检索结果-南通市图书馆

NIR-Ⅱ responsive Janus nanoparticles am.lify im.unogenic cell death.for enh.nced cancer im.unoth.rapy

Science Ch.na(Tech.ological Sciences) 2024年第1期67卷 321-329页

作者： Ch.N BeiBei GUO KangLi wang h.oRan XU Fu-Jian wang JuLin Zh.O NaNa State Key Laboratory of Ch.m.cal Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Biom.dical m.terials of Natural m.crom.lecules(Beijing University of Ch.m.cal Tech.ology) Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of m.terials Sciences and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Electroch.m.cal Process and Tech.ology for m.terials Beijing University of Chemical TechnologyBeijing 100029China

Im.unoth.rapy brings new h.pe for tum.r treatm.nt by inducing im.unogenic cell death.ICD)of tum.r ***,insufficient im.unogenicity and low im.une response rate greatly lim.t antitum.r ***,by optim.zing th. com.osition and m.rph.logy,th. rational design of Janus nanoparticles com.osed of Fe_(3)O_(4) nanosph.res and SiO_(2)nanorods was realized for enh.nced cancer im.unoth.rapy th.ough.am.lified *** glucose oxidase(GOx)was loaded by th. Janus nanoparticles,th. resultant m.FS-GOx consum.s glucose at tum.r sites to generate gluconic acid and h.drogen peroxide(h.(2)O_(2))for starvation th.rapy wh.le th. h.(2)O_(2)supply prom.tes th. production of h.gh.y toxic·Oh.to ach.eve effective ch.m.dynam.c th.rapy(CDT).Under a 1064 nm.ligh. irradiation,th. ph.toth.rm.l effect of m.FS-GOx enh.nces th. enzym. activity of GOx for im.roved starvation ***,both.tum.r-associated antigens released during th. process of ICD and th. intrinsic im.unoadjuvant property of m.FS-GOx stim.late dendritic cell m.turation to activate antitum.r im.une *** work provides a prom.sing strategy for th. construction of Janus nanoparticles to ach.eve enh.nced cancer im.unoth.rapy th.ough.com.ination th.rapy-am.lified ICD.

关键词： Janus nanoparticles im.unogenic cell death cancer im.unoth.rapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Developm.nt of a Novel Noise Reduction Algorith. for Sm.rt Ch.ckout RFID System.in Retail Stores

引用

Com.uters, m.terials & Continua 2024年第7期80卷 1277-1304页

作者： Sh.zielya Sh.m.ul m.h.m.ed A.h.Ali Salwa h.nim.Abdul-Rash.d Atef m.Gh.leb Fah.d m.Alqah.ani Departm.nt of m.ch.nical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur50603Malaysia Centre for Sustainable and Sm.rt m.nufacturing(CSSm. Faculty of EngineeringUniversiti MalayaKuala Lumpur50603Malaysia Departm.nt of Industrial Engineering College of EngineeringAlfaisal UniversityRiyadh11533Saudi Arabia Departm.nt of Industrial Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

Th.s paper presents a sm.rt ch.ckout system.designed to m.tigate th. issues of noise and errors present in th. existing barcode and RFID-based system. used at retail stores’ch.ckout *** is ach.eved by integrating a novel AI algorith.,called Im.roved Laser Sim.lator Logic(ILSL)into th. RFID *** enh.nced RFID system.was able to im.rove th. accuracy of item.identification,reduce noise interference,and stream.ine th. overall ch.ckout *** potential of th. system.or noise detection and elim.nation was initially investigated th.ough.a sim.lation study usingm.TLAB and ILSL ***,it was deployed in a sm.ll-scale environm.nt to validate its real-world *** sh.w th.t RFID with.th. proposed new algorith. ILSL and AI basket is capable of accurately detecting th. related item.wh.le elim.nating noise originating from.nrelated objects,ach.eving an accuracy rate of 88%.

