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棉花抗黄萎病QTL初步定位

分子植物育种 2010年第4期8卷 680-686页

作者：吴翠翠简桂良王安乐刘方张先亮宋国立黎绍惠陈朝辉王春英张香娣王坤波中国农业科学院棉花研究所农业部棉花遗传改良重点实验室安阳455000 山西省农业科学院棉花研究所运城044000 中国农业科学院植物保护研究所北京100193 开封市农林科学研究院开封475141

本研究以高抗黄萎病的海岛棉品种海7124和高感黄萎病的陆地棉品种邯郸14组配的F2群体184个株系,构建了一个分子标记遗传连锁图,包括了142个位点和30个连锁群,标记间的平均距离为8.24cM,全长1169.6cM,覆盖棉花总基因组约23.4%。用复合区... 详细信息

本研究以高抗黄萎病的海岛棉品种海7124和高感黄萎病的陆地棉品种邯郸14组配的F2群体184个株系,构建了一个分子标记遗传连锁图,包括了142个位点和30个连锁群,标记间的平均距离为8.24cM,全长1169.6cM,覆盖棉花总基因组约23.4%。用复合区间作图分析共检测到12个抗黄萎病相关QTL,其中田间抗病性检测到不同时期7个病情指数相关QTL,1个病株率相关QTL,温室苗期抗病性定位4个病株率相关QTL。从绝对量上看,各QTL加性效应从2.20到42.39,显性效应从1.65到32.25,解释表型变异1.09%～22.73%,且田间抗病性获得的QTL与温室苗期抗病性得到的QTL基本相同,其中qFDI711-30-0.01位点距MUSS294仅为0.01cM,加性效应较高解释表型变异22.32%,这对于培育优质抗病材料用于标记辅助育种具有一定的参考价值。

关键词：棉花黄萎病 SSR QTL

Nesfatin-1和Vaspin在老年高血脂和高血压患者中的水平及临床意义

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国际检验医学杂志 2023年第S1期44卷 22-26页

作者：谢国丽刘芳刘宇刘峻宏张偲郭建廷颜书海昆明市第二人民医院云南昆明650000 北大荒集团牡丹江医院黑龙江鸡西158399 娄底经济开发区涟滨街道社区卫生服务中心湖南娄底417009

目的测定老年高血脂和高血压患者血清人新饱食分子蛋白1(Nesfatin-1)和人内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平,为老年高血脂和高血压患者在诊断、治疗、疗效观察方面提供临床依据。方法随机选取2020年7月至2021年7月期间与昆... 详细信息

目的测定老年高血脂和高血压患者血清人新饱食分子蛋白1(Nesfatin-1)和人内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平,为老年高血脂和高血压患者在诊断、治疗、疗效观察方面提供临床依据。方法随机选取2020年7月至2021年7月期间与昆明市第二人民医院住院不同类型老年代谢性疾病患者101例,其中老年高血脂(HL)组40例,老年高血压(HT)组61例。收集同期健康老年人47例作为对照组。检测和收集一般临床指标,比较不同分组之间血浆Nesfatin-1和Vaspin水平。结果各组各指标差异性比较,HL组与HT组和对照组相比,Nesfatin-1、三酰甘油(TG)、总胆固醇(TC)、载脂蛋白B(ApoB)和ApoE表达水平显著升高,差异有统计学意义(P<0.05);高密度脂蛋白胆固醇(HDL-C)表达水平显著降低,差异有统计学意义(P<0.05)。HL组与对照组相比,空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、低密度脂蛋白胆固醇(LDL-C)、ApoA和血红蛋白(Hb)表达水平显著升高,差异有统计学意义(P<0.05)。均值图走向结果显示,在HL、HT和对照组三组间,Nesfatin-1、Vaspin和ApoB表达水平趋势是一样的,而各组年龄层段的走势、HDL-C表达水平和Nesfatin-1、Vaspin和ApoB正好相反;FINS、HOMA-IR、Hb的走势一致;TG、TC、LDL-C、APOE几乎是一致的。Pearson相关性分析,Nesfatin-1与空腹血糖(FPG)、脂蛋白a(Lpa)、糖化血红蛋白(HbAlc)、胰岛素抵抗指数(HOMA-IR)呈显著负相关性(r=-0.168,-0.139,-0.221,-0.151;P=0.016,0.046,0001,0.031);Vaspin只和收缩压呈显著负相关(r=-0.145,P=0.033)。多元线性回归分析结果显示,ApoB、C反应蛋白(CRP)(β=0.571、-0.249,P<0.05)为血清Nesfatin-1的影响因素。结论在老年人群中,随着高血脂的发生,血清中Nesfatin-1的表达水平升高,调节血脂并参与了胰岛素抵抗的发生,血清Nesfatin-1与ApoB和CRP相关。Vaspin与血管收缩有关,可能与Nesfatin-1在调节糖脂代谢上有共同的作用。

关键词：老年代谢性疾病人新饱食分子蛋白1 人内脏脂肪特异性丝氨酸蛋白酶抑制剂脂质代谢

基于多中心真实世界数据的胃癌围手术期化疗患者生存分析

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中华胃肠外科杂志 2021年第5期24卷 403-412页

