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用单克隆抗体研究人类结肠癌的相关抗原

癌症 1986年第3期 298-298页

作者：孙去病,Jenny HO.,Young s k.m 湖南医学院肿瘤研究室加利福尼亚大学内科加利福尼亚大学内科

用人类大肠癌细胞株hi29作抗原,融合成三株杂交瘤细胞（Hb3·Ab5和Ad5）。用间接免疫荧光检查,发现这三株细胞产生的抗体,对人类结肠癌组织反应的阳性率分别为86％、45％和58％。三株抗体也对胃癌、胰腺癌和肺癌反应阳性,但对肾癌和各... 详细信息

用人类大肠癌细胞株hi29作抗原,融合成三株杂交瘤细胞（Hb3·Ab5和Ad5）。用间接免疫荧光检查,发现这三株细胞产生的抗体,对人类结肠癌组织反应的阳性率分别为86％、45％和58％。三株抗体也对胃癌、胰腺癌和肺癌反应阳性,但对肾癌和各种肉瘤组织阴性。三株抗体对正常结肠上皮阴性,所以能鉴别结肠癌和正常大肠上皮组织,具有相对的器管特异性。此外,抗体对A、B、O型血及人类皮下成纤

关键词：结肠癌抗体组织反应肠上皮组织人类大肠癌细胞株间接免疫荧光检查抗原分子

神经节苷脂GM1对新生大鼠缺氧缺血后海马CA1区神经细胞凋亡的影响

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新生儿科杂志 2002年第6期17卷 255-257页

作者：张艺李志骏罗劲松江利国江钟炎杭州市第一人民医院儿科武汉大学人民医院儿科 310006

为研究神经节苷脂GM1对新生大鼠缺氧缺血后神经细胞凋亡的影响,将63只7日龄sD大鼠分为4组:假手术组,对照组、保护组、治疗组,制成缺氧缺血性脑损伤(hiBD)模型,分别于缺氧缺血(hi)前及hi后腹腔注射GM1和生理盐水,通过HE染色、原位末端脱... 详细信息

为研究神经节苷脂GM1对新生大鼠缺氧缺血后神经细胞凋亡的影响,将63只7日龄sD大鼠分为4组:假手术组,对照组、保护组、治疗组,制成缺氧缺血性脑损伤(hiBD)模型,分别于缺氧缺血(hi)前及hi后腹腔注射GM1和生理盐水,通过HE染色、原位末端脱氧核糖核酸转移酶介导的生物素化的脱氧尿苷三磷酸缺口末端标记(TUNEL)和电镜观察,比较各组神经细胞凋亡。结果显示对照组阳性细胞数明显高于保护组、治疗组(t=7.16,5.08,p0.05)。本实验显示GM1确实能减少新生大鼠脑组织缺氧缺血后海马CA1区细胞凋亡,且GM1在hi前或后应用同样有效。

关键词：神经节苷脂类脑缺氧脑缺血细胞凋亡新生儿

巴基斯坦志愿者中天花疫苗接种史与丙肝抗体阳性的关系

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 53-53页

作者： Aslam M Aslam J Mitchell B.D Munir k.M 程欣 31/10-AAbu Bak. Block N ew Gardentown Lahore Pakistan

Goals: To determine whether the smallpox vaccination program has significantly contributed to the widespread prevalence of hepatitis C infection in Pak.stan. Back.round: Hepatitis C virus has become a worldwide pandemic and has especially devastated developing nations such as Pak.stan. There continues to be an increa se in fatalities due to hepatitis C-related cirrhosis in Pak.stan. study: We st udied 523 volunteers in the city of Lahore to determine whether the smallpox vac cination program, which ran from 1964 to 1982 in Pak.stan, may be responsible fo r the national surge in hepatitis C viral infection,perhaps because of repetitiv e use of vaccination devices without proper sterilization or to contaminated vac cine contents. Results:There was a significantly higher lik.lihood of hepatitis C antibody seroprevalence in individuals vaccinated for smallpox versus nonvacci nated individuals (21.0%vs. 4.6%, P sted odds ratio, 3.39; 95 %confidence interval, 1.36-8.46). subjects with positive hepatitis C serology were also more lik.ly to have a history of transfusions (19.2%vs. 9.0%,P = 0.0 1), but anti-HCV positive serology was not significantly associated with a hist ory of surgery or dental procedures. Following adjustment for age, sex, and hist ory of other conditions,including transfusion, the association between prior sma llpox vaccination and hepatitis C antibody seroprevalence remained strong and hi ghly significant (multivariate adjusted odds ratio,6.11; 95%confidence interval , 2.58-14.51). Conclusion: These results suggest that the widespread prevalence of hepatitis C infection in Pak.stan may be an unintended consequence of the co untry’s smallpox vaccination program and that blood transfusion is also a signi ficant risk.factor.

