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Comparison of paroxetine and dapoxetine, a novel selective serotonin reuptake inhibitor in the treatment of premature ejaculation

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Asian Journal of Andrology 2014年第5期16卷 725-727,I0008,I0009页

作者： Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan gurbuz Department of Urology Haseki Research and Training Hospital Fatih Istanbul Department of Urology Sisli Etfal Research and Training Hospital Istanbul Turkey

Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor and the first drug approved for the on-demand treatment of premature ejaculation （PE）, Our objective in this study was to characterize the efficacy of on-demand dapoxetine （30 and 60 mg） and daily paroxetine （20 mg） usage in treating PE, We conducted a 1 month study involving a total of 150 patients. Patients were divided into three groups of 50, Group 1 were treated with on-demand dapoxetine （30 mg）, Group 2 with on-demand dapoxetine （60 mg） and Group 3 with daily paroxetine （20 rag）, Our outcome measurement was increased from baseline intravaginal ejaculatory latency time （IELT） after treatment, The IELT increased from baseline to posttreatment by 117%, 117% and 170% in the paroxetine group （P 〈 0,01）, 30 mg dapoxetine group （P 〈 0,01） and 60 mg dapoxetine group （P 〈 0.01）, respectively, The increase from baseline IELT were similar for the 30 mg dapoxetine and paroxetine groups （P 〉 0,05）, while the 60 mg dapoxetine group had a larger posttreatment IELT increase compared with the 30 mg dapoxetine （P〈 0.05） and paroxetine （P〈 0.01） groups, Dapoxetine （60 mg） 1-3 h before planned intercourse is a very effective treatment modality for PE. However, an on-demand dose of 30 mg dapoxetine is no more effective than the currently prescribed paroxetine treatment.

关键词： dapoxetine paroxetine premature ejaculation selective serotonin reuptake inhibitor

Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations

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World Journal of Hepatology 2016年第8期8卷 385-394页

作者： Fernando Bessone melisa Dirchwolf Department of Gastroenterology and Hepatology School of MedicineUniversity of Rosario Department of Hepatology Muniz Hospital

The proportion of hepatitis B virus(HBV) previously exposed patients who receive immunosuppressive treatment is usually very small. However, if these individuals are exposed to potent immunosuppressive compounds, the risk of HBV reactivation(HBVr) increases with the presence of hepatitis B surface antigen(HBsAg) in the serum. Chronic HBsAg carriers have a higher risk than those who have a total IgG anticore as the only marker of resolved/occult HBV disease. The loss of immune control in these patients may results in the reactivation of HBV replication within hepatocytes. Upon reconstitution of the immune system, infected hepatocytes are once again targeted and damaged by immune surveillance in an effort to clear the virus. There are different virological scenarios, and a wide spectrum of associated drugs with specific and stratified risk for the development of HBVr. Some of this agents can trigger a severe degree of hepatocellular damage, including hepatitis, acute liver failure, and even death despite employment of effective antiviral therapies. Currently, HBVr incidence seems to be increasing around the world; a fact mainly related to the incessant appearance of more powerful immunosuppressive drugs launched to the market. Moreover, there is no consensus on the length of prophylactic treatment before the patients are treated with immunosuppressive therapy, and for how long this therapy should be extended once treatment is completed. Therefore, this review article will focus on when to treat, when to monitor, what patients should receive HBV therapy, and what drugs should be selected for each scenario. Lastly, we will update the definition, risk factors, screening, and treatment recommendations based on both current and different HBV management guidelines.

关键词： Anti-tumor necrosis factor-α drugs Acute liver failure Biologic therapy Immunosuppressive therapy Hepatitis B

Importance of Synergistic Value in the Context of Business Combination： A Case Study From Turkey

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Economics World 2018年第1期6卷 49-60页

作者： gurbuz Gokcen Ozgur Teraman Marmara University Istanbul Turkey Istanbul Aydm University Istanbul Turkey

