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Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis

World Journal of Gastroenterology 2019年第6期25卷 729-743页

作者： Dalma Dobszai Péter Mátrai Zoltan gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Clinical Medicine Doctoral School University of SzegedSzeged 6720Hungary Institute for Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy University of SzegedSzeged 6720Hungary Division of Gastroenterology First Department of MedicineUniversity of PécsMedical SchoolPécs 7624Hungary János Szentágothai Research Center University of PécsPécs 7624 Hungary MTA-SZTE Momentum Translational Gastroenterology Research Group University of SzegedSzeged 6720Hungary 不详

BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the *** To quantify the association between subgroups of BMI and the severity and mortality of *** A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number *** A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality

关键词： Acute pancreatitis Body-mass index Obesity Severity Mortality Prognostic Meta-analysis

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Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1443-1450页

作者： Zoltan Griger Katalin Danko Gabor Nemeth Ziad Hassan Zsuzsa Aszalos Katalin szabo Levente Bodoki Rudolf Gesztelyi Judit Zsuga Peter Szodoray Adam Kemeny-Beke Division of Clinical Immunology Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Ophthalmology Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Ophthalmology Borsod-Abauj-Zemplen County Hospital and University Teaching HospitalMiskolc 3526Hungary Orbi-Dent Refractive Surgery and Medical Center Debrecen 4032Hungary Department of Rheumatology Institute of MedicineFaculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Pharmacology and Pharmacotherapy Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Health Systems Management and Quality Management in Health Care Faculty of Public HealthUniversity of DebrecenDebrecen 4032Hungary Department of Immunology RikshospitaletOslo University HospitalOslo 0372Norway

AIM:To evaluate detailed anterior segment parameters of patients with idiopathic inflammatory myopathies(IIM),including polymyositis(PM),and dermatomyositis(DM),and to clarify the associations between these data and clinical variables of ***:Totally 57 PM,41 DM patients and 62 controls were enrolled in this cross-sectional,observational,case-control *** study participants underwent Pentacam *** investigations consisted of different antibody assays,while extramuscular clinical assessments included Raynaud’s phenomenon,dysphagia,interstitial lung disease,arthritis/arthralgia,and weight *** signs and subjective symptoms of dry eye disease(DED)were also ***:All pachymetric parameters[center,apex,thinnest and maximal keratometry(Kmax)]and corneal volume(CV)of both sides of PM patients proved to be significantly *** pachymetric data were also noticed as significantly decreased compared to those of *** significant differences were traced between anterior segment values and extramuscular manifestations of myositis,largely in case of arthritis/arthralgia and weight loss,whereas associations between anterior segment parameters and antibodies were *** clinical tests of DED were also significantly decreased in IIM ***:The results suggest that all IIM patients have thinner corneas compared with those of controls,and decreased corneal parameters are significantly associated with the occurrence of some extramuscular *** addition,IIM patients tend to develop objective signs of DED.

关键词： dry eye extramuscular manifestations dermatomyositis polymyositis Scheimpflug imaging

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Ytong建筑结构抗震性能研究

Ytong建筑结构抗震性能研究

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2015年全国砌体结构领域基本理论与工程应用暨国际砌体结构学术会议

作者： TORSTEN Schoch ANTAL szabo 凯莱技术和研究有限责任公司上海德材凯莱投资咨询有限公司

关于抗震性能,大多数决策者的观点是墙体材料强度越高越安全,但是一般强度高的墙体材料其容重也高,且作为填充墙会对主体结构产生不利影响导致结构破坏.伊通产品的轻质则能有效减小地震惯性力.此外,由于地震往往伴随着火灾,此时蒸压加... 详细信息

关于抗震性能,大多数决策者的观点是墙体材料强度越高越安全,但是一般强度高的墙体材料其容重也高,且作为填充墙会对主体结构产生不利影响导致结构破坏.伊通产品的轻质则能有效减小地震惯性力.此外,由于地震往往伴随着火灾,此时蒸压加气混凝土制品的不燃和防火又是一个优势.蒸压加气混凝土制品的抗压强度虽然较低,但其具有相对较高的抗拉强度,远高于多孔粘土砖等的墙体材料.在独立研究机构进行的几个典型案例研究可以帮助决策者了解低密度AAC砌体的抗震性能,这样在满足更高的节能要求的条件下,可以保证甚至提高建筑物的抗震安全.对伊通产品在地震中的优点进行了概述,并对几个最近的研究课题进行了简要介绍.

