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Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression

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Neural Regeneration Research 2019年第9期14卷 1530-1535页

作者： Hae June lee Yeonghoon Son Minyoung lee Changjong Moon Sung Ho Kim In Sik Shin Miyoung Yang Sangwoo Bae Joong Sun Kim Division of Basic Radiation Bioscience Korea Institute of Radiological&Medical Sciences(KIRMAS)SeoulRepublic of Korea National Primate Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)CheongjuRepublic of Korea College of Pharmacy Kyungpook National UniversityDaeguRepublic of Korea College of Veterinary Medicine Veterinary Medical Research InstituteChonnam National UniversityGwangjuRepublic of Korea School of Medicine Wonkwang UniversityJeonbukRepublic of Korea Research Center Dongnam Institute of Radiological&Medical Sciences(DIRAMS)BusanRepublic of Korea

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain *** investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 gy cranial *** impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after *** also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic ***-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** butyrate pretreatment reversed these *** findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval ***16-0002)on December 30,2016.

关键词： sodium butyrate radioprotector ionizing radiation hippocampal damage cAMP response element binding brain-derived neurotrophic factor histone deacetylase inhibitor neurogenesis

Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

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Cellular & Molecular Immunology 2024年第4期21卷 393-408页

作者： Sujin lee Yeunjung Ko Hyun Woo lee Won Joon Oh Hun Gi Hong Dinuka Ariyaratne Se Jin Im Tae Jin Kim Department of Immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of Immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:Immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and IL-10-secreting capacities than did CD80^(low)MZ B ***,CD80^(high)MZ B cells survived 2-gy whole-body irradiation,whereas CD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of CD80^(low)MZ B cells led to accelerated development of type II collagen(CII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BCRs)that recognized double-stranded DNA or CII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BCR sequences than CD80^(low)MZ B *** transfer experiments showed that CD21^(+)CD23^(+)transitional 2 MZ precursors preferentially generated CD80^(low)MZ B cells and that a proportion of CD80^(low)MZ B cells were converted into CD80^(high)MZ B cells;in contrast,CD80^(high)MZ B cells stably remained CD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their CD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BCR specificity.

关键词： Marginal Zone B Cell CD80 Autoreactivity Radioresistance

Comparison of linac-based fractionated stereotactic radiotherapy and tomotherapy treatment plans for intra-cranial tumors

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Chinese Physics C 2010年第11期34卷 1768-1774页

作者： Jang Bo Shim Suk lee Sam Ju Cho Sang Hoon lee Juree Kim Kwang Hwan Cho Chul Kee Min Hyun Do Huh Rena lee Dae Sik Yang Young Je Park Won Seob Yoon Chul Yong Kim Soo Il Kwon Department of Radiation Oncology College of MedicineKorea University Department of Medical Physics Kyonggi University Department of Radiation Oncology College of MedicineEulji University Department of Radiation Oncology Cheil General Hospital & Women's Healthcare CenterKwandong University College of Medicine Department of Radiation Oncology Soonchunhyang University Boocheon Hospital Department of Radiation Oncology Konyang University Hospital Department of Radiation Oncology Inha University Hospital Department of Radiation Oncology School of MedicineEwha Womans University

This study compares and analyzes stereotactic radiotherapy using tomotherapy and linac-based fractionated stereotactic radiotherapy in the treatment of intra-cranial tumors,according to some *** this study,linac-based fractionated stereotactic radiotherapy and tomotherapy treatment were administered to five patients diagnosed with intra-cranial cancer in which the dose of 18–20 gy was applied on 3–5 separate *** tumor dosing was decided by evaluating the inhomogeneous index （II） and conformity index （CI）.Also,the radiation-sensitive tissue was evaluated using low dose factors V1,V2,V3,V4,V5,and V10,as well as the non-irradiation ratio volume （NIV）.The values of the II for each prescription dose in the linacbased non-coplanar radiotherapy plan and tomotherapy treatment plan were （0.125±0.113） and （0.090±0.180）,respectively,and the values of the CI were （0.899±0.149） and （0.917±0.114）,*** low dose areas,V1,V2,V3,V4,V5,and V10,in radiation-sensitive tissues in the linac-based non-coplanar radiotherapy plan fell into the ranges 0.3%–95.6%,0.1%–87.6%,0.1%–78.8%,38.8%–69.9%,26.6%–65.2%,and 4.2%–39.7%,respectively,and the tomotherapy treatment plan had ranges of 13.6%–100%,3.5%–100%,0.4%–94.9%,0.2%– 82.2%,0.1%–78.5%,and 0.3%–46.3%,*** the NIV for each organ,it is possible to obtain similar values except for the irradiation area of the brain *** percentages of NIV10%,NIV20%,and NIV30%for the brain stem in each patient were 15%–99.8%,33.4%–100%,and 39.8%–100%,respectively,in the fractionated stereotactic treatment plan and 44.2%–96.5%,77.7%–99.8%,and 87.8%–100%,respectively,in the tomotherapy treatment *** order to achieve higher-quality treatment of intra-cranial tumors,treatment plans should be tailored according to the isodose target volume,inhomogeneous index,conformity index,position of the tumor upon fractionated stereotactic radiosurgery,and radiation dosage for radiation-sensitive tissues.

