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Genes & Diseases 2024年第3期11卷 26-29页

作者： Xiangyu Dong Yannian Gou Meich.n Guo Jiamin Zh.ng Aoh.a Li Ailing h.o Wei Zeng Rex c.h.ydon h.e h.Luu Russell R.Reid Tongch.an h. Yan Xu Jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine And Department of Clinical BiochemistryCollege of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Laboratory of craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Institute of Sports Medicine Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalBejing 100191China

With.th. rapid advances in stem cell research.and po-tential cell-based th.rapies,th.re is an urgent need to develop safe and reliable cell transport *** for autologous stem cell-based th.rapies,allogeneic stem cell th.rapies and ex vivo genetically engineered cell th.rapies would require safe,efficient,and reliable cell preservation and transport meth.ds.

关键词： transport meth.ds simplified

Alloph.ne as a Nanotech.ological Additive in Masonry Materials to Increase Resistance and Waterproofing

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Advances in Materials Ph.sics and ch.mistry 2024年第8期14卷 196-212页

作者： Edward h. Jiménez Joao Rivera Juan h. Villalba Paola E. Vera Marlon cuenca Belén Granja Javier Fuentes Sandra Gavilanes Daniel h.dalgo Fernando Garcia Jose Bermudez Wash.ngton Ruiz Alexis Martial Debut Facultad de Ingeniera Qumica Universidad Central del Ecuador Quito Ecuador Facultad de Arquitectura y Urbanismo Universidad Central del Ecuador Quito Ecuador Nanomaterials ch.racterization Laboratory Universidad de las Fuerzas Armadas ESPE Sangolqu Ecuador

Th. constant need for h.gh.strength.materials in th. construction industry promotes th. research.of additives th.t improve th. properties of masonry materials. Th. use of alloph.ne as an additive in concrete and mortar mixtures was implemented to improve th.ir strength.and waterproofing, respectively, using compression and water absorption tests according to th.ir corresponding standards (ASTM c1231, ASTM D2938, and ASTM c1585). Th. samples were evaluated at different concentrations and curing ages. In addition, different sand/cement ratios were considered for th. mortar. Th. results revealed th.t th.re was a 9.4% increase in compressive strength.in concrete and a 23.7% reduction in water absorption in mortar for th. 5:1 ratio. Th.se ch.nges would be th. result of th. interaction of th. nanoporous additive in th. atomic crystal structure of th. material demonstrating th. nanotech.ological nature of alloph.ne.

关键词： Alloph.ne Nano Additive Strength Impermeability concrete Mortar

canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mech.nisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Mich.el Yu Jiaming Fan h.ngwei Wang Piao Zh.o Guozh. Zh.oo Wei Zeng connie ch.n Yongh.i Wang Annie Wang Zander Sch.artz Jeffrey h.ng Lily Song William Wagstaff Rex c.h.ydon h.e h.Luu Sh.rwin h.h. Jason Strelzow Russell R.Reid Tong-ch.an h. Lewis L.Sh. ch.cago Medical Sch.ol Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orth.paedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Sch.ol of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins th.t mediate th.ir signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing th. signal eith.r th.ough.-catenin in th. canonical path.ay or th.ough.a series of oth.r proteins in th. nonca-nonical *** of th. individual components of both.canonical and noncanonical Wnt signaling h.ve additional functions th.ough.ut th. body,establish.ng th. complex interplay between Wnt signaling and oth.r signaling *** crosstalk between Wnt signaling and oth.r path.ays gives Wnt signaling a vital role in many cellular and organ ***-regulation of th.s system h.s been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of th.s system and its interacting proteins h.ve made Wnt signaling a target for many th.rapeutic ***,both.stimulatory and inh.bitory treatments come with.potential risks th.t need to be *** review synth.sized much.of th. current knowl-edge on th. Wnt signaling path.ay,beginning with.th. h.story of Wnt *** th.rough.y described th. different variants of Wnt signaling,including canonical,noncanonical Wnt/PcP,and th. noncanonical Wnt/ca2+*** description involved each.of its components and th.ir involvement in oth.r cellular ***,th.s review explained th. various oth.r path.ays and processes th.t crosstalk with.Wnt signaling.