关键词：伊通地震抗震性能

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Enhanced Photocatalytic Activity of TiO2 Nanofibers and Their Flexible Composite Films： Decomposition of Organic Dyes and Efficient H2 Generation from Ethanol-Water Mixtures

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Nano Research 2011年第4期4卷 360-369页

作者： Ming-Chung Wu Andras Sapi Anna Avila Maria szabo Jussi Hiltunen Mika Huuhtanen Geza Toth Akos Kukovecz Zoltan Konya Riitta Keiski Wei-Fang Su Heli Jantunen Krisztian Kordas Department of Electrical and Information Engineering University of Oulu P.O. Box 4500 FI-90014 University of Oulu Finland Department of Applied and Environmental Chemistry University of Szeged 6720 Szeged Rerrich Bela ter 1 Hungary Department of Process and Environmental Engineering P.O. Box 4300 F1-90014 University of Oulu Finland Department of Materials Science and Engineering National Taiwan University Taipei 106-17 Taiwan China

与磅和 Pd nanoparticles 装饰的 TiO2 nanofibers 在各种各样的 photocatalytic 过程被综合了并且学习。在水里的器官的染料的分解的优秀 photocatalytic 行为，灵活独立纤维素 / 催化剂的表面上的器官的污点的降级合成电影并且在从乙... 详细信息

与磅和 Pd nanoparticles 装饰的 TiO2 nanofibers 在各种各样的 photocatalytic 过程被综合了并且学习。在水里的器官的染料的分解的优秀 photocatalytic 行为，灵活独立纤维素 / 催化剂的表面上的器官的污点的降级合成电影并且在从乙醇用的氢的产生推迟了并且使不能调动催化剂被表明。基于 nanofiber 的 TiO2 材料的表演是在某情况 outperformstheir 的竞争 withand 常规基于 nanoparticle 的对应物。在所有情况中，装饰 Pd 的 TiO2 nanoparticles 和 nanofibers 证明了比他们的基于磅的对应物更有效，它能在在 TiO2 和金属 nanoparticles 之间的接触根据缩放 nano 的 Schottky 接口的形成被解释。形成纤维素 / 催化剂 composites 的可行性提供在大区域的涂层和独立电影利用光催化剂材料的一个新奇方法。

关键词： TiO2纳米纳米纤维有机染料复合薄膜光催化活性二氧化钛纳米粒子乙醇分解

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灰色链霉菌产生的一种链霉素——Park核苷酸复合物

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国外医药（抗生素分册） 1990年第4期11卷 261-263页

作者： Istvan szabo 唐建国

在最近几十年里,关于抗生素生物作用出现了种种推测,其中一些已被实验结果所证实,而另一些纯粹是一种假说。我们开始研究链霉素生物作用时,发现了该菌细胞壁合成和抗生素合成之间的相互作用,细胞壁合成的许多抑制剂会增加链霉素的产量... 详细信息

在最近几十年里,关于抗生素生物作用出现了种种推测,其中一些已被实验结果所证实,而另一些纯粹是一种假说。我们开始研究链霉素生物作用时,发现了该菌细胞壁合成和抗生素合成之间的相互作用,细胞壁合成的许多抑制剂会增加链霉素的产量。由于细胞壁及链霉素均明显含有糖类,我们假定两种生物合成途径都存在一种共同前体,为研究这种共同前体而分离出一种具有抗生素活性的未知结构化合物(X)。本文将讨论链霉素和Park核苷酸共价复合物的分离及化学结构。肽葡聚糖的组成灰色链霉菌菌丝体(24小时菌龄)用超声粉碎,差速离心分离。十二烷基硫酸钠洗涤以除去非肤葡聚糖组份。24小时酸水解,氨基酸分析发现肽葡聚糖含有二氨基庚二酸、丙氨酸、甘氨酸和谷氨酸。

关键词：灰色链霉菌链霉素 Park核苷酸

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Adsorption of Three Commercial Dyes onto Chitosan Beads Using Spectrophotometric Determination and a Multivariate Calibration Method

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Journal of Water Resource and Protection 2013年第4期5卷 446-457页

作者： Manuela Mincea Viorica Patrulea Ana Negrulescu Robert szabo Vasile Ostafe Advanced Environmental Research Laboratories West University of Timisoara Timisoara Romania Faculty of Mathematics and Computer Science West University of Timisoara Timisoara Romania

A simple and rapid analytical method for the simultaneous quantification of three commercial azo dyes—Tartrazine (TAR), Congo Red (CR), and Amido Black (AB) in water is presented. The simultaneous assessment of the individual concentration of an organic dye in mixtures using a spectrophotometric method is a difficult procedure in analytical chemistry, due to spectral overlapping. This drawback can be overcome if a multivariate calibration method such as Partial Least Squares Regression (PLSR) is used. This study presents a calibration model based on absorption spectra in the 300 - 650 nm range for a set of 20 different mixtures of dyes, followed by the prediction of the concentrations of dyes in 6 validation mixtures, randomly selected, using the PLSR method. Estimated limits of detection (LOD) were 0.106, 0.047 and 0.079 mg/L for TAR, CR, and AB, respectively, and limits of quantification (LOQ) were 0.355, 0.157 and 0.265 mg/L for TAR, CR, and AB, respectively. Quantitative determination of the three azo dyes was performed following optimized adsorption experiments onto chitosan beads of mixtures of TAR, CR and AB. Adsorption isotherm and kinetic studies were carried out, proving that the proposed PLSR method is rapid, accurate and reliable.

关键词： Univariate Calibration Multivariate Calibration Spectral Overlap Partial Least Squares Regression Commercial Dyes Adsorption

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Anti-microbial antibodies in celiac disease:Trick or treat?

