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Use of the American Society of Anesthesiologists Classification as an Additional Planning Tool for Renal Cell Carcinoma Assessment

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Journal of Cancer Therapy 2013年第9期4卷 7-14页

作者： Daniel Beltrame Ferreira Stenio de Cassio Zequi Walter Henriques da Costa Diego Abreu Clavijo Ricardo Decia Deusdedit Cortez Neto Renato Rosa de Oliveira gustavo cardoso guimaraes Ademar Lopes Urology Division Department of Pelvic SurgeryA.C.Camargo Cancer CenterSao PauloBrazil Department of Urology Pasteur HospitalMontevideoUruguay

Objective: To determine the prognostic value of the American Society of Anesthesiologists (ASA) classification and of the main clinical pathologic variables in renal cell carcinoma (RCC) patients who underwent surgical treatment. Methods: In this international collaborative study, 376 RCC patients who underwent partial nephrectomy (PN) or radical nephrectomy (RN) during the period 1989-2009 were assessed. The pathological data were reviewed by a single pathologist, and all of the surgically treated patients had been previously evaluated by a team of anesthesiologists and classified as ASA 1, ASA 2, or ASA 3. Results: In total, 318 patients were included in the study, with a mean followup of 48 months. Incidental tumors represented 47% of the cases, while 11.6% presented with metastases at diagnosis. Among the patients assessed, 38 (11.9%) were classified as ASA 1, 213 (67%) as ASA 2, and 67 (21.1%) as ASA 3. An association between the ASA classification and the main clinicopathological variables of RCC was observed. The univariate analysis for overall survival (OS) revealed significant differences in the survival curves according to the ASA classification (p < 0.001). High-grade neoplasms, the presence of metastasis at diagnosis, clinical stage III/IV, and incidental tumors remained as independent predictors of survival. Moreover, the multivariate analysis revealed a negative impact of the ASA classification on OS (p = 0.001). Conclusions: The present study demonstrated a correlation between the ASA classification and the main prognostic factors of RCC and its impact on survival rates. ASA 3 patients had more aggressive tumors, increased risk of perioperative complications, and worse outcomes compared with ASA1 or ASA 2. Thus, the ASA classification may be considered an additional tool for assessing and planning the treatment of RCC patients.

关键词： Comorbidity Renal Cell Carcinoma ASA Prognosis Oncology

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Performance of the Multiprofessional Team in Cytoreductive Surgeries with Intraperitoneal Hyperthermic Chemotherapy:Experience Reporting

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Journal of Pharmacy and Pharmacology 2018年第11期6卷 965-969页

作者： Cecília da Silva Angelo(RN) Ademar Lopes(PhD) Catharina Ferreira de Meira Pachioni(MSc) Eduardo Henrique Giroud Joaquim(MSc) Samuel Aguiar Junior(PhD) gustavo cardoso guimaraes(PhD) Glauco Baiocchi Neto(PhD) Felipe JoséFernandez Coimbra(PhD) Isabel Miranda Bonfim(MSc) Rita de Cassia Burgos de Oliveira(PhD) Tailine Ligia Tadini(RN) A.C.Camargo Cancer Center Sao Paulo04002-010Brazil

Purpose:This study aims at reporting the experience of a cancer hospital’s multiprofessional team with surgery patients in performing cytoreductive surgeries associated with hyperthermic intraperitoneal ***:It is a reporting about the experience of the multiprofessional team at AC Camargo Cancer Center’s surgery center,which operates in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,thus guaranteeing the surgery patient’s ***:No safety report for the surgery patient subjected to intraperitoneal hypothermic chemotherapy was found in the ***,the surgery center’s multiprofessional team’s practice was based on standards for manipulating chemotherapeutic agents and for safely administering medication.A checklist was elaborated for cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy based on the surgery patient safety protocol and the institution’s multiprofessional team’s ***:From the multiprofessional team’s experiences in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,the importance of elaborating a checklist to promote the quality of assistance and guarantee patient safety during the entire intraoperative phase became evident.

