Vitamin B_(12) Deficiency in Newborns and their Mothers_Novel Approaches to Early Detection,Treatment and Prevention of a Global Health Issue

作     者：Gwendolyn Gramer Georg F.Hoffmann Gwendolyn Gramer;Georg F.Hoffmann

作者机构：University Hospital HeidelbergCenter for Pediatric and Adolescent MedicineDivision of Neuropediatrics and Metabolic MedicineDietmar Hopp Metabolic CenterIm Neuenheimer Feld 6691 Heidelberg 69120Germany 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2020年第40卷第5期

页      面：801-809页

核心收录：

学科分类：0303[法学-社会学] 03[法学] 030302[法学-人口学] 

基　　金：Dietmar Hopp Foundation 

主　　题：vitamin B_(12)deficiency prevention treatment mother and child health newborn screening maternal 

摘      要：Vitamin B 12 deficiency,mostly of maternal origin in newborns,is a well treatable condition but can cause severe neurologic *** women of childbearing age and pregnant women worldwide vitamin B12 deficiency has been reported with frequencies of 10%-50%.Children with vitam in B I2 deficiency are asym ptom atic at birth but may develop severe multisystemic symptoms,including irreversible developmental impairment in the second halfyear of *** detection of vitamin B12 deficiency allows for presymptomatic *** article provides an overview over the function of vitamin B12 and discusses causes and frequency of vitamin B12 deficiency in newborns,infants,and women of childbearing *** describes novel successful approaches to newborn screening(NBS)for vitamin B,2 deficiency and results of a pilot study which performed systematic NBS for vitamin B12 deficiency using so-called second-tier strategies by measuring homocysteine and methylmalonic acid in dried blood *** for diagnostics in mothers of children with vitamin B12 deficiency are described as well as results of systematic work-up in mothers and treatment and follow-up of children with vitamin B12 deficiency detected by *** options of vitamin B12 deficiency are presented including a newly developed standardized supplementation scheme with exclusively oral vitamin BI2 *** for preventive approaches to vitamin Bl2 deficiency for children and mothers are *** children worldwide could benefit from systematic inclusion of vitamin B12 deficiency into NBS *** addition,preventive approaches to maternal vitamin B12 deficiency should be implemented systematically during maternal care.