Considering International Financial Reporting Standards （henceforth IFRS）, although fair value is suggested in the conceptual framework and related standards, concept of measurement is used instead of concept of valuation. Determining the fair value of the acquiree specific into business combination, is needed to identify the fair value of the valuation made beyond the measurement of either monetary items or non-monetary items in the financial statements. Essential reason of the difference between acquired entity＇s fair values as a basis of financial reporting standards and valuation standards, the fair value according to IFRS is equivalent to the market value according to International Valuation Standards （henceforth IVS）. The fair value in accordance with IVS, the combination of the market value, and the synergistic value of the asset are subject to valuation in terms of special purchaser. When business is concerned, considering parameters such as the position in the industry, brand awareness, intellectual capital, geography, cannot be expected to be equal to the fair value of business which simply consists of market value among market participants. The ultimate aim of the study is to illustrate how to determine synergistic value in the terms oflVS which shows the difference between the market value and fair value. Based on the findings of the study, if acquired assets and liabilities are recognized in accordance with IFRS, goodwill comes out during the acquisition. Though, when fair value is determined based on IVS, goodwill is not found, even profitable business combination is realized. This is the result of considered fair value based on IVS Framework, that is the combination of market value of an asset in question and total synergistic value.

关键词： international valuation standards international financial reporting standards business combination market value fair value synergistic value

The microbial content of unexpired pasteurized milk from selected supermarkets in a developing country

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 205-211页

作者： melisa Anderson Patrice Hinds Stacyann Hurditt Princena Miller Donovan McGrowder Ruby Alexander-Lindo Department of Pathology Faculty of Medical SciencesUniversity of the West Indies School of Allicd Health and Nursing College of Health SciencesUniversity of Technology Department of Basic Medical Sciences Faculty of Medical SciencesUniversity of the West Indies

Objective:To determine the presence and levels of microbes in unexpired pasteurized milk from randomly selected supermarkets in Kingston,***:The quantitative study used a stratified random sampling technique in the selection of the 20 representative milk samples from six(6) *** tests such as methylene blue reduction,standard plate count(SPC),coliform plate count(CPC),purity plate culture,gram staining and biochemical tests were performed to examine the microbes in purchased unexpired pasteurized ***:One sample(BCr016) had a pH of 4.0.a rancid odour and curdled *** decolourized within one hour during the methylene blue reduction test and was classified as class 4 *** of the samples were sterile with no microbe growth on the plate count agar and violet red bile salt agar(VRBA).The milk samples that appeared to be safe for consumption were all 10,11,12 and 13 days before *** VRBA sample BCr016,had a colony count of 13 400 CFU/ *** was the presence of Escherichia coli in sample LCr021 which had a standard plate count of 1 580 SPC/mL and a coliform count of 500 CFU/*** *** present in colonies from BCr016 and all the other milk ***:Unacceptable levels of Entembacter *** Escherichia coli were found in most of the *** measures to ensure safe milk for human consumption such as the phosphatase test and methylene blue reduction test should be routinely performed on each batch of milk processed by dairy plants.

关键词： Microbial content Pasteurized milk Supermarkets Microbe Microbiological test Escherichia coli Enterobacter spp Milk Dairy plant Developing country

Role of systemic inflammation in cirrhosis:From pathogenesis to prognosis

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World Journal of Hepatology 2015年第16期7卷 1974-1981页

作者： melisa Dirchwolf Andres Eduardo Ruf Hepatopatias Infecciosas Hospital Francisco J Muniz Fundacion para la Docencia e Investigacion de las Enfermedades del Higado (FUNDIEH) Liver Transplant Unit British Hospital of Buenos Aires

The natural history of cirrhosis can be divided into an initial stage, known as compensated cirrhosis, and an advanced stage which encompasses both decompensated cirrhosis and acute-on-chronic liver failure(ACLF). The latter syndrome has been recently described as an acute deterioration of liver function in patients with cirrhosis, which is usually triggered by a precipitating event and results in the failure of one or more organs and high short-term mortality rates. Each stage is characterized by distinctive clinical manifestations and prognoses. One of the key elements involved in cirrhosis physiopathology is systemic inflammation, recently described as one of the components in the cirrhosis-associated immune dysfunction syndrome. This syndrome refers to the combination of immune deficiency and exacerbated inflammation that coexist during the course of cirrhosis and relates to the appearance of clinical complications. Since systemic inflammation is often difficult to assess in cirrhosis patients, new objective, reproducible and readily-available markers are needed in order to optimize prognosis and lengthen survival. Thus, surrogate serum markers and clinical parameters of systemic inflammation have been sought to improve disease follow-up and management, especially in decompensated cirrhosis and ACLF. Leukocyte counts(evaluated as total leukocytes, total eosinophils or neutrophil:lymphocyte ratio) and plasma levels of procalcitonin or C-reactive protein have been proposed as prognostic markers, each with advantages and shortcomings. Research and prospective randomized studies that validate these and other markers are clearly warranted.

