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先进控制技术在常减压装置的应用

中外能源 2019年第9期24卷 74-81页

作者：高国勇中国石化长岭分公司

常减压装置是炼油企业的龙头装置,其平稳控制不仅有利于本装置的优化生产,而且为下游装置的平稳生产创造有利条件。在常减压装置实施先进控制技术,通过预测、解藕、多变量协调等先进控制技术,克服装置运行中的时滞、干扰和耦合,将装置... 详细信息

常减压装置是炼油企业的龙头装置,其平稳控制不仅有利于本装置的优化生产,而且为下游装置的平稳生产创造有利条件。在常减压装置实施先进控制技术,通过预测、解藕、多变量协调等先进控制技术,克服装置运行中的时滞、干扰和耦合,将装置控制得更平稳、更精细,达到提高装置处理量、提高产品收率、节能降耗的目的,可实现加热炉各进料支路的温度平衡、减少局部炉管过热现象的发生、提高炉管的使用寿命。通过软仪表技术可实现质量指标的实时计算,实现常压塔、减压塔侧线产品精准切割,减少质量浪费、提高产品的拔出率,提高经济效益。常减压装置APC项目实施后,常压炉、减压炉、常压塔、减压塔实现了自动协调控制,装置抗干扰能力增强,装置稳定性和主要被控参数的平稳性明显提高,常顶、常一线抽出温度等关键工艺参数实现了卡边控制,石脑油、航煤、柴油等产品质量控制精度均显著提高,降低了操作人员的劳动强度。

关键词：先进控制常减压应用效果

Characterization of 2,2’,4,4’-tetrabromodiphenyl ether(BDE47)-induced testicular toxicity via single-cell RNA-sequencing

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Precision Clinical Medicine 2022年第3期5卷 139-152页

作者： Wei Zhang Siyu Xia Xiaoru Zhong guoyong gao Jing Yang Shuang Wang Min Cao Zhen Liang Chuanbin Yang Jigang Wang Department of Geriatrics Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China Department of Spine Surgery Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Center for Reproductive Medicine Dongguan Maternal and Child Health Care HospitalSouthern Medical UniversityDongguan 523125China

Background:The growing male reproductive diseases have been linked to higher exposure to certain environmental compounds such as 2,2,4,4-tetrabromodiphenyl ether(BDE47)that are widely distributed in the food ***,the specific underlying molecular mechanisms for BDE47-induced male reproductive toxicity are not completely ***:Here,for the first time,advanced single-cell RNA sequencing(ScRNA-seq)was employed to dissect BDE47-induced prepubertal testicular toxicity in mice from a pool of 76859 ***:Our ScRNA-seq results revealed shared and heterogeneous information of differentially expressed genes,signaling pathways,transcription factors,and ligands-receptors in major testicular cell types in mice upon BDE47 *** from disruption of hormone homeostasis,BDE47 was discovered to downregulate multiple previously unappreciated pathways such as double-strand break repair and cytokinesis pathways,indicative of their potential roles involved in BDE47-induced testicular ***,transcription factors analysis of ScRNA-seq results revealed that Kdm5b(lysine-specific demethylase 5B),a key transcription factor required for spermatogenesis,was downregulated in all germ cells as well as in Sertoli and telocyte cells in BDE47-treated testes of mice,suggesting its contribution to BDE47-induced impairment of ***:Overall,for the first time,we established the molecular cell atlas of mice testes to define BDE47-induced prepubertal testicular toxicity using the ScRNA-seq approach,providing novel insight into our understanding of the underlying mechanisms and pathways involved in BDE47-associated testicular injury at a single-cell *** results can serve as an important resource to further dissect the potential roles of BDE47,and other relevant endocrine-disrupting chemicals,in inducing male reproductive toxicity.

关键词： single-cell RNA-sequencing spermatogenesis BDE47 reproductive toxicity

采用DOM、DLG、Skyline方法完成的辽宁省盘锦市地籍调查

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现代测绘 2006年第5期29卷 29-30页

作者：张奇高国勇辽宁省第三测绘院辽宁沈阳110034

本文叙述了对辽宁省盘锦市进行的以彩色航空摄影资料为基础的采用正射影像图(DOM)、数字线划图(DLG)、三维漫游、影观浏览(Skyline)等多种方法互补的地籍调查测绘技术方案。

关键词： DOM DLG Skyline 地籍调查

经皮椎间孔入路内镜下治疗复发性腰椎椎间盘突出症的临床研究

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中华骨科杂志 2018年第8期38卷 477-484页

作者：刘俊良镇万新高国勇杨大志罗常暨南大学第二临床医学院、广东省深圳市人民医院脊柱外科深圳518020

目的探讨经皮椎间孔入路内镜下微创手术治疗复发性腰椎间盘突出症的临床应用价值。方法选择2011年5月至2015年12月共47例诊断为复发性腰椎间盘突出症且经保守治疗无效的患者,男31例,女16例;年龄29~62岁,平均（43.45±13.37）岁。突出... 详细信息

