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公路路基路面施工质量的控制及防范措施

科技创新与生产力 2024年第6期45卷 85-87页

作者：金国钧甘肃昶通公路养护科技有限公司甘肃兰州730000

由于公路施工过程的繁杂性,实际施工过程会受多种因素的影响,而开展质量控制就是公路工程路基路面施工的重点内容之一,是整体质量控制的关键。本文针对公路工程中路基路面施工质量控制及防范措施进行了研究,强调了公路路基路面施工质量... 详细信息

由于公路施工过程的繁杂性,实际施工过程会受多种因素的影响,而开展质量控制就是公路工程路基路面施工的重点内容之一,是整体质量控制的关键。本文针对公路工程中路基路面施工质量控制及防范措施进行了研究,强调了公路路基路面施工质量的重要性,罗列了路基路面施工中的基本要求。同时,分析路基路面施工过程中常见的质量问题,并给出相应的防范措施,以供参考。

关键词：公路工程路基路面质量控制施工管理防范措施

Dietary sodium acetate and sodium butyrate attenuate intestinal damage and improve lipid metabolism in juvenile largemouth bass(Micropterus salmoides) fed a high carbohydrate diet by reducing endoplasmic reticulum stress

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Animal Nutrition 2024年第1期16卷 443-456页

作者： Liulan Zhao Liangshun Cheng Yifang Hu Xiaohui Li Yihui Yang jin Mu Lianfeng Shen guojun Hu Kuo He Haoxiao Yan Qiao Liu Song Yang College of Animal Science and Technology Sichuan Agricultural University

High-carbohydrate(HC) diets decrease the intestinal levels of sodium acetate(SA) and sodium butyrate(SB) and impair the gut health of largemouth bass; however, SA and SB have been shown to enhance immunity and improve intestinal health in farmed animals. Thus, the present study was to investigate the effects of dietary SA and SB on HC diet-induced intestinal injury and the potential mechanisms in juvenile largemouth bass. The experiment set five isonitrogenous and isolipidic diets, including a lowcarbohydrate diet(9% starch)(LC), a high carbohydrate diet(18% starch)(HC), and the HC diet supplemented with 2 g/kg SA(HCSA), 2 g/kg SB(HCSB) or a combination of 1 g/kg SA and 1 g/kg SB(HCSASB).The feeding experiment was conducted for 8 weeks. A total of 525 juvenile largemouth bass with an initial body weight of 7.00 ± 0.20 g were used. The results showed that dietary SA and SB improved the weight gain rate and specific growth rate (P<0.05) and ameliorated serum parameters(alkaline phosphatase, acid phosphatase, glutamate transaminase, and glutamic oxaloacetic transaminase)(P<0.05). And, importantly, dietary SA and SB repaired the intestinal barrier by increasing the expression levels of zonula occludens-1, occludin, and claudin-7(P<0.05), reduced HC-induced intestinal damage, and alleviated intestinal inflammation and cell apoptosis by attenuating HC-induced intestinal endoplasmic reticulum stress(P<0.05). Further results revealed that dietary SA and SB reduced HC-induced intestinal fat deposition by inhibiting adipogenesis and promoting lipolysis(P<0.05). In summary, this study demonstrated that dietary SA and SB attenuated HC-induced intestinal damage and reduced excessive intestinal fat deposition in largemouth bass.

关键词： Sodium acetate Sodium butyrate High carbohydrate diet Endoplasmic reticulum stress Intestine health Lipid metabolism

Interface-induced topological phase and doping-modulated bandgap of two-dimensioanl graphene-like networks

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Chinese Physics B 2023年第1期32卷 434-439页

作者：杨柠境杨海金国钧 School of Physics Science and Technology Kunming UniversityKunming 650214China National Laboratory of Solid State Microstructures Department of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Biphenylene is a new topological material that has attracted much attention *** amplifying its size of unit cell,we construct a series of planar structures as homogeneous carbon allotropes in the form of polyphenylene *** first use the low-energy effective model to prove the topological three periodicity for these ***,through first-principles calculations,we show that the topological phase has the Dirac *** the size of per unit cell increases,the influence of the quaternary rings decreases,leading to a reduction in the anisotropy of the system,and the Dirac cone undergoes a transition from type II to type *** confirm that there are two kinds of non-trivial topological phases with gapless and gapped bulk ***,we add a built-in electric field to the gapless system by doping with B and N atoms,which opens a gap for the bulk ***,by manipulating the built-in electric field,the dispersion relations of the edge modes will be transformed into a linear *** findings provide a hopeful approach for designing the topological carbon-based materials with controllable properties of edge states.