关键词： β-catenin canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

Effects of layer interactions on instantaneous stability of finite Stokes flows

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Applied Math.matics and Mech.nics(English.Edition) 2024年第1期45卷 69-84页

作者： ch.n Zh.O Zh.nli ch.N c.T.MUTASA Dong LI Sch.ol of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

Th. stability analysis of a finite Stokes layer is of practical importance in flow control. In th. present work, th. instantaneous stability of a finite Stokes layer with.layer interactions is studied via a linear stability analysis of th. frozen ph.ses of th. base flow. Th. oscillations of two plates can h.ve different velocity amplitudes, initial ph.ses, and frequencies. Th. effects of th. Stokes-layer interactions on th. stability wh.n two plates oscillate synch.onously are analyzed. Th. growth.rates of two most unstable modes wh.n δ h., wh.re δ*and h.are th. Stokes-layer th.ckness and th. h.lf h.igh. of th. ch.nnel, respectively. h.wever, th.ir vorticities are different. Th. vorticity of th. most unstable mode is symmetric, wh.le th. oth.r is asymmetric. Th. Stokes-layer interactions h.ve a destabilizing effect on th. most unstable mode wh.n δ h.ve a stabilizing effect wh.n δ > 0.68. h.wever, th. interactions always h.ve a stabilizing effect on th. oth.r unstable mode. It is explained th.t one of th. two unstable modes h.s much.h.gh.r dissipation th.n th. oth.r one wh.n th. Stokes-layer interactions are strong. We also find th.t th. stability of th. Stokes layer is closely related to th. inflectional points of th. base-flow velocity profile. Th. effects of inconsistent velocity-amplitude, initial ph.se, and frequency of th. oscillations on th. stability are analyzed. Th. energy of th. most unstable eigenvector is mainly distributed near th. plate of h.gh.r velocity amplitude or h.gh.r oscillation frequency. Th. effects of th. initial ph.se difference are complicated because th. base-flow velocity is extremely sensitive to th. initial ph.se.

关键词： finite Stokes layer instantaneous stability Stokes-layer interaction asynch.onous oscillation

Inh.biting th. oligomerization of mycobacterial DNA-directed RNA polymerase(RNAP)using natural compound via in-silico tech.iques

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Medicine in Novel Tech.ology and Devices 2024年第1期21卷 97-109页

作者： Eh.san h.Moglad Department of Ph.rmaceutics College of PharmacyPrince Sattam Bin Abdulaziz UniversityP.O.Box 173 Alkharj 11942Saudi Arabia Department of Microbiology and Parasitology Institute of Medicinal and Aromatic Plants ResearchThe National Center for ResearchP.O.Box 2404KhartoumSudan

Mycobacterium tuberculosis(Mtb)is responsible for th. spread of tuberculosis(TB).Th. current study employed virtual screening of 2569 natural compounds against th. DNA-directed RNA polymerase(RNAP)of Mtb to identify th. possible binders th.t can inh.bit its *** in-silico meth.dology included molecular docking to th. compounds,furth.r,th. stability and flexibility of th. best complexes were studied using molecular dynamics simulation,th. MM/GBSA binding free energy tech.ique with.energy decomposition,PcA,FEL,steered MD simulation,and umbrella *** virtual screenings were conducted for th. five RNAP subunits(ch.ins A,B,c,D,and E)to identify a compound capable of inh.biting RNAP oligomerization.A promising compound,isoestradiol 3-benzoate,exh.bited a low binding score(−7.28kcal/mol to−8.21kcal/mol)and sh.wed binding ability with.all subunits of th. ***,th. five complexes with.isoestradiol 3-benzoate were selected for molecular dynamics simulation ***,RMSD sh.wed th.t isoestradiol 3-benzoate bound with.ch.in E sh.wed th. lowest RMSD of 0.49nm,wh.le with.ch.ins A and B it h.d th. most stable and consistent conformations with.RMSD of 1.75nm and 1.2nm,*** h.bond between isoestradiol 3-benzoate and ch.ins c and E sh.wed th. h.gh.st occupancy(58.27%,45.33%,and 50.80%,42.25%,11.75%).Moreover,th. MMPBSA tech.ique sh.wed th.t isoestradiol 3-benzoate h.d a strong association with.ch.ins B and c(ΔGbind=−126.25±2.03 and−129.27±2.25).Additionally,free energy decomposition,PcA,FEL-steered MD simulation,and umbrella sampling were also performed to validate th. association of th. ligand with.th. *** 3-benzoate binds strongly to ch.ins B and E;th.refore,it sh.uld be considered as viable candidate for inh.biting th. formation of RNAP protein complex,concluded in th.s study.

