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Antitumor Research on Artemisinin and Its Bioactive Derivatives

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Natural Products and Bioprospecting 2018年第4期8卷 303-319页

作者： Yunqin Zhang guowei xu Shuqun Zhang Dong Wang PSaravana Prabha Zhili Zuo State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of the Chinese Academy of Sciences Beijing 100049China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming 650201YunnanChina

Cancer is the leading cause of human death which seriously threatens human *** antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer ***,a variety of target-selective artemisinin-related compounds with high efficiency have been *** researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects,including inhibiting the proliferation of tumor cells,promoting apoptosis,inducing cell cycle arrest,disrupting cancer invasion and metastasis,preventing angiogenesis,mediating the tumor-related signaling pathways,and regulating tumor *** importantly,artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer ***,we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 *** is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.

关键词： Artemisinin Artemisinin derivatives Antitumor Activity Mechanism

Box-Behnken响应面法结合层次分析法优化萸仙茅炮制工艺

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中国中医药信息杂志 2025年第1期32卷 134-139页

作者：徐国伟王巍刘思翰洪艺丹张立强鞠成国辽宁中医药大学药学院辽宁大连116600 国家中医药管理局中药炮制技术传承基地辽宁大连116600

目的优选萸仙茅炮制工艺。方法在单因素试验基础上,以料液比、炒制时间和炒制温度为影响因素,以仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷含量及外观性状的综合评分为评价指标,利用Box-Behnken响应面法结合层次分析法优化萸仙茅最佳炮... 详细信息

目的优选萸仙茅炮制工艺。方法在单因素试验基础上,以料液比、炒制时间和炒制温度为影响因素,以仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷含量及外观性状的综合评分为评价指标,利用Box-Behnken响应面法结合层次分析法优化萸仙茅最佳炮制工艺,并进行工艺验证。结果萸仙茅最佳炮制工艺为:取生仙茅饮片,加入等量吴茱萸汁拌匀,置密闭容器内,闷润至药汁被完全吸尽,于130℃炒制6min,取出,60℃干燥。每100kg仙茅用吴茱萸10kg。吴茱萸汁制法:取吴茱萸10kg,加12倍量水浸泡60min,煎煮50min,提取3次,合并滤液,浓缩至100kg。结论本研究优化所得萸仙茅的炮制工艺可行、稳定。

关键词：萸仙茅 Box-Behnken响应面法层次分析法炮制工艺

N-doping offering higher photodegradation performance of dissolved black carbon for organic pollutants: experimental and theoretical studies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 340-356页

作者： Yong GUO Mengxia CHEN Ting CHEN Ying GUO Zixuan xu guowei xu Soukthakhane SINSONESACK Keophoungeun KANMANY Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of EducationCollege of EnvironmentHohai UniversityNanjing 210093China Key Laboratory of Environmental Engineering of Jiangsu Province Jiangsu Provincial Academy of Environmental ScienceNanjing 210036China State Key Laboratory of Pollution Control and Resource Reuse Nanjing UniversityNanjing 210023China Central Environmental Laboratory Natural Resources and Environment Research InstituteMinistry of Natural Resources and EnvironmentVientiane 999012Laos

We investigated the influence mechanism of N-doping for dissolved black carbon(DBC)photodegradation of organic *** degradation performance of N-doped dissolved black carbon(NDBC)for tetracycline(TC)(71%)is better than that for methylene blue(MB)(28%)under *** levels are both better than DBC degradation performances for TC(68%)and MB(18%)under *** species quenching experiments suggest that h and-O,are the main reactive species for NDBC photodegraded TC,while-OH and h*are the main reactive species for NDBC photodegraded MB.-OH is not observed during DBC photodegradation of *** is likely because N-doping increases valence-band(VB)energy from 1.55 eV in DBC to 2.04 eV in NDBC;the latter is strong enough to oxidize water to ***,N-doping increases the DBC band gap of 2.29 to 2.62 eV in NDBC,resulting in a higher separation efficiency of photo-generated electrons-holes in NDBC than in *** these factors give NDBC stronger photodegradation performance for TC and MB than ***-performance liquid chromatography-mass spectrometry(HPLC-MS)characterization and toxicity evaluation with the quantitative structure-activity relationship(QSAR)method suggest that TC photodegradation intermediates produced by NDBC have less aromatic structure and are less toxic than those produced by *** adopted a theoretical approach to clarify the relationship between the surface groups of NDBC and the photoactive species *** results add to the understanding of the photochemical behavior of NDBC.

关键词： Dissolved black carbon(DBC) N-doping Organic pollutants Band gap Photodegradation

Effect of bone marrow stromal cell transplantation to the hippocampal CA1 region on electroencephalographic activity in epileptic rats

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Neural Regeneration Research 2008年第10期3卷 1074-1077页

作者： Hong xu guowei xu Zhongtang Feng Tinghua Wang Jia Yang Qingying Wu Zhicheng Xiao Department of Neurology the First Affiliated Hospital of Kunming Medical College Kunming 650032 Yunnan Province China Department of Neurology Central Hospital of Zhengzhou Zhengzhou 450007 Henan Province China Institute of Neuroscience Kunming Medical College Kunming 650031 Yunnan Province China Institute of Molecular Cell Biology Singapore 117609

BACKGROUND： Animal experiments have confirmed that bone marrow stromal cell （BMSC） transplantation can serve as a treatment for epilepsy. OBJECTIVE： BMSCs derived from green fluorescent protein （GFP） mice were transplanted into the hippocampal CA1 region of epileptic rats. The aim of the study was to record electroencephalogram （EEG）, analyze survival and migration of BMSCs, and validate the effect of BMSC transplantation for the treatment of epilepsy. DESIGN, TIME AND SETTING： A randomized block design experiment was performed at the Institute of Neuroscience, Kunming Medical College from March 2005 to February 2006. MATERIALS： Homozygous C57BL/6CrSlcTgN （acr-EGFP） OsbC 14-Y01-FM 131 mice, 8-12 weeks of age, were selected for preparation of cell suspension. Sprague Dawley rats were selected for establishing epilepsy models. METHODS： Rats were randomly divided into 4 groups： control （n = 8）, model （n = 8）, normal saline （n = 24）, and BMSC （n = 24）. In the model, normal saline, and BMSC groups, epilepsy was established with penicillin （3 × 10^7 U/kg i.p. ×7 days）. Rats in the BMSC group received a BMSC suspension derived from green fluorescent protein mice into the fight hippocampal CA1 region. Rats in the vehicle control group were injected with the same volume of normal saline into the hippocampal CA1 region. MAIN OUTCOME MEASURES： The electroencephalogram was used to monitor brain activity. Survival and migration of the transplanted BMSCs was observed using fluorescence microscopy at 1, 2, and 4 weeks after transplantation. RESULTS： In BMSC group, fluorescent cells were observed at the transplantation site and in the adjacent tissue, as well as in the tissue surrounding the needle tract, indicating the migration of implanted cells. Fluorescent cells were not detected in the vehicle control group. The electroencephalogram of the control animals exhibited 7-9 Hzα waves, with a wave amplitude 〈 50 μV. In the model and vehicle control groups random spike-and-wave disc

关键词： bone marrow stromal cells electroencephalogram epilepsy green fluorescent protein transplantation

高机动目标的改进强跟踪CKF自适应IMM算法

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中国惯性技术学报 2024年第7期32卷 715-723页

作者：成怡刘铭阳徐国伟天津工业大学控制科学与工程学院天津300387 天津工业大学机械工程学院天津300387

为提升高机动目标跟踪精度,提出了一种改进的强跟踪CKF自适应交互多模型跟踪算法。在IMM算法运动模型集中引入CS-Jerk模型,增强对高机动目标的适应能力,采用奇异值分解(SVD)算法解决模型集中因模型扩维而导致CKF算法无法Cholesky分解的... 详细信息

为提升高机动目标跟踪精度,提出了一种改进的强跟踪CKF自适应交互多模型跟踪算法。在IMM算法运动模型集中引入CS-Jerk模型,增强对高机动目标的适应能力,采用奇异值分解(SVD)算法解决模型集中因模型扩维而导致CKF算法无法Cholesky分解的问题;提出了一种改进的强跟踪CKF算法,降低强跟踪CKF算法的计算量;利用模型的后验信息对IMM算法模型转移概率进行自适应调整,提高跟踪精度。仿真结果表明,基于所提算法目标的位置均方根误差均值和速度均方根误差均值较IMM-CKF算法分别降低了22.50%和16.58%,有效提高了目标跟踪精度。

关键词：高机动目标目标跟踪自适应交互多模型强跟踪CKF SVD分解

The Discovery, Design and Synthesis of Selective Agonist of Adenylyl Cyclase Type 2 by Virtual Screening Combining Biological Evaluation

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The Discovery, Design and Synthesis of Selective Agonist of ...

低碳经济下消费者参与环保公益活动的动机及其影响机制研究

2019中国化学会第十五届全国计算（机）化学学术会议

作者： guowei xu Yaqing Yang Yanming Yang Liang-Liang Wang Zhiying Wengb 左之利 State Key Laboratory of Phytochemistry and Plant Resources in West China Institute of Botany Chinese Academy of Sciences 中科院昆明植物所

＜正＞Adenylate cyclases （ACs）, play a critical role in the conversion of adenosine triphosphate （ATP） into the second messenger cyclic adenosine monophosphate （c AMP）. Studies have indicated adenylyl cyclase type 2 （AC2） is potential drug targets for many diseases, however up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists.

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经济问题探索 2010年第8期 8-17页

作者：徐国伟卢东山东交通学院济南250023 西南交通大学经济管理学院成都610031

低碳经济的发展离不开企业和公众的参与。本研究基于亲社会行为理论识别了消费者参与环保公益活动动机,并构建了消费者参与动机对参与行为和公司品牌态度的影响模型。实证调查研究发现,感知企业社会责任、社会规范,感知效能和自我强化... 详细信息

低碳经济的发展离不开企业和公众的参与。本研究基于亲社会行为理论识别了消费者参与环保公益活动动机,并构建了消费者参与动机对参与行为和公司品牌态度的影响模型。实证调查研究发现,感知企业社会责任、社会规范,感知效能和自我强化正向影响,而参与成本抑制消费者参与行为;公司品牌态度受感知企业社会责任和参与行为的正向影响。研究结论有助于企业管理者正确应用环境定位策略,提高消费者的参与行为。

关键词：低碳经济企业社会责任消费者参与品牌态度

远隔缺血适应对静脉溶栓后急性缺血性脑卒中患者神经功能、脑损伤标志物及血管炎症介质的影响

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新乡医学院学报 2024年第6期41卷 575-580页

作者：薛芳李岸徐国卫新乡医学院河南新乡453003 郑州大学附属郑州中心医院神经内科河南郑州450007

目的探讨远隔缺血适应(RIC)对急性缺血性脑卒中(AIS)患者静脉溶栓后神经功能、脑损伤标志物及血管炎症介质的影响。方法选择2022年5月至2022年10月郑州大学附属郑州中心医院神经内科收治的90例AIS患者为研究对象,按治疗方法将患者分为RI... 详细信息

