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Inhibiting DNA methylation alleviates cisplatininduced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K/AKT pathway

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1305-1321页

作者： Yingzi He Zhiwei Zheng Chang Liu Wen Li Liping Zhao guohui nie Huawei Li ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200031China Department of Otolaryngology and Institute of Translational Medicine Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShanghai 200032China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShenzhen 518035China

Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to irreversible hearing *** study aimed to assess the potential effect of the DNA methyltransferase(DNMT)inhibitor RG108 on cisplatin-induced ***,apoptosis assay,and auditory brainstem response(ABR)were employed to determine the impacts of RG108 on cisplatin-induced injury in murine hair cells(HCs)and spiral ganglion neurons(SGNs).Rhodamine 123 and TMRM were utilized for mitochondrial membrane potential(MMP)*** oxygen species(ROS)amounts were evaluated by Cellrox green and Mitosox-red *** respiratory function evaluation was performed by determining oxygen consumption rates(OCRs).The results showed that RG108 can markedly reduce cisplatin induced damage in HCs and SGNs,and alleviate apoptotic rate by protecting mitochondrial function through preventing ROS ***,RG108 upregulated BCL-2 and downregulated APAF1,BAX,and BAD in HEI-OC1 cells,and triggered the PI3K/AKT *** expression of low-density lipoprotein receptor-related protein 1(LRP1)and high methylation of the LRP1 promoter were observed after cisplatin ***108 treatment can increase LRP1expression and decrease LRP1 promoter *** conclusion,RG108 might represent a new potential agent for preventing hearing loss induced by cisplatin via activating the LRP1-PI3K/AKT pathway.

关键词： Cisplatin DNMT Apoptosis Hair cell Spiral ganglion neurons RG108 Mitochondrial dysfunction ROS

Recent advances in anisotropic two-dimensional materials and device applications

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Nano Research 2021年第4期14卷 897-919页

作者： Jinlai Zhao Dingtao Ma Cong Wang Zhinan Guo Bin Zhang Jianqing Li guohui nie Ni Xie Han Zhang Institute of Microscale Optoelectronics and Second Peoples Hospital Health Science CenterShenzhen UniversityShenzhen 518060China Faculty of Information Technology Macao University of Science and TechnologyAvenida Wai LongTaipaMacao 999078China College of Materials Science and Engineering Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsShenzhen 518060China

Two-dimensional(2D)materials,such as transition metal dichalcogenides(TMDs),black phosphorus(BP),MXene and borophene,have aroused extensive attention since the discovery of graphene in *** have wide range of applications in many research fields,such as optoelectronic devices,energy storage,catalysis,owing to their striking physical and chemical *** them,anisotropic 2D material is one kind of 2D materials that possess different properties along different directions caused by the intrinsic anisotropic atoms5 arrangement of the 2D materials,mainly including BP,borophene,low-symmetry TMDs(ReSe2 and ReSa)and group IV monochalcogenides(SnS,SnSe,GeS,and GeSe).Recently,a series of new devices has been fabricated based on these anisotropic 2D *** this review,we start from a brief introduction of the classifications,crystal structures,preparation techniques,stability,as well as the strategy to discriminate the anisotropic characteristics of 2D ***,the recent advanced applications including electronic devices,optoelectronic devices,thermoelectric devices and nanomechanical devices based on the anisotropic 2D materials both in experiment and theory have been ***,the current challenges and prospects in device designs,integration,mechanical analysis,and micro-/nano-fabrication techniques related to anisotropic 2D materials have been *** review is aimed to give a generalized knowledge of anisotropic 2D materials and their current devices applications,and thus inspiring the exploration and development of other kinds of new anisotropic 2D materials and various novel device applications.

