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Exploring influences and risk of bias of studies on return to sport and work after lateral ankle sprain:A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第1期12卷 11-25页

作者： Priscilla A Maria gwendolyn vuurberg Gino MMJ Kerkhoffs Department of Orthopaedic Surgery and Sports Medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Amsterdam Movement Sciences Amsterdam UMCAmsterdam 1105 AZNetherlands Amsterdam Collaboration on Health and Safety in Sports Amsterdam UMCAmsterdam 1105 AZNetherlands Academic Center for Evidencebased Sports medicine Amsterdam UMCAmsterdam 1105 AZNetherlands Faculty of Medicine University of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiology and Nuclear Medicine Rijnstate ArnhemArnhem 6815ADNetherlands Department of Radiology and Nuclear Medicine Amsterdam UMCAmsterdam 1105 AZNetherlands Faculty of Medicine University of AmsterdamAmsterdam1105 AZNetherlands

BACKGROUND Lateral ankle sprains are the most common traumatic musculoskeletal injuries of the lower extremity,with an incidence rate of 15%-20%.The high incidence and prevalence highlights the economic impact of this *** sprains lead to a high socioeconomic burden due to the combination of the high injury incidence and high medical *** to 40%of patients who suffer from an ankle sprain develop chronic ankle *** instability can lead to prolonged periods of pain,immobility and injury *** of factors that influence return to work(RTW)and return to sports(RTS)after a lateral ankle sprain(LAS)may help seriously reduce healthcare *** To explore which factors may potentially affect RTW and RTS after sustaining an *** EMBASE and PubMed were systematically searched for relevant studies published until June *** criteria were as follows:(1)Injury including LAS or chronic ankle instability;(2)Described any form of treatment;(3)Assessment of RTW or RTS;(4)Studies published in English;and(5)Study designs including randomized controlled clinical trials,clinical trials or cohort *** criteria were:(1)Studies involving children(age<16 year);or(2)Patients with concomitant ankle injury besides lateral ankle ligament damage.A quality assessment was performed for each of the included studies using established risk of bias *** quality of evidence was assessed using the GRADEpro tool in cases where outcomes were included in the quantitative analysis.A best evidence synthesis was performed in cases of qualitative outcome *** all studied outcomes suitable for quantitative analysis a forest plot was created to calculate the effect on RTW and *** A total of 8904 patients were included in 21 studies,10 randomized controlled trials,7 retrospective cohort studies and 4 prospective cohort *** studies were eligible for *** overall RTS rate ranged wer

关键词： Ankle sprain Prognostic factors Bias Return to work Return to sport Preoperative motivation

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Clinical efficacy of the Ankle Spacer for the treatment of multiple secondary osteochondral lesions of the talus

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World Journal of Orthopedics 2022年第2期13卷 178-192页

作者： Jari Dahmen J Nienke Altink gwendolyn vuurberg Coen A Wijdicks Sjoerd AS Stufkens Gino MMJ Kerkhoffs Department of Orthopedic Surgery Amsterdam UMCLocation AMCAmsterdam 1105AZNetherlands Department of Orthopedic Research ArthrexNaplesFL 34108United States

BACKGROUND The Ankle Spacer was developed as a joint-sparing alternative to invasive endstage ***,there are no clinical studies on the Ankle *** To describe the operative technique and the clinical efficacy of the Ankle Spacer for the treatment of multiple,cystic osteochondral lesions of the talus in patients with failed prior operative *** This is a prospective study during which patients were assessed preoperatively,at 2-and 6 wk,and at 3,6,12 and 24 mo *** with multiple,cystic or large(≥15 mm)osteochondral lesions of the talus after failed prior surgery were *** primary outcome measure was the numeric rating scale(NRS)for pain during walking at 2 years *** outcome measures included the NRS in rest and during stair climbing,the American Orthopaedic Foot and Ankle Society Hindfoot Score,the Foot and Ankle Outcome Score,the Short-Form 36 physical and mental component scale,and the Range of Motion(ROM).Radiographic evaluations were conducted to evaluate prosthetic loosening and *** rates and complications were also *** Two patients underwent an Ankle Spacer implantation on the *** NRS during walking improved from 6 and 7 preoperatively to 2 and 2 points postoperatively at 2 years,in patient 1 and 2,*** other patient-reported outcome measures also improved *** were no re-operations nor *** imaging showed no loosening of the implant and no change of implant *** The Ankle Spacer showed clinically relevant pain reduction during walking,improvement in clinical outcomes as assessed with PROMs,and no complications or *** treatment option may evolve as a joint-sparing alternative to invasive end-stage surgeries.

