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Brain development in newborns and infants after ECMO

World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan lu-Kun Tang Fei-Fan Xiao Peng Zhang guo-Qiang Cheng Lai-Shuan Wang Chun-Mei lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng Zhou Tian-Tian Xiao Yan Xu Zhao-Qing Yin Gang-Feng Yan guo-ping lu Qi Li Wen-Hao Zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

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Simultaneous nitrogen and phosphor removal in an aerobic submerged membrane bioreactor

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Journal of Environmental Sciences 2006年第3期18卷 439-445页

作者： WANG Zhi-wei WU Zhi-chao GU guo-wei YU guo-ping MA lu-ming State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and Engineering Tongji University Shanghai200092 China.

Simultaneous nitrification and denitrification （SND） effect and phosphor removal were investigated in a one-staged aerobic submerged membrane bioreactor on pilot-scale with mixed liquor suspended solids （MLSS） 19--20 g/L. The effects of DO concentration, sludge floc size distribution on SND were studied. Test results suggested that SND was successfully performed in the membrane bioreactor （MBR） and about 70% total nitrogen removal efficiency was achieved when DO concentration was set to 0.2-- 0.3 mg/L. The main mechanisms governing SND were the suitable sludge floc size and the low DO concentration which was caused by low oxygen transfer rate with such a high MLSS concentration in the MBR. In the meantime, phosphor removal was also studied with polymer ferric sulfate （PFS） addition and 14 mg/L dosage of PFS was proper for the MBR to remove phosphor. PFS addition also benefited the MBR operation owing to its reduction of extracellular polymer substances （EPS） of mixed liquor.

关键词： membrane bioreactor (MBR) flat-sheet membrane simultaneous nitrification and denitrifiction (SND) phosphorremoval wastewater treatment oxygen transfer rate

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The synergistic catalysis on Co nanoparticles and CoNx sites of aniline-modified ZIF derived Co@NCs for oxidative esterification of HMF

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Chinese Chemical Letters 2021年第2期32卷 685-690页

作者： Tao Rui guo-ping lu Xin Zhao Xun Cao Zhong Chen School of Chemical Engineering Nanjing University of Science&TechnologyNanjing 210094China School of Materials Science&Engineering Nanyang Technological UniversitySingapore 639798Singapore

An efficient sustainable and scalable strategy for the synthesis of porous cobalt/nitrogen co-doped carbons(Co@NCs) via pyrolysis of aniline-modified ZIFs,has been *** can coordinate and absorb on the surface of ZIF(ZIF-CoZn3-PhA),accelerate the precipitation of ZIFs,thus resulting in smaller ZIF particle ***,the aniline on the surface of ZIF-CoZn3-PhA promotes the formation of the protective carbon shell and smaller Co nanoparticles,and increases nitrogen content of the *** of these prope rties of Co@NC-PhA-3,the oxidative esterification of 5-hydroxymethylfurfural can be carried out under ambient *** to our experimental and computational results,a synergistic catalytic effect between CoNx sites and Co nanoparticles has been established,in which both Co nanoparticles and CoNx can activate O2 while Co nanoparticles bind and oxidize ***,the formation and release of active oxygen species in CoNx sites are reinfo rced by the electronic interaction between Co nanoparticles and CoNx.

关键词： Aniline-modified ZIF Porous cobalt/nitrogen co-doped carbon Synergistic catalysis on CoNx sites and Co nanoparticles Oxidative esterification 5-Hydroxymethylfurfural

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Lignin-derived Zn single atom/N-codoped porous carbon forα-alkylation of aromatic ketones with alcohols via borrowing hydrogen strategy

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Nano Research 2022年第3期15卷 1874-1881页

作者： Xueping Zhang guo-ping lu Kun Wang Yamei Lin Pengcheng Wang Wenbin Yi School of Chemistry and Chemical Engineering Nanjing University of Science&TechnologyXiaolingwei 200Nanjing 210094China School of Pharmaceutical Sciences Wenzhou Medical CollegeUniversity TownChashanWenzhou 325035China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityWenyuanstreet 200Nanjing 210032China

A green and scalable strategy has been developed for the synthesis of lignin-derived Zn single atom/N-codoped porous carbon(LCN@Zn-SAC)containing similar ZnNx sites with carbonic *** catalyst exhibits superior activity on theα-alkylation of ketones with alcohols via borrowing hydrogen strategy(TON up to 15 h^(−1))than most of previously reported *** dehydrogenation of benzyl alcohol is the rate-determining step based on kinetic experiment *** to experimental and theoretical calculation results,Zn electron density is inversely proportional to reaction energy barriers,because Zn sites with less positive charge(ZnN_(4) and ZnN_(3)C)in Zn-SACs display better borrowing hydrogen ability than other Zn ***,this catalyst can be recycled by simple centrifugation,which can be reused at least 8 runs with no obvious lose in *** the best of our knowledge,this is the first example of non-noble metal-SAC-catalyzedα-alkylation via borrowing hydrogen strategy.