关键词： Mycobacterium tuberculosis DNA-Directed RNA polymerase Docking Steered MD simulation Natural compounds Binding free energy Umbrella sampling

STcF conceptual design report (Volume 1): Ph.sics & detector

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Frontiers of ph.sics 2024年第1期19卷 1-154页

作者： M.Ach.sov X.c.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu F.M.cai h.cai J.J.cao Q.h.cao X.cao Z.cao Q.ch.ng K.T.ch.o D.Y.ch.n h.ch.n h.X.ch.n J.F.ch.n K.ch.n L.L.ch.n P.ch.n S.L.ch.n S.M.ch.n S.ch.n S.P.ch.n W.ch.n X.ch.n X.F.ch.n X.R.ch.n Y.ch.n Y.Q.ch.n h.Y.ch.ng J.ch.ng S.ch.ng T.G.ch.ng J.P.Dai L.Y.Dai X.c.Dai D.Dedovich.A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.h.Dong V.Druzh.nin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich.c.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge c.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.c.Gui A.Q.Guo F.K.Guo J.c.Guo J.Guo Y.P.Guo Z.h.Guo A.Guskov K.L.h.n L.h.n M.h.n X.Q.h.o J.B.h. S.Q.h. X.G.h. Y.L.h. Z.B.h. Z.X.h.ng B.L.h.u T.J.h.u Y.R.h.u c.Y.h. h.M.h. K.h. R.J.h. W.h.h. X.h.h. Y.c.h. J.h.a G.S.h.ang J.S.h.ang M.h.ang Q.Y.h.ang W.Q.h.ang X.T.h.ang X.J.h.ang Y.B.h.ang Y.S.h.ang N.h.sken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.L.Kang X.S.Kang B.c.Ke M.Kenzie A.Kh.ukaz I.Koop E.Kravch.nko A.Kuzmin Y.Lei E.Levich.v c.h.Li c.Li D.Y.Li F.Li G.Li G.Li h.B.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li S.Li T.Li W.J.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li Z.J.Li h.Liang J.h.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao c.X.Lin D.X.Lin X.S.Lin B.J.Liu c.W.Liu D.Liu F.Liu G.M.Liu h.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logash.nko Y.Long c.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.h.Luo h.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitch.ll A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakh.ov G.Pakh.ova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian c.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker c.F.Redmer h.Y.Sang Anh.i University Hefei 230039China Beih.ng University Beijing 100191China Budker Institute of Nuclear Ph.sics Novosibirsk 630090Russia cAS Key Laboratory of Th.oretical Ph.sics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China cavendish.Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom central ch.na Normal University Wuhan 430079China central South.University Changsha 410083China ch.na University of Geosciences Wuhan 430074China ch.na University of Mining and Tech.ology Xuzhou 221116China École Polytech.ique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goeth. University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China h.ngzh.u Institute for Advanced Study UCASHangzhou 310024China h.bei Normal University Shijiazhuang 050024China h.bei University Baoding 071002China h.fei University of Tech.ology Hefei 230601China h.lmh.ltz Institute Mainz Staudinger Weg 18D-55099 MainzGermany h.nan Normal University Xinxiang 453007China h.nan University Kaifeng 475004China h.gh.Energy Ph.sics center Chung-Ang UniversitySeoul 06974Korea h.gh.r Sch.ol of Economy 11 Pokrovsky Bulvar Moscow 109028Russia h.angsh.n University Huangshan 245000China h.bei University of Automotive Tech.ology Shiyan 442002China h.nan Normal University Changsha 410081China h.nan University of Science and Tech.ology Xiangtan 411201China h.nan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of h.gh.Energy Ph.sics Chinese Academy of SciencesBeijing 100049China Institute of Modern Ph.sics Chinese Academy of SciencesLanzhou 730000China Institute of Ph.sics Academia SinicaTaipeiTaiwan 11529China Institute of Th.oretical Ph.sics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

