein *** glycoconjugates elicit a robust im.unoglobulin G(IgG)im.une response in *** anti-h.O2G-3a IgG antibodies possess a m.ch.stronger binding affinity with.th. LPS and bacteria of *** O2 th.n th. anti-h.O2G-2b IgG *** is no cross-reaction between both.sera IgG antibodies with.LPS and bacteria of *** O1,O6,and *** results dem.nstrate th. trisacch.ride h.O2G-3a is a prom.sing candidate for *** vaccine developm.nt.

关键词： Glycoconjugates h.licobacter pylori Im.unology m.croarrays O-antigen Oligosacch.rides

Im.roving th. Transm.ssion Security of Vein Im.ges Using a Bezier Curve and Long Sh.rt-Term.m.m.ry

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Com.uters, m.terials & Continua 2024年第6期79卷 4825-4844页

作者： Ah.ed h.Alh.deth. Ikram.Sm.oui Ah.ed Fakh.akh.Saad m.Darwish Com.uter Science and Sch.ol of Electronics and Telecom.unications University of SfaxSfax3029Tunisia LETI Laboratory University of SfaxSfax3029Tunisia Digital Research.Center of Sfax Technopark of SfaxSfax3029Tunisia Departm.nt of Inform.tion Tech.ology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt

Th. act of transm.tting ph.tos via th. Internet h.s becom. a routine and significant *** th. security m.asures to safeguard th.se im.ges from.counterfeiting and m.difications is a critical dom.in th.t can still be furth.r *** study presents a system.th.t em.loys a range of approach.s and algorith.s to ensure th. security of transm.tted venous *** m.in goal of th.s work is to create a very effective system.for com.ressing individual biom.trics in order to im.rove th. overall accuracy and security of digital ph.tograph. by m.ans of im.ge *** paper introduces a content-based im.ge auth.ntication m.ch.nism.th.t is suitable for usage across an untrusted network and resistant to data loss during *** em.loying scale attributes and a key-dependent param.tric Long Sh.rt-Term.m.m.ry(LSTm.,it is feasible to im.rove th. resilience of digital signatures against im.ge deterioration and strength.n th.ir security against m.licious ***,th. successful im.lem.ntation of transm.tting biom.tric data in a com.ressed form.t over a wireless network h.s been *** applications involving th. transm.ssion and sh.ring of im.ges across a *** suggested tech.ique utilizes th. scalability of a structural digital signature to attain a satisfactory equilibrium.between security and picture *** effective adaptive com.ression strategy was created to length.n th. overall lifetim. of th. network by sh.ring th. processing of *** sch.m. ensures a large reduction in com.utational and energy requirem.nts wh.le m.nim.zing im.ge quality *** approach.em.loys m.lti-scale ch.racteristics to im.rove th. resistance of signatures against im.ge *** proposed system.attained a Gaussian noise value of 98%and a rotation accuracy surpassing 99%.

关键词： Im.ge transm.ssion im.ge com.ression text h.ding Bezier curve h.stogram.of Oriented Gradients(h.G) LSTm im.ge enh.ncem.nt Gaussian noise rotation

Adult Urological Cancers at Zinder National h.spital

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Open Journal of Urology 2024年第5期14卷 267-276页

作者： h.lidou m.azou m.nzo m. S. Ousm.ne Ch.ibou Soum.na Abdoulaye Kodo Idrissa Seriba Abdoulrazak R. h. Zakou Soum.na Am.dou Departm.nt of Urology University of Zinder Zinder Niger Departm.nt of Urologie University of Niamey Niamey Niger Departm.nt of m.#233 dicale Oncology National H&#244pital of Zinder Zinder Niger Departm.nt of Anatom. Path.logy Universit&#233 of Zinder Zinder Niger

Th. aim.of th.s study was to present th. epidem.ological, clinical and th.rapeutic aspects of adult urological cancers in th. departm.nt of urology at Zinder National h.spital. Patients and m.th.ds: Th.s was a cross-sectional study of adult prim.ry urologic cancers during th. period of January 2019 to Decem.er 2023. Data were obtained from.th. record of patients adm.tted to urology, and th. m.dical oncology departm.nt. Th. param.ters studied were;frequency, age, sex, urogenital distribution, anatom.path.logical type, and th.rapeutic aspects. Data were recorded on Excel 2013 and analyzed with.Epi-info version 7.2.5. Results: Epidem.ology: About 289 cancers were diagnosed th.ough.6017 consultations during th. period, corresponding to 4.80% of urological path.logies: prostate cancer (n = 221;76.47%), bladder cancer (n = 46;15.92%), kidney cancer (n = 13;04.5%), testis cancer (n = 09;03.11%). m.dian age of patients was 50.42 years. Prostate cancer: was Adenocarcinom. in 100% (n = 221) with.Gleason scores > 7 (77.83%) and prostatique specific antigen (PSA) > 20 ng/m. in 90.04%. Extension evaluation 134 cases (60.63%). Treatm.nt was ch.rurgical castration in (62.44%) and resistance to castration appeared between 8 and 11 m.nth.. h.spital m.rtality for prostate cancer was 16.29%. Bladder cancer was found in 46 cases with.Sex ratio 7/1. Cystoscopy was perform.d for all. h.stology revealed squam.us cell carcinom. (n = 41;89.13%), and (n = 5;10.87%) uroth.lial. Endoscopic resection perform.d (n = 14;30.43%). Kidney cancers were 13 cases (10 m.n, 03 wom.n). Neph.ectom. was perform.d in (n = 8;61.54%) cases and h.stology revealed renal cell cancer in 76.92%. Testicular cancers were diag 09 cases. h.story of cryptorch.dism.was found in 4 cases, 4-year infertility in 3 cases. Orch.dectom. was done in all cases. Ch.m.th.rapy in 3 cases. Conclusion: urological cancers are frequent, dom.nated by prostate cancer. Th. endem.city of bilh.rziasis h.s increased squam.us cell carcinom.. T

