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Celiac disease as potential obstacle to childbearing

Open Journal of Obstetrics and Gynecology 2014年第2期4卷 75-80页

作者： Mónika Kovács Mária Szenes Tihamér Horváth gyorgy vajda Beáta Gasztonyi gyorgy Bártfai Department of Internal Medicine Zala County HospitalZalaegerszegHungary Department of Obstetrics and Gynecology Zala County HospitalZalaegerszegHungary Faculty of Medicine Obstetrics and Gynecology Department Albert Szent-Gyorgyi Clinical Center of University SzegedSzegedHungary

AIM: The authors have aimed at confirming or excluding gluten sensitivity in infertile couples. PATIENTS AND METHODS: Between 2004 and 2010, at our outpatient clinics of immunology, both partners of 223 couples, who had striven for having a child unsuccessfully, underwent history taking, physical examination, laboratory and immuno-serologic tests including anti-tissue-transglutaminase antibody (antitTG), as well as deep duodenal biopsy in antibody-carrying patients. RESULTS: Antibodies against tissue transglutaminase were positive in 6/223 female patients of whom the diagnosis of celiac disease was histologically confirmed in 3/223 cases (1.34%). Of the male patients 2/223 (0.9%) have proven to be carriers of the antibody;histology was pathognomonic in both of them. Curiously, one of the male patients with celiac disease has been the partner of a woman who also had celiac disease diagnosed by the authors. In the followup period, a female patient and the female member of the couple with celiac disease gave birth to healthy newborns after spontaneous conception, as the result of a strictly kept gluten-free diet, as well as occasional treatments of acetylsalicylate for antiphos-pholipid syndrome or levothyroxine for latent hypothyroidism due to autoimmune thyroiditis. CONCLUSION: The results underline that it is worth performing a screening for celiac disease in both partners of couples assessed due to the lack of success in having a child, as infertility can be ceased by an appropriate diet.

关键词： Celiac Disease Gluten-Free Diet Anti-Tissue-Transglutaminase Antibody Infertile Couples

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Long noncoding RNA-mediated activation of androgen receptor in prostate cancer

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Asian Journal of Andrology 2014年第3期16卷 418-419页

作者： gyorgy Petrovics Shiv Srivastava Center for Prostate Disease Research Department ofSurgery Uniformed Services University of the HealthSciences Maryland USA.

Remarkable progress has been made in molecular characterization of prostate cancer （PCa） with continued innovations in high throughput technologies evaluating human cancer？-3 Since the completion of the Human Genome Project it has been estimated that only about 1.5%-2% of our genome codes for proteins. Various genome-wide approaches, e.g. the ENCODE project, revealed that a much larger percent of the genome is transcribed as non-protein coding （nc） RNA, including long noncoding （lnc） RNA （over 200bps long）. Although the biological roles of IncRNA （the ＇dark matter of the genome＇） are not nearly as well-understood as the protein coding mRNAs, it is increasingly clear that they play important roles in almost every aspects of biology, including cancer biology.4＇5 This is exemplified by recent genome-wide association studies revealing that over 80% of cancer-associated single nucleotide polymorphisms （SNPs） are in noncoding regions of the genome.

关键词： Remarkable progress androgen receptor characterization

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Sarcopenic obesity in liver cancer: it is SO complicated

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 560-562页

作者： gyorgy Baffy Department of Medicine VA Boston Healthcare System and Brigham and Women's HospitalHarvard Medical SchoolBostonMAUSA

Sarcopenia is defined as a generalized and progressive loss ofskeletal muscle mass,strength and function(1).Sarcopenia,while initially described in the aging general population,affects many patients with various chronic diseases in allage *** muscle volume and performance isassociated with lower endurance,frailty,disability,and poordisease outcomes.

关键词： obesity diseases skeletal

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Antimicrobial impacts of selected Lamiaceae plants on bacteria isolated from vegetables and their application in edible films

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Food Bioscience 2023年第1期51卷 618-624页

作者： Eva gyorgy Eva Laslo Bernadette Salamon Sapientia Hungarian University of Transylvania(Cluj-Napoca Romania)Faculty of EconomicsSocio-Human Sciences and EngineeringDepartment of Food ScienceMiercurea CiucRomania

Fresh vegetables can be contaminated with spoilage and food-borne pathogenic bacteria during cultivation,harvesting,transport and further *** essential oils seem a promising solution for preserving vegetables incorporated in edible *** the study it was determined the prevalence of allochthonous bacteria on some fresh vegetables with classical cultivation and molecular biology *** evaluation of the antibacterial effect of Thymus vulgaris,Origanum vulgare,Mentha piperita and Melissa officinalis essential oils against identified bacteria from vegetables and on some standard foodborne pathogenic bacteria was realized with agar diffusion *** prevalence of allochthonous bacteria in the examined vegetables was *** some cases,high contamination level could be detected reaching the level of 104 colony forming units/*** identified bacteria belong to different genera like Bacillus,Enterobacter,Pseudomonas *** the tested plant essential oils,the most pronounced antibacterial effect was detected in the case of thyme and oregano,with over 30 mm inhibition *** isolated bacteria from vegetables showed higher resistance to the used essential *** results suggest that edible films containing thyme and oregano essential oils possess efficient antibacterial effect against mesophilic aerobic bacteria and Staphylococcus *** findings seem a promising solution for preserving vegetables with natural antimicrobial containing edible films.