关键词： lignin zinc single atom catalyst N-doped porous carbon α-alkylation borrowing hydrogen

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Deuterated N-difluoromethylthiophthalimide:A stable,scalable reagent for radical and electrophilic deuteriodifluoromethylthiolations

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Chinese Chemical Letters 2022年第9期33卷 4293-4297页

作者： Chunyang Hu Fangming Chen guo-ping lu Wen-Bin Yi School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Organofluorine Chemistry Shanghai Institute Organic ChemistryChinese Academy of SciencesShanghai 200032China

A new,stable and scalable reagent for deuteriodifluoromethylthiolation(deuterated N-difluoromethylthiophthalimide,PhthSCF_(2)D)has been *** reagent can be applied for the photocatalytic radical deuteriodifluoromethylthiolation of various olefins and aldehydes(30 examples).Meanwhile,it can achieve the electrophilic deuteriodifluoromethylthiolation of a series of electrophilic substrates including electron-rich arenes,aryl/vinylboronicacids,alkynes,amines,thiols andβ-ketoesters(22 examples).Some complex molecules can also be applied in both radical and electrophilic deuteriodifluoromethylthiolation using PhthSCF_(2)D as the reagent.

关键词： Deuteration Deuteriodifluoromethylthiolation Photocatalytic Electrophilic Radical

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Carbohydrate-derived porous carbon materials:An ideal platform for green organic synthesis

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Chinese Chemical Letters 2022年第1期33卷 186-196页

作者： Yamei Lin Jie Yu Xing Zhang Jingkun Fang guo-ping lu He Huang School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210023China School of Pharmaceutical Sciences Nanjing Tech UniversityNanjing 210009China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

Porous carbon materials have attracted much attention in the field of organic synthesis in recent years,due to their tunable properties,excellent catalytic activity and ***-based carbohydrates emerge as an ideal precursor for the generation of these materials owing to their renewability,low cost,non-toxicity and high content of functional ***,carbon materials prepared from carbohydrates is of considerable importance for the sustainable development of organic *** present review not only summarizes recent examples of carbohydrate-derived porous carbon material-catalyzed organic reactions including the oxidation,hydrogenation,cross-coupling,esterification and condensation reactions,but also introduces the preparation and functionalization strategies of these ***,the challenges and opportunities of organic synthesis over these sustainable materials have also been *** review will stimulate further research on exploring novel carbohydrate-derived porous carbon materials and new sustainable organic synthetic processes over these materials.

关键词： Carbohydrates Carbon materials Green chemistry Catalysis Organic synthesis

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World Journal of Clinical Cases 2021年第13期9卷 3070-3078页

作者： Qiao-Feng Ye Guang-Fei Wang Yi-Xue Wang guo-ping lu Zhi-ping Li Department of Clinical Pharmacy National Children's Medical CenterChildren's Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Intensive Care Unit National Children's Medical CenterChildren's Hospital of Fudan UniversityShanghai 201102China

BACKGROUND Vancomycin is often used as an anti-infective drug in patients receiving antitumor *** are concerns about its adverse drug reactions during treatment,such as nephrotoxicity,ototoxicity,hypersensitivity reactions,***,potential convulsion related to high plasma concentrations of vancomycin in children receiving chemotherapy has not been *** SUMMARY A 3.9-year-old pediatric patient with neuroblastoma receiving vancomycin to treat post-chemotherapy infection developed an unexpected *** other potential disease conditions could explain the occurrence of the *** subsequently measured overly high plasma concentrations of vancomycin could possibly provide a clue to the occurrence of this *** peak and trough plasma concentrations of vancomycin were 59.5 mg/L and 38.6 mg/L,respectively,which were much higher than the safe *** with the Bayesian approach using MwPharm software showed that the area under the concentration-time curve over 24 h was 1086.6 mg·h/***,vancomycin was immediately stopped and teicoplanin was administered instead combined with meropenem and fluconazole as the anti-infective treatment *** Unexpected convulsion occurring in a patient after chemotherapy is probably due to toxicity caused by abnormal pharmacokinetics of *** evaluation and close therapeutic drug monitoring should be conducted to determine the underlying etiology and to take the necessary action as soon as possible.