关键词： two-dimensional(2D)materials low-symmetry anisotropic properties black phosphorus device applications

Two‑Dimensional Platinum Diselenide:Synthesis,Emerging Applications,and Future Challenges

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Nano-Micro Letters 2020年第12期12卷 194-227页

作者： Youning Gong Zhitao Lin Yue‑Xing Chen Qasim Khan Cong Wang Bin Zhang guohui nie Ni Xie Delong Li Institute of Microscale Optoelectronics College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Faculty of Information Technology Macao University of Science and TechnologyMacao 519020People’s Republic of China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooONCanada Otolaryngology Department and Biobank of the First Affiliated Hospital Shenzhen Second People’s HospitalHealth Science CenterShenzhen UniversityShenzhen 518060People’s Republic of China

In recent years,emerging two-dimensional(2D)platinum diselenide(PtSe2)has quickly attracted the attention of the research community due to its novel physical and chemical *** the past few years,increasing research achievements on 2D PtSe2 have been reported toward the fundamental science and various potential applications of *** this review,the properties and structure characteristics of 2D PtSe2 are discussed at ***,the recent advances in synthesis of PtSe2 as well as their applications are *** last,potential perspectives in exploring the application of 2D PtSe2 are reviewed.

关键词： Platinum diselenide Two-dimensional materials Photodetector Photocatalytic Photoelectric

Inhibition of histone methyltransferase PRMT5 attenuates cisplatininduced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

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Journal of Pharmaceutical Analysis 2023年第6期13卷 590-602页

作者： Zhiwei Zheng Benyu Nan Chang Liu Dongmei Tang Wen Li Liping Zhao guohui nie Yingzi He ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceNHC Key Laboratory of Hearing Medicine(Fudan University)Fudan UniversityShanghai200031China Department of Otorhinolaryngology-Head and Neck Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou325000ZhejiangChina Department of Otolaryngology-Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou510630China Department of Otolaryngology Shenzhen Institute of Translational MedicineShenzhen Second People's HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen518035GuangdongChina

This study aimed to evaluate the therapeutic potential of inhibiting protein arginine methyltransferase 5(PRMT5)in cisplatin-induced hearing *** effects of PRMT5 inhibition on cisplatin-induced auditory injury were determined using immunohistochemistry,apoptosis assays,and auditory brainstem *** mechanism of PRMT5 inhibition on hair cell survival was assessed using RNA-seq and Cleavage Under Targets and Tagment-quantitative polymerase chain reaction(CUT&Tag-qPCR)analyses in the HEI-OC1 cell *** inhibition of PRMT5 significantly alleviated cisplatin-induced damage to hair cells and spiral ganglion neurons in the cochlea and decreased apoptosis by protecting mitochondrial function and preventing the accumulation of reactive oxygen ***&Tag-qPCR analysis demonstrated that inhibition of PRMT5 in HEI-OC1 cells reduced the accumulation of H4R3me2s/H3R8me2s marks at the promoter region of the Pik3ca gene,thus activating the expression of *** findings suggest that PRMT5 inhibitors have strong potential as agents against cisplatininduced ototoxicity and can lay the foundation for further research on treatment strategies of hearing loss.

关键词： Protein arginine methyltransferase 5 (PRMT5) LLY-283 Cisplatin Hearing loss Hair cell Spiral ganglion neuron

Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme

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Nano Research 2024年第3期17卷 1827-1836页

作者： Daji Wang Jie Wang Dan Liu Jiuyang He Meiying Wang Haibing Huang guohui nie Hui Ding Xiyun Yan Nanozyme Synthesis Center Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China Shenzhen Key Laboratory of nanozymes and Translational Cancer Research Department of Otolaryngologyand Shenzhen Institute of Translational MedicineShenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Rheumatology and Immunology Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518055China

The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively *** continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early *** this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural *** peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol *** integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting ***,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC *** sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ***,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection *** conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of *** innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.

关键词： iron-porphyrin single-atom nanozyme(SANzyme) chemiluminescence strips Epstein-Barr virus(EBV) nasopharyngeal carcinoma(NPC) antibody detection

Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses

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Science China(Life Sciences) 2021年第3期64卷 352-362页

作者： Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie guohui nie Xiyun Yan Minmin Liang Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Institute of Post-transcriptional Medicine Shenzhen Second People’s HospitalThe First Affiliatied Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518035China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative *** ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable *** ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton ***,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative *** expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional *** mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal *** ferritins are heteropolymers assembled by H-and L-chains in different *** mitochondrial ferritins are homopolymers and distributed in restricted *** play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are *** ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement *** review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein.