关键词：天花疫苗丙肝抗体接种史疫苗接种丙型肝炎丙肝病毒感染病毒污染血清学输血史牙科手术

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249株流感嗜血杆菌的分离与耐药性分析

实用预防医学 2011年第4期18卷 713-715页

作者：曹敏晖曹友德李浩蔡瑞云湖南省人民医院湖南长沙410005

目的了解流感嗜血杆菌(hi)的检出状况与耐药情况,指导临床合理用药。方法统计分析2007-2010年我院hi的分离与耐药情况。结果在1 052份痰及咽拭子标本中分离出hi 210株,在242份胆汁标本中分离出hi16株,在203份胸腹水标本中分离出hi 12株,... 详细信息

目的了解流感嗜血杆菌(hi)的检出状况与耐药情况,指导临床合理用药。方法统计分析2007-2010年我院hi的分离与耐药情况。结果在1 052份痰及咽拭子标本中分离出hi 210株,在242份胆汁标本中分离出hi16株,在203份胸腹水标本中分离出hi 12株,在163份眼、耳拭子标本中分离出hi 11株。体外药敏结果显示hi对复方磺胺甲恶唑耐药性最高为63.5%,氨苄西林次之为46.2%,而对阿莫西林/棒酸、利福平、头孢呋辛、头孢噻肟、亚氨培南敏感,耐药率≤2.0%。结论 hi在呼吸道标本中的检出率最高,眼、耳拭子标本中次之,在胆汁、胸腹水中亦有检出。建议眼、耳拭子及胆汁、胸腹水标本作细菌培养时也应同时接种哥伦比亚血平板(COs)、淋球菌选择性平板(VCA)及嗜血杆菌选择性平板(HAE),hi感染的治疗应首选复方阿莫西林、头孢二代或三代类抗生素。

关键词：流感嗜血杆菌耐药性药物敏感试验

华北平原不同年代冬小麦品种响应气候变暖的试验研究

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中国科学：地球科学 2024年第12期54卷 3903-3915页

作者：姜朝阳房世波吴东刘馨赵花荣郭杰张心如朱永超李璇武英洁邬定荣中国气象科学研究院灾害天气国家重点实验室北京100081 安徽农业大学资源与环境学院合肥230036 饶阳国家气候观象台衡水053900 中国气象局气象探测中心北京100081 山东省气象数据中心济南250031

到21世纪初,华北平原麦作区已实现六次大规模的品种更替.气候变化背景下,揭示不同年代培育的冬小麦品种对气候变暖的响应十分必要.为此,本文选择20世纪60年代至21世纪00年代培育的10个冬小麦品种,自2017~2022年在固城和饶阳农业气象试... 详细信息

到21世纪初,华北平原麦作区已实现六次大规模的品种更替.气候变化背景下,揭示不同年代培育的冬小麦品种对气候变暖的响应十分必要.为此,本文选择20世纪60年代至21世纪00年代培育的10个冬小麦品种,自2017~2022年在固城和饶阳农业气象试验站开展田间试验.利用两个试验站的自然温差(两地平均气温相差1℃),配合施肥与不施肥两种处理,构造双因子二水平田间试验,揭示不同年代培育的冬小麦品种对气候变暖响应的异同.结果表明:(1)各品种冬小麦在升温环境中均能实现增产.分离升温与施肥的作用可见,仅升温处理下,冬小麦各品种的增产幅度随品种育成年代递减;升温叠加施肥处理下,冬小麦各品种的增产幅度随品种育成年代递增.(2)中晚期品种冬小麦耐高肥力与耐高温之间有较强的相关性,升温与施肥交互作用的增产效果显著.升温有明显的产量增益作用,显著放大了施肥条件下中晚期品种冬小麦的增产效果,晚期品种的平均增产幅度达到67%.(3)升温环境中,冬小麦生长季的日最低气温均值大幅度提高,0℃以下日数减少,显著缩短了冬小麦的越冬期,进而缩短生育期,但剔除越冬期后的有效发育日数(>0℃日数)基本保持不变.(4)升温有助于大蘖形成,增加冬小麦各品种的叶面积和干物质积累,降低不孕小穗的比率.升温环境中,晚期育成的冬小麦品种不孕小穗比率显著低于早中期品种,收获指数(hi)明显提高,有效增加了产量.本文试验研究的结果反映了不同年代育种策略和目标下培育的冬小麦品种适应气候变化的潜力,对于应对气候变化的冬小麦育种有一定的参考意义.

关键词：气候变暖冬小麦品种育种施肥响应

南亚人和加勒比黑人糖尿病患者行超声乳化术后糖尿病视网膜病变的进展和视力情况

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 33-33页

作者：秦雪娇 Chatterjee s savant V.V stavrou P. Birming ham and Midland Eye Centre City Hospital NHS TrustDudley RoadBir ming ham B187QUUnited Kingdom