目的探讨远隔缺血适应(RIC)对急性缺血性脑卒中(AIS)患者静脉溶栓后神经功能、脑损伤标志物及血管炎症介质的影响。方法选择2022年5月至2022年10月郑州大学附属郑州中心医院神经内科收治的90例AIS患者为研究对象,按治疗方法将患者分为RIC组(n=29)、假RIC组(n=30)和对照组(n=31)。3组患者均给予阿替普酶静脉溶栓治疗;溶栓24 h后,RIC组患者给予RIC治疗,假RIC组给予假性RIC治疗,对照组不做RIC治疗;3组患者均治疗14 d。收集3组患者的年龄、性别、吸烟、饮酒、高血压、糖尿病、冠状动脉性心脏病及卒中病史等基本资料;入院24 h内抽取患者空腹外周静脉血4~5 mL,离心取上层血清,检测三酰甘油(TG)、总胆固醇(TC)、糖化血红蛋白(HbA1c)、血肌酐(Scr)水平;应用凝血分析仪检测纤维蛋白原(FIB)与D-二聚体水平。RIC治疗前、治疗7 d、治疗14 d时抽取3组患者外周静脉血4~5 mL,离心取上层血清,采用酶联免疫吸附试验法检测S100钙结合蛋白β(S100β)、脂蛋白相关磷脂酶A2(Lp-PLA2)、白细胞介素-6(IL-6)水平;采用双抗体夹心酶联免疫吸附法检测神经元特异烯醇化酶(NSE)水平。应用美国国立卫生研究院卒中量表(NIHSS)和改良Rankin量表(mRS)评估3组患者神经功能损伤程度。记录3组患者RIC治疗过程中的不良反应情况。结果对照组、假RIC组和RIC组治疗总有效率分别为90.32%(28/31)、90.00%(27/30)和100.00%(29/29),3组患者的治疗总有效率比较差异无统计学意义(χ^(2)=3.059,P>0.05)。对照组、假RIC组和RIC组患者治疗前TG、TC、HbA1c、Scr、FIB和D-二聚体表达水平比较差异无统计学意义(P>0.05)。治疗前,3组患者血清Lp-PLA2、IL-6、S100β、NSE表达水平比较差异无统计学意义(P>0.05)。3组患者治疗7、14 d时血清Lp-PLA2、IL-6、S100β、NSE水平显著低于治疗前(P0.05)。治疗前,3组患者NIHSS、mRS评分比较差异无统计学意义(P>0.05)。3组患者治疗7、14 d时的NIHSS评分及治疗14、90 d时的mRS评分显著低于治疗前(P0.05)。RIC组在治疗过程中有2例患者出现上肢疼痛、麻木,暂停治疗后患者不适感觉消失;假RIC组和对照组无不良反应发生。结论静脉溶栓后给予RIC治疗能显著促进AIS患者神经功能恢复,降低血管炎症介质和脑损伤标志物水平,减轻脑损伤。

关键词：远隔缺血适应静脉溶栓急性缺血性脑卒中脑损伤标志物血管炎症介质

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基于GPU并行计算的雷达杂波模拟研究

计算机工程 2020年第11期46卷 306-314页

作者：徐国伟陈建成怡天津工业大学电气工程与自动化学院天津300387 天津工业大学天津市电工电能新技术重点实验室天津300387

现代雷达杂波模拟需使用杂波数据实时分析与处理回波信号,然而传统球不变随机过程(SIRP)方法生成杂波数据耗时较长。通过对SIRP方法进行改进,提出一种利用图形处理器(GPU)并行计算提升杂波生成实时性的方法。在计算统一设备架构(CUDA)下... 详细信息

现代雷达杂波模拟需使用杂波数据实时分析与处理回波信号,然而传统球不变随机过程(SIRP)方法生成杂波数据耗时较长。通过对SIRP方法进行改进,提出一种利用图形处理器(GPU)并行计算提升杂波生成实时性的方法。在计算统一设备架构(CUDA)下,对相关相干K分布杂波算法进行多任务串-并行分析,采用cuBLAS库对细粒度卷积计算进行优化,利用OpenMP+CUDA多任务调度机制改进粗粒度任务并行计算,以提高CPU-GPU利用率并减少数据等待时间。实验结果表明,该方法生成杂波数据的实时性显著提升,且随着杂波数据量增大其加速效果更好,相较传统GPU方法计算速率提高61%。

关键词：雷达杂波 GPU并行计算球不变随机过程法卷积计算 cuBLAS库