关键词： Essential oils Antimicrobial activity Fresh vegetables Allochthonous bacteria Food-borne pathogens

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Highlights from the prostate cancer genome report

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Asian Journal of Andrology 2011年第5期13卷 659-660页

作者： Shyh-Han Tan gyorgy Petrovics Shiv Srivastava Center for Prostate Disease Research Department of Surgery Uniformed Services University of the Health Sciences Rockville MD 20852 USA

Prostate cancer （CAP） is the second most frequently diagnosed cancer of men worldwide （899 000 new cases, 13.6% of the total）, with nearly 75% of the registered cases occurring in developed countries （644 000 cases）.1 Blood prostate-specific antigen test has revolutionized the early detection of CaP and organ-confined CaP is effectively managed by state-of-the-art treatments including radical prostatectomy or radiation therapy.2 In the past decade, tremendous progress has also been made in our understanding of the biology and common genomic alterations in CaP.3＇4 New molecular marker assays have promise in improving CaP diagnosis.5-8 Despite these advances, major challenges remain with our ability to distinguish indolent cancers from the more aggressive cancers detected early due to widely used prostate-specific antigen test. Furthermore, development of molecular stratification of CaP for targeted and more effective therapies is critically needed.

关键词： Cytokines Tuberculosis

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Tilted pulse front pumping techniques for efficient terahertz pulse generation

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Light(Science & Applications) 2023年第11期12卷 2291-2308页

作者： gyorgy Toth Gyula Polonyi Janos Hebling University of Pecs Pecs 7624Hungary Szentagothai Research Centre Pecs 7624Hungary HUN-REN-PTE High-Field Terahertz Research Group Pecs 7624Hungary

Optical rectification of femtosecond laser pulses has emerged as the dominant technique for generating single-and few-cycle terahertz(THz)*** advent of the tilted pulse front pumping(TPFP)velocity matching technique,proposed and implemented two decades ago,has ushered in significant advancements of these THz sources,which are pivotal in the realm of THz pump-probe and material control experiments,which need THz pulses with microjoule energies and several hundred kV/cm electric field ***,these THz sources are poised to play a crucial role in the realization of THz-driven particle accelerators,necessitating millijoule-level pulses with tens of MV/cm electric field *** has enabled the efficient velocity matching in lithium niobate crystals renowned for their extraordinary high nonlinear ***,its adaptation to semiconductor THz sources has resulted in a two-hundred-times enhancement in conversion *** this comprehensive review,we present the seminal achievements of the past two *** expound on the conventional TPFP setup,delineate its scaling limits,and elucidate the novel generation TPFP configurations proposed to surmount these constraints,accompanied by their preliminary ***,we provide an in-depth analysis of the THz absorption,refractive index,and nonlinear coefficient spectra of lithium niobate and widely used semiconductors employed as THz generators,which dictate their suitability as THz *** underscore the far-reaching advantages of tilted pulse front pumping,not only for LN and semiconductor-based THz sources but also for selected organic crystal-based sources and Yb-laserpumped GaP sources,previously regarded as velocity-matched in the literature.

关键词： pumping pulse realization

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ON TERM BY TERM DYADIC DIFFERENTIABILITY OF WALSH-KACZMARZ SERIES

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Analysis in Theory and Applications 2003年第1期19卷 55-75页

作者： gyorgy Gdt(College of Nyiregyhaza, Hungary) 1. Inst. of Math. and Comp. Sci. College of Nyíregyháza P. O. Box 166. H-4400 Nyíregyháza Hungary

The aim of this paper is to prove the following theorem concerning the term by term differentiation the-orem of Walsh-Kaczmarz series. Let (ck) be a decreasing real sequence withare integrable functions and f(x) is a.... 详细信息

关键词： dyadic (Butzer and Wagner) differentiability Walsh-Kaczmarz series monotone coefficients Fejer kernels

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Characterization of Gradual Porous Ceramic Structures Obtained by Powder Sedimentation

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Journal of Materials Science & Technology 2012年第4期28卷 362-366页

作者： Ioan Vida-Simiti Nicolaie Jumate Valentin Moldovan gyorgy Thalmaier Niculina Sechel Materials Science and Engineering Department Technical University of Cluj-Napoca 103-105 Muncii Avenue 400641 Cluj-Napoca Romania

Asymmetric membranes present better separation and service characteristics than the symmetric ones. In our preliminary studies the possibility of obtaining sintered porous materials with gradual structure by sedimentation of metallic and ceramic powders was demonstrated. Zirconium silicate （ZrSiO4） particles were used for the manufacturing of the porous supports, and mullite powder was deposited by sedimentation in order to achieve the active layer with pores size gradient. The used powders and the obtained structures were characterized by laser scattering particle size analyzer, scanning electron microscopy and mercury porosimetry. The permeability and the filtration fineness of the structures were also determined. By using a thin active layer made of small particles deposited onto a macro-porous support, one can achieve membranes with high flow rates and filtration fineness in the microfiltration area.

关键词： Powder sedimentation Ceramic membrane Porous material Porosity gradient

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Mapping the geography of editors-in-chief

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Journal of Data and Information Science 2024年第1期9卷 124-137页

作者： gyorgy Csomos Department of Civil Engineering University of Debrecen4028 DebrecenOtemeto utca.2-4Hungary

Purpose:This study aims to explore the geography of editors-in-chief to demonstrate which countries exercise the highest-level decision-making in scholarly *** addition,the study seeks to investigate the potential relationships between the origin and nationality of academic publishers and the geography of ***/methodology/approach:The analysis involves 11,915 journals listed in Web of Science’s Social Sciences Citation Index(SSCI)and Science Citation Index Expanded(SCIE).These journals employ 15,795 scholars as *** geographical locations of the institutions the editors-in-chief are affiliated with were identified;then,the data were aggregated at the country ***:The results show that most editors-in-chief are located in countries of the Anglosphere,primarily the United States and the United *** addition,most academic publishers and professional organizations that publish academic journals were found to be based in the United States and the United Kingdom,where most editors-in-chief are also *** limitations:The analysis involves journals indexed in the Web of Science’s SCIE/SSCI databases,which are demonstrably biased toward the English ***,the study only takes a snapshot of the geography of editors-in-chief for the year 2022,but it does not investigate *** implications:The study maps the highest-level decision-making in scholarly ***/value:The study explores and maps the geography of editors-in-chief by using a massive dataset.

关键词： Editor-in-chief Highest-level decision-making Academic publisher Web of Science Anglosphere

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High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer

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World Journal of Clinical Cases 2022年第13期10卷 4084-4096页

作者： Zoltan Herold Magdolna Herold gyorgy Herczeg Agnes Fodor Attila Marcell Szasz Magdolna Dank Aniko Somogyi Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest H-1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest H-1088Hungar Department of General Surgery Szent Imre University Teaching HospitalBudapest H-1115Hungary

BACKGROUND Colorectal cancer(CRC)is often associated with elevated platelet count(>400×10^(9)/L),known as *** role of CD40 ligand(CD40L),a member of the tumor necrosis factor family,is controversial in *** CD40L is higher in CRC,but its relationship with disease staging and local and distant metastasis is not *** most of the circulating CD40L is produced by platelets,no previous study investigated its relationship with CRC-related *** To investigate the role of CD40L to predict the outcome of CRC and its relation to *** A total of 106 CRC patients and 50 age and sex-matched control subjects were enrolled for the *** data including comorbidities and histopathological data were *** measurements were performed at the time of CRC diagnosis and 1.5 mo and at least 6 mo after the surgical removal of the *** CD40L and thrombopoietin were measured via enzyme-linked immunosorbent assay,while plasma interleukin-6 was measured via electrochemiluminescence *** follow-ups were terminated on January 31,*** Plasma CD40L of CRC patients was tendentiously higher,while platelet count(P=0.0479),interleukin-6(P=0.0002),and thrombopoietin(P=0.0024)levels were significantly higher as opposed to the control *** of the 106 CRC patients(11.3%)had *** higher CD40L was found in the presence of distant metastases(P=0.0055)and/or thrombocytosis(P=0.0294).A connection was found between CD40L and platelet count(P=0.0045),interleukin-6(P=0.0130),and thrombocytosis(P=0.0155).CD40L was constant with the course of CRC,and all baseline differences persisted throughout the whole *** pre-and postoperative elevated platelet count,CD40L,and interleukin-6 level were associated with poor overall and disease-specific survival of *** negative effect of CD40L and interleukin-6 on patient survival remained even after the stra

关键词： CD40 ligand Colorectal neoplasms Interleukin-6 Thrombocytosis Thrombopoietin

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