*** determine diabetic reti nopathy or maculopathy progression and visual outcome foll owing phacoemulsifica-tion in south -Asian and Afro-Caribbean patients with *** of notes of p atients with type II diabetes undergoing phacoemulsification by one *** inclusion criteria were :(a)south-Asian or Afro-Caribbean ethnicity,(b)-monocular cases with a minimum postoperative follow-up of 6months,and(c)binocular cases with an interval of at least 6mo nths between the operation in the two *** nonoperated eye was used as *** development or progression of diabetic retinopathy or maculopathy and final visual acuity were *** all,30diabetic patients were *** were 19south-Asians(Pak.stani,Indian,and Bangladeshi )and *** mean(±sD)age was 68.9(±10)*** or maculopathy progression was noted in seven patie nts(23.4%),two south-Asians,and five *** was no significant difference in the number of operated and fellow eyes whose retinopathy or maculopathy progressed *** of retinopathy or maculopathy oc-curred more often in Afro-Caribbean s compared to south-Asians(P=0.02,logistic regression analysis).The mean(±sD)postoperative follow-up was 12.4(±6.5)*** acuity improved by at least two or more snellen lines in 19eyes(63.3%);26eyes(86.7%)achieved a final visual acuity of at l east 6/***-Caribbeans may be at a hi gher risk.of progres-sion of retinopathy or maculopathy a fter phacoemulsification.

关键词：超声乳化术视力情况白内障超声乳化黄斑病变视网膜病变加勒比孟加拉人无显著性差异

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化脓性汗腺炎伴发坏疽性脓皮病

世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 46-46页

作者： Ah-Weng A. Langtry J.A.A. Velangi s. 冯义国 Department of Dermatology Sunderland Royal Hospital Kayll Road Sunderland SR4 7TP United Kingdom

Pyoderma gangrenosum (PG) is associated with a number of systemic diseases. PG in association with hidradenitis suppurativa (Hs) has been rarely reported. We describe six patients (three men, three women; aged 35- 51 years),who developed PG on a back.round of Hs. The onset of PG occurred only after Hs had been present for at least two decades. No relationship in disease activity between the two conditions was observed. Three patients described previous severe adolescent acne vulgaris, one had concurrent systemic lupus erythematosus and another had chronic iron- deficiency anaemia. The course of PG was severe and refractory in four patients,who required treatment including high- dose oral corticosteroids, ciclosporin, intravenous immunoglobulin and intravenous cyclophosphamide.

关键词：坏疽性脓皮病化脓性汗腺炎寻常型痤疮系统性红斑狼疮静脉输注环孢菌素疾病活动度系统性疾病

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无线胶囊内窥镜在社区胃肠疾病检查中的应用

世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 42-42页

作者： Napierk.wsk. J.J. Maydonovitch C.L. Belle L.s. 樊菁 78 Mahealani Pl. Kailua HI 96734 United States Dr.

Goals: This study was performed to evaluate the use of wireless capsule endos copy in a community gastroenterology practice. Back.round: Experience with wirel ess capsule endoscopy at referral centers has been reported, but little has been reported about community gastroenterologists’ experience. study: A retrospect ive review of charts and wireless capsule endoscopies performed at a community h ospital was performed. Results: A total of 99 wireless capsule endoscopies were reviewed and complete data were available in 72 cases. Indications included susp ected obscure GI bleeding in 97% of cases; 55% of patients were tak.ng anti - platelet or anti- coagulant medications; 71% of examinations were complete . Pathologic findings included angioectasias (36% ), gastritis/erosions (21% ) , bleeding (18% ), small bowel ulcers (16% ), duodenitis (7% ), and small bow el erosions (6% ). strictures, Crohn’ s disease, and tumors were each seen in 3% . There were no abnormal findings in 37% . One complication, nonnatural exc retion of the capsule, caused a transient bowel obstruction but passed without e ndoscopic intervention or surgery. Conclusions: In a community- based gastroent erology setting, wireless capsule endoscopy is a safe tool that shows abnormalit ies in a significant proportion of exams.

关键词：胶囊内窥镜胃肠疾病十二指肠炎小肠溃疡医生经验病理发现血管扩张克罗恩病抗凝药物

囊胚经系列培养基培养后冻存用于移植的妊娠率

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世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 13-13页

作者： k.sasa T.s McNamee P.I Morton C 朱晓明 1319 Punahou st Honolulu HI 96826 United States.Dr

Objective: This study was undertak.n to determine the pregnancy rate after transfer of cryopreserved blastocysts. study design: Retrospective review of 61 patients from January 1, 2002, to December 31, 2003, who were transferred with blastocyst embryos cryopreserved on day 5 or 6 after culture in a sequential media. The cryopreserved blastocysts were thawed by using a 7- step dilution process after rapid thawing half hour to 2 hours before embryo transfer. Results: The pregnancy rate after transfer of 61 patients with cryopreserved blastocysts was 66% , with 49% having cardiac activity. The pregnancy rate after transfer of 3 blastocysts was 71% and after transfer of 2 blastocysts was 66% . The pregnancy rate of blastocysts cryopreserved after intracytoplasmic sperm injection was 56% . Conclusion: Cryopreservation and transfer of blastocysts appears to be a reliable procedure, and that the human blastocyst can be cryopreserved and thawed without a significant loss of viability.

关键词：显微注射卵母细胞胎心搏动稀释法前经移植技术研究设计生存能力日至