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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1648-1667页

作者： Xiaoqun Lv guoxiong xu Department of Pharmacy Jinshan HospitalFudan UniversityShanghai 201508China Research Center for Clinical Medicine Jinshan HospitalFudan UniversityShanghai 201508China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Gastrointestinal(GI)cancer,including esophageal,gastric,and colorectal cancer,is one of the most prevalent types of malignant carcinoma and the leading cause of cancer-related *** significant advances in therapeutic strategies for GI cancers in recent decades,drug resistance with various mechanisms remains the prevailing cause of therapy failure in GI *** evidence has demonstrated that the transforming growth factor(TGF)-βsignaling pathway has crucial,complex roles in many cellular functions related to drug *** review summarizes current knowledge regarding the role of the TGF-βsignaling pathway in the resistance of GI cancers to conventional chemotherapy,targeted therapy,immunotherapy,and traditional *** processes,including epithelial-mesenchymal transition,cancer stem cell development,tumor microenvironment alteration,and microRNA biogenesis,are proposed as the main mechanisms of TGF-β-mediated drug resistance in GI *** studies have already indicated the benefit of combining antitumor drugs with agents that suppress the TGF-βsignaling pathway,but this approach needs to be verified in additional clinical ***,the identification of potential biological markers that can be used to predict the response to TGF-βsignaling pathway inhibitors during anticancer treatments will have important clinical implications in the future.

关键词： Drug resistance Gastrointestinal cancer Transforming growth factor-β Epithelial-mesenchymal transition Cancer stem cells MicroRNAs

Fluorescent glycan nanoparticle-based FACS assays for the identification of genuine drug-resistant cancer cells with differentiation potential

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Nano Research 2020年第11期13卷 3110-3122页

作者： Chenglong Wang Wencai Guan Rong Chen Yael Levi-Kalisman Yichun xu Liwen Zhang Min Zhou guoxiong xu Hongjing Dou The State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Research Center for Clinical Research Jinshan HospitalFudan UniversityShanghai200540China Department of Respiratory and Critical Care Medicine Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200025China Institute of Respiratory Diseases School of MedicineShanghai Jiao Tong UniversityShanghai200025China The Center for Nanoscience and Nanotechnology and the Institute of Life Sciences Hebrew University of JerusalemJerusalem91905Israel Shanghai Biochip Co.Ltd. National Engineering Center for Biochip at ShanghaiShanghai201203China

Herein we develop a unique differentiated-uptake strategy capable of efficient and high-purity isolation of genuine drug-resistant(DR)cells from three types of drug-surviving cancer cells,which include paclitaxel-surviving human ovarian OVCAR-3 cancer cells and human lung carcinoma A549/Taxol cells,and doxorubicin-surviving human immortalized myelogenous leukemia K562/ADR *** using this strategy which relies on fluorescent glycan nanoparticle(FGNP)-based fluorescence-activated cell sorting(FACS)assays,two subpopulations with distinct fluorescences existing in drug-surviving OVCAR-3 cells were separated,and we found that the lower fluorescence(LF)subpopulation consisted of DR cells,while the higher fluorescence(HF)subpopulation was comprised of non-DR ***,the DR cells and their progenies were found distinct in their increased expression of drug-resistant *** intriguingly,by using the FGNP-based FACS assay to detect DR/non-DR phenotypes,we found that the DR phenotype had a potential to differentiate into the non-DR progeny,which demonstrates the differentiation feature of stem-like cancer *** research disclosed that the assay can quantitatively detect the degree of drug resistance in DR cells,as well as the reversal of drug resistance that are tackled by various therapeutic *** strategy thus paves the way to develop theranostic approaches associated with chemotherapy-resistance and cancer stemness.

