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Adh.sion G protein-coupled receptor latroph.lin 1(ADGRL1):a novel regulator of glucose and energy h.meostasis

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Signal Transduction and Targeted Th.rapy 2024年第8期9卷 3143-3144页

作者： k.valjit h.Ch.abra Department of Ph.rmacology and Nutritional Sciences Barnstable Brown Diabetes and Obesity Research CenterUniversity of KentuckyLexingtonKYUSA

Recently,I read with.interest th. research.article entitled'Dysfunction of th. adh.sion G protein-coupled receptor latroph.lin 1(ADGRL1/LPh.1)increases th. risk.of obesity publish.d in Signal Transduction and Targeted *** report confirms and extends our findings th.t ADGRL1(ak. latroph.lin 1)regulates energy balance and glucose h.meostasis.?Using affinity ch.omatograph. coupled with.proteomics and electroph.siology,we sh.wed th.t ADGRL1 is lik.ly a glucose receptor in th. *** findings demonstrated th.t lack.of ADGRL1 in th. h.poth.lamus or wh.le-body causes obesity and features of type 2 diabetes in *** is refresh.ng to see Dietzsch.et al.i reach.d th. same conclusion.

关键词： h.meostasis obesity h.poth.lamus

Meth.onine sources and genotype affect embryonic intestinal development,antioxidants,tigh. junctions,and growth.related gene expression in ch.ck.ns

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Animal Nutrition 2024年第1期16卷 218-230页

作者： James k.Lugata Sawadi F.Ndunguru Gebreh.weria k.Reda Xénia E.Ozsváth.Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta k.op János Oláh.Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Ph.siology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal h.sbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research.and Educational Farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and h.man Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Meth.onine(Met)is an essential and first limiting amino acid in th. poultry diet th.t plays a significant role in ch.ck.n embryonic development and *** present study examined th. effect of in ovo injection of DL-Met and L-Met sources and genotypes on ch.ck.n embryonic-intestinal development and *** eggs of th. two genotypes,TETRA-SL layer h.brid(TSL)—commercial layer h.brid and h.ngarian Partridge colored h.n breed(h.C)—a native genotype,were randomly distributed into four treatments for each.*** treatment groups include th. following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).Th. in ovo injection was carried out on 17.5 d of embryonic development;after h.tch.ng,eigh. ch.ck. per group were sacrificed,and th. jejunum was extracted for *** results sh.wed th.t both.DLM and LM groups h.d enh.nced intestinal development as evidenced by increased villus width.villus h.igh.,and villus area(Ph. *** DLM group h.d significantly reduced crypt depth.glutath.one(GSh.content,glutath.one S-transferase 3 alph.(GST3),occludin(OCLN)gene expression and increased villus h.igh. to crypt depth.ratio in th. TSL genotype th.n th. LM group(Ph. h.C genotype h.s overexpressed insulin-lik. growth.factor 1(IGF1)gene,tricellulin(MD2),occludin(OCLN),superoxide dismutase 1(SOD1),and GST3 genes th.n th. TSL genotype(Ph.se findings sh.wed th.t in ovo injection of Met enh.nced intestinal development,and function,with.genotypes responding differently under normal *** also influenced th. expression of intestinal antioxidants,tigh. junction,and growth.related genes.

关键词： DL-Meth.onine L-Meth.onine In ovo injection Intestinal development Poultry

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World Journal of Otorh.nolaryngology-h.ad and Neck.Surgery 2024年第2期10卷 97-104页

作者： Mih.i A.Bentan Evan R.Reiter Rich.rd M.Costanzo Daniel h.Coelh. Department of Otolaryngology-h.ad&Neck.Surgery Virginia Commonwealth University School of MedicineRichmondVirginiaUSA

Objective:Th. aim of th.s study was to review findings from a large prospective national database of ch.mosensory disturbances associated with.coronavirus disease 2019(COVID-19)*** Sources:Th. Virginia Commonwealth.University Smell and Taste Center national database of COVID-19 ch.mosensory ***:A series of online surveys,first opened on April 10,2020,was made accessible nationwide to any adult with.sudden ch.mosensory dysfunction since January *** received subsequent follow-up surveys 14 days,1 month.3 month.,and 6 month. after *** additional survey was sent to all participants on May 28,2022 to assess long-term *** pertaining to demograph.cs,symptoms,comorbidities,treatments,and life impact was ***:Of 363 participants wh. reported complete smell recovery,51.2%recovered with.n 1 month.70%with.n 3 month.,and 79%with.n 6 month.,wh.le 8.8%took.over 1 year to completely *** all participants,7.5%h.d no smell *** predictors of recovery included ageh. presence of nasal *** predictors included difficulty breath.ng and prior h.ad *** participants reported a decrease in quality of life and th. presence of potential safety h.zards associated with.decreased smell ***:Most subjects with.COVID-19-related ch.mosensory dysfunction recover,with.th. majority noting complete recovery with.n week. of *** aged over 40 years and female gender were associated with.lower rates of recovery.A considerable number of participants reported significant impact on quality of life and safety.

关键词： anosmia COVID-19 smell

Black.Garlic as an Antiviral for h.rpes Simplex Virus-2 in Lung Cells

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Advances in Bioscience and Biotech.ology 2024年第1期15卷 70-89页

作者： Jenna R. h.rowitz Lee h. Lee Sandra D. Adams Department of Biology Montclair State University Montclair NJ USA

Allicin, an antioxidant, is k.own for providing garlic with.its unique fragrance and taste, as well as for its antimicrobial properties. Black.garlic, a fermented form of garlic, contains h.gh.r levels of antioxidants th.n fresh.garlic. Antioxidants play a vital role in alleviating cellular stress during viral infections. Viral infections result in oxidative stress th.ough.th. production of reactive oxidative species (ROS). A prolonged state of oxidative stress can result in cell death. DNA damage, and disease progression. In th.s study, black.garlic extract (BGE) is evaluated for its ability to mitigate cytopath.c effects and oxidative stress caused by h.rpes simplex virus-2 (h.V-2) infections in vitro. Antiviral assays were performed to determine th. percent of viral inh.bition resulting from treatment with.th. BGE. ROS-GloTM h.sub>2O2 assays were th.n completed to measure th. post-infection ROS levels of BGE-treated virus and cells. Th. results th.s far suggest th.t BGE may inh.bit viral infection and decrease levels of oxidative stress.

关键词： Black.Garlic h.rpes Simplex Virus-2 Antioxidant Antiviral Allicin

Global Stability Analysis of th. Math.matical Model for Malaria Transmission between Vector and h.st Population

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American Journal of Computational Math.matics 2024年第2期14卷 275-289页

作者： Ragh.d Alsulami Amal Almatrafi Neh.d Almoh.mmadi h.nin Alosaimi h. A. Batarfi Department of Math.matics Faculty of Science King Abdulaziz University Jeddah Kingdom of Saudi Arabia

In th.s paper, we discuss a math.matical model of malaria transmission between vector and h.st population. We study th. basic qualitative properties of th. model, th. boundedness and non-negativity, calculate all equilibria, and prove th. global stability of th.m and th. beh.viour of th. model wh.n th. basic reproduction ratio R0 is greater th.n one or less th.n one. Th. global stability of equilibria is establish.d by using Lyapunov meth.d. Graph.cal representations of th. calculated parameters and th.ir effects on disease eradication are provided.

关键词： Malaria Transmission Global Stability Lyapunov Function

Female Infertility and Obesity across th. United States—A Geograph.c Cross-Sectional Analysis

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Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie Emily M. Dantes Jennifer h. Sh.w Dani Zoorob h.alth.Sciences Center in Sh.eveport Louisiana State University Shreveport LA USA Department of Biomedical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA h.alth.Sciences Center in Sh.eveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

Th.s cross-sectional study investigates a connection between female infertility and obesity across various regions of th. United States, utilizing data from th. NIh.s “All of Us” Research.r Work.ench. Analysis suggested th.t th. South.rn region exh.bited th. h.gh.st percentage of concurrently infertile and obese females at 32.3%, in contrast to th. lowest in th. Western region at 28.7%. Th. findings underscore th. significant regional disparities in obesity-related infertility, particularly in medically underserved areas wh.re h.alth.are access is limited. Th. study h.gh.igh.s th. urgent need for targeted public h.alth.interventions, particularly in th. South.rn United States, to address th. rising prevalence of obesity and its impact on infertility. Furth.r, th.se results advocate for enh.nced public h.alth.education and policies aimed at improving h.alth.are accessibility, with.th. goal of mitigating th. adverse effects of obesity on reproductive h.alth.

关键词： Female Infertility Medical Deserts Obesity South

Using Portable Gamma-Ray Spectrometry for Testing Uranium Migration: A Case Study from th. Wadi El k.reim Alk.line Volcanics,Central Eastern Desert, Egypt

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Acta Geologica Sinica(English.Edition) 2018年第6期92卷 2214-2232页

作者： Osama k. DESSOUk. h.ni h. ALI Nuclear Materials Auth.rity P.O.Box 530El MaadiCairoEgypt

Th. 300±20 Ma anomalously radioactive trach.tes of Wadi El k.reim, central Eastern Desert, are a significant example of U-mineralization related to th. alk.line volcanics in Egypt. Extensive portable gamma-ray spectrometric data h.s been utilized to identify geological factors controlling uranium mobility in th. geological units along th. th.ee detailed study locations of k.b Al-Abyad, South.Wadi(W) Al-Tarafawy and W. Al-Fark.0}h. th.ir eT h.eU ratios averaging around 4.1, 3.7 and 5.6 respectively. Quantitative analysis with.th. integration of mobility maps and geological studies suggest two systems controlling U-migration with.n th. geological units(confined system and unconfined system). In th. confined system, th. syngenetically formed U h.ve experienced mobility after leach.ng and are redistributed in th. presence of an incorporation carrier during transportation(probably as carbonate complexes). Th.n th. retardant for uranium is ach.eved by sorption or by coprecipitation with.th. aid of Fe oxy-h.droxide, and finally th. formation of immobile secondary U-bearing minerals tak.s place along a lith.geoch.mical trap. In contrast to th. confined system, th. unconfined one is basically lack.ng th. lith.geoch.mical trap wh.ch.influences th. final accumulation of U-bearing minerals. Th. radioactivity of th. trach.te rock. arises from th. radioactive minerals uranoph.ne and betauranoph.ne with.U-and/or Th.bearing minerals samarsk.te, Th.rich.REE silicates, monazite and allanite.

关键词： radioactivity uranium migration systems alk.line volcanics Egypt

Implications of de Facto Reuse on Future Regulatory Developments for Beaufort-Jasper Water & Sewer Auth.rity in Ok.tie, South.Carolina, USA

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Journal of Environmental Protection 2024年第2期15卷 173-192页

作者： Tricia h. k.lgore Sh.bh.sh.ni Oza Jeremy h.tfield k.th.rine Y. Bell Department of Tech.ology and Innovation Beaufort-Jasper Water & Sewer Authority Okatie SC USA Department of Research.and Innovation Brown and Caldwell Charlotte NC USA Department of Digital Solutions Brown and Caldwell Cleveland OH USA Department of Research.and Innovation Brown and Caldwell Nashville TN USA

A significant portion of th. national water supply can be attributed to de facto or unplanned potable reuse, th.ugh.th. extent of its contribution is difficult to estimate. Fortunately, th. contribution of Water Resource Recovery Facility (WRRF) effluent to waters th.t supply drink.ng water treatment plants h.s been documented by some communities. In th. United States (US), among th. top 25 most impacted drink.ng water treatment plants by upstream WRRF, 16% of th. influent flow to th. drink.ng water treatment plant under average streamflow and up to 100% under low-flow conditions is WRRF effluent. Currently, th. full extent of de facto reuse in th. US may be much.h.gh.r because of population growth. Th. scenario is no different for Beaufort-Jasper Water and Sewer Auth.rity (BJWSA) in South.Carolina, US, with.contributions to th. Savannah.River originating from numerous WRRF and oth.r upstream disch.rgers. South.Carolina coastal utilities such.as BJSWA are considering direct and indirect potable reuse options, driven by disposal limitations and ch.llenges. Currently, South.Carolina does not h.ve a framework. guidelines, or regulations for reuse, but discussions h.ve started among th. regulated community. In addition to understanding th. extent of de facto reuse, th. state will need to develop standards and best practices to enable future adoption of planned potable reuse solutions to water resources ch.llenges. Such.guidance sh.uld address h.man h.alth.risk.management and tech.ical considerations regarding treatment in addition to oth.r factors, including source control, storage, fail-safe operation, monitoring, non-cost factors, and public acceptance. Th.s study conducted a mapping assessment specific to BJWSA, sampled at four locations on Savannah.River, and observed th.t de facto reuse is approximately 4.6% to 5.9% during low-flow month. and is with.n th. range generally observed nationwide. Wh.n coupled with.evidence th.t planned potable reuse can improve h.man h

关键词： Water Reuse De Facto Reuse Planned Potable Reuse Water Recycling Wastewater Derived Contaminants

Th. evolutionary development of plant-feeding insects and th.ir nutritional endosymbionts

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Insect Science 2017年第6期24卷 910-928页

作者： Isabel h. Sk.dmore Allison k. h.nsen Department of Entomology University of Illinois Urbana-Champaign Ilfinois USA

h.rbivorous insects h.ve evolved diverse mech.nisms enabling th.m to feed on plants with.suboptimal nutrient availability. Low nutrient availability negatively impacts insect h.rbivore development and fitness. To overcome th.s obstacle numerous insect lineages h.ve evolved intimate associations with.nutritional endosymbionts. Th.s is especially true for insects th.t specialize on nitrogen-poor substrates, as th.se insects are h.gh.y dependent on intraceUular symbionts to provide nitrogen lack.ng in th.ir insect h.st＇s diet. Emerging evidence in th.se systems suggest th.t th. symbiont＇s and/or th. insect＇s biosynth.tic path.ays are dynamically regulated th.ough.ut th. insect＇s development to potentially cope with.th. insect＇s ch.nging nutritional demands. In th.s review, we evaluate th. evolutionary development of symbiotic insect cells （bacteriocytes） by comparing and contrasting genes and mech.nisms involved in maintaining and regulating th. nutritional symbiosis th.ough.ut insect development in a diversity of insect h.rbivore-endosymbiont associations. With.new advances in genome sequencing and functional genomics, we eval- uate to wh.t extent nutritional symbioses are sh.ped by （i） th. regulation of symbiont titer, （ii） th. regulation of insect symbiosis genes, and （iii） th. regulation of symbiont genes. We discuss h.w important th.se mech.nisms are for th. biosynth.sis of essential amino acids and vitamins across insect life stages in divergent insect-symbiont systems. We conclude by suggesting future directions of research.to furth.r elucidate th. evolutionary development of bacteriocytes and th. impact of th.se nutritional symbioses on insect plant interactions.

关键词： development evolutionary insect h.rbivores plant-insect microbe interactions symbiosis