作者：丁学伟郑志超赵群翟刚梁寒吴欣朱正纲王海江何庆泗何显力杜义安陈路川花亚伟黄昌明薛英威周烨周岩冰吴丹房学东代佑果张洪伟曹家庆李乐平柴杰陶凯雄李国立揭志刚葛杰徐忠法张文斌李其云赵平马志强严志龙郑国良晏阳汤小龙周祥天津医科大学肿瘤医院胃部肿瘤科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心300060 辽宁省肿瘤医院胃外科沈阳110042 河北医科大学第四医院外三科石家庄050011 山西省肿瘤医院普通外一科太原030013 解放军总医院第一医学中心普通外科医学部北京100853 上海交通大学医学院附属瑞金医院普通外科上海消化外科研究所上海市胃肿瘤重点实验室200025 新疆医科大学附属肿瘤医院胃肠外科乌鲁木齐830011 山东大学齐鲁医院胃肠外科济南250012 空军军医大学唐都医院普通外科西安710038 浙江省肿瘤医院胃外科杭州310022 福建省肿瘤医院胃肠肿瘤外科福州350014 河南省肿瘤医院普通外科郑州450008 福建医科大学附属协和医院胃外科福州350004 哈尔滨医科大学附属肿瘤医院胃肠外科 150081 复旦大学附属肿瘤医院胃外科上海200032 青岛大学附属医院胃肠外科 266003 浙江大学医学院附属第二医院外科杭州310009 吉林大学中日联谊医院胃肠结直肠肛门外科长春130033 云南省肿瘤医院胃与小肠外科昆明650118 江苏省无锡明慈心血管病医院消化病诊疗中心 214101 南昌大学第二附属医院胃肠外科 330006 山东第一医科大学附属省立医院胃肠外科济南250021 山东大学附属山东省肿瘤医院胃外科济南250117 华中科技大学同济医学院附属协和医院胃肠外科武汉430022 东部战区总医院普通外科南京210002 南昌大学第一附属医院胃肠外科 330006 中南大学湘雅医院胃肠外科长沙410008 山东第一医科大学第三附属医院普通外科济南250031 新疆医科大学第一附属医院普通外科乌鲁木齐830000 江西省肿瘤医院腹部肿瘤外一科南昌330029 四川省肿瘤医院胃肠外科成都610041 中国医学科学院北京协和医院基本外科 100730 浙江省宁波市第一医院胃肠、疝外科 315000

目的探索真实世界中,围手术期化疗对胃癌患者预后的影响。方法采用回顾性队列研究方法,收集2014年1月1日至2016年1月31日期间辽宁省肿瘤医院、天津医科大学肿瘤医院等全国33家医院胃癌围手术期化疗及手术+辅助化疗病例的真实世界资料。... 详细信息

目的探索真实世界中,围手术期化疗对胃癌患者预后的影响。方法采用回顾性队列研究方法,收集2014年1月1日至2016年1月31日期间辽宁省肿瘤医院、天津医科大学肿瘤医院等全国33家医院胃癌围手术期化疗及手术+辅助化疗病例的真实世界资料。病例纳入标准:(1)经病理组织学确诊的胃腺癌,临床分期cT_(2~4)aN_(0-3)M_(0)(AJCC第8版);(2)行D2胃癌根治手术;(3)至少完成1周期的新辅助化疗;(4)至少完成4周期辅助化疗[SOX(替吉奥+奥沙利铂)或CapeOX(卡培他滨+奥沙利铂)]。排除标准:(1)合并其他恶性肿瘤;(2)接受过放疗;(3)资料数据不全者。将入组患者中接受了新辅助化疗和辅助化疗者纳入围手术期化疗组,将单纯接受术后辅助化疗的患者纳入手术+辅助化疗组。采用倾向性评分匹配法控制和减小选择性偏倚。结局指标为两组患者倾向评分匹配后的总生存时间(OS)和肿瘤无进展生存时间(PFS),OS定义为第1次新辅助化疗时间(手术+辅助化疗组自手术时间)至末次有效随访时间或患者死亡时间;PFS定义为第1次新辅助化疗时间(手术+辅助化疗组自手术时间)至患者首次影像学诊断进展时间或死亡时间。采用Kaplan-Meier法估计生存率,使用Cox比例风险回归模型比较两组患者的OS和PFS。结果纳入病例2045例,其中手术+辅助化疗组1293例,围手术期化疗组752例。倾向评分匹配后,围手术期化疗组和手术+辅助化疗组各492例患者资料纳入研究,两组患者性别、年龄、体质指数、治疗前肿瘤分期、肿瘤部位的差异均无统计学意义(均P>0.05)。与手术+辅助化疗组相比,围手术期化疗组患者的全胃切除术比例更高(χ^(2)=40.526,P0.05);胃体、胃窦部位肿瘤获益更明显(P<0.05)。结论新辅助化疗能够改善胃癌患者的预后。

关键词：胃肿瘤真实世界研究倾向性得分匹配新辅助治疗

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can fang Jian fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian fang Wenxing fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector