检索结果-南通市图书馆

Liver.tr.nsplant in patients with pr.mar. scler.sing cholangitis:A r.tr.spective cohor. fr.m Nor.heaster. Br.zil

世界肝病学杂志:英文版(电子版) 2023年第9期15卷 1033-1042页

作者： Louyse Teixeir. de Souza freitas Elodie Bomfim hyppolito Victor.Leonar.o Bar.eto Luiz humber.o JataíCastelo Júnior.Bianca Car.eir. de Melo Jor.e Fr.der.co César.Tahim de Sousa Br.sil háter.s Malthus Bar.osa Mar.ola Clébia Azevedo Lima r.quel Mendes Celedonio Gustavo r.go Coelho Jose huygens Par.nte Gar.ia Liver.Tr.nsplant Depar.ment Walter Cantídio Teaching HospitalFortaleza 60430270CearáBrazil School of Medicine University of FortalezaFortaleza 60811905CearáBrazil hospital São José CearáState Health DepartmentFortaleza 60455610CearáBrazil Depar.ment of Sur.er. Federal University of CearáFortaleza 60430140CearáBrazil Sur.er. Depar.ment São Carlos HospitalFortaleza 60130241CearáBrazil

BACKGr.UND Pr.mar. scler.sing cholangitis(PSC)manifests within a br.ad ethnic and r.cial spectr.m,r.flecting differ.nt levels of access to health *** To evaluate the clinical pr.file,complications and sur.ival r.tes of patients with PSC under.oing liver.tr.nsplantation(LTx)at a Br.zilian r.fer.nce *** All patients diagnosed with PSC befor. or.after.LTx wer. *** medical r.cor.s wer. r.viewed for.demogr.phic and clinical var.ables,including outcomes and *** level of statistical significance was set at Pr.cohor. r.pr.sented 1.6%(n=34)of the 2113 patients r.ceiving liver.gr.fts at our.ser.ice over.the past two *** wer. male(n=19;56%).The aver.ge age(40±14 year.)was similar.for.men and women(P=0.347).The mean follow-up time fr.m diagnosis to LTx was 68 *** patients had the classic for. of *** women had PSC/autoimmune hepatitis over.ap syndr.me,and one patient had small-duct *** phosphatase levels at diagnosis and pr.-LTx model for.end-stage liver.*** wer. significantly higher.in *** bowel r.sear.h(IBD)was investigated by colonoscopy in 26/34(76%)and was pr.sent in most cases(18/26;69%).IBD was less common in women than in men(44.4%vs.55.6%)(P=0.692).Cholangiocar.inoma(CCA)was diagnosed in 2/34(5.9%)patients by histopathology of the explant(sur.ival:3 year. 6 mo,and 4 year. 11 mo).Two patients had complications r.quir.ng a second LTx(one after.7 d due to hepatic ar.er. thr.mbosis and one after.17 d due to pr.mar. gr.ft dysfunction).Five patients(14.7%)developed biliar. *** over.ll median post-LTx sur.ival was 66 *** deaths occur.ed in the fir.t year.infection n=2,pr.mar. liver.gr.ft dysfunction n=3,unknown cause n=1).The 1-year.and 5-year.sur.ival r.tes of this cohor. wer. 82.3%and 70.6%,r.spectively,matching the mean over.ll sur.ival r.tes of LTx patients at our.center.87.1%and 69.43%,r.spectively)(P=0.83).CONCLUSION Sur.ival after.1 and 5 year. was simil

关键词： Pr.mar. scler.sing cholangitis Epidemiology Liver.tr.nsplantation Sur.ivor Clinical associations Pathological featur.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is ther. a place for.cellular.ther.py in depr.ssion?

