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Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

Zoological Research 2024年第2期45卷 398-414页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Sohi Kang Joong-Sun kim Sung-Ho kim Hongbing Wang Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea Department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(EAE)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in EAE *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase(11 days post-immunization,DPI)and chronic phase(28DPI).EAE-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(DG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and DG subregions in the early phase of EAE,but only reduced in the DG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(ERK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

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Crystallographically vacancy‐induced MOF nanosheet as rational single‐atom support for accelerating CO_(2)electroreduction to CO

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Carbon Energy 2024年第8期6卷 49-62页

作者： Jin Hyuk Cho Joonhee Ma Chaehyeon Lee Jin Wook Lim Youngho kim Ho Yeon Jang Jaehyun kim Myung‐gi Seo Youngheon Choi Youn Jeong Jang Sang Hyun ahn Ho Won Jang Seoin Back Jong‐Lam Lee Soo Young kim Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Department of Chemical and Biomolecular Engineering Sogang UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Lotte Chemical R&D Center DaejeonRepublic of Korea Department of Chemical Engineering Hanyang UniversitySeoulRepublic of Korea School of Chemical Engineering and Material Science Chung‐Ang UniversitySeoulRepublic of Korea

To attain a circular carbon economy and resolve CO_(2)electroreduction technology obstacles,single‐atom catalysts(SACs)have emerged as a logical option for electrocatalysis because of their extraordinary catalytic *** SACs,metal–organic frameworks(MOFs)have been recognized as promising support materials because of their exceptional ability to prevent metal *** study shows that atomically dispersed Ni single atoms on a precisely engineered MOF nanosheet display a high Faradaic efficiency of approximately 100%for CO formation in H‐cell and three‐compartment microfluidic flow‐cell reactors and an excellent turnover frequency of 23,699 h−1,validating their intrinsic catalytic *** results suggest that crystallographic variations affect the abundant vacancy sites on the MOF nanosheets,which are linked to the evaporation of Zn‐containing organic linkers during ***,using X‐ray absorption spectroscopy and density functional theory calculations,a comprehensive investigation of the unsaturated atomic coordination environments and the underlying mechanism involving CO^(*)preadsorbed sites as initial states was possible and provided valuable insights.

关键词： 2‐dimensional material carbon dioxide reduction metal-organic frameworks single‐atom catalysts vacancy sites

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Single-atom catalysts for the electrochemical reduction of carbon dioxide into hydrocarbons and oxygenates

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Carbon Energy 2024年第3期6卷 64-117页

作者： Karl Adrian Gandionco Juwon kim Lieven Bekaert Annick Hubin Jongwoo Lim Department of Chemistry Seoul National UniversitySeoulRepublic of Korea Research Group Electrochemical and Surface Engineering(SURF) Department of Materials and ChemistryVrije Universiteit BrusselBrusselsBelgium

The electrochemical reduction of carbon dioxide offers a sound and economically viable technology for the electrification and decarbonization of the chemical and fuel *** this technology,an electrocatalytic material and renewable energy-generated electricity drive the conversion of carbon dioxide into high-value chemicals and carbon-neutral *** the past few years,single-atom catalysts have been intensively studied as they could provide near-unity atom utilization and unique catalytic ***-atom catalysts have become one of the state-of-the-art catalyst materials for the electrochemical reduction of carbon dioxide into carbon ***,it remains a challenge for single-atom catalysts to facilitate the efficient conversion of carbon dioxide into products beyond carbon *** this review,we summarize and present important findings and critical insights from studies on the electrochemical carbon dioxide reduction reaction into hydrocarbons and oxygenates using single-atom *** is hoped that this review gives a thorough recapitulation and analysis of the science behind the catalysis of carbon dioxide into more reduced products through singleatom catalysts so that it can be a guide for future research and development on catalysts with industry-ready performance for the electrochemical reduction of carbon dioxide into high-value chemicals and carbon-neutral fuels.

关键词： electrocatalysis electrochemical CO_(2)reduction hydrocarbons oxygenates single-atom catalysts

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Status of biomarker development for frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第10期19卷 2117-2118页

作者： Yue Yang Qi Cheng Jianqun Gao Woojin Scott kim Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNSWAustralia Department of Neurology and Neurophysiology Liverpool HospitalSydneyNSWAustralia Stroke and Neurology Research Group Ingham Institute for Applied Medical ResearchSydneyNSWAustralia Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation ShanghaiChina Clinical Research Center for Anesthesiology and Perioperative Medicine ShanghaiChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina

Frontotemporal dementia(FTD) and amyotrophic lateral sclerosis(ALS) are neurodegenerative diseases that belong to the same disease spectrum,with overlapping of genetic and pathological *** mutations in TARDBP,C9ORF72,... 详细信息

关键词： amyotrophic sclerosis diseases

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A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-Ha Shin Hwa-Ryeon kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

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NOON-state interference in the frequency domain

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Light(Science & Applications) 2024年第5期13卷 843-851页

作者： Dongjin Lee Woncheol Shin Sebae Park Junyeop kim Heedeuk Shin Department of Physics Pohang University of Science and Technology(POSTECH)Pohang 37673South Korea

The examination of entanglement across various degrees of freedom has been pivotal in augmenting our understanding of fundamental physics,extending to high dimensional quantum states,and promising the scalability of quantum *** this paper,we demonstrate the photon number path entanglement in the frequency domain by implementing a frequency beam splitter that converts the single-photon frequency to another with 50%probability using Bragg scattering four-wave *** two-photon NOON state in a single-mode fiber is generated in the frequency domain,manifesting the two-photon interference with two-fold enhanced resolution compared to that of single-photon interference,showing the outstanding stability of the *** successful translation of quantum states in the frequency domain will pave the way toward the discovery of fascinating quantum phenomena and scalable quantum information processing.

关键词： quantum state showing

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Two-stage dynamic recrystallization and texture evolution in Al-7Mg alloy during hot torsion

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1900-1911页

作者： Kwang Tae Son Chang Hee Cho Myoung Gyun kim Ji Woon Lee School of Mechanical Industrialand Manufacturing EngineeringOregon State UniversityCorvallis OR 97331USA Department of Materials Science Engineering Northwestern UniversityEvanston IL 60208USA Research Institute of Industrial Science and Technology(RIST) Pohang 37673Rep.of Korea Division of Advanced Materials Engineering Kongju National UniversityCheonan 31080Rep.of Korea Center for Advanced Materials and Parts of Powders Kongju National UniversityCheonan 31080Rep.of Korea

Hot torsion tests were performed on the Al-7Mg alloy at the temperature ranging from 300 to 500℃ and strain rates between 0.05 and 5 s^(-1) to explore the progressive dynamic recrystallization(DRX)and texture *** DRX behavior of the alloy manifested two distinct stages:Stage 1 at strain of≤2 and Stage 2 at strains of≥*** Stage 1,there was a slight increase in the DRXed grain fraction(X_(DRX))with predominance of discontinuous DRX(DDRX),followed by a modest change in X_(DRX) until the transition to Stage *** 2 was marked by an accelerated rate of DRX,culminating in a substantial final X_(DRX) of~*** backscattered diffraction(EBSD)analysis on a sample in Stage 2 revealed that continuous DRX(CDRX)predominantly occurred within the(121)[001]grains,whereas the(111)[110]grains underwent a geometric DRX(GDRX)evolution without a noticeable sub-grain ***,a modified Avrami’s DRX kinetics model was utilized to predict the microstructural refinement in the Al-7Mg alloy during the DRX *** this kinetics model did not accurately capture the DDRX behavior in Stage 1,it effectively simulated the DRX rate in Stage *** texture index was employed to assess the evolution of the texture isotropy during hot-torsion test,demonstrating significant improvement(>75%)in texture randomness before the commencement of Stage *** initial texture evolution is attributed to the rotation of parent grains and the substructure evolution,rather than to an increase in X_(DRX).

关键词： Al-7Mg alloys hot deformation hot torsion tests dynamic recrystazlliation microstructure texture

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Network traffic classification:Techniques,datasets,and challenges

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Digital Communications and Networks 2024年第3期10卷 676-692页

作者： ahmad Azab Mahmoud Khasawneh Saed Alrabaee kim-Kwang Raymond Choo Maysa Sarsour College of Information Technology and Systems Victorian Institute of TechnologyAustralia College of Engineering Al Ain UniversityAbu DhabiUnited Arab Emirates Information Systems and Security College of ITUnited Arab Emirates UniversityAl Ain15551United Arab Emirates Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78260USA School of Photovoltaic and Renewable Energy Engineering University of New South WalesSydneyNSW2052Australia

In network traffic classification,it is important to understand the correlation between network traffic and its causal application,protocol,or service group,for example,in facilitating lawful interception,ensuring the quality of service,preventing application choke points,and facilitating malicious behavior *** this paper,we review existing network classification techniques,such as port-based identification and those based on deep packet inspection,statistical features in conjunction with machine learning,and deep learning *** also explain the implementations,advantages,and limitations associated with these *** review also extends to publicly available datasets used in the ***,we discuss existing and emerging challenges,as well as future research directions.

关键词： Network classification Machine learning Deep learning Deep packet inspection Traffic monitoring

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok kim Bruno Rigo Gabriella Wong Yoon Jae Lee Woon‑Hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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Artificial intelligence in physiological characteristics recognition for internet of things authentication

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Digital Communications and Networks 2024年第3期10卷 740-755页

作者： Zhimin Zhang Huansheng Ning Fadi Farha Jianguo Ding kim-Kwang Raymond Choo School of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China Beijing Engineering Research Center for Cyberspace Data Analysis and Applications Beijing100083China Faculty of Informatics Engineering Aleppo UniversityAleppoSyria Department of Computer Science Blekinge Institute of Technology37179KarlskronaSweden Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249-0631USA

Effective user authentication is key to ensuring equipment security,data privacy,and personalized services in Internet of Things(IoT)***,conventional mode-based authentication methods(e.g.,passwords and smart cards)may be vulnerable to a broad range of attacks(e.g.,eavesdropping and side-channel attacks).Hence,there have been attempts to design biometric-based authentication solutions,which rely on physiological and behavioral *** characteristics need continuous monitoring and specific environmental settings,which can be challenging to implement in ***,we can also leverage Artificial Intelligence(AI)in the extraction and classification of physiological characteristics from IoT devices processing to facilitate ***,we review the literature on the use of AI in physiological characteristics recognition pub-lished after *** use the three-layer architecture of the IoT(i.e.,sensing layer,feature layer,and algorithm layer)to guide the discussion of existing approaches and their *** also identify a number of future research opportunities,which will hopefully guide the design of next generation solutions.

关键词： Physiological characteristics recognition Artificial intelligence Internet of things Biological-driven authentication

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