关键词： Urologic Cancers Epidem.ology h.stology Zinder

Enh.nced angiogenesis in porous poly(ε-caprolactone) scaffolds fortified with.m.th.crylated h.aluronic acid h.drogel after subcutaneous transplantation

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Biom.terials Translational 2024年第1期5卷 59-68页

作者： Yang h. Zh.ng m. Zh.ng Y. Li C. Lai J.h.C. Zh.ng Q. Ch.n K.W.Y. Wang h. Zh.o X. Yang Z. Xu C. Departm.nt of Biom.dical Engineering City University of Hong Kong Hong Kong Center for Pluripotent Stem.Cell Research.and Engineering Research Institute of Tsinghua Guangdong Province Guangzhou China Departm.nt of Applied Biology and Ch.m.cal Tech.ology The Hong Kong Polytechnic University Hong Kong

A com.osite scaffold com.osed of a porous scaffold and h.drogel filling can facilitate engraftm.nt, survival, and retention in cell transplantation processes. Th.s study presents a com.osite scaffold m.de of poly(ε-caprolactone) (PCL) and m.th.crylated h.aluronic acid (m.h.) h.drogel and describes th. corresponding ph.sical properties (surface area, porosity, and m.ch.nical strength. and h.st response (angiogenesis and fibrosis) after subcutaneous transplantation. Specifically, we synth.sise m.h. with.different degrees of substitution and fabricate a PCL scaffold with.different porosities. Subsequently, we construct a series of PCL/m.h. com.osite scaffolds by com.ining th.se h.drogels and scaffolds. In experim.nts with.m.ce, th. scaffold com.osed of 3% PCL and 10–100 kDa, degree of substitution 70% m.h. results in th. least fibrosis and a h.gh.r degree of angiogenesis. Th.s study h.gh.igh.s th. potential of PCL/m.h. com.osite scaffolds for subcutaneous cell transplantation, given th.ir desirable ph.sical properties and h.st response. © 2024, Ch.nese m.dical m.ltim.dia Press Co Ltd. All righ.s reserved.

关键词： angiogenesis cell transplantation h.aluronic acid poly(ε-caprolactone) scaffold

Search.for production of dark ferm.on candidates in association with.h.avy neutral gauge boson decaying to dim.on in proton-proton collisions at√s=8 TeV using Cm. open data

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Ch.nese Ph.sics C 2024年第4期48卷 6-13页

作者： Y.m.h.oud h.Abdallah.m.T.h.ssein S.Elgam.al Centre for th.oretical ph.sics The British University in EgyptEgypt Ph.sics Departm.nt Faculty of ScienceCairo UniversityEgypt

In th.s study,we conducted a search.for dark m.tter using a part of th. data recorded by th. Cm. experim.nt during run-I of th. Lh. in 2012 with.a center of m.ss energy of 8 TeV and an integrated lum.nosity of 11.6 fb−*** data were gath.red from.th. Cm. open *** m.tter,in th. fram.work of th. sim.lified m.del(m.no-Z′),can be produced from.proton-proton collisions in association with.a new h.poth.tical gauge boson,Z′.Th.s,th. search.was conducted in th. dim.on plus large m.ssing transverse m.m.ntum.*** bench.ark scenario of m.no-Z′,wh.ch.is known as ligh. vector,was used for interpreting th. Cm. open *** evidence of dark m.tter was observed,and exclusion lim.ts were set on th. m.sses of dark m.tter and Z′at 95%confidence level.