关键词： Immune dysfunction Cirrhosis Acute-onchronic liver failure Prognosis Systemic inflammation

Growth efficiency,intestinal biology,and nutrient utilization and requirements of black soldier fly(Hermetia illucens)larvae compared to monogastric livestock species:a review

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1262-1281页

作者： Mohammad M.Seyedalmoosavi Manfred Mielenz Teun Veldkamp gurbuz Das Cornelia C.Metges Research Institute for Farm Animal Biology(FBN) Institute of Nutritional Physiology18196 DummerstorfGermany Wageningen UR Livestock ResearchP.O.Box 3386700AH WageningenNetherlands

In recent years,interest in the larvae of black soldier fly(BSF)(Hermetia illucens)as a sustainable protein resource for livestock feed has increased ***,knowledge on the nutritional and physiological aspects of this insect,especially compared to other conventional farmed animals is *** review presents a critical comparison of data on the growth potential and efficiency of the BSF larvae(BSFL)compared to conventional monogastric livestock *** of BSFL over other monogastric livestock species includes their high growth rate and their ability to convert low-grade organic waste into high-quality protein and fat-rich biomass suitable for use in animal *** using literature data suggest that BSFL are more efficient than broilers,pigs and fish in terms of conversion of substrate protein into body mass,but less efficient than broilers and fish in utilization of substrate gross energy to gain body *** growth efficiency varies greatly depending on the nutrient quality of their dietary *** might be associated with the function of their gastrointestinal tract,including the activity of digestive enzymes,the substrate particle characteristics,and their intestinal microbial *** conceived advantage of BSFL having an environmental footprint better than conventional livestock is only true if BSFL is produced on low-grade organic waste and its protein would directly be used for human ***,their potential role as a new species to better close nutrient cycles in agro-ecological systems needs to be reconsidered,and we conclude that BSFL is a complementary livestock species efficiently utilizing organic waste that cannot be utilized by other *** addition,we provide comparative insight into morpho-functional aspects of the gut,characterization of digestive enzymes,gut microbiota and fiber ***,current knowledge on the nutritional utilization and requirements of BSFL in te

关键词： Black soldier fly Comparative growth performance Farm animals Insects as feed Intestinal function Nutrient cycles Nutrition and physiology

Functional strategies and distribution of climbing plant communities in different vegetation patches in a subtropical dry forest, central Argentina

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Journal of Plant Ecology 2019年第1期12卷 23-33页

作者： María Cecilia Ferrero Sebastián R.Zeballos Juan I.Whitworth-Hulse melisa A.Giorgis Diego E.Gurvich Instituto Multidisciplinario de Biología Vegetal CONICET-Universidad Nacional de CórdobaAv.Vélez Sársfield 1611CP X5016ZAACórdobaArgentina Facultad de Ciencias Exactas Físicas y NaturalesUniversidad Nacional de CórdobaAv.Vélez Sársfield 299CP X5000JJCCórdobaArgentina