关键词： Hemi-arthroplasty Ankle Spacer Talar surface implant Osteochondral lesions of the talus Endstage

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Integrity of the hip capsule measured with magnetic resonance imaging after capsular repair or unrepaired capsulotomy in hip arthroscopy

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World Journal of Orthopedics 2022年第4期13卷 400-407页

作者： Niels H Bech Lode A van Dijk Sheryl de Waard gwendolyn vuurberg Inger N Sierevelt Gino MMJ Kerkhoffs Daniël Haverkamp Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands Department of Orthopedic Surgery Tergooi ZiekenhuisHilversum 1213 XZNetherlands Department of Radiology and Nuclear Medicine Rijnstate HospitalArnhem 6815 ADNetherlands Department of Radiology and Nuclear Medicine Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Academic Center for Evidence-Based Sports Medicine Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Amsterdam Collaboration on Health and Safety in Sports Amsterdam UMC/IOC Research CenterAmsterdam 1105 AZNetherlands

BACKGROUND Current literature shows no clear answer on the question how to manage the capsule after hip *** patient reported outcome measures there seems to be no difference between capsular repair or unrepaired *** To evaluate and compare the integrity of the hip capsule measured on a magnetic resonance imaging(MRI)scan after capsular repair or unrepaired *** A case series study was performed;a random sample of patients included in a trial comparing capsular repair vs unrepaired capsulotomy had a postoperative MRI *** presence of a capsular defect and gap size were independently evaluated on *** A total of 28 patients(29 hips)were *** demographics were comparable between treatment *** were 2 capsular defects in the capsular repair group and 7 capsular defects in the unrepaired capsulotomy group(P=0.13).In the group of patients with a defect,median gap sizes at the acetabular side were 5.9 mm(range:2.7-9.0)in the repaired and 8.0 mm(range:4.5-18.0)in the unrepaired group(P=0.462).At the muscular side gap sizes were 6.6 mm(range:4.1-9.0)in the repaired group and 11.5 mm(range:3.0-18.0)in the unrepaired group(P=0.857).The calculated Odds ratio(OR)for having a capsular defect with an increasing lateral center-edge(CE)angle was 1.12(P=0.06).The OR for having a capsular defect is lower in the group of patients that underwent a labral repair with an OR of 0.1(P=0.05).CONCLUSION There is no significant difference in capsular defects between capsular repair or unrepaired *** clinical characteristics our case series shows that a larger CE angle increases the likelihood of a capsular defect and the presence of a labral repair decreases the likelihood of a capsular defect.

关键词： Hip Arthroscopy Magnetic resonance imaging Capsule Thickness

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口袋里的精神科医生

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科技纵览 2024年第7期 44-49,4页

作者： gwendolyn Rak 不详

亚历克斯·廖(Alex Leow)科医生兼计算机科学家,从孩童时期起,她几乎每天都弹钢琴。有些是伊利诺伊大学芝加哥分校的精神日子她弹得很好,而有些日子节奏就会慢半拍,手指也会弹错键。这些年来,她注意到一个规律:她的弹奏水平取决于当时... 详细信息

亚历克斯·廖(Alex Leow)科医生兼计算机科学家,从孩童时期起,她几乎每天都弹钢琴。有些是伊利诺伊大学芝加哥分校的精神日子她弹得很好,而有些日子节奏就会慢半拍,手指也会弹错键。这些年来,她注意到一个规律:她的弹奏水平取决于当时的情绪。情绪低落或睡眠不足时,她的弹奏几乎总是出错,效果欠佳。

关键词：伊利诺伊大学计算机科学家精神科医生亚历克斯孩童时期慢半拍弹钢琴睡眠不足

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MagQuest寻求新的全球地磁图

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科技纵览 2024年第1期 12-13页

作者： gwendolyn Rak 不详

全球地磁模型对导航至关重要。该模型将全球各点位磁场的精确测量结果汇编成一张地图,提供不断变化的磁场数据,但目前用于收集这些重要数据的系统已经很陈旧了。美国一家情报机构参与了开发新技术取代陈旧系统的竞赛,现在,竞赛正处于最... 详细信息

全球地磁模型对导航至关重要。该模型将全球各点位磁场的精确测量结果汇编成一张地图,提供不断变化的磁场数据,但目前用于收集这些重要数据的系统已经很陈旧了。美国一家情报机构参与了开发新技术取代陈旧系统的竞赛,现在,竞赛正处于最后的阶段。人们希望将来拥有一个更准确的全球地磁模型。全球地磁模型在手机、飞机和军事应用中非常重要。“我们每天都会用它来判断应该往左还是往右。”

关键词：情报机构地磁模型地磁图精确测量竞赛重要数据

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英特尔希望超越竞争对手

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科技纵览 2024年第1期 32-33,56页

作者： gwendolyn Rak 不详

这家芯片制造商将希望寄托于新型晶体管、供电技术和新的代工业务。过去5年,英特尔在先进芯片制造方面一直落后于台湾积体电路制造公司(以下简称台积电)和三星。现在,为,了重新获得领先地位,该公司正在采取一项大胆而冒险的行动,在用于... 详细信息

这家芯片制造商将希望寄托于新型晶体管、供电技术和新的代工业务。过去5年,英特尔在先进芯片制造方面一直落后于台湾积体电路制造公司(以下简称台积电)和三星。现在,为,了重新获得领先地位,该公司正在采取一项大胆而冒险的行动,在用于台式机和笔记本电脑的Arrow Lake处理器中引入两项新技术,计划于2024年底推出。

关键词：笔记本电脑芯片制造商英特尔供电技术台式机

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Vitamin B_(12) Deficiency in Newborns and their Mothers_Novel Approaches to Early Detection,Treatment and Prevention of a Global Health Issue

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Current Medical Science 2020年第5期40卷 801-809页

作者： gwendolyn Gramer Georg F.Hoffmann University Hospital Heidelberg Center for Pediatric and Adolescent MedicineDivision of Neuropediatrics and Metabolic MedicineDietmar Hopp Metabolic CenterIm Neuenheimer Feld 6691 Heidelberg 69120Germany

Vitamin B 12 deficiency,mostly of maternal origin in newborns,is a well treatable condition but can cause severe neurologic *** women of childbearing age and pregnant women worldwide vitamin B12 deficiency has been reported with frequencies of 10%-50%.Children with vitam in B I2 deficiency are asym ptom atic at birth but may develop severe multisystemic symptoms,including irreversible developmental impairment in the second halfyear of *** detection of vitamin B12 deficiency allows for presymptomatic *** article provides an overview over the function of vitamin B12 and discusses causes and frequency of vitamin B12 deficiency in newborns,infants,and women of childbearing *** describes novel successful approaches to newborn screening(NBS)for vitamin B,2 deficiency and results of a pilot study which performed systematic NBS for vitamin B12 deficiency using so-called second-tier strategies by measuring homocysteine and methylmalonic acid in dried blood *** for diagnostics in mothers of children with vitamin B12 deficiency are described as well as results of systematic work-up in mothers and treatment and follow-up of children with vitamin B12 deficiency detected by *** options of vitamin B12 deficiency are presented including a newly developed standardized supplementation scheme with exclusively oral vitamin BI2 *** for preventive approaches to vitamin Bl2 deficiency for children and mothers are *** children worldwide could benefit from systematic inclusion of vitamin B12 deficiency into NBS *** addition,preventive approaches to maternal vitamin B12 deficiency should be implemented systematically during maternal care.