关键词： Patient safety chemotherapy for cancer by regional perfusion checklist

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Determination and Removal of Endocrine Disruptors in Wastewater by Activated Carbon

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Journal of Civil Engineering and Architecture 2017年第7期11卷 653-662页

作者： MarceloA. Nolasco Kamila O. guimaraes Grace cardoso School of Arts Sciences and Humanities University of Sao Paulo-USP Sao Paulo 03828-000 Brazil Graduate Program in Architecture and Urbanism (PPGARQ) Meridional Faculty (IMED) Passo Fundo-RS 99070-220 Brazil

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Cumulative sum analysis score and phacoemulsification competency learning curve

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1088-1093页

作者： gustavo Vedana Filipe G.cardoso Alexandre S.Marcon Licio E.K.Araújo Matheus Zanon Daniella C.Birriel Guilherme Watte Albert S.Jun Wilmer Eye Institute Johns Hopkins Medical Institutions Irmandade Santa Casa Misericórdia Federal University of Rio Grande do Sul

AIM： To use the cumulative sum analysis score（CUSUM） to construct objectively the learning curve of phacoemulsification ***： Three second-year residents and an experienced consultant were monitored for a series of 70 phacoemulsification cases each and had their series analysed by CUSUM regarding posterior capsule rupture（PCR） and best-corrected visual acuity. The acceptable rate for PCR was 〈5%（lower limit h） and the unacceptable rate was 〉10%（upper limit h）. The acceptable rate for bestcorrected visual acuity worse than 20/40 was 〈10%（lower limit h） and the unacceptable rate was 〉20%（upper limit h）. The area between lower limit h and upper limit h is called the decision interval. RESULTS： There was no statistically significant difference in the mean age, sex or cataract grades between groups. The first trainee achieved PCR CUSUM competency at his 22 nd case. His best-corrected visual acuity CUSUM was in the decision interval from his third case and stayed there until the end, never reaching competency. The second trainee achieved PCR CUSUM competency at his 39^ th case. He could reach best-corrected visual acuity CUSUM competency at his 22 ^nd case. The third trainee achieved PCR CUSUM competency at his 41 st case. He reached bestcorrected visual acuity CUSUM competency at his 14 ^th ***： The learning curve of competency in phacoemulsification is constructed by CUSUM and in average took 38 cases for each trainee to achieve it.

关键词： phacoemulsification learning curve cumulative sum analysis score posterior capsule rupture best corrected visual acuity cataract surgery

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Initial Growth and Gas Exchanges of Plants of Colored Cotton Submitted to Saline Stress

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Agricultural Sciences 2018年第12期9卷 1652-1663页

作者： Hallyson Oliveira Ronaldo do Nascimento Samuel Silva José Alberto Ferreira cardoso Rafaela Felix Basílio guimaraes Elka Costa Santos Nascimento Post-Graduated of Agricultural Engineer Federal University of Campina GrandeCampina GrandeBrazil

The objective of the research was to evaluate the effects of saline stress on the initial growth and physiological parameters of three varieties of cotton plants, being two cultivars of colored fiber (BRS Topázio and BRS Verde) and one of white fiber (BRS 286). The experiment was conducted under greenhouse conditions. After chemical depletion with sulfuric acid, five seeds were seeded in polyethylene pots of 20 kg, leaving only one plant per pot after thinning. The experimental design was completely randomized, with a factorial scheme of 3 × 5, with five replications, totaling 75 plots, being three cotton varieties and five saline stress treatments—1.1;3.1;5.1;7.1;9.1 dS m−1. The evaluations occurred at 15 and 30 days after the beginning of the treatments (DAT) for growth variables (plant height, stem diameter, number of leaves and leaf area) and gas exchange (stomatal conductance, net photosynthesis rate and transpiration. The variety that was most resistant to the salt stress levels studied was BRS 286, followed by BRS Topazio and BRS Verde.

关键词： Photosynthesis Stomatal Conductance Dry Mass Resistance Cultivars

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Characterization of the Biological Potential of the Essential Oils from Five Species of Medicinal Plants

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American Journal of Plant Sciences 2017年第2期8卷 154-170页

作者： Danubia Aparecida Carvalho Selvati Rezende Rafaela Vieira Souza Maisa Lamounier Magalh?es Alex Rodrigues Silva Caetano Marcos Schleiden Sousa Carvalho Ellen Cristina de Souza Luiz gustavo de Lima guimaraes David Lee Nelson Luís Roberto Batista Maria das Gra?as cardoso Departamento de Química Universidade Federal de LavrasLavrasBrasil Departamento de Ciencia dos Alimentos Universidade Federal de LavrasLavrasMGBrasil Departamento de Ciência dos Alimentos Universidade Federal de LavrasLavrasMGBrasil Departamento de Agricultura Universidade Federal de LavrasLavrasMGBrasil Universidade Federal de Sao Joao del-Rei Sao Joao del-ReiBrasil Universidade Federal do Vale do Jequitinhonha e Mucuri DiamantinaMGBrasil