关键词： fractionated stereotactic radiotherapy tomotherapy treatment plan virtual organ delineation

Nondestructive Skeletal Imaging of Hyla suweonensis Using Micro-Computed Tomography

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Asian Herpetological Research 2017年第4期18卷 235-243页

作者： Eunbin KIM Hacheol SUNG Donghyun lee geunjoong KIM Dongha NAM Etmgsam KIM School of Biological Sciences and Biotechnology Chonnam National University 77 Yongbong-ro Bukgu Gwangju 61186 South Korea2 u 61186 South Korea

We successfully obtained 3D skeletal images of Hyla suweonensis, employing a nondestructive method by applying appropriate anesthesia and limiting the radiation dose. H. suweonensis is a tree frog endemic to Korea and is on the list of endangered species. Previous studies have employed caliper-based measurements and two-dimensional （2D） X-ray imaging for anatomical analyses of the skeletal system or bone types of H. suweonensis. In this work we reconstructed three-dimensional （3D） skeletal images of H. suweonensis, utilizing a nondestructive micro-computed tomography （micro-CT） with a short scan and low radiation dose （i.e. 4 min and 0.16 gy）. Importantly, our approach can be applied to the imaging of 3D skeletal systems of other endangered frog species, allowing both versatile and high contrast images of anatomical structures without causing any significant damages to the living animal.

关键词： Hyla suweonensis Micro-computed tomography 3D skeletal structure Nondestructive imaging,Endangered species Radiation dose.

Strength and stiffness variation of frozen soils according to confinement during freezing

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Research in Cold and Arid Regions 2015年第4期7卷 335-339页

作者： Sangyeob Kim JongSub lee School of Civil Environmental and Architectural EngineeringKorea University

When water between soil particles is frozen, the strength and stiffness behavior of soils significantly change. Thus, nu- merous experimental studies in the laboratory have been carried out to characterize the strength and stiffness of frozen soils. The goals of this study are to evaluate the strength characteristics of frozen soils, which underwent confinement in freezing and shearing stages, and to estimate the stiffness variation by shear wave velocity during shear phase. The specimens are prepared in a brass cell by mixing sand and silt with 10% degree of saturation at a relative density of 60%. The applied normal stresses as confining stresses are 5, 10, 25 and 50 kPa. When the temperature of the specimens is lowered up to -5 ~C, direct shear tests are carried out. Furthermore, shear waves are continuously measured through bender elements during shearing stage for the investigation of stiffness change. Test results show that shear strength and stiffness are significantly affected by the confining stress in freezing and shearing phases. This study suggests that the strength and stiffness of frozen soils may be dependent on the confining stresses applied during freezing and shearing.

关键词： frozen soil strength stiffness shear confinement

Graphene-based saturable absorber and mode-locked laser behaviors under gamma-ray radiation

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Photonics Research 2019年第7期7卷 57-62页

作者： Dohyun Kim Nam Hun Park Hyunju lee Jaegoan lee Dong-Il Yeom Jungwon Kim School of Mechanical and Aerospace Engineering Korea Advanced Institute of Science and Technology (KAIST)Daejeon 34141South Korea Department of Energy Systems Research & Department of Physics Ajou UniversitySuwon 16499South Korea

We investigate optical and electrical behaviors of a graphene saturable absorber (SA) and mode-locking performance of a graphene-SA-based mode-locked Er fiber laser in gamma-ray radiation. When irradiated up to 4.8 kgy at ~ 100 gy/hr dose rate, the overall nonlinear transmittance in transverse electric mode was increased, while maintaining modulation depth to >10%. The corresponding *** loss was reduced at a 1.2-dB/kgy rate. In the electrical properties, the charge carrier mobility was reduced, and the Dirac voltage shift was increased to positive under gamma-ray radiation. The radiation-induced optical and electrical changes turned out to be almost recovered after a few days. In addition, we confirmed that the graphene-SA-based laser showed stable CW mode-locking operation while the inserted graphene SA was irradiated for 2-kgy at a 45-gy/hr dose rate, which corresponds to >40 years of operation in low Earth orbit *** the best of our knowledge, this is the first evaluation of graphene SAs and graphene-SA-based mode-locked lasers in gamma-ray radiation, and the measured results confirm the high potential of graphene SAs and graphene-SA-based lasers in various outer-space environments as well as other radiation environments, including particle accelerators and radiationbased medical instruments.