关键词： Vancomycin Neuroblastoma Convulsion Children Adverse drug reaction Case report

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2016 Chinese guidelines for the management of dyslipidemia in adults

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Journal of Geriatric Cardiology 2018年第1期15卷 1-29页

作者： Jun-Ren ZHU Run-Lin GAO Shui-ping ZHAO guo-ping lu Dong ZHAO Jian-Jun LI Joint committee for guideline revision

Abbreviations ACS： acute coronary syndrome ALT： alanine aminotransferase Apo： apolipoprotein ASCVD： atherosclerotic cardiovascular disease AST： aspartate aminotransferase

关键词： Adults Chinese guidelines Dyslipidemia

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Establishment of a Rat Model of Capillary Leakage Syndrome Induced by Cardiopulmonary Resuscitation After Cardiac Arrest

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当代医学科学(英文) 2023年第4期43卷 708-715页

作者： Xiao-lei ZHANG Ye CHENG Chun-lin XING Jia-yun YING Xue YANG Xiao-di CAI guo-ping lu Department of Pediatric Emergency Medicine and Critical Care Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Critical Care Medicine Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Objective:Cardiopulmonary resuscitation(CPR)after cardiac arrest(CA)is one of the main causes of capillary leakage syndrome(CLS).This study aimed to establish a stable CLS model following the CA and cardiopulmonary resuscitation(CA-CPR)model in Sprague-Dawley(SD)***:We conducted a prospective,randomized,animal model *** adult male SD rats were randomly divided into a normal group(group N),a sham operation group(group S),and a cardiopulmonary resuscitation group(group T).The SD rats of the three groups were all inserted with 24-G needles through their left femoral arteries and right femoral *** group S and group T,the endotracheal tube was *** group T,CA induced by asphyxia(AACA)was caused by vecuronium bromide with the endotracheal tube obstructed for 8 min,and the rats were resuscitated with manual chest compression and mechanical *** and postresuscitation measurements,including basic vital signs(BVS),blood gas analysis(BG),routine complete blood count(CBC),wet-to-dry ratio of tissues(W/D),and the HE staining results after 6 h were ***:In group T,the success rate of the CA-CPR model was 60%(18/30),and CLS occurred in 26.6%(8/30)of the *** were no significant differences in the baseline characteristics,including BVS,BG,and CBC,among the three groups(P>0.05).Compared with pre-asphyxia,there were significant differences in BVS,CBC,and BG,including temperature,oxygen saturation(SpO_(2)),mean arterial pressure(MAP),central venous pressure(CVP),white blood cell count(WBC),hemoglobin,hematocrit,pH,pCO_(2),pO_(2),SO_(2),lactate(Lac),base excess(BE),and Na+(P<0.05)after the return of spontaneous circulation(ROSC)in group *** 6 h after ROSC in group T and at 6 h after surgery in groups N and S,there were significant differences in temperature,heart rate(HR),respiratory rate(RR),SpO_(2),MAP,CVP,WBC,pH,pCO_(2),Na+,and K+among the three groups(P<0.05).Compared with the other two groups,the rats in group

关键词： cardiac arrest cardiopulmonary resuscitation capillary leakage model

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2023 China Guidelines for Lipid Management

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老年心脏病学杂志:英文版 2023年第9期20卷 621-663页

作者： Jian-Jun LI Shui-ping ZHAO Dong ZHAO guo-ping lu Dao-Quan PENG Jing LIU Zhen-Yue CHEN Yuan-Lin guo Na-Qiong WU Sheng-Kai YAN Zeng-Wu WANG Run-Lin GAO National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical SciencesBeijingChina The Second Xiangya Hospital of Central South University ChangshaHunanChina Beijing Anzhen Hospital Capital Medical UniversityBeijingChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina Affiliated Hospital of Zunyi Medical University School of Laboratory Medicine of Zunyi Medical UniversityZunyiGuizhouChina

Atherosclerotic cardiovascular disease(ASCVD)is the leading cause of death among urban and rural residents in China,and elevated low-density lipoprotein cholesterol(LDL-C)is a risk factor for *** the increasing burden of ASCVD,lipid management is of the utmost *** recent years,research on blood lipids has made breakthroughs around the world,hence a revision of China guidelines for lipid management is imperative,especially since the target lipid levels in the general population vary in respect to the risk of *** level of LDL-C,which can be regarded as appropriate in a population without frisk factors,can be considered abnormal in people at high risk of developing *** a result,the“Guidelines for the prevention and treatment of dyslipidemia”were adapted into the“China Guidelines for Lipid Management”(henceforth referred to as the new guidelines)by an Experts’committee after careful *** new guidelines still recommend LDL-C as the primary target for lipid control,with CVD risk stratification to determine its target *** guidelines recommend that moderate intensity statin therapy in adjunct with a heart-healthy lifestyle,be used as an initial line of treatment,followed by cholesterol absorption inhibitors or/and proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors,as *** new guidelines provide guidance for lipid management across various age groups,from children to the *** aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by guiding clinical practice.

关键词： Lipid prevention hence

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