关键词： Sm.rt ch.ckout system RFID tech.ology im.roved laser sim.lator logic(ILSL) reduce noise ch.ckout process

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genom.c m.saicism.of th. Brain:Origin,Im.act,and Utility

引用

Neuroscience Bulletin 2024年第6期40卷 759-776页

作者： Jared h.Grah.m.Joh.nnes C.m.Sch.ach.tzki Xiaoxu Yang m.rtin W.Breuss Departm.nt of Pediatrics Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Departm.nt of Cellular and m.lecular m.dicine University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Departm.nt of Neurosciences University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady Ch.ldren’s Institute for Genom.c m.dicine San Diego92123CAUSA

Genom.c m.saicism.describes th. ph.nom.non wh.re som. but not all cells with.n a tissue h.rbor unique genetic ***,research.focused on th. im.act of genom.c m.saicism.on clinical ph.notype—m.tivated by its involvem.nt in cancers and overgrowth.*** recently,we increasingly sh.fted towards th. pleth.ra of neutral m.saic variants th.t can act as recorders of cellular lineage and environm.ntal ***,we sum.arize th. current state of th. field of genom.c m.saicism.research.with.a special em.h.sis on our current understanding of th.s ph.nom.non in brain developm.nt and *** th. field of genom.c m.saicism.h.s a rich.h.story,tech.ological advances in th. last decade h.ve ch.nged our approach.s and greatly im.roved our *** will provide current definitions and an overview of contem.orary detection approach.s for genom.c ***,we will discuss th. im.act and utility of genom.c m.saicism.

关键词： Genom.cs Brain developm.nt Brain h.m.ostasis Genom.c m.saicism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

m.tal-organic fram.work h.brid m.terials of ZIF-8/RGO for im.obilization of D-am.no acid deh.drogenase

引用

Nano Research 2024年第1期17卷 290-296页

作者： h.ngbin Lei Qian Zh.ng Xiaoyan Xiang Liang Jiang Sh.yan wang Lingxuan Duan Sh.zh.n wang Departm.nt of Ch.m.cal and Bioch.m.cal Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Xiam.n Key Laboratory of Synth.tic Biotech.ology Xiamen UniversityXiamen 361005China

Im.obilization of D-am.no acid deh.drogenase(DAADh.by th. assem.ly of peptide linker was studied for th. biosynth.sis of *** m.terial of zeolitic im.dazolate fram.work-8(ZIF-8)com.ined with.reduced graph.ne oxide(RGO)was applied for th. im.obilization of DAADh.from.Ureibacillus *** recovery rate of DAADh.ZIF-8/RGO was 165.6%.DAADh.ZIF-8/RGO rem.ined 53.4%of its initial activity at 50°C for 10 h.wh.le th. free enzym. was ***/ZIF-8/RGO m.intained 70.5%activity in h.peralkaline solution with.ph.*** param.ters indicated th.t DAADh.ZIF-8/RGO h.d greater affinity of ph.nylpyruvate as V_(m.x)/K_(m.of DAADh.ZIF-8/RGO was 1.27-fold th.n free *** seven recycles,th. activity of DAADh.ZIF-8/RGO rem.ined 64.3%.Furth.rm.re,one-step separation and in situ im.obilization of DAADh.by ZIF-8/RGO/Ni was carried out with.1.5-fold activity *** peptide linker and m.tal-organic fram.work(m.F)im.obilization,th.rm.stability and activity of th. im.obilized DAADh.were significantly im.roved.

关键词： D-Am.no acid deh.drogenase im.obilization m.tal-organic fram.works zeolitic im.dazolate fram.work-8(ZIF-8) reduced graph.ne oxide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

12.6μm.Th.ck Asym.etric Com.osite Electrolyte with.Superior Interfacial Stability for Solid-State Lith.um.m.tal Batteries

引用

Nano-m.cro Letters 2024年第9期16卷 397-409页

作者： Zh.ng Zh.ng Jingren Gou Kaixuan Cui Xin Zh.ng Yujian Yao Suqing wang h.ih.i wang Beijing Key Laboratory for m.m.rane m.terials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China Sch.ol of Ch.m.stry and Ch.m.cal Engineering South China University of TechnologyGuangzhou 510000People’s Republic of China

Solid-state lith.um.m.tal batteries(SSLm.s)sh.w great prom.se in term. of h.gh.energy-density and h.gh.safety ***,th.re is an urgent need to address th. com.atibility of electrolytes with.h.gh.voltage cath.des/Li anodes,and to m.nim.ze th. electrolyte th.ckness to ach.eve h.gh.nergy-density of ***,we develop an ultrath.n(12.6μm.asym.etric com.osite solid-state electrolyte with.ultraligh. areal density(1.69 m. cm.(−2))for *** electrolyte com.ining a garnet(LLZO)layer and a m.tal organic fram.work(m.F)layer,wh.ch.are fabricated on both.sides of th. polyeth.lene(PE)separator separately by tape *** PE separator endows th. electrolyte with.flexibility and excellent m.ch.nical *** LLZO layer on th. cath.de side ensures h.gh.ch.m.cal stability at h.gh.*** m.F layer on th. anode side ach.eves a stable electric field and uniform.Li flux,th.s prom.ting uniform.Li^(+)*** to th. well-designed structure,th. Li sym.etric battery exh.bits an ultralong cycle life(5000 h.,and h.gh.voltage SSLm.s ach.eve stable cycle *** assem.led pouch.cells provided a gravim.tric/volum. energy density of 344.0 Wh.kg^(−1)/773.1 Wh.L^(−1).Th.s sim.le operation allows for large-scale preparation,and th. design concept of ultrath.n asym.etric structure also reveals th. future developm.nt direction of SSLm.s.

关键词： Solid-state lith.um.m.tal batteries Com.osite solid-state electrolyte Ultrath.n asym.etric structure Pouch.cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sodium.nitroprusside as a signal m.lecule for up-regulating m.m.rane ch.racteristics,antioxidant defense system.to im.rove flax productivity under water stress

引用

Oil Crop Science 2024年第3期9卷 160-169页

作者： N.m.Al-Ash.ar B.A.Bakry h.m.S.El-Bassiouny m.m.S.Abdallah.m.S.Sadak Botany Departm.nt Agricultural and Biological Research InstituteNational Research Centre33 El Bohouth Street P.O.12622DokkiGizaEgypt Field Crops Research.Departm.nt Agricultural and Biological Research InstituteNational Research Centre33 El Bohouth Street P.O.12622DokkiGizaEgypt

Water stress is a critical environm.ntal adversity th.t significantly im.acts th. growth.developm.nt,and yield of flax *** th.s study,flax seeds were cultivated under different water irrigation requirem.nts(WIR)(100%,75%,and 50%)to investigate th. effects of exogenously supplied nitric oxide(NO)donor sodium.nitroprusside(SNP)as foliar treatm.nts at concentrations of 0.0 m.ol/L,0.5 m.ol/L,1.0 m.ol/L,and 2.0 m.ol/*** stress led to a significant decrease in plant growth.ph.tosynth.tic pigm.nts,yield com.onents such.as oil and total carboh.drate *** also resulted in an increase in leaf h.O2 production,lipid peroxidation levels and activities of enzym.tic antioxidants including polyph.nol oxidase,superoxide dism.tase,and nitrate reductase ***,foliar application of SNP im.roved ph.tosynth.tic pigm.nts and antioxidant defense system.wh.ch.m.tigated th. negative im.act of water stress on growth.and yield productivity by reducing oxidative dam.ge caused by reactive oxygen species *** use of SNP also decreased h.(2)O_(2) accum.lation levels,lipid peroxidation levels,and im.roved m.m.rane *** treatm.nt at concentration of 2 m.ol/L sh.wed superior results com.ared to oth.r concentrations with.extrem.ly significant increases observed in yield ch.racteristics such.as oil content,total carboh.drate percentages,and unsaturated fatty acids to saturated fatty acids ratio.

关键词： Flax Fatty acid Sodium.nitroprusside Antioxidant enzym.s Yield

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ch.m.stry : structure and dynam.cs / Jam.s N. Spencer, George m. Bodner, Lym.n h. Rickard.

引用

1999年

作者： Jam.s N. Spencer George m. Bodner Lym.n h. Rickard.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Baicalein suppresses Coxsackievirus B3 replication by inh.biting caspase-1 and viral protease 2A

引用

Virologica Sinica 2024年第4期39卷 685-693页

作者： Yanyan Dong Enze Sh.o Siwei Li Ruiqi wang Dan wang Lixin wang h.ng Yang Yingxia h. Tian Luan Yang Ch.n Yao wang Lexun Lin Yan wang Zh.oh.a Zh.ng Wenran Zh.o Departm.nt of Cell Biology Harbin Medical UniversityHarbin 150081China Departm.nt of m.crobiology Harbin Medical UniversityHarbin 150081China

m.ocarditis is an inflam.atory disease of th. cardiac m.scle and one of th. prim.ry causes of dilated *** B coxsackievirus(CVB)is one of th. leading causative path.gens of viral m.ocarditis,wh.ch.prim.rily affects ch.ldren and young *** to th. lack of vaccines,th. developm.nt of antiviral m.dicines is crucial to controlling CVB infection and th. progression of *** th.s study,we investigated th. antiviral effect of baicalein,a flavonoid extracted from.Scutellaria *** results dem.nstrated th.t baicalein treatm.nt significantly reduced cytopath.c effect and increased cell viability in CVB3-infected *** addition,significant reductions in viral protein 3D,viral RNA,and viral particles were observed in CVB3-infected cells treated with.*** found th.t baicalein exerted its inh.bitory effect in th. early stages of CVB3 *** also suppressed viral replication in th. m.ocardium.and effectively alleviated m.ocarditis induced by CVB3 *** study revealed th.t baicalein exerts its antiviral effect by inh.biting th. activity of caspase-1 and viral protease *** togeth.r,our findings dem.nstrate th.t baicalein h.s antiviral activity against CVB3 infection and m.y serve as a potential th.rapeutic option for th. m.ocarditis caused by enterovirus infection.

关键词： Baicalein Coxsackievirus B(CVB) m.ocarditis 2A protease Caspase-1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering biom.m.tic nanosystem.targeting m.ltiple tum.r radioresistance h.llm.rks for enh.nced radioth.rapy

引用

Science Ch.na(Life Sciences) 2024年第7期67卷 1398-1412页

作者： Sh.xiang wang h.ngm.i Cao Cui-Cui Zh.o Qian wang Dianyu wang Jinjian Liu Lijun Yang Jianfeng Liu State Key Laboratory of Advanced m.dical m.terials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear MedicineKey Laboratory of Radiopharmacokinetics for Innovative DrugsTianjin Institutes of Health ScienceInstitute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Tianjin m.dical University Cancer Institute and h.spital National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy(Tianjin)Key Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China

Tum.r cells establish.a robust self-defense system.ch.racterized by h.poxia,antioxidant overexpression,DNA dam.ge repair,and so forth.to resist *** one of th.se features is insufficient to overcom. radioresistance due to th. feedback m.ch.nism. initiated by tum.r cells under ***,we h.rein developed an engineering biom.m.tic nanosystem.m.h.Pt)m.sked with.tum.r cell m.m.ranes and loaded with.a h.bridized protein-based nanoparticle carrying oxygens(O_(2))and cisplatin prodrugs(Pt(Ⅳ))to target m.ltiple tum.r radioresistance h.llm.rks for enh.nced *** adm.nistration,m.h.Pt actively targeted and sm.oth.y accum.lated in tum.r cells by virtue of its innate h.m.ng abilities to realize efficient co-delivery of O_(2)and Pt(Ⅳ).O_(2)introduction induced h.poxia alleviation cooperated with.Pt(Ⅳ)reduction caused glutath.one consum.tion greatly am.lified radioth.rapy-ignited cellular oxidative ***,th. released cisplatin effectively h.ndered DNA dam.ge repair by crosslinking with.radioth.rapy-produced DNA ***,m.h.Pt-sensitized radioth.rapy significantly suppressed th. proliferation of lung cancer h.975 cells with.an extrem.ly h.gh.sensitizer enh.ncem.nt ratio of 1.91 and th. progression of h.975 tum.r m.dels with.an excellent tum.r inh.bition rate of 94.7%.Overall,th.s work provided a feasible strategy for tum.r radiosensitization by overcom.ng m.ltiple radioresistance m.ch.nism..

关键词： biom.m.tic nanosystem h.poxia alleviation glutath.one consum.tion oxidative stress am.lification DNA dam.ge fixation radiosensitization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lum.nescence regulation of Sb^(3+)in 0D h.brid m.tal h.lides by h.drogen bond network for optical anti-counterfeiting

引用

Opto-Electronic Advances 2024年第3期7卷 15-25页

作者： Deh.i Liang Saif m.h.Qaid Xin Yang Sh.angyi Zh.o Binbin Luo Wensi Cai Qingkai Qian Zh.gang Zang Key Laboratory of Optoelectronic Tech.ology&System.(m.nistry of Education) Chongqing UniversityChongqing 400044China Departm.nt of Ph.sics&Astronom. College of SciencesKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Departm.nt of Ch.m.stry and Ch.m.cal Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China Departm.nt of Oil Army Logistics Academy of PLAChongqing 401311China

Th. Sb^(3+) doping strategy h.s been proven to be an effective way to regulate th. band gap and im.rove th. ph.toph.sical properties of organic-inorganic h.brid m.tal h.lides(OIh.h.).h.wever,th. em.ssion of Sb^(3+) ions in OIh.h. is prim.rily confined to th. low energy region,resulting in yellow or red *** date,th.re are few reports about green em.ssion of Sb^(3+)-doped ***,we present a novel approach.for regulating th. lum.nescence of Sb^(3+) ions in 0D C_(10)h.(2)_(2)N_(6)InCl_(7)·h.(2)O via h.drogen bond network,in wh.ch.water m.lecules act as agents for h.drogen ***^(3+)-doped C_(10)h.(2)2N_(6)InCl_(7)·h.(2)O sh.ws a broadband green em.ssion peaking at 540 nm.and a h.gh.ph.tolum.nescence quantum.yield(PLQY)of 80%.It is found th.t th. intense green em.ssion stem. from.th. radiative recom.ination of th. self-trapped excitons(STEs).Upon rem.val of water m.lecules with.h.at,C_(10)h.(2)_(2)N_(6)In_(1-x)Sb_(x)Cl_(7) generates yellow em.s-sion,attributed to th. breaking of th. h.drogen bond network and large structural distortions of excited *** water m.lecules are adsorbed by C_(10)h.(2)_(2)N_(6)In_(1-x)Sb_(x)Cl_(7),it can subsequently em.t green *** water-induced reversible em.ssion switch.ng is successfully used for optical security and inform.tion *** findings expand th. under-standing of h.w th. local coordination structure influences th. ph.toph.sical m.ch.nism.in Sb^(3+)-doped m.tal h.lides and provide a novel m.th.d to control th. STEs em.ssion.

关键词： indium.based h.lides Sb^(3+)doping h.drogen bonding network optical anti-counterfeiting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：