Effects of psychostimulant challenge following perinatal psychostimulant exposure in rats
作者单位：Dept.Pharmacol. ＆ Pharmacotherapy Semmelweis Univ.. Dept.Pharmacol. ＆ Pharmacotherapy Semmelweis Univ.. Chinoin Co. Ltd Sanofi - Aventis Group Budapest. Dept.Pharmacol.＆ Pharmacotherapy Semmelweis Univ. Hungarian Academy of Sci.- Semmelweis Univ. Neuropsychopharmacol.Group.
会议名称：《第十五届国际药理学大会》
会议日期：2006年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
基 金：This study was supported by Hungarian grant OTKA K - 60999
摘 要：正 Objectives: Effect of psychomotorstimulants [（ + ） methylenedioxy - metham phetamine- ecstasy, MDMA and （ + ） methamphetamine - MA] challenge was investigated in offspring of dams treated with either MDMA or MA during the gestation and lactation periods. Methods: Pregnant females were treated daily with either 3 mg/kg sc. MDMA or MA until the 21st postpartum day. when the offspring was separated. Spontaneous locomotor activity （SLA）, drug- induced locomotor activity （CONDUCTA, Experimetria Ltd）, and behaviour in elevated plus maze test （EPM） were measured two or three days after separation. Results: 1. There was no difference in the EPM behaviour of offspring. 2. SLA was higher in the animals exposed to perinatal MDMA or MA. 3. The locomotor enhancing effect of MDMA or MA was reduced in animals exposed to perinatal drug treatment. Conclusion: Perinatal exposure to psychomotor stimulants alters the locomotor behaviour and decreases the sensitivity to the succeeding drug challenge, psychostimulants, perinatal, locomotor activity