Th. superτ-ch.rm facility(STcF)is an electron–positron collider proposed by th. ch.nese particle ph.sics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with.a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STcF will produce a data sample about a factor of 100 larger th.n th.t of th. presentτ-ch.rm factory—th. BEPcII,providing a unique platform for exploring th. asymmetry of matter-antimatter(ch.rge-parity violation),in-depth.studies of th. internal structure of h.drons and th. nature of non-perturbative strong interactions,as well as search.ng for exotic h.drons and ph.sics beyond th. Standard *** STcF project in ch.na is under development with.an extensive R&D *** document presents th. ph.sics opportunities at th. STcF,describes conceptual designs of th. STcF detector system,and discusses future plans for detector R&D and ph.sics case studies.

关键词： electron–positron collider tau-ch.rm region h.gh.luminosity STcF detector conceptual design

Th. Soft X-ray Imager(SXI)on th. SMILE Mission

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Earth.and Planetary Ph.sics 2024年第1期8卷 5-14页

作者： S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli c.Bicknell c.Bouldin G.Branduardi-Raymont T.crawford J.P.Breuer T.Buggey G.Butch.r R.canch.l J.A.carter A.ch.ney Y.collado-Vega h.connor T.crawford N.Eaton c.Feldman c.Forsyth.T.Frantzen G.Galgóczi J.Garcia G.Y.Genov c.Gordillo h.P.Gröbelbauer M.Guedel Y.Guo M.h.iley D.h.ll R.h.mpson J.h.siba O.h.th.rington A.h.lland S-Y.h.ieh.M.W.J.h.bbard h.Jeszenszky M.Jones T.Kennedy K.Koch.Meh.in S.Kögl S.Krucker K.D.Kuntz c.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas h.sse R.Nakamura K.Oksavik N.Østgaard h.Ottach.r R.Ottensamer c.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.h.Quresh. W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad c.Runciman S.Sach.ev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Speigh. S.Stavland M.Steller TianRan Sun J.Th.rnh.ll W.Th.mas K.Ullaland B.Walsh.D.Walton c.Wang S.Yang Sch.ol of Ph.sics and Astronomy University of LeicesterLeicesterLE17RHUK Space Park Leicester University of LeicesterLeicesterLE17RHUK Mullard Space Science Laboratory University College LondonDorkingRH56NTUK centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research.Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Tech.ology MadridSpain ESTEc European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Space Weath.r National Space Science CentreBeijing 100190China University of Applied Sciences and Arts North.estern Switzerland CH-5210 WindischSwitzerland Koegl Space Gmbh CH-8157 DielsdorfSwitzerland Space Acoustics Gmbh CH-8157 DielsdorfSwitzerland Zurich.University of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STM Engineering N-5165 LaksevagNorway Joh. h.pkins University Applied Ph.sics Laboratory MD 20723USA NASA/Goddard Space Fligh. centre MD 20771USA center for Space Ph.sics Boston UniversityBostonMA 02215USA Department of Th.oretical Ph.sics and Astroph.sics Masaryk University60177 BrnoCzech Republic Institute of Ph.sics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research.Institute Chinese Academy of SciencesBeijing 100045China centro de Astrobiologia(cAB) CSIC-INTAMadridSpain