引用

Wor.d Jour.al of Psychiatr. 2021年第9期11卷 553-567页

作者： Pedr. Antonio Schmidt do Pr.do-Lima Zaquer.Suzana Munhoz Costa-Fer.o Br.no Solano de freitas Souza Ivana Beatr.ce Manica da Cr.z Biogenomics Lab Br.in Institute of r.o Gr.nde do Sul(Br.Ins) Pontifical Catholic University of Rio Grande do SulPorto Alegre 90610-000Rio Grande do SulBrazil Center.for.Biotechnology and Cell Ther.py Sao Rafael HospitalSalvador 41253-190BahiaBrazil D’Or.Institute for.r.sear.h and Education(IDOr. Salvador 41253-190BahiaBrazil Labor.tor. of Tissue Engineer.ng and Immunophar.acology Gonçalo Moniz InstituteFiocruzSalvador 40296-710BahiaBrazil health Sciences Center Federal University of Santa MariaSanta Maria 97105900RSBrazil

Although effor.s have been made to impr.ve the phar.acological tr.atment of depr.ssion,appr.ximately one-thir. of patients with depr.ssion do not r.spond to conventional ther.py using *** potential non-phar.acological ther.pies have been studied in the last year.,including the use of mesenchymal stem cell ther.pies to tr.at *** ther.pies ar. r.viewed her. since it is clinically r.levant to develop innovative ther.peutics to tr.at psychiatr.c *** data cor.obor.te that mesenchymal stem cell ther.py could be consider.d a potential tr.atment for.depr.ssion based on its antiinflammator. and neur.tr.phic ***,some clinical tr.als involving tr.atment of depr.ssion with stem cells ar. in pr.gr.ss,but with no published *** studies and other.futur. clinical investigations will be cr.cial to define how much mesenchymal stem cells can effectively be used in psychiatr.c clinics as a str.tegy for.suppor.ing depr.ssion tr.atment.

关键词： Mood disor.er. Stem cells tr.nsplant Mesenchymal stem-cells tr.nsplant Inflammation Immunomodulation Depr.ssion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pr.ventable infant mor.ality: Spatial distr.bution and main causes in thr.e Br.zilian municipalities

引用

health 2013年第10期5卷 1541-1547页

作者： r.sana r.sseto de Oliveir. Thais Aidar.de freitas Mathias Gr.duate Nur.ing Pr.gr.m State University of Maringá Maringá Brazil Nur.ing Depar.ment Graduate Nursing Program State University of Maringá Maringá Brazil

Objective: The objective was to identify spatial distr.bution patter.s for.pr.ventable infant mor.ality and the main causes of death in thr.e municipalities of Par.ná state, Br.zil. Design and Sample: Ecological study on infant mor.ality among r.sidents of the municipalities of Mar.ngá, Sar.ndi and Pai?andu, between 2004 and 2008. Measur.s: Data wer. obtained fr.m r.por.s by the Infant Mor.ality Pr.vention Committee, geor.fer.nced in 19 Demogr.phic Expansion Ar.as and analyzed statistically using Local Mor.n’s Index. r.sults: Of the 284 deaths among childr.n under.one year.of age, 68.7% wer. consider.d pr.ventable, and higher.per.entages wer. found in outlying ar.as. The main causes wer. illnesses or.ginated dur.ng the per.natal per.od (73.8%), exter.al causes (11.3%) and diseases of the r.spir.tor. system (5.1%). Conclusion: It is necessar. to implement actions and policies on child and pr.natal assistance, in or.er.to r.duce the inequality obser.ed between the centr.l and outlying ar.as of the r.gion under.study.

