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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung min Bitna Yang You-Sun Kim gyeong min park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models

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Cyborg and Bionic Systems 2023年第1期4卷 178-195页

作者： Seon-Jin Kim min-Gyun Kim Jangho Kim Jessie SJeon Jinsoo park Hee-gyeong Yi Department of Rural and Biosystems Engineering College of Agriculture and Life SciencesChonnam National UniversityGwangjuRepublic of Korea Department of Convergence Biosystems Engineering College of Agriculture and Life SciencesChonnam National UniversityGwangjuRepublic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju 61186Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Mechanical Engineering Chonnam National UniversityRepublic of Korea

Dysfunctional blood vessels are implicated in various diseases,including cardiovascular diseases,neurodegenerative diseases,and *** studies have attempted to prevent and treat vascular diseases and understand interactions between these diseases and blood vessels across different organs and *** studies were conducted using 2-dimensional(2D)in vitro and animal ***,these models have difficulties in mimicking the 3D microenvironment in human,simulating kinetics related to cell activities,and replicating human pathophysiology;in addition,3D models involve remarkably high ***,in vitro bioengineered models(BMs)have recently gained *** created through biofabrication based on tissue engineering and regenerative medicine are breakthrough models that can overcome limitations of 2D and animal *** can also simulate the natural microenvironment in a patient-and target-specific *** this review,we will introduce 3D bioprinting methods for fabricating bioengineered blood vessel models,which can serve as the basis for treating and preventing various vascular ***,we will describe possible advancements from tubular to vascular ***,we will discuss specific applications,limitations,and future perspectives of fabricated BMs.

关键词： Blood organs printing

Physiological and Biochemical Modulations upon Root Induction in Rose Cuttings as Affected by Growing Medium

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Horticultural Plant Journal 2018年第6期4卷 257-264页

作者： KIM Soohoon ABINAYA Manivannan park Yoo gyeong JEONG Byoung Ryong Division of Applied Life Science (BK21 Plus Program) Graduate School Gyeongsang National University Institute of Agriculture and Life Science Gyeongsang National University Research Institute of Life Science Gyeongsang National University

Two cut rose(Rosa hybrida) cultivars ‘Sherbet'(easy-to-root) and ‘Alibaba'(difficult-to-root) were propagated by single nodal cuttings on preformed media. Four commercial media such as Tosilee, Ellepot, rockwool and phenolic foam RC, and four newly-developed foam media namely Oasis PU 14-S1, Oasis TP-S1, Oasis PU-7 B and Oasis PU 15-S1 were employed in this study. All media were manufactured to fit into50-cell plug trays. The experiment was laid out in a complete randomized block design with three replications on a propagation bench with a plastic tunnel installed in a glasshouse, with(98 ± 2)% relative humidity and over 50% shading of the natural sunlight. After four weeks of experiment, growth parameters, localization of superoxide radicals, and activities of rooting biochemical markers were measured. The results suggested that the newly-developed foam media Oasis TP-S1 and Oasis PU-7 B enhanced the growth, density of leaf stomata, and consisted of lesser harmful superoxide radicals in similar manner with the existing commercial media. Moreover, the Oasis TP-S1 and Oasis PU-7 B media significantly enhanced the total phenol content and the activities of important enzymes involved in the phenol metabolism which plays a vital role in the formation of roots. Thus, the understanding of both physiological and biochemical changes implicated by the growing medium during the rooting of cuttings would aid in the selection of optimal growing medium for the propagation of rose cuttings.

关键词： foam medium peroxidase phenol phenylalanine ammonia lyase(PAL) superoxide localization

Polyurethane-based Actuators with Various Polyols

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Journal of Materials Science & Technology 2010年第8期26卷 763-768页

作者： Nam-Ju Jo Do-Hee Lim gyeong-Mi Bark Ho-Hwan Chun In-Won Lee Hyun park Department of Polymer Science and Engineering Pusan National University Advanced Ship Engineering Research Center Pusan National University

This study dealt with the electrostrictive responses of polyurethane （PU） actuators with different microphase separation structure, which was a promising candidate for a material used in polymer actuators. In order to construct PUs with different higher-order structure, PUs with various types of polyol were synthesized： poly（neopentyl glycol adipate）（PNAD）, poly（tetramethylene glycol）（PTMG）, and poly（dimethyl siloxnae）（PDMS）. Synthesized PU was characterized by Fourier transform-infrared （FT-IR） spectroscopy and gel per- meation chromatography （GPC）. Thermal analysis and mechanical properties of PU films were carried out with differential scanning calorimetry （DSC） and UTM （universal testing machine）, respectively. And PU actuator was formed in a type of monomorph, which was made by carbon black electrodes on the both surfaces of PU film by spin coating method. Actuation behavior was mainly influenced on microphase separation struc- ture and mechanical property of PU. In result, PU actuator with PNAD, polyester urethane, had the largest field-induced displacement.