Aims In the context of global change,the impacts of forest structure alter-ation on climbing plants in extra-tropical ecosystems are poorly *** also remains little explored,the functional strategies among climbing plant species and its relationship with the local-scale distribution of climbing plant ***,we aimed at three goals:(i)we studied how climbing plant community com-position responds to the modification of the original forest structure in a subtropical dry forest;(ii)we characterized climbing plant spe-cies according to functional traits related to the acquisition and use of resources;and(iii)we examined whether functional strategies at the community level are also responding to vegetation structure change,a much less addressed topic in the ecology of climbing *** The study was carried out in the Chaco forest of Córdoba Mountains,central *** selected 18 patches of‘native forests’,‘shrublands’and‘Ligustrum lucidum forests’.We counted and identified climbing plant individuals in each patch,including woody and herbaceous *** each spe-cies,we measured 10 functional traits:leaf area,leaf area ratio,leaf dry matter content,leaf tensile strength,specific leaf area,stem density,wood saturated water content,inter-node length,petiole length and plant *** compared climbing plant composition,richness and abundance among the three vegeta-tion ***,we assessed trends of functional variation of climbing plant species by performing a principal component ***,we investigated whether simple mean,weighted mean and Functional Richness index of principal component analysis(PCA)axes differed among the climbing plant communi-ties of the three vegetation *** Findings Multivariate analysis revealed that climbing plant composition of native forests significantly differed from that of shrublands and *** ***,*** forests had the lowest climb-ing plant species *** var

关键词： vines functional traits Chaco Serrano climbing plant species richness community weighted means

粗糙抛物次线性算子和交换子的抛物广义局部Morrey空间估计（英文）

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数学进展 2017年第5期46卷 765-792页

作者： Ferit gurbuz 安卡拉大学理学院数学系土耳其安卡拉Tandogan06100

引入了抛物广义局部Morrey空间,并得到了其上一大类抛物粗糙算子的有界性.还创建了其在抛物广义局部Morrey空间上交换子的抛物局部Campanato空间估计·带粗糙核的抛物次线性算子及其交换子的对应结果可作为特例而得到,作为应用,得到了... 详细信息

引入了抛物广义局部Morrey空间,并得到了其上一大类抛物粗糙算子的有界性.还创建了其在抛物广义局部Morrey空间上交换子的抛物局部Campanato空间估计·带粗糙核的抛物次线性算子及其交换子的对应结果可作为特例而得到,作为应用,得到了抛物广义局部Morrev空间上一些解析半群抛物分数次幂的有界特征.

关键词：抛物次线性算子抛物分数次积分算子粗糙核抛物广义局部Morrey空间抛物局部Campanato空间交换子

弹性假黄瘤的脉络膜新生血管和血管样条纹症(英文)

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国际眼科杂志 2011年第9期11卷 1508-1510页

作者： melisa Nika Cagri G Besirli 密歇根大学医学院凯洛格眼科中心眼科及视觉科学

目的:报告1例表现为双眼视力模糊的48岁女子患弹性假黄瘤病(pseudoxanthoma elasticum,PXE)的病例。方法:病例报告。结果:患者,女,48岁,双眼视力模糊,右眼视物变形。10a前因左眼患血管样条纹症接受激光手术,残余视力较差。右眼视力为20/... 详细信息

目的:报告1例表现为双眼视力模糊的48岁女子患弹性假黄瘤病(pseudoxanthoma elasticum,PXE)的病例。方法:病例报告。结果:患者,女,48岁,双眼视力模糊,右眼视物变形。10a前因左眼患血管样条纹症接受激光手术,残余视力较差。右眼视力为20/60,左眼6英尺数指。眼底检查可见视网膜下出血和右侧黄斑增厚及左侧椭圆形黄斑瘢痕伴病灶萎缩性色素上皮病变。双眼有血管样条纹和橙色视网膜色素图案。外部检查发现颈部侧面和后面有几处黄色皮肤丘疹和斑块,以及明显的颏皱褶。皮肤切片病理检查证实了PXE的诊断,显示有网状真皮层深层的钙沉积和成碎片的成丛的弹性纤维。患者对玻璃体内注射贝伐单抗反应良好,右眼视力提高到20/25。强调预防保健的重要性,建议患者求助于心脏病学、胃肠病学和人类遗传学咨询服务。结论:PXE是一个累及多系统的疾病,它影响着皮肤、眼和心血管系统。在固有的皮肤变化和明显的颏皱褶的存在下,血管样条纹症和脉络膜新生血管的眼科发现能提高PXE的评估。

关键词：血管样条纹症弹性假黄瘤橘皮样变