关键词： glycan nanoparticle FACS assays drug resistance tumor heterogeneity diagnose

深圳市龙华地区快速城市化过程中的景观结构研究 Ⅲ农业用地结构及异质性分析

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北京大学学报（自然科学版） 2000年第2期36卷 221-230页

作者：曾辉江子瀛喻红许国雄北京大学城市与环境学系北京100871

利用多时段景观遥感制图信息和景观格局分析方法，对深圳市龙华地区快速城市化过程中农业用地的结构和空间分布特征进行了研究。主要结论如下：（１）快速城市化过程导致农田面积显著减少，对果园的总体规模影响不大；（２）１９９２... 详细信息

利用多时段景观遥感制图信息和景观格局分析方法，对深圳市龙华地区快速城市化过程中农业用地的结构和空间分布特征进行了研究。主要结论如下：（１）快速城市化过程导致农田面积显著减少，对果园的总体规模影响不大；（２）１９９２年是工作区内城市化过程影响最为剧烈的年份，农田的碎裂化过程可以分成两个不同的阶段；（３）农田和果园的空间分布均维持了相对微观异质性随机分布，但均匀性程度有所降低。果园在中尺度区间的空间分布与农田相比表现出显著的差异，连续尺度的空间分布表现出不均匀（小尺度：滑箱边长小于８个像元） —均匀（中小尺度：边长在８～５０个像元之间） —不均匀（中尺度：边长在５０～２００个像元之间） —均匀（中大尺度：边长大于２００个像元）的变化规律；（４）人为改造作用是景观动态变化的主要驱动力来源，并且表现为一种中尺度影响过程，地形因子则为背景性影响因素；（５）景观改造活动由于未能兼顾农业组分在区域生态稳定性维护方面的价值，两种组分的整体结构和功能稳定性有所降低。

关键词：城市化景观结构农业用地深圳市异质性分析

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多载波DS CDMA并行干扰消除算法分析

华中科技大学学报（自然科学版） 2005年第6期33卷 47-50页

作者：张援农徐国雄黄天锡武汉大学电子信息学院湖北武汉430079 中原工学院电子信息学院河南郑州450007

将频率分集合并技术与并行干扰抵消算法相结合,提出了多载波DSCDMA系统的并行干扰消除算法(FDC-PIC),并对这一算法的误码性能进行了计算机仿真.结果表明:FDC-PIC获得了明显优于相关接收的性能,且随着干扰消除级的增加,系统性能将得到进... 详细信息

将频率分集合并技术与并行干扰抵消算法相结合,提出了多载波DSCDMA系统的并行干扰消除算法(FDC-PIC),并对这一算法的误码性能进行了计算机仿真.结果表明:FDC-PIC获得了明显优于相关接收的性能,且随着干扰消除级的增加,系统性能将得到进一步地改善,其中最初2级的干扰消除可获得最大的性能改善,但到第3级干扰消除,性能不再有明显的改善,表明2级FDC-PIC具有最佳的性能/复杂度.仿真结果表明:在具有相同干扰消除级数的情况下,基于软判决反馈的FDC-PIC性能上总优于硬判决反馈FDCPIC.

关键词：多载波直接序列码分多址并行干扰消除

卡铂@葡聚糖纳米载体的自组装/聚合一步法制备及生物应用

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高等学校化学学报 2019年第6期40卷 1301-1309页

作者：高苗苗王成龙窦红静许国雄上海交通大学材料科学与工程学院金属基复合材料国家重点实验室上海200240 复旦大学附属金山医院中心实验室上海201508

在接枝共聚辅助自组装(GISA)制备葡聚糖纳米载体的过程中,利用丙烯酸单体与卡铂之间的非共价键作用,使得卡铂参与到葡聚糖纳米载体的形成中,从而一步实现了卡铂@葡聚糖纳米载体的制备,并使用肿瘤还原性环境敏感的二硫键来交联纳米载体,... 详细信息

在接枝共聚辅助自组装(GISA)制备葡聚糖纳米载体的过程中,利用丙烯酸单体与卡铂之间的非共价键作用,使得卡铂参与到葡聚糖纳米载体的形成中,从而一步实现了卡铂@葡聚糖纳米载体的制备,并使用肿瘤还原性环境敏感的二硫键来交联纳米载体,得到了对肿瘤还原环境响应的纳米药物载体.对纳米药物载体的结构、粒径及形貌进行表征,结果显示,纳米药物载体粒径为(92±0.2) nm, Zeta 电位为(-8±0.3) eV.通过体外药物释放研究发现,在还原性环境中,载体可持续72 h释放药物,最大释放量达80%.细胞摄取实验表明负载卡铂的纳米药物载体可在4 h内高效地进入细胞核;其半抑制浓度(IC50)为25.32 μg/mL,达到和相同浓度游离卡铂相仿的促肿瘤细胞凋亡效果.此一步法所制备的卡铂@葡聚糖纳米载体具有良好的生物应用前景.