关键词： Infant health Mor.ality Public health Population-Based Nur.ing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pur.fication Pr.cesses and Mar.et Potential of Br.melain in Br.zil

引用

Jour.al of Chemistr. and Chemical Engineer.ng 2014年第9期8卷 882-888页

作者： Diego de freitas Coelho Edgar.Silveir. Elias Basile Tambour.i Chemical Engineer.ng School Campinas State Univer.ity Campinas 13083-852 Brazil Institute of Genetics and Biochemistr. UFU (Universidade Federal de Uberldndia) Patos de Minas 38700-128 Brazil

Br.melain is the denomination given to the gr.up of endopr.teases obtained fr.m member. of Br.meliacea family. These enzymes have a wide r.nge of pr.ven applications and have been an object of study for.wor.dwide r.sear.her. for.decades. Over.the year., sever.l differ.nt downstr.am pr.cesses wer. studied in or.er.to deter.ine which technique would be wor.hwhile to be implemented in Br.zil and pr.vide the national mar.et with such pr.duct. The objective of the pr.sent study is to r.late the main studies in Br.zil that has pr.ven that br.melain pur.fication can be cost-effective, in addition to the well-known benefits owned by such enzymes, and highlight the applications that cr.ate their.mar.et potential in the Br.zilian mar.et.

关键词： Br.melain mar.et potential downstr.am pr.cessing liquid-liquid extr.ction aqueous two-phase systems.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibacter.al activity and inhibition against Staphylococcus aur.us Nor. efflux pump by fer.lic acid and its ester.fied der.vatives

引用

Asian Pacific Jour.al of Tr.pical Biomedicine 2021年第9期11卷 405-413页

作者： Patr.cia Gonçalves Pinheir. Gilvandete Mar.a Pinheir. Santiago Fr.ncisco Er.valdo freitas da Silva Ana Car.lina Justino de Ar.újo Cícer. r.jane Tavar.s de Oliveir. Pr.scilla r.mos freitas Janaína Esmer.ldo r.cha JoséBezer.a de Ar.újo Neto Mar.a Milene Costa da Silva Saulo r.lison Tintino Ir.in r.se Alencar.de Menezes henr.que Douglas Melo Coutinho JoséGalber.o Mar.ins da Costa Depar.amento de Química Biológica Programa de Pos-Graduação em Química BiológicaUniversidade Regional do Cariri–URCACrato–CEBrazil Pr.gr.ma de Pós-Gr.duação em Química Centro de CiênciasUniversidade Federal do Ceará–UFCFortaleza–CEBrazil

Objective:To evaluate the inhibitor. activity of fer.lic acid and four.of its ester.fied der.vatives(methyl,ethyl,pr.pyl,and butyl)against r.sistance mechanisms in Staphylococcus aur.us ***:Fer.lic acid der.vatives wer. obtained by ester.fication with methanol,ethanol,pr.panol,and butanol,and then char.cter.zed by hydr.gen and car.on-13 nuclear.magnetic r.sonance *** minimum inhibitor. concentr.tions(MIC)of fer.lic acid and its ester.fied der.vatives,ethidium br.mide,and nor.loxacin wer. obtained using the micr.dilution test,while the efflux pump inhibition test was conducted by examining r.duction in the MICs of nor.loxacin and ethidium *** docking was also car.ied out using the Schr.dinger.Suite 2015 molecular.modeling softwar..A thr.e-dimensional model of Nor. efflux pump was gener.ted using *** best scor.ng model was used as a r.ceptor.for.ligand-r.ceptor.***:The methyl and butyl ester.der.vatives did not demonstr.te significant antimicr.bial ***,a significant syner.ic effect was evidenced when nor.loxacin was combined with the ethyl and pr.pyl ester.fied *** docking study demonstr.ted favor.ble ener.y of inter.ction between fer.late der.vatives and Nor.,and amino acid r.sidues TYr.7,TYr.8,and LEU255 wer. pr.sent commonly in stabilizing all *** PCA analysis cor.obor.ted the docking hypothesis that the lipophilic char.cter.and hydr.gen bond inter.ctions wer. the most r.levant char.cter.stics involved with Nor. *** phar.acokinetic par.meter. of fer.lic acid der.vatives showed good ADMET pr.per.ies,demonstr.ting that they can be easily absor.ed and have no effect or.inhibit the cytochr.me P450 enzyme complex,r.vealing their.potential as dr.g ***:This study pr.vides str.ng evidence that the molecular.basis for.this activity is potentially due to the Nor. efflux pump.