关键词： absorber modelocked laser accelerators

Routine defunctioning stoma after chemoradiation and total mesorectal excision:A single-surgeon experience

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World Journal of Gastroenterology 2013年第11期19卷 1797-1804页

作者： Shao-Chieh Lin Po-Chuan Chen Chung-Ta lee Hong-Ming Tsai Peng-Chan Lin Helen HW Chen Yuan-Hwa Wu Bo-Wen Lin Wen-Pin Su Jenq-Chang lee Division of Colorectal Surgery Department of SurgeryNational Cheng Kung University HospitalCollege of Medicine National Cheng Kung University Tainan 704Taiwan Department of Pathology National Cheng Kung University HospitalCollege of Medicine Department of Radiology National Cheng Kung University HospitalCollege of Medicine Department of Oncology National Cheng Kung University HospitalCollege of Medicine Department of Radiation Oncology National Cheng Kung University HospitalCollege of Medicine

AIM:To investigate the 10-year results of treating low rectal cancer by a single surgeon in one ***:From Oct 1998 to Feb 2009,we prospectively followed a total of 62 patients with cT2-4 low rectal cancer with lower tumor margins measuring at 3 to 6 cm above the anal *** patients received neoadjuvant chemoradiation(CRT) for 6 *** them,85% of the patients received 225 mg/m2/d 5-fluorouracil using a portable infusion *** whole pelvis received a total dose of 45 gy of irradiation in 25 fractions over 5 *** interval from CRT completion to surgical intervention was planned to be approximately 6-8 *** mesorectal excision(TME) and routine defunctioning stoma construction were performed by one *** distal resection margin,circumferential resection margin,tumor regression grade(TRG) and other parameters were *** used TRG to evaluate the tumor response after neoadjuvant *** evaluated anal function outcomes using the Memorial Sloan-Kettering Cancer Center anal function scores after closure of the defunctioning ***:The median distance from the lower margin of rectal cancer to the anal verge was 5 cm:6 cm in 9 patients,5 cm in 32 patients,4 cm in 10 patients,and 3 cm in 11 *** receiving neoadjuvant CRT,45 patients(72.6%) had a cT3-4 tumor,and 21(33.9%) patients had a cN1-2 lymph node *** CRT,30 patients(48.4%) had a greater than 50% clinical reduction in tumor *** final pathology reports revealed that 33 patients(53.2%) had a ypT3-4 tumor and 12(19.4%) patients had ypN1-2 lymph node *** patients completed the entire course of neoadjuvant *** patients developed only Grade 1-2 toxicities during *** patients(21%) achieved a pathologic complete *** post-operative complications *** 90% of the defunctioning stomas were closed within 6 *** local recurrence rate was 3.2%.Pathologic lymph node involvement was the only prognostic factor predicting

关键词： Rectal cancer Neoadjuvant chemoradiation Total mesorectal excision Pathologic complete response Defunctioning stoma

T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1950-1957页

作者： Chia Ching lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey Department of Radiation Oncology National University Cancer InstituteNational University HospitalTan Tock Seng HospitalSingapore 119228Singapore Department of Medical Oncology Tan Tock Seng HospitalSingapore 308433Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Department of Respiratory and Critical Care Medicine Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of *** with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and *** date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation *** SUMMARY A 67-year-old gentleman who presented with dysphagia and weight *** and imaging revealed a T4N1M0 cervical esophageal squamous cell *** received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was *** discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 gy in 25 *** months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and *** patient remains cancer-free at two year on *** response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of *** This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies.

关键词： Esophageal cancer Chemoradiotherapy Fistula Stenting T4 Case report

Predictors of post-treatment stenosis in cervical esophageal cancer undergoing high-dose radiotherapy

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World Journal of Gastroenterology 2018年第7期24卷 862-869页

作者： Jun Won Kim Tae Hyung Kim Jie-Hyun Kim Ik Jae lee Department of Radiation Oncology Gangnam Severance Hospital Yonsei University College of Medicine Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

AIM To evaluate toxicity and treatment outcome of highdose radiotherapy(RT) for cervical esophageal cancer(CEC).METHODS We reviewed a total of 62 consecutive patients who received definitive RT for stage Ⅰ to Ⅲ cervical esophageal cancer between 2001 and 2015. Patients who received gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded. Treatment failures were divided into local(occurring within the RT field), outfield-esophageal, and regional [occurring in regional lymph node(s)] failures. Factors predictive of esophageal stenosis requiring endoscopic dilation were *** Grade 1, 2, and 3 esophagitis occurred in 19(30.6%), 39(62.9%), and 4 patients(6.5%), respectively, without grade ≥ 4 toxicities. Sixteen patients(25.8%) developed post-RT stenosis, of which 7 cases(43.8%) were malignant. Four patients(6.5%) developed tracheoesophageal fistula(TEF), of which 3(75%) cases were malignant. Factors significantly correlated with post-RT stenosis were stage T3/4(P = 0.001), complete circumference involvement(P gy) was not associated with occurrence of postRT stenosis or TEF. With a median follow-up of 24.3(range, 3.4-152) mo, the 2 y local control, outfield esophageal control, progression-free survival, and overall survival(OS) rates were 78.9%, 90.2%, 49.6%, and 57.3%, respectively. Factors significantly correlated with OS were complete circumference involvement(P = 0.023), stenosis at diagnosis(P < 0.0001), and occurrence of post-RT stenosis or TEF(P < 0.001) in univariate analysis, while stenosis at diagnosis(P = 0.004) and occurrence of post-RT stenosis or TEF(P = 0.023) were significant in multivariate

关键词： Chemoradiotherapy Post-radiotherapy stenosis High-dose radiotherapy Cervical esophageal cancer