关键词： dark m.tter large h.dron collider Cm. open data search.for new ph.sics dark ferm.on

New Antenna Array Beam.orm.ng Tech.iques Based on h.brid Convolution/Genetic Algorith. for 5G and Beyond Com.unications

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Com.uter m.deling in Engineering & Sciences 2024年第3期138卷 2749-2767页

作者： Sh.m.a m.Am.r Ash.af A.m.Kh.laf Am. h.h.ssein Salm.n A.Alqah.ani m.stafa h.Dah.h.n h.ssam.m.Kassem Electronics and Com.unications Engineering Departm.nt Higher Institute of Engineering and TechnologyKafr ElsheikhEgypt Electronics and Electrical Com.unications Engineering Departm.nt Faculty of EngineeringMinia UniversityMiniaEgypt Electronics and Electrical Com.unications Engineering Departm.nt Faculty of EngineeringTanta UniversityTantaEgypt Electronics and Electrical Com.unications Engineering Departm.nt Faculty of EngineeringHorus University EgyptNew DamiettaEgypt Departm.nt of Com.uter Engineering College of computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Sch.ol of Com.uting Mathematics and EngineeringCharles Sturt UniversityBathurstNSW2795Australia

Side lobe level reduction(SLL)of antenna arrays significantly enh.nces th. signal-to-interference ratio and im.roves th. quality of service(QOS)in recent and future wireless com.unication system. starting from.5G up to ***,it im.roves th. array gain and directivity,increasing th. detection range and angular resolution of radar *** study proposes two h.gh.y efficient SLL reduction *** tech.iques are based on th. h.bridization between eith.r th. single convolution or th. double convolution algorith.s and th. genetic algorith.(GA)to develop th. Conv/GA andDConv/GA,*** convolution process determ.nes th. elem.nt’s excitations wh.le th. GA optim.zes th. elem.nt *** m.elem.nts linear antenna array(LAA),th. convolution of th. excitation coefficients vector by itself provides a new vector of excitations of length.N=(2m.1).Th.s new vector is divided into th.ee different sets of excitations including th. odd excitations,even excitations,and m.ddle excitations of length. m.m.1,andm.*** th. sam. elem.nt spacing as th. original LAA is used,it is noticed th.t th. odd and even excitations provide a m.ch.lower SLL th.n th.t of th. LAA but with.am.ch.wider h.lf-power beam.idth.h.BW).Wh.le th. m.ddle excitations give th. sam. h.BWas th. original LAA with.a relatively h.gh.r *** th. increased h.BWof th. odd and even excitations,th. elem.nt spacing is optim.zed using th. ***,th. synth.sized arrays h.ve th. sam. h.BW as th. original LAA with.a two-fold reduction in th. ***,for extrem. SLL reduction,th. DConv/GA is *** th.s tech.ique,th. sam. procedure of th. aforem.ntioned Conv/GA tech.ique is perform.d on th. resultant even and odd excitation *** provides a relatively wider h.BWth.n th. original LAA with.about quad-fold reduction in th. SLL.

关键词： Array synth.sis convolution process genetic algorith.(GA) h.lf power beam.idth.h.BW) linear antenna array(LAA) side lobe level(SLL) quality of service(QOS)

A new tech.ique for fault diagnosis in transform.r insulating oil based on infrared spectroscopy m.asurem.nts

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h.gh.Voltage 2024年第2期9卷 319-335页

作者： m.h.m.d m.F.Darwish.m.h.m.d h.A.h.ssan Nagat m.K.Abdel-Gawad m.tti Leh.onen Diaa-Eldin A.m.nsour Departm.nt of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Departm.nt of Electrical Engineering and Autom.tion School of Electrical EngineeringAalto UniversityEspooFinland Departm.nt of Electrical Power Engineering Egypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityEgypt Departm.nt of Electrical Power and m.ch.nes Engineering Faculty of EngineeringTanta UniversityTantaEgypt

Condition m.nitoring of th. insulating system.with.n power transform.rs h.s a m.ssive im.ortance according to th. electrical *** gas analysis(DGA)is frequently used for th.s ***,DGA lacks th. necessary level of accuracy to identify all equipm.nt faults,particularly in th.ir initial stages of ***,it does not h.ve th. capability for real-tim. m.nitoring and relies on m.nual sam.ling and laboratory testing,causing potential delays in fault ***,th. interpretation of DGA data necessitates specialised expertise,wh.ch.m.y pose difficulties for sm.ller entities th.t h.ve lim.ted access to ***,th. contribution of th.s research.is to use infrared spectroscopy m.asurem.nts as a new effective tech.ique substituting th. DGA m.th.d for fault diagnosis in insulating *** inception faults th.t were considered in th.s study were th. electrical fault(disch.rges of h.gh.energy)and th. th.rm.l fault(300°Cm.eratureh.t,two test cells were crafted especially for serving th. sim.lation processes inside th. laboratory for both.types of inception ***,six sam.les of pure paraffinic m.neral oil were taken to be degraded in th. *** th.t,all of th.m.besides anoth.r sam.le th.t were not subjected to any kind of faults were taken to be exam.ned by Fourier transform.infrared(FTIR)spectroscopy to obtain an overview of th. oil's beh.viour in each.fault *** th.t,th. FTIR analysis was initially verified utilising th. DGA ***,for furth.r affirm.tion,th. dielectric dissipation factor(DDF)for all sam.les was *** th. final analysis,th. verification tests provide experim.ntal evidence about th. outperform.nce of th.s new optical tech.ique in detecting th. transform.r's inception faults in addition to proving its potential for being a superior alternative to th. well-known traditional diagnostic tech.iques.

关键词： fault diagnosis spectroscopy