关键词： ferritin iron homeostasis oxidative responses antioxidant Fenton reaction

A natural nanozyme in life is found:the iron core within ferritin shows superoxide dismutase catalytic activity

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Science China(Life Sciences) 2021年第8期64卷 1375-1378页

作者： Jianlin Zhang Shimin Li Ni Xie guohui nie Aifa Tang Xian-En Zhang Minmin Liang Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute of Translational Medicine Shenzhen Second People's HospitalThe First Affiliation Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518035China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shenzhen Luohu Hospital Group The 3rd Affiliated Hospital of Shenzhen UniversityShenzhen 518001China Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

Nanozymes are nanomaterials exhibiting intrinsic enzymatic properties,which suggests that inorganic nanoparticles could be ***’s in 2007,when we introduced the biological methodologies for natural enzymes to systematically study the enzymatic properties of iron oxide nanoparticles,we discovered *** found that nanozymes,just as natural enzymes,are able to catalyze biochemical reactions under the physiological conditions,following the similar enzymatic kinetics and catalytic mechanisms(Gao et al.,2007).Since then,the developments of nanozymes bloomed,and lots of nanomaterials were found exhibiting various enzymatic activities(Huang et ah,2019).

关键词： enzymatic catalytic kinetics

Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

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Light(Science & Applications) 2020年第1期9卷 479-493页

作者： Zhongjian Xie Minhua Peng Ruitao Lu Xiangying Meng Weiyuan Liang Zhongjun Li Meng Qiu Bin Zhang guohui nie Ni Xie Han Zhang Paras N.Prasad Shenzhen International Institute for Biomedical Research Shenzhen 518116 GuangdongPR China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055 GuangdongPR China School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436 GuangdongPR China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Institute of Microscale Optoelectronicsand Otolaryngology Department and Biobank of the First Affiliated HospitalShenzhen Second People’s HospitalHealth Science CenterShenzhen UniversityShenzhen 518060PR China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100PR China Department of Chemistry Institute for LasersPhotonicsand BiophotonicsUniversity at BuffaloStateUniversity of New YorkBuffaloNYUSA

Here,we describe a combination strategy of black phosphorus(BP)-based photothermal therapy together with anti-CD47 antibody(aCD47)-based immunotherapy to synergistically enhance cancer *** resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance,along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment,remains a significant challenge for cancer ***47,an agent for CD47/SIRPαaxis blockade,induces modest phagocytic activity and a low response rate for monotherapy,resulting in failures in clinical *** showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation,improving the inherently poor immunogenicity of tumours,which is particularly useful for enhancing cancer *** in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses,thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic *** combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy.

关键词： immunotherapy cancer mediated

Two-Dimensional Borophene:Properties,Fabrication,and Promising Applications

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Research 2020年第1期2020卷 412-434页

作者： Zhongjian Xie Xiangying Meng Xiangnan Li Weiyuan Liang Weichun Huang Keqiang Chen Jianming Chen Chenyang Xing Meng Qiu Bin Zhang guohui nie Ni Xie Xiaobing Yan Han Zhang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Institute of Microscale Optoelectronics and Otolaryngology Department and Biobank of the First Affiliated HospitalShenzhen Second People’s HospitalHealth Science CenterShenzhen UniversityShenzhen 518060China Shenzhen International Institute for Biomedical Research 518116 ShenzhenGuangdongChina National-Local Joint Engineering Laboratory of New Energy Photovoltaic Devices Key Laboratory of Digital Medical Engineering of Hebei ProvinceCollege of Electron and Information EngineeringHebei UniversityBaoding 071002China Nantong Key Lab of Intelligent and New Energy Materials College of Chemistry and Chemical EngineeringNantong UniversityNantong226019 JiangsuChina Center for Stretchable Electronics and Nanoscale Systems Key Laboratory of Optoelectronic Devices and Systems of Ministry of EducationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China

Monoelemental two-dimensional(2D)materials(Xenes)aroused a tremendous attention in 2D science owing to their unique properties and extensive ***,one emerging and typical Xene,has been regarded as a promising agent for energy,sensor,and biomedical ***,the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical *** this review,we describe its excellent properties including the optical,electronic,metallic,semiconducting,photoacoustic,and photothermal *** fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down *** the end,the challenges of borophene in the latest applications are presented and perspectives are discussed.

关键词： properties boron Bor