关键词： vitamin B_(12)deficiency prevention treatment mother and child health newborn screening maternal

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In situ measurement of ECM rheology and microheterogeneity in embedded and overlaid 3D pancreatic tumor stroma co-cultures via passive particle tracking

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 26-34页

作者： Dustin P.Jones William Hanna gwendolyn M.Cramer Jonathan P.Celli Department of Physics University of Massachusetts Boston Boston MA 02215USA

Tumor growth is regulated by a diverse set of extraellular infuences,including paracrine crosstalk with stromal partners,and biophysical interactions with surrounding cells and *** elucidating the role of physical force and the mechanical properties of the extracellular matrix(ECM)itself as regulators of tumor growth and invasion have been greatly catalyzed by the use of in ritro three-dimensional(3D)tumor *** systems provide the ability to systematically isolate,manipulate,and evaluate impact of stromal components and extracellular mechanics in a platform that is both conducive to imaging and biologically ***,recognizing that mechanoregulatory crosstalk is bi-directional and fully utilizing these models requires complementary methods for in situ measurements of the local mechanical ***,in 3D tumor/fbroblast co-culture models of pancreatic canocer,a discase characterized by its prominent stromal involvement,we evaluate the use of particle-tracking microrhoology to probe dynamic mechanical *** videos of fuorescently labeled polystyrene micro-spheres embedded in ollagen I ECM,we measure spatiotemporal changes in the Brownian motion of probes to report local ECM shear modulus and *** approach reveals st ffening of collagen in fibroblast co-cultures relative to cultures with cancer cells only,which exhibit degraded ECM with heterogeneous *** further show that these effects are dependent on culture geometry with contrast ing behavior for embedded and overlay *** addition to potential application to screening stroma targeted therapeutics,this work also provides insight into how the compoition and plating geometry impact the mechanical propertios of 3D cell cultures that are increasingly widey used in cancer biology.

关键词： Microrheology 3D tumor models matrix remodeling mechanobiology stromal depletion

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A Review of Native Hawaiian Benefits Received through the Inflation Reduction Act of 2022

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Journal of Environmental Protection 2023年第3期14卷 206-212页

作者： gwendolyn A. Richardson University of Wisconsin-Parkside Kenosha USA

On August 16th, 2022, Public Law 117-169, The Inflation Reduction Act of 2022, was signed into law by the President of the United States, Joseph R. Biden Jr. The Inflation Reduction Act of 2022 provides the Native Hawaiian community an opportunity to engage in activities of climate resilience and adaptation through making funds available to support such actions. This article provides a preliminary policy analysis of the Inflation Reduction Act of 2022 to identify the opportunities presented by this legislation that can provide ecological and cultural benefit to the Native Hawaiian community. Findings suggest policy language included in this Act is broad which emphasizes the need for the Senior Program Director of the Office of Native Hawaiian Relations, who is tasked with fund distribution, to rely upon the knowledge of the Native Hawaiian community and ecological experts to direct funds in a manner that best benefits the Native Hawaiian community.

关键词： Inflation Reduction Act Climate Crisis Environmental Law Hawaii

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Federal and State Land Acquisition in Hawaii: Conservation in the Epicenter of Extinction

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Journal of Environmental Protection 2022年第12期13卷 953-971页

作者： gwendolyn A. Richardson University of Wisconsin-Parkside Kenosha USA

The Land and Water Conservation Fund Act of 1965, reinstated in 2018 through the John D. Dingell, Jr. Conservation, Management, and Recreation Act, provided the United States Federal Government the ability to acquire and fund land acquisition for the purpose of preservation, development, and public enjoyment. In 2005, the state of Hawaii passed Act 156 which was later amended by Hawaii Revised Statues §173A. Established through this legislation is a land conservation fund providing the state government of Hawaii analogous land acquisition abilities to that of the federal government. It is through these laws that the federal government and state of Hawaii can reinforce the conservation of the fragile Hawaiian tropical rainforest ecosystem. This paper will identify discontinuities as well as opportunities in the implementation of this legislation to provide recommendations to improve the ability of both state and federal government to protect and conserve at risk ecosystems and lands like those present in Hawaii.

关键词： Hawaii Endemism Extinction Land Conservation Public Policy

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