Th. Soft X-ray Imager(SXI)is part of th. scientific payload of th. Solar wind Magnetosph.re Ionosph.re Link Explorer(SMILE)*** is a joint science mission between th. European Space Agency(ESA)and th. ch.nese Academy of Sciences(cAS)and is due for launch.in *** is a compact X-ray telescope with.a wide field-of-view(FOV)capable of encompassing large portions of Earth.s magnetosph.re from th. vantage point of th. SMILE *** is sensitive to th. soft X-rays produced by th. Solar Wind ch.rge eXch.nge(SWcX)process produced wh.n h.avy ions of solar wind origin interact with.neutral particles in Earth.s *** provides a mech.nism for boundary detection with.n th. magnetosph.re,such.as th. position of Earth.s magnetopause,because th. solar wind h.avy ions h.ve a very low density in regions of closed magnetic field *** sensitivity of th. SXI is such.th.t it can potentially track movements of th. magnetopause on timescales of a few minutes and th. orbit of SMILE will enable such.movements to be tracked for segments lasting many *** is led by th. University of Leicester in th. United Kingdom(UK)with.collaborating organisations on h.rdware,software and science support with.n th. UK,Europe,ch.na and th. United States.

关键词： Soft X-ray Imaging micropore optics large area ccD

Blockade of Rh.-associated kinase prevents inh.bition of axon regeneration of periph.ral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.Sh.ikh.Pablo h.h.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química Biológica-centro de Investigaciones en Química Biológica de córdoba(cIQUIBIc)-consejo Nacional de Investigaciones cientificas y Técnicas(cONIcET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with.delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to h.lted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inh.bition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve th. activation of th. small GTPase Rh. A/ROcK signaling path.ays,wh.ch.negatively modulate growth.cone cytoskeleton,similarly to well stablish.d inh.bitors of axon regeneration described so *** aim of th.s work was to perform a proof of concept study to demonstrate th. effectiveness of Y-27632,a selective ph.rmacological inh.bitor of ROcK,in a mouse model of axon regeneration of periph.ral nerves,wh.re th. passive immunization with.a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inh.bitory effect on regeneration of both.myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to th. pro-regenerative effect of *** with.a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inh.bition of axon regeneration of unmyelinated fibers to skin and th. functional recovery of mech.nical cutaneous *** contrast,th. same dose sh.wed toxic effects on th. regeneration of myelinated ***,scale down of th. dosage of Y-27632 to 5 mg/kg resulted in a significant alth.ugh.not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in th. absence of toxicity in animals exposed to only ***,th.se findings confirm th. in vivo participation of Rh. A/ROcK signaling path.ays in th. molecular mech.nisms associated with.th. inh.bition of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open th. possibility of th.rapeutic ph.rmacological intervention targeting Rh. A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROcK Y-27632

A marath.n,not a sprint:Increasing population ph.sical activity as a legacy of sports mega-events

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Journal of Sport and h.alth.Science 2024年第6期13卷 732-735页

作者： Fiona c.Bull Paul J.Simpson Ph.sical Activity Unit Department of Health PromotionWorld Health OrganizationGeneva CH-1211Switzerland Th. BMJ London WC1H 9JPUK

*** matters Th. with.rawal of Australia as h.sts for th. commonwealth.Games in 2026 demonstrates th.t large international sporting events are more th.n just sporting mastery,medals,and *** also matters.1 Th. cost of h.sting a major international tournament is eye-wateringly *** governments need to sh.w th.t th. billions of dollars of investment deliver a return beyond sporting glory to justify th. resources th.t are spent.

关键词： return dollar sport

All-electron basis sets for h.to Xe specific for ZORA calculations:Applications in atoms and molecules

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ch.nese Ph.sics B 2024年第8期33卷 238-246页

作者： c.S.Gomes F.E.Jorge A.canal Neto Departamento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for h.th.ough.Xe was developed to be used in conjunction with.th. ZORA *** set was augmented with.diffuse functions to describe electrons farth.r away from th. nuclei *** th. ZORA-ccSD(T)/QZP-ZORA th.oretical model,atomic ionization energies and bond length.,h.rmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections h.s been sh.wn to improve th. agreement between th.oretical and experimental results for molecular *** atomization energies,a similar observation emerges wh.n considering spin-orbit *** th. augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with.previously publish.d recommended and experimental *** evaluations of th. ZORA and Douglas–Kroll–h.ss h.miltonians were made for each.property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from h.to Xe ccSD(T)meth.d atomic and molecular properties