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World Journal of Gastroenterology 2009年第31期15卷 3891-3900页

作者： Maria Papp Ildiko Foldi Istvan Altorjay Eszter Palyu Miklos Udvardy Judit Tumpek Sandor Sipka Ilma Rita Korponay-szabo Eva Nemes Gabor Veres Tamas Dinya Attila Tordai Hajnalka Andrikovics Gary L Norman Peter Laszlo Lakatos 2nd Department of Medicine University of Debrecen Laboratory of Clinical Immunology University of Debrecen Department of Pediatrics University of DebrecenDebrecenH-4032HungaryIlma Rita Korponay-SzaboCeliac Disease CenterHeim Pal Children's Hospital 1st Department of Pediatrics Semmelweis University Institute of Surgery University of Debrecen Department of Molecular Diagnostics Hungarian National Blood Transfusion Service INOVA Diagnostics Inc. 1st Department of Medicine Semmelweis University

AIM:To determine the prevalence of a new set of anti-glycan and anti-outer membrane protein (anti-OMP) antibodies in a Hungarian cohort of adult Celiac disease (CD) ***:190 consecutive CD patients [M/F:71/119, age:39.9 (SD:14.1) years], 100 healthy, and 48 gastrointestinal controls were tested for glycan anti-Saccharomyces cerevisiae (gASCA), anti-laminaribioside (ALCA), anti-chitobioside, anti-mannobioside, anti-OMP antibodies and major NOD2/CARD15 mutations. Thirty out of 82 CD patients enrolled at the time of diagnosis were re-evaluated for the same antibodies after longstanding gluten-free diet (GFD).RESULTS: 65.9% of the CD patients were positive for at least one of the tested antibodies at the time of the diagnosis. Except anti-OMP and ALCA, anti-microbial antibodies were exclusively seen in untreated CD; however, the overall sensitivity was low. Any glycan positivity (LR+:3.13;95% CI:2.08-4.73) was associated with an increased likelihood ratio for diagnosing CD. Significant correlation was found between the levels of anti-glycan and anti-endomysial or anti-transglutaminase antibodies. Anti-glycan positivity was lost after longstanding GFD. Anti-glycan antibody titers were associated with symptoms at presentation, but not the presence of NOD2/CARD15 mutations. Patients with severe malabsorption more frequently had multiple antibodies at diagnosis (P=0.019).CONCLUSION: The presence of anti-glycan antibodies in CD seems to be secondary to the impaired small bowel mucosa which can lead to increased antigen presentation. Furthermore, anti-glycan positivity may be considered an additional marker of CD and dietary adherence.

关键词：抗微生物疾病腹腔抗体蛋糖

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Effects of psychostimulant challenge following perinatal psychostimulant exposure in rats

Effects of psychostimulant challenge following perinatal psy...

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第十五届国际药理学大会

作者： Gyarmati Zsuzsanna Timar Julia szabo Anna FürstZsuzsanna Dept.Pharmacol. ＆ Pharmacotherapy Semmelweis Univ.. Dept.Pharmacol. ＆ Pharmacotherapy Semmelweis Univ.. Chinoin Co. Ltd Sanofi - Aventis Group Budapest. Dept.Pharmacol.＆ Pharmacotherapy Semmelweis Univ. Hungarian Academy of Sci.- Semmelweis Univ. Neuropsychopharmacol.Group.

＜正＞ Objectives: Effect of psychomotorstimulants [（ + ） methylenedioxy - metham phetamine- ecstasy, MDMA and （ + ） methamphetamine - MA] challenge was investigated in offspring of dams treated with either MDMA or MA during the gestation and lactation periods. Methods: Pregnant females were treated daily with either 3 mg/kg sc. MDMA or MA until the 21st postpartum day. when the offspring was separated. Spontaneous locomotor activity （SLA）, drug- induced locomotor activity （CONDUCTA, Experimetria Ltd）, and behaviour in elevated plus maze test （EPM） were measured two or three days after separation. Results: 1. There was no difference in the EPM behaviour of offspring. 2. SLA was higher in the animals exposed to perinatal MDMA or MA. 3. The locomotor enhancing effect of MDMA or MA was reduced in animals exposed to perinatal drug treatment. Conclusion: Perinatal exposure to psychomotor stimulants alters the locomotor behaviour and decreases the sensitivity to the succeeding drug challenge, psychostimulants, perinatal, locomotor activity

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《青少年》

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牡丹 2015年第11期 2-2页

作者： Joseph szabo

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抗癌自行车王兰斯·阿姆斯特朗

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空中英语教室（高级版．彭蒙惠英语） 2010年第3期 16-18,41,42页

作者： Liz szabo

全世界唯一7连霸环法自行车赛的兰斯·阿姆斯特朗．可能也是最为人所知的癌症存活者．而他还年和全球其他癌症存活者保持密切联系．他们纷纷表示．阿姆斯特朗的抗癌经历鼓舞了他们．

关键词：环法自行车赛阿姆斯特朗抗癌全世界存活癌症

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