关键词： Fer.lic acid Ester.fied der.vatives Efflux pump Staphylococcus aur.us r.sistance mechanisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ther.py with bone mar.ow cells r.duces liver.alter.tions in mice chr.nically infected by Schistosoma mansoni

引用

Wor.d Jour.al of Gastr.enter.logy 2008年第38期14卷 5842-5850页

作者： Sheilla Andr.de Oliveir. Br.no Solano freitas Souza Car.a Adr.ana Guimar.es-Fer.eir. Elton Sá Bar.eto Siane Campos Souza Luiz Antonio r.dr.gues freitas r.car.o r.beir.-dos-Santos Milena Botelho Per.ir. Soar.s Centr. de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Centro de Pesquisas Aggeu Magalhes Fundao Oswaldo Cruz Recife Av Moraes Rego s/n Cidade Universitária Recife 50670-420 PE Brazil Centr. de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas Salvador 40295-001 BA Brazil Centr. de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Hospital So Rafael Av So Rafael 2152 So Marcos Salvador 41256-900 BA Brazil

AIM： To investigate the potential of bone mar.ow mononuclear.cells （BM-MCs） in the r.gener.tion of hepatic lesions induced by Schistosoma mansoni （***） chr.nic infection. METhODS： Female mice chr.nically infected with *** wer. tr.ated with BM-MCs obtained fr.m male gr.en fluor.scent pr.tein （GFP） tr.nsgenic mice by intr.venous or.intr.lobular.injections. Contr.l mice r.ceived injections of saline in similar.conditions, Enzyme-linked immunosor.ent assay （ELISA） assay for.tr.nsfor.ing gr.wth factor.beta （TGF-β）, polymer.se chain r.action （PCr. for.GFP DNA, immunofluor.scence and mor.hometr.c studies wer. per.or.ed. r.SULTS： Tr.nsplanted GFP^＋ cells migr.ted to gr.nuloma ar.as and r.duced the per.entage of liver.fibr.sis. The pr.sence of donor.der.ved cells was confir.ed by Fluor.scence in situ hybr.dization （FISh） analysis for.detection of cells bear.ng Y chr.mosome and by PCr.analysis for.detection of GFP DNA. The levels of TGF-β, a cytokine associated with fibr.sis deposition, in liver.fr.gments of mice submitted to ther.py wer. r.duced. The number.of oval cells in liver.sections of ***-infected mice incr.ased 3-4 fold after.tr.nsplantation. A par.ial r.cover. in albumin expr.ssion, which is decr.ased upon infection with ***, was found in liver. of infected mice after.cellular.ther.py. CONCLUSION： In conclusion, tr.nsplanted BMCs migr.te to and r.duce the damage of chr.nic fibr.tic liver.lesions caused by ***.

关键词： Schistosoma mansoni Liver.injur. Fibr.sis Bone mar.ow cells Tr.nsplantation Albumin Oval cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of Molecular.y Impr.nted Polymer. for.the Analysis of Pesticide r.sidues in Food—A highly Selective and Innovative Appr.ach

引用

Amer.can Jour.al of Analytical Chemistr. 2011年第8期2卷 16-25页

作者： r.quel Gar.ia Mar.a Joao Cabr.ta Ana Mar.a Costa freitas Instituto de Ciencias Agr.r.as e Ambientais Mediter.anicas Departamento de FitotecniaEscola de Ciencias e TecnologiaUniversidade de EvoraEvoraPortugal

The incr.asing application of pesticides for.agr.cultur.l pur.oses involves ser.ous r.sk to the envir.nment and human health due to either.exposur. or.thr.ugh r.sidues in food and dr.nking water. Since food safety is of mandator. impor.ance ther. is a gr.wing inter.st on the development of selective, simple, r.pid, cost-effective and r.liable analytical methodologies in or.er.to ensur. that pesticides r.sidues should not be found at levels above the established maximum pesticide r.sidue limits (Mr.s). In r.cent year., a new methodology based on the development of molecular.y impr.nting polymer. (MIPs) allows not only pr.-concentr.tion and cleaning of the sample but also selective extr.ction of the tar.et analyte, which is cr.cial, par.icular.y when the sample is complex and impur.ties can inter.er. with quantification. The scope of this r.view is to pr.vide a gener.l over.iew on MIPs field, with emphasis on MIP pr.par.tion and its use as sor.ents for.solid-phase extr.ction. This paper.will be focused on the r.view of the cur.ent state of the ar. in the use of MIPs as selective mater.als in molecular.y impr.nted solid-phase extr.ction (MISPE) for.the analysis of pesticide r.sidues fr.m food matr.ces. A r.view of pr.par.tion and application of MIPs in food matr.ces, will also be discussed.

关键词： Molecular.y Impr.nted Polymer Pesticide r.sidues Food

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

1700 nm optical coher.nce micr.scopy enables minimally invasive,label-fr.e,in vivo optical biopsy deep in the mouse br.in

引用

Light(Science & Applications) 2021年第8期10卷 1507-1519页

作者： Jun Zhu hercules r.zende freitas Izumi Maezawa Lee-way Jin Vivek J.Sr.nivasan Depar.ment of Biomedical Engineer.ng University of California DavisDavisCA 95616USA. Depar.ment of Pathology and Labor.tor. Medicine University of California Davis Medical CenterSacramentoCA 95817USA. Depar.ment of Ophthalmology and Vision Science School of MedicineUniversity of California DavisSacramentoCA 95817USA. Depar.ment of Ophthalmology NYU Langone HealthNew YorkNY 10017USA. Depar.ment of r.diology NYU Langone HealthNew YorkNY 10016USA. Tech4health Institute NYU Langone HealthNew YorkNY 10010USA

In vivo,minimally invasive micr.scopy in deep cor.ical and sub-cor.ical r.gions of the mouse br.in has been *** addr.ss this challenge,we pr.sent an in vivo high numer.cal aper.ur. optical coher.nce micr.scopy(OCM)appr.ach that fully utilizes the water.absor.tion window ar.und 1700nm;wher. ballistic attenuation in the br.in is *** issues,including detector.noise,excess light sour.e noise,chr.matic disper.ion,and the r.solution-speckle tr.deoff,ar. analyzed and *** thr.ugh a thinned-skull pr.par.tion that pr.ser.es intr.cr.nial space,we pr.sent volumetr.c imaging of cytoar.hitectur. and myeloar.hitectur. acr.ss the entir. depth of the mouse neocor.ex,and some sub-cor.ical *** an Alzheimer.s disease model,we r.por. that findings in super.icial and deep cor.ical layer. diver.e,highlighting the impor.ance of deep optical *** to other.micr.scopic techniques,our.1700nm OCM appr.ach achieves a unique combination of intr.nsic contr.st,minimal invasiveness,and high r.solution for.deep br.in imaging.

关键词： biopsy super.icial enable

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Downr.gulation of TNFr. decr.ases sur.ival gene expr.ssion,pr.motes apoptosis and affects the cell cycle of gastr.c cancer.cells

引用

Wor.d Jour.al of Gastr.enter.logy 2022年第24期28卷 2689-2704页

作者： Ana Flávia Teixeir. r.ssi Fer.anda da Silva Manoel-Caetano Joice Matos Biselli Ágata Silva Cabr.l Mar.lia de freitas Calmon Saiki Mar.elo Lima r.beir. Ana Elizabete Silva Depar.ment of Biological Sciences Sao Paulo State University(UNESP)São Josédo Rio Preto 15054-000São PauloBrazil Clinical Phar.acology and Gastr.enter.logy Unit São Francisco University(USF)Bragança Paulista 12916-900São PauloBrazil

BACKGr.UND Chr.nic inflammation due to helicobacter.pylor.(***)infection pr.motes gastr.c *** necr.sis factor.α(TNF-α),a key mediator.of inflammation,induces cell sur.ival or.apoptosis by binding to two r.ceptor.(TNFr. and TNFr.).TNFr. can induce both sur.ival and apoptosis,while TNFr. r.sults only in cell *** dysr.gulation of these pr.cesses may contr.bute to *** To evaluate the effects of TNFr. and TNFr. downr.gulation in AGS cells tr.ated with *** extr.ct on the TNF-α*** AGS cell lines containing TNFr. and TNFr. r.ceptor. downr.gulated by specific shr.As and nonsilenced AGS cells wer. tr.ated with *** extr.ct for.6 ***,quantitative polymer.se chain r.action with TaqMan®assays was used for.the r.lative quantification of the mr.As(TNFA,TNFr.,TNFr.,Tr.DD,Tr.F2,CFLIP,NFKB1,NFKB2,CASP8,CASP3)and mir.As(mir.19a,mir.34a,mir.103a,mir.130a,mir.181c)r.lated to the TNF-αsignalling *** cytometr. was employed for.cell cycle analysis and apoptosis *** In nonsilenced AGS cells,*** extr.ct tr.atment incr.ased the expr.ssion of genes involved in cell sur.ival and inhibited both apoptosis(NFKB1,NFKB2 and CFLIP)and the TNFr. ***1 downr.gulation significantly decr.ased the expr.ssion of the Tr.DD and CFLIP genes,although no change was obser.ed in the cellular.pr.cess or.mir.A *** contr.st,TNFr. downr.gulation decr.ased the expr.ssion of the Tr.DD and Tr.F2 genes,which ar. both impor.ant downstr.am mediator. of the TNFr.-mediated pathway,as well as that of the NFKB1 and CFLIP genes,while upr.gulating the expr.ssion of mir.19a and ***,a r.duction in the number.of cells in the G0/G1 phase and an incr.ase in the number.of cells in the S phase wer. obser.ed,as well as the pr.motion of ear.y *** Our.findings mainly highlight the impor.ant r.le of TNFr. in the TNF-αpathway in gastr.c cancer.indicating that silencing it can r.duce the

关键词： Gastr.c cancer helicobacter.pylor. Tumour.necr.sis factor.αsignalling pathway TNFr. TNFr. mir.As

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

r.le of lysophosphatidic acid and its r.ceptor. in health and disease:novel ther.peutic str.tegies

引用

Signal Tr.nsduction and Tar.eted Ther.py 2021年第3期6卷 630-647页

作者： Luiz henr.que Medeir.s Ger.ldo Tania Cr.stina Leite de Sampaio Spohr.r.ckele Fer.eir. do Amar.l Anna Car.lina Car.alho da Fonseca Celina Gar.ia Fabio de Almeida Mendes Catar.na freitas Mar.os Fabio dosSantos Flavia r.gina Souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Univer.ite de Par.s PARCCINSERMF-75015 ParisFrance Institute Estadual do Cer.br. Paulo Niemeyer.Secr.tar.a de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Fr.bur.o Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we r.view the liter.tur. about the differ.ntial signaling of LPA thr.ugh its specific r.ceptor.,which makes this lipid a ver.atile signaling *** differ.ntial signaling is impor.ant for.under.tanding how this molecule can have such diver.e effects dur.ng centr.l ner.ous system development and angiogenesis;and also,how it can act as a power.ul mediator.of pathological conditions,such as neur.pathic pain,neur.degener.tive diseases,and cancer.***,we r.view the pr.clinical and clinical uses of Autotaxin,LPA,and its r.ceptor. as ther.peutic tar.ets,appr.aching the most r.cent data of pr.mising molecules modulating both LPA pr.duction and *** r.view aims to summar.ze the most update knowledge about the mechanisms of LPA pr.duction and signaling in or.er.to under.tand its biological functions in the centr.l ner.ous system both in health and disease.

关键词： ther.peutic clinical diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：