关键词：一步法接枝聚合诱导自组装卡铂@葡聚糖纳米载体还原环境敏感

Adenovirus-delivered angiopoietin-1 suppresses NF-κB and p38 MAPK and attenuates inflammatory responses in phosgene-induced acute lung injury

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Adenovirus-delivered angiopoietin-1 suppresses NF-κB and p3...

第十三次全国劳动卫生与职业病学术会议

作者： Dai-Kun He Yi-Ru Shao Lin Zhang Jie Shen Zhi-Yue Zhong Jing Wang guoxiong xu Center of Emergency & Intensive Care Unit Fudan University Medical Center of Chemical injury Fudan University Center Laboratory Jinshan HospitalFudan University

Animals exposed to phosgene(Psg)result in acute lung injury(ALI).We have recently reported that angiopoietin-1(Ang1)reduces inflammation and vascular hyperpermeability in ALI *** this study,we examined whether the beneficial effects of adenovirus-delivered Angi(Ad/Ang1)on inflammatory responses in Psg-induced ALI rats are due to the suppression of the nuclear factor-kappa B(NF-κB)and p38 mitogen-activated protein kinase(MAPK)pathways,which play crucial roles in inflammatory responses in *** demonstrated that Psg increased Ang2 and inflammatory cytokines,such as tumor necrosis factor-a(TNF-a),interleukin(IL)-4(IL-4),IL-6,IL-8,and IL-10,in the serum and bronchoalveolar lavage fluid of ALI rats,determined by ***1 inhibits pro-inflammatory mediators(TNF-a,IL-6 and IL-8)and has no effect on anti-inflammatory mediators(IL-4 and IL-10).Furthermore,the inhibitory action of Ang1 was mediated by the suppression of the NF-κB and p38 MAPK pathways,leading to the attenuation of inflammatory responses of ***,Ad/Ang1 may provide a useful tool for the effective treatment in Psg-induced ALI.

关键词： Acute lung injury angiopoietin-1 cytokine NF-κB p38 MAPK phosgene

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高渗稠油油田保护储层修井液的研发

油田化学 2018年第4期35卷 613-617页

作者：徐国雄陈华兴庞铭徐方雪中海油能源发展股份有限公司工程技术分公司天津300452 中海石油(中国)有限公司天津分公司天津300452

高孔高渗的渤海S稠油油田采用水源井水修井后,漏失量大、产能恢复效果差。为了降低外来工作液对储层的损害,开发了保护储层的修井液体系。通过室内实验优选了配制前置液所用的边界膜清洗剂、降黏剂、阻垢剂和助排剂,评价了暂堵液的增黏... 详细信息

高孔高渗的渤海S稠油油田采用水源井水修井后,漏失量大、产能恢复效果差。为了降低外来工作液对储层的损害,开发了保护储层的修井液体系。通过室内实验优选了配制前置液所用的边界膜清洗剂、降黏剂、阻垢剂和助排剂,评价了暂堵液的增黏性及其对岩心的封堵性能和破胶后岩心渗透率的恢复率。研究结果表明,配方为15%边界膜清洗剂GXXJ+1.5%降黏剂JN-01+0.5%阻垢剂ZG-02+1%助排剂ZP-01的前置液的洗油率、降黏率均达到90%以上,能够抑制钙镁垢形成,可将返排压力降低50%以上。配方为3%油溶性暂堵剂BH-ZD+0.7%增黏剂BH-VIS+3%破胶剂JPC(海水配制)的暂堵液在压力3.5数4 MPa、温度60℃的条件下封堵效果良好,破胶后岩心的渗透率恢复率在80%以上。采用该前置液加暂堵液体系修井能够有效预防有机质沉淀、油水乳化和无机垢堵塞等储层伤害。该体系已在S油田应用,修井后工作液漏失量低且产能恢复较好。

关键词：稠油油藏高渗透率修井前置液暂堵液乳化无机垢

Parallel Interference Cancellation with Frequency Diversity Combining for Multi-Carrier DS-CDMA+

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Parallel Interference Cancellation with Frequency Diversity ...