关键词： Electroactive polymer Polyurethane actuator Polyol type Maxwell stress effect Electrostriction effect

Microstructural Investigation of Alloy 617 Creep-ruptured at High Temperature in a Helium Environment

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Journal of Materials Science & Technology 2013年第12期29卷 1177-1183页

作者： gyeong-Geun Lee Sujin Jung Jae-Young park Woo-Gon Kim Sung-Deok Hong Yong-Wan Kim Nuclear Materials Division Korea Atomic Energy Research Institute

A very high temperature reactor （VHTR） is one of the next-generation nuclear reactors chosen by the Generation IV International Forum. A Ni-base superalloy, Alloy 617, is considered as a primary candidate material for an intermediate heat exchanger （IHX） and hot gas duct （HGD） of the VHTR because of the superior creep resistance at a high temperature above 850 ~C. In this study, the microstructures of the specimens creep- ruptured at high temperatures in a helium environment were investigated. The decrease in rupture time was more pronounced with increasing creep temperature. In the specimens crept at 950 ~C, the external Cr-oxide layer of the specimens increased in thickness with increasing creep rupture time, and delaminated after a long-time creep. The high creep stress induced a deep penetration of carbide depletion along the grain boundaries at the early stage of the creep test. The creep temperature enhanced the growth rate of the decarburized zone depth clearly, but the temperature effect on the growth of the external oxide and internal oxide was not well understood as the surface reaction and creep stress affected the microstructures complexly.

关键词： Alloy 617 Microstructure Creep Helium Oxide

HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

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Plant Communications 2023年第4期4卷 225-239页

作者： gyeongik Ahn Hee Jin park Song Yi Jeong gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik Kim min Gab Kim Dae-Jin Yun Woe-Yeon Kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,controls flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,CO,and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with COP1,an E3 ubiquitin ligase for GI *** analyses of the hos15 cop1 double mutant revealed that repression of flowering by HOS15 is dependent on COP1 at 16℃.However,the HOS15-COP1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 cop1 double mutant,indicating that HOS15 acts independently of COP1 in GI turnover at low ambient *** study proposes that HOS15 controls GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to coordinate appropriate flowering time in response to ambient environmental conditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

Application of cationic liposomes for delivery of nucleic acids

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Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 72-80页

作者： Gayong Shim Mi-gyeong Kim Joo Yeon park Yu-Kyoung Oh College of Pharmacy Seoul National UniversityDaehak-dongSeoul 151-742South Korea

Nucleic acid-based bioactive substances have recently emerged as a new class of nextgeneration therapeutics, but their development has been limited by their relatively weakdelivery into target cells. Cationic liposomes have been studied as a means to enhance thestability of nucleic acid therapeutics in the bloodstream and improve their cellular *** nucleic acid therapeutics, siRNA and plasmid DNA have been extensively tested fordelivery using cationic liposomes. This review discusses recent progress in the applicationof cationic liposomes for the delivery of nucleic acid therapeutics.

关键词： Cationic lipid Liposomes Delivery Nucleic acid therapeutics siRNA Plasmid DNA

Hydrophobic surface induced pro-metastatic cancer cells for in vitro extravasation models

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Bioactive Materials 2024年第4期34卷 401-413页

作者： minseok Lee Seunggyu Kim Sun Young Lee Jin gyeong Son Joonha park Seonghyeon park Jemin Yeun Tae Geol Lee Sung Gap Im Jessie S.Jeon Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and TechnologyDaehak-ro 291Yuseong-guDaejeon34141Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaehak-ro 291Yuseong-guDaejeon34141Republic of Korea Bioimaging Team Safety Measurement InstituteKorea Research Institute of Standards and Science(KRISS)Gajeong-ro 267Yuseong-guDaejeon34113Republic of Korea KAIST Institute for the NanoCentury(KINC) Korea Advanced Institute of Science and TechnologyDaehak-ro 291Yuseong-guDaejeon34141Republic of Korea

In vitro vascularized cancer models utilizing microfluidics have emerged as a promising tool for mechanism study and drug ***,the lack of consideration and preparation methods for cancer cellular sources that are capable of adequately replicating the metastatic features of circulating tumor cells contributed to low relevancy with in vivo experimental ***,we show that the properties of cancer cellular sources have a considerable impact on the validity of the in vitro metastasis ***,with a hydrophobic surface,we can create highly metastatic spheroids equipped with aggressive invasion,endothelium adhesion capabilities,and activated metabolic *** these metastatic spheroids with the well-constructed microfluidic-based extravasation model,we validate that these metastatic spheroids exhibited a distinct extravasation response to epidermal growth factor(EGF)and normal human lung fibroblasts compared to the 2D cultured cancer cells,which is consistent with the previously reported results of in vivo ***,the applicability of the developed model as a therapeutic screening platform for cancer extravasation is validated through profiling and inhibition of *** believe this model incorporating hydrophobic surface-cultured 3D cancer cells provides reliable experimental data in a clear and concise manner,bridging the gap between the conventional in vitro models and in vivo experiments.