Essential oils from Mentha piperita, Cymbopogon citratus, Rosmarinus officinalis, Peumus boldus and Foeniculum vulgare were extracted by hydrodistillation, chemically characterized and quantified by GC/MS and GC/FID. The principal componentes in the essential oil of M. piperita (carvone and limonene), C. citratus (geranial, neral and myrcene), R. officinalis (1,8-cineole, camphor and α-pinene), P. boldus (α-terpinyl formate, p-cymene and 1,8-cineole) and F. vulgare (methyl chavicol, limonene and fenchone) were identified. The oils were tested for antioxidant activity employing the DPPH (2,2-diphenyl-1-picryl-hydrazyl) radical-capture method, the oxidation of the β-carotene/linoleic acid system, and the ABTS radical-capture method. The essential oils were not effective. The antioxidant activities of the oils were determined by the hydroxyl method, and the highest activity (62.80%) was observed with the essential oil from M. piperita. Activities of 1.54 and 1.82 μg μg-1, respectively, were observed for the essential oils from C. citratus and P. Boldus using the phosphomolybdenum method. No activity was observed with respect to reducing power. The essential oil from C. citratus was effective in inhibiting the growth of L. monocytogenes (15.63 mg·L-1), S. choleraesuis (15.63 mg·L-1) and E. coli (31.25 mg·L-1), and the essential oil from P. boldus inhibited the growth of S. aureus (62.5 mg·L-1). No essential oil inhibited the growth of P. aeruginosa. A low antioxidant activity and a promising antibacterial activity were observed for these essential oils.

关键词： Natural Products Antioxidant Antibacterial Activity

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Essential Oils from the Leaves and Flowers of Callistemon viminalis:Chemical Characterization and Evaluation of the Insecticide and Antifungal Activities

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American Journal of Plant Sciences 2017年第10期8卷 2516-2529页

作者： Thais Aparecida Sales Maria Das Gracas cardoso Luiz gustavo De Lima guimaraes Karen Caroline Camargo Danúbia Aparecida De Carvalho Selvati Rezende Rafaela Magalhães Brandao Rafaela Vieira Souza Vanúzia Rodrigues Fernandes Ferreira Ana Ermelinda Marques Maísa Lamounier Magalhaes David Lee Nelson epartment of Chemistry Federal University of LavrasLavrasBrazil Department of Natural Science Federal University of Sao Joao Del ReiSao Joao Del ReiBrazil Department of Food Science Federal University of LavrasLavrasBrazil Pro-Reitoria de Pesquisa e Pós-Graduacao Federal University of the Jequitinhonha and Mucuri ValleysDiamantinaBrazil

The chemical compositions of the essential oils from the leaves and flowers of Callistemon viminalis and their insecticide and fungitoxic activities were determined. The essential oil was extracted by the hydrodistillation method using a modified Clevenger apparatus. The chemical characterization was performed by GC-MS and GC-FID. The evaluation of the insecticidal activity was performed with the Myzus persicae aphid, and the antifungal potential was determined via the inhibition of the mycelial growth of Alternaria alternata, Fusarium oxysorum and Botrytis cinérea phytopathogenic fungi. The principal components of the essential oils from the leaves and flowers were eucalyptol (84.60% and 61.47%), α-pinene (10.28% and 21.48%) and α-terpineol (2.59% and 2.79%), respectively. The use of a 0.5% concentration of the essential oil from the flowers influenced the preference of aphids and their reproduction. The number of adult aphids decreased within a period of 48 hours in the presence of the essential oil from the leaves. In the test with no chance of choice, the mean number of adults decreased with both oils within 48 hours. No inhibition of the mycelial growth of the A. alternate microorganism was observed in any of the treatments with the two essential oils. However, the growth of F. oxysporum and B. cinerea fungi was inhibited. The mycelial growth of F. oxysporum was inhibited with the concentration of 100 μL·Lˉ1 of the oil from the flowers and 250 μL·Lˉ1 of the oil from the leaves. The inhibition of the growth of B. cinerea was observed at concentrations of 500 and 100 μL·Lˉ1 for the oils from the flowers and leaves, respectively. The essential oils presented insecticidal and antifungal potentials. However, further studies are needed for these oils to be used in integrated pest management.

关键词： Myzus persicae Biological Activity Phytopathogenic Fungi Natural Products

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Adenosquamous Carcinoma Affecting the Maxilla: A Case Report and Review

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Journal of Cancer Therapy 2017年第3期8卷 286-295页

作者： Marcos Martins Curi Marcelo Ferraz de Oliveira Anthony Froy Benites Condezo Heliton gustavo Lima Andréia Aparecida da Silva Carlos César DeAntoni Camila Lopes cardoso Department of Oral and Maxillofacial Surgery Hospital Santa Catarina S&atilde o Paulo Brazil Department of Implantology P-I Branemark Institute S&atilde o Paulo Brazil Department of Oral Surgery Universidade do Sagrado Cora&ccedil ã o S&atilde o Paulo Brazil Department on Oral Pathology University of S&ccedil o Paulo S&ccedil o Paulo Brazil

Adenosquamous carcinoma of the head and neck (ASC) is a rare and aggressive variant of squamous cell carcinoma, a locally aggressive malignancy characterized by the presence of two distinct components: a squamous cell carcinoma and an adenocarcinoma. The purpose of this study was to report an additional rare case of adenosquamous carcinoma affecting the maxilla, with clinical microscopic features and a complex mid-facial rehabilitation.