目的探讨经皮椎间孔入路内镜下微创手术治疗复发性腰椎间盘突出症的临床应用价值。方法选择2011年5月至2015年12月共47例诊断为复发性腰椎间盘突出症且经保守治疗无效的患者,男31例,女16例;年龄29~62岁,平均（43.45±13.37）岁。突出复发的椎间盘位于L 3,4节段4例,L 4,5节段32例,L 5S1节段11例。初次手术至再次手术的时间间隔为10~185个月,平均49个月。初次手术方式为显微内镜椎间盘切除术 11例,椎板开窗减压椎间盘髓核摘除术36例。再次手术均采取俯卧位局麻下经皮穿刺椎间孔入路内镜下微创手术,术中行椎管及神经根管减压、摘除椎间盘髓核组织、探查松解神经根。术后定期随访,采用Oswestry功能障碍指数（Oswestry disability index,ODI）、疼痛视觉模拟评分（visual analogue scale,VAS）和改良Macnab标准评定手术疗效。根据术前、末次随访时腰椎侧位X线片观察手术节段椎间隙高度变化,腰椎动力位X线片测量椎间角度,并计算腰椎活动度（range of motion,ROM）。结果所有患者均顺利完成内镜手术,手术时间平均（63.5±11.6） min,手术出血量平均（10.3±2.7） ml。所有患者术后均获得随访,随访时间18~52个月,平均（35.5±5.1）个月。ODI由术前平均51.35%±15.29%下降至末次随访时3.31%±2.17%,差异有统计学意义（P〈0.05）;VAS评分由术前平均（8.11±1.05）分下降至末次随访时（1.03±0.81）分,差异有统计学意义（P〈 0.05）,术后疼痛明显改善;末次随访按照改良MacNab标准评定疗效,优32例、良9例、可6例,优良率为87.2％。手术前后及末次随访时手术节段椎间隙前、后缘高度的差异无统计学意义（P〉0.05）,手术节段腰椎ROM的差异亦无统计学意义（P〉0.05）。术中及术后随访期间均未发生神经根损伤、硬脊膜损伤、脑脊液漏、肌力下降、二便障碍、腰椎不稳等严重并发症。结论在严格把握手术适应证的前提下,经皮椎间孔入路内镜下微创手术治疗复发性腰椎间盘突出症临床疗效可靠。该术式采用侧方入路,不影响术后的脊柱稳定性,具有创伤小、并发症少、安全有效等优点。

关键词：腰椎椎间盘移位复发内窥镜检查治疗结果外科手术微创性

基于改进Canny算子的齿轮边缘缺陷检测方法

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工具技术 2024年第9期58卷 145-151页

作者：高昕甄国涌储成群王子硕中北大学仪器与电子学院

针对Canny算子在齿轮边缘缺陷检测中存在识别相似度低、因图像噪声影响导致微弱边缘难以提取、边缘连续性与鲁棒适应性差的问题,提出了一种改进Canny算子的齿轮边缘缺陷检测技术。改进滤波器,使用梯度双边滤波进行图片预处理,平滑图像... 详细信息

针对Canny算子在齿轮边缘缺陷检测中存在识别相似度低、因图像噪声影响导致微弱边缘难以提取、边缘连续性与鲁棒适应性差的问题,提出了一种改进Canny算子的齿轮边缘缺陷检测技术。改进滤波器,使用梯度双边滤波进行图片预处理,平滑图像并减少图像噪声;改进了卷积核,在45°和135°梯度方向上对像素点进行非极大值抑制,增加了微弱边缘被保留的概率;采用最大类间方差法(Otsu算法)计算图像的高阈值,通过双阈值的办法自适应寻找图像强弱边缘;将Prewitt算子和Canny算法以及改进算法进行对比实验验证。结果表明,改进算法可以提取更完整的齿轮边缘,处理后图片的峰值信噪比(PSNR)相比Canny算法提升了16%,检测效果提升了30%,重叠系数高达81.9%,提升了25.1%,为齿轮边缘缺陷检测提供了一定的参考价值。

关键词：梯度双边滤波齿轮边缘缺陷检测最大类间方差法峰值信噪比

Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

Gas production mechanism of Irgamet 39 and its long‐term corrosion resistance

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High Voltage 2023年第5期8卷 931-942页

作者： Huiying Xiang Yuan Yuan guoyong Liu Xue gao Cheng Zhang Jiang Zhou Ruijin Liao College of Materials Science and Engineering Chongqing UniversityChongqingChina State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina Dongfang Electric Machinery Co. LtdDeyangChina

The phenomenon of transformer failure caused by oil‐sulphur corrosion of oil₋paper insulation system has always been concerned by *** 39 is the most used metal passivator for inhibiting sulphur ***,Irgamet 39 causes abnormal dissolved gas in oil during the process of exerting anti‐corrosion ***,the gas production mechanism of Irgamet 39 and its long‐term corrosion resistance were *** with other metal passivators,the Irgamet 39 produces more dissolved gases in oil,especially H_(2),CO and CO_(2).The main sources of free radicals in the gas production process are from the branched chains of the Irgamet 39 structure(−CH_(2)N(C_(8)H_(17))_(2)and−CH_(3)).Furthermore,the ageing products of insulating paper and oil promote the cleavage of the chain in the Irgamet 39 molecule,which then causes Irgamet 39 to generate more dissolved *** 39 exhibits excellent long‐term corrosion inhibition properties,while it also leads to abnormal gases in the oil,which can affect the interpretation of the dissolved gas analysis data and thus interfere with the *** work provides useful information for the practical application of Irgamet 39 and helps electrical workers make reasonable predictions for transformer problems.

关键词： corrosion resistance mechanism

Molecular phylogeny and divergence time estimates using the mitochondrial genome for the hadal snailfish from the Mariana trench

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Science Bulletin 2017年第16期62卷 1106-1108页

作者： Yanjun Shen Wei Dai Zhaoming gao guoyong Yan Xiaoni Gan Shunping He The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100039China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China

Snailfishes are an important component of the hadal fish fauna[1].Based on osteological and other morphological characters,Kido[2]recognized the Cyclopteridae as a sister group to the Liparidae and the superfamily Cot... 详细信息

关键词：狮子鱼分子系统发育马里亚纳海沟线粒体基因组时间估计超深分化分子数据

保留后方韧带复合体的改良式单开门椎板成形术治疗多节段脊髓型颈椎病

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中华生物医学工程杂志 2020年第3期26卷 268-273页

作者：刘俊良镇万新杨大志高国勇袁正彬深圳市人民医院脊柱外科暨南大学第二临床医学院南方科技大学第一附属医院脊柱外科深圳518020

目的研究保留后方韧带复合体的改良式单开门颈椎板成形术治疗多节段脊髓型颈椎病的临床疗效。方法选择2012年5月至2018年5月我科45例诊断为多节段脊髓型颈椎病予行保留后方韧带复合体的改良式颈椎单开门椎板成形术的患者作为研究组;选... 详细信息

目的研究保留后方韧带复合体的改良式单开门颈椎板成形术治疗多节段脊髓型颈椎病的临床疗效。方法选择2012年5月至2018年5月我科45例诊断为多节段脊髓型颈椎病予行保留后方韧带复合体的改良式颈椎单开门椎板成形术的患者作为研究组;选择同期43例行传统单开门椎板成形术的患者作为对照组。均采用钛钢板螺钉固定开门侧椎板及侧块。记录两组患者的手术时间、手术出血量、手术并发症情况,记录两组患者术前、术后3个月及末次随访时的日本骨科学会(JOA)评分、颈部功能障碍指数(NDI)评分、颈椎活动度(ROM)、颈椎曲度及术后颈部轴性症状的情况,末次随访按Odom标准评价疗效优良率。结果平均手术时间、平均出血量两组差异无统计学意义(P>0.05);末次随访时JOA评分改善率差异无统计学意义(P>0.05);NDI评分,术前及术后3个月组间比较无统计学差异(P>0.05),末次随访时组间差异有统计学意义(P<0.05),组内比较两组术前及末次随访时NDI评分差异有统计学意义(P<0.05)。末次随访时,对照组的颈椎整体平均曲度较术前减少(3.85±1.52)度,而研究组的颈椎整体平均曲度较术前减少(1.51±1.37)度,差异有统计学意义(P<0.05);对照组的整体颈椎活动度ROM较术前减少(6.81±2.31)度,研究组ROM较术前减少(4.68±1.93)度,差异有统计学意义(P<0.05)。术后对照组12例(27.9%)、研究组2例(4.4%)发生颈部轴性症状或加重,组间比较差异有统计学意义(P<0.05)。末次随访按Odom标准,对照组优32例,良6例,可5例,优良率88.4%;研究组优35例,良7例,可3例,优良率93.3%,组间比较差异有统计学意义(P<0.05)。结论保留后方韧带复合体的改良式单开门颈椎板成形术治疗多节段的脊髓型颈椎病临床疗效确切,相比传统单开颈椎板成形术,改良术式轴性症状发生率较低,术后颈椎曲度及颈椎活动度的影响小。

关键词：脊髓型颈椎病椎板成形术单开门后方韧带复合体