关键词： polyphenylene interface band structure Zak phase edge state

Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2613-2630页

作者： Xuemin He Siying Wen Xixiang Tang Zheyao Wen Rui Zhang Shasha Li Rong Gao jin Wang Yanhua Zhu Dong Fang Ting Li Ruiping Peng Zhaotian Zhang Shiyi Wen Li Zhou Heying Ai Yan Lu Shaochong Zhang guojun Shi Yanming Chen Department of Endocrinology and Metabolic Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Diabetology&Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical Immunology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Ophthalmology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Fundus Shenzhen Eye Hospital of Jinan UniversityShenzhen 518048China

Glucagon-like peptide-1 receptor agonists(GLP-1 RAs)protect against diabetic cardiovascular diseases and ***,their activity in diabetic retinopathy(DR)remains *** retrospective cohort study involving 1626 T2DM patients revealed superior efficacy of GLP-1 RAs in controlling DR compared to other glucose-lowering medications,suggesting their advantage in DR *** single-cell RNA-sequencing analysis and immunostaining,we observed a high expression of GLP-1R in retinal endothelial cells,which was down-regulated under diabetic *** of GLP-1 RAs significantly restored the receptor expression,resulting in an improvement in retinal degeneration,vascular tortuosity,avascular vessels,and vascular integrity in diabetic *** and GSEA analyses further implicated enhanced mitochondrial gene translation and mitochondrial functions by GLP-1 ***,the treatment attenuated STING signaling activation in retinal endothelial cells,which is typically activated by leaked mitochondrial *** of STING mRNA was positively correlated to the levels of angiogenic and inflammatory factors in the endothelial cells of human fibrovascular *** investigation revealed that the cAMP-responsive element binding protein played a role in the GLP-1R signaling pathway on suppression of STING *** study demonstrates a novel role of GLP-1 RAs in the protection of diabetic retinal vasculature by inhibiting STING-elicited inflammatory signals.

关键词： GLP-1 RAs STING signaling Retinal endothelial cells Mitochondrial leakage Retinal vascular dysfunction Diabetic retinopathy CREB Inflammation

Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in Apoe^(-/-)mice

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Life Metabolism 2024年第3期3卷 46-59页

作者： Yajuan Deng Xiaoyu Yang Xueru Ye Youwen Yuan Yanan Zhang Fei Teng Danming You Xuan Zhou Wenhui Liu Kangli Li Shenjian Luo Zhi Yang Ruxin Chen guojun Shi jin Li Huijie Zhang Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityShanxi Medical UniversityTaiyuanShanxi 030001China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China

Atherosclerosis is the major contributor to cardiovascular mortality *** day fasting(ADF)has gained growing attention due to its metabolic ***,the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal *** present study was designed to investigate the effects of ADF on atherosclerosis in apolipoprotein E-deficient(Apoe^(-/-))***-week-old male Apoe^(-/-)mice fed with Western diet(WD)were randomly grouped into ad libitum(AL)group and ADF group,and ADF aggravated both the early and advanced atherosclerotic lesion formation,which might be due to the disturbed cholesterol profiles caused by ADF *** significantly altered cholesterol metabolism pathways and down-regulated integrated stress response(ISR)in the *** hepatic expression of activating transcription factor 3(ATF3)was suppressed in mice treated with ADF and hepatocyte-specific overexpression of Aft3 attenuated the effects of ADF on atherosclerotic plaque formation in Apoe^(-/-)***,the expression of ATF3 could be regulated by Krüppel-like factor 6(KLF6)and both the expressions of ATF3 and KLF6 were regulated by hepatic cellular ISR *** conclusion,ADF aggravates atherosclerosis progression in Apoe^(-/-)mice fed on *** inhibits the hepatic ISR signaling pathway and decreases the expression of KLF6,subsequently inhibiting ATF3 *** suppressed ATF3 expression in the liver mediates the deteriorated effects of ADF on atherosclerosis in Apoe^(-/-)*** findings suggest the potentially harmful effects when ADF intervention is applied to the population at high risk of atherosclerosis.