关键词： Squamous Cell Carcinoma Adenosquamous Carcinoma Implant Supported Prosthesis Maxillofacial Rehabilitation

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Preparation of the Rutin-SBA-16 Drug Delivery System

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Journal of Biomaterials and Nanobiotechnology 2020年第1期11卷 1-13页

作者： Juliana Camila Fischer Karnopp Teofilo Fernando Mazon cardoso Daniel Araujo Goncalves Aline Regina Hellman Carollo gustavo Rocha de Castro Adriana Pereira Duarte Marco Antonio Utrera Martines Institute of Chemistry Federal University of Mato Grosso do SulCidade UniversitariaCampo GrandeMSBrazil Faculty of Pharmaceutical Sciences Food and NutritionFederal University of Mato Grosso do SulCidade UniversitariaCampo GrandeMSBrazil Department of Chemistry Minas Gerais State UniversityItuiutabaMGBrazil Institute of Biosciences Sao Paulo State UniversityBotucatuSPBrazil

This study sets out a scheme for a controlled release delivery system using SBA-16 as a carrier matrix and Rutin as a drug (Rutin-SBA-16). Physicochemical characterizations were performed to confirm the structure of the SBA-16 for post-synthesis by scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM) and X-ray Diffraction (XRD). The presence of Rutin-SBA-16 was confirmed by Fourier-transform infrared spectroscopy (FTIR) and Nitrogen adsorption-desorption isotherms at 77 K. The dissolution kinetics was evaluated by the Zero Order, First Order and Higuchi models, and Rutin quantification was carried out by High Performance Liquid Chromatography (HPLC). The best impregnation time, which was 8 hours, adsorbing 284 μg Rutin per mg of silica, and the maximum degree of dissolution occurred in a period of 20 - 25 h. The release kinetics of the Rutin was called Higuchi, and showed high linearity, with a correlation coefficient (R2) of 0.999 compared with 0.905 and 0.980 of the zero order and first order models respectively. The study shows the benefits of Rutin-SBA-16 as a drug delivery system.

关键词： Rutin Controlled Release Systems Kinetic Study Mesoporous Silica Flavonoid

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Trends and predictions for gastric cancer mortality in Brazil

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World Journal of Gastroenterology 2016年第28期22卷 6527-6538页

作者： Angela Carolina Brandao de Souza Giusti Pétala Tuani Candido de Oliveira Salvador Juliano dos Santos Karina cardoso Meira Amanda Rodrigues Camacho Raphael Mendonca guimaraes Dyego LB Souza Federal University of Rio Grande do Norte Graduate Program in Collective Health Natal 59010-000 Brazil Health School Federal University of Rio Grande do Norte Natal 59010-000 Brazil National Cancer Institute Cancer Hospital III Rio de Janeiro Natal 59010-000 Brazil Federal University of Rio Grande do Norte University Hospital Onofre Lopes Natal 59010-000 Brazil Polytechnic Health School Joaquim Venancio Oswaldo Cruz Foundation (FIOCRUZ) Natal 59010-000 Brazil Department of Collective Health Graduate Program in Collective Health Federal University of Rio Grande do Norte Natal 59010-000 Brazil

AIM: To analyze the effect of age-period and birth cohort on gastric cancer mortality, in Brazil and across its five geographic regions, by sex, in the population over 20 years of age, as well as make projections for the period ***: An ecological study is presented herein,which distributed gastric cancer-related deaths in Brazil and its geographic regions. The effects of ageperiod and birth cohort were calculated by the Poisson regression model and projections were made with the age-period-cohort model in the statistical program R. RESULTS: Progressive reduction of mortality rates was observed in the 1980's, and then higher and lower mortality rates were verified in the 2000's, for both sexes, in Brazil and for the South, Southeast and Midwest regions. A progressive decrease in mortality rates was observed for the Northeast(both sexes) and North(men only) regions within the period 1995-1999, followed by rising rates. CONCLUSION: Regional differences were demonstrated in the mortality rates for gastric cancer in Brazil, and the least developed regions of the country will present increases in projected mortality rates.

关键词： Gastric neoplasms Brazil Projections Mortality

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