关键词： Initiated chemical vapor deposition Cancer spheroid Cancer extravasation Organ-on-a-chip In vitro disease model

Embolization of pancreatic arteriovenous malformation:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1471-1476页

作者： So Yeon Yoon gyeong Sik Jeon Shin Jae Lee Dae Joong Kim Chang Il Kwon Mi Hyun park Department of Radiology CHA Bundang Medical CenterCollege of MedicineCHA UniversitySeongnam-si 13496Gyeonggi-doSouth Korea Department of Radiology Research Institute of Radiological ScienceYongin Severance HospitalYonsei University College of MedicineYongin-si 17046South Korea Department of Internal Medicine Digestive Disease CenterCHA Bundang Medical CenterCollege of MedicineCHA UniversitySeongnam-si 13496Gyeonggi-doSouth Korea Department of Radiology Dankook University HospitalChungcheongnam-do 31116South Korea

BACKGROUND Pancreatic arteriovenous malformation(AVM)is a rare disease with a number of different reported treatment methods,but there are as yet no established or definite treatments for the *** SUMMARY A 43-year-old man visited the hospital due to periumbilical *** patient underwent imaging study and laboratory testing for evaluation of *** AVM associated with pancreatitis was suspected on computed tomography and magnetic resonance *** patient was diagnosed with pancreatic AVM with pancreatitis on imaging study and *** arterial embolization with various embolic materials was ***-up computed tomography scan revealed progressive regression of AVM and improvement of *** two-year follow-up,the patient showed no recurrence of symptom or *** Transcatheter arterial embolization can be considered an effective treatment modality for selective cases of pancreatic AVM.

关键词： Pancreas Arteriovenous malformation Pancreatitis Pancreatic pseudocyst Embolization Therapeutic Case report

Red cell distribution width/albumin ratio and 90-day mortality after burn surgery

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Burns & Trauma 2022年第1期10卷 768-777页

作者： Young Joo Seo Jihion Yu Jun-Young park Narea Lee Jiwoong Lee Ji Hyun park Hee Yeong Kim Yu-gyeong Kong Young-Kug Kim Department of Anesthesiology and Pain Medicine Hangang Sacred Heart HospitalHallym University College of MedicineSeoul 07247Republic of Korea Department of Anesthesiology and Pain Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Anesthesiology and Pain Medicine National Medical CenterSeoul 04564Republic of Korea Department of Anesthesiology and Pain Medicine CHA Gangnam Medical CenterCHA University School of MedicineSeoul 06135Republic of Korea

Background:Red cell distribution width(RDW)and serum albumin concentration are associated with postoperative ***,the usefulness of the RDW/albumin ratio in burn surgery remains ***,we evaluated the association between RDW/albumin ratio and 90-day mortality after burn ***:Between 2013 and 2020,a retrospective review of patients in a burn intensive care unit(ICU)was *** operating characteristic curve,multivariate Cox logistic regression,multivariate logistic regression and Kaplan-Meier analyses were conducted to evaluate the associ-ation between RDW/albumin ratio and 90-day mortality after burn ***,prolonged ICU stay rate(>60 days)and ICU stay were ***:Ninety-day mortality was 22.5%(210/934)in burn *** factors for 90-day mortality were RDW/albumin ratio at postoperative day 1,age,American Society of Anesthesiologists physical status,diabetes mellitus,inhalation injury,total body surface area burned,hypotensive event and red blood cell transfusion *** area under the curve of the RDW/albumin ratio at postoperative day 1 to predict 90-day mortality,after adjusting for age and total body surface area burned,was 0.875(cut-off value,6.8).The 90-day mortality was significantly higher in patients with RDW/albumin ratio>6.8 than in those with RDW/albumin ratio≤6.8(49.2%vs 12.3%,pmin ratio>6.8 than in those with RDW/albumin ratio≤6.8(34.5%vs 26.5%;21[11-38]vs 18[7-32]days).Conclusion:RDW/albumin ratio>6.8 on postoperative day 1 was associated with higher 90-day mortality,higher prolonged ICU stay rate and longer ICU stay after burn surgery.

关键词： Red cell distribution width Albumin ratio Mortality Mortality Burn Risk factor Surgery