关键词： alternate day fasting atherosclerosis cholesterol integrated stress response activating transcription factor 3

用非法律手段维护新闻出版秩序——浅析世界新闻出版管理的普遍性与多样性

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出版发行研究 2010年第9期 66-68页

作者：靳国君黑龙江省人大常委会

新闻出版是社会重要的子系统。世界各国对新闻出版的管理,均是以法律为依据,辅之以行政调节、半行政调节、财团调控、市场调节、行业自律、公众监督、特殊调节等多种方式。以保护人权为责任,以建立良好传播秩序为方向的管理,是维护新闻... 详细信息

新闻出版是社会重要的子系统。世界各国对新闻出版的管理,均是以法律为依据,辅之以行政调节、半行政调节、财团调控、市场调节、行业自律、公众监督、特殊调节等多种方式。以保护人权为责任,以建立良好传播秩序为方向的管理,是维护新闻出版自由的保障。

关键词：新闻出版管理新闻出版自由新闻法普遍性多样性

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新闻出版管理与新闻自由

学术交流 2010年第4期 1-6页

作者：靳国君黑龙江省人大常委会教科文卫委员会哈尔滨150001

对新闻出版进行管理和调控,追求和争取其政治认同效益、文化与科技传播效益和经济效益三个效益的最大化,是世界性的国家共同行为。世界各国对新闻出版的管理,均把法律作为根本规范,以法律为依据,辅之以多种方式。当代新闻出版的管理,已... 详细信息

对新闻出版进行管理和调控,追求和争取其政治认同效益、文化与科技传播效益和经济效益三个效益的最大化,是世界性的国家共同行为。世界各国对新闻出版的管理,均把法律作为根本规范,以法律为依据,辅之以多种方式。当代新闻出版的管理,已经不单是传统媒体的管理,还包括对新兴媒体互联网的管理。新闻出版管理和新闻出版自由是一枚硬币的两面,相辅相承,缺一不可,以保护人权为责任,以建立良好传播秩序为方向的管理,是维护言论自由、新闻出版自由的保障。新闻出版自由,是具体的、相对的,就一个国家而言,同新闻出版的管理一样,在不同的历史时期或阶段,有不同的特点,侧重的方面也不相同,保护范围、力度和程度也有较大的差异,世界上任何一个国家都没有超越时代、超越文化传统、超越经济发展、超越法律的自由。新闻责任论融进新闻自由相对论理念,是西方新闻学和新闻理论的一个世纪性新变化。新闻责任论出现后,少数发达国家对外却仍然主张绝对的新闻自由,国际上称之为新闻自由的双重标准。如何应对新闻自由的双重标准,关键是构建本国健康、良好的传播秩序,保护国家的表达权、信息安全、文化安全和国家安全,不断改善和提高本国的人权和表达权的保护水平,同时发展壮大经济实力,发展新闻出版产业,在世界传播领域占有自己应有的地位,进而使新闻自由的双重标准及其包藏的意识形态目的无法奏效。

关键词：新闻出版管理新闻自由新闻自由的相对性

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我国有线电视发展“十一五”规划思考

广播与电视技术 2005年第7期32卷 17-22页

作者：金国钧北京有线电视台

我国的有线电视经过“八五”、“九五”时期的发展,在“十五”期间进入了数字化的变革阶段。“十一五”期间应该如何发展?专家提出四点建议:(1)以发展农村有线电视市场为重点,调整我国广播电视的覆盖结构;(2)以节目为纽带,加快有线数字... 详细信息

我国的有线电视经过“八五”、“九五”时期的发展,在“十五”期间进入了数字化的变革阶段。“十一五”期间应该如何发展?专家提出四点建议:(1)以发展农村有线电视市场为重点,调整我国广播电视的覆盖结构;(2)以节目为纽带,加快有线数字电视的发展;(3)以开发数据业务为动力,加快HFC双向系统的升级改造;(4)以科研为先导,推动有线电视产业化发展。

关键词：有线电视数字化城域网 “十一五”规划广播电视业运营体制中国

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DOCSIS 3.0启示录(下)

广播与电视技术 2007年第3期34卷 70-70,72-74,76-77页

作者：金国钧北京有线电视台

3．2 DOCSIS3．0系统参考结构（1）DOCSIS1．1／2．0系统参考结构如图2所示。（2）DOCSIS3．0系统参考结构如图3所示。①由图3可见．DOCSIS3．0为增加信道绑定功能．在系统前端增加了CMTS核模块（Modular-CMTS Core）．其功能是执行网... 详细信息

3．2 DOCSIS3．0系统参考结构（1）DOCSIS1．1／2．0系统参考结构如图2所示。（2）DOCSIS3．0系统参考结构如图3所示。①由图3可见．DOCSIS3．0为增加信道绑定功能．在系统前端增加了CMTS核模块（Modular-CMTS Core）．其功能是执行网络侧接口（NSI）与上行RF接口间和在边缘QAM（*** QAM）上的下行射频（RF）接口问的通信管理。2006年1月．Broadcom公司已推出的BCM3255芯片（416脚、塑胶球栅阵列（PBGA）封装）．已能支持120Mb／s的下行速率．其万片售价约每片32美元。M-CMTS Core的转发管理功能．如图4（a）所示。

关键词： DOCSIS Broadcom公司参考结构通信管理 F接口 CMTS Edge