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Advancement in stroke research

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Stroke & Vascular Neurology 2019年第2期4卷 61-62页

作者： guo-yuan yang Neuroscience and Neuroengineering Center Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

Stroke is the second most common cause of death in the world especially in the ageing population.1 Thrombolysis and intravascular embolectomy are the main treatment and populated rapidly.23 However,the benefi-ciary is still limited because the mechanistic studies are *** basic research on stroke is improved because of new devices,novel techniques and the development of other disciplines.4 The update of a broad range of topics related to stroke is a widely appreciated *** order to improve the understanding of cellular and molecular mechanisms of stroke,the 2nd Summit of Chinese Basic Science Research on Stroke 2018 has been held in Beijing,China.

关键词： population. death intravascular

Deposition of TiN/TiAlN multilayers by plasma-activated EB-PVD:tailored microstructure by jumping beam technology

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Rare Metals 2017年第8期36卷 651-658页

作者： guo-yuan yang Hui Peng Hong-Bo guo Sheng-Kai Gong School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory for Advanced Functional Material and Thin Film Technology Beihang UniversityBeijing 100191China Key Laboratory of Aerospace Materials and Performance(Ministry of Education) Beihang UniversityBeijing 100191China

Plasma-activated electron beam-physical vapor deposition（EB-PVD）was used for depositing nitride multilayer coatings in this *** from the conventional coating methods,the multilayers were obtained by manipulating electron beam（EB）to jump between two different evaporation sources alternately with variable frequencies（jumping beam technology）.The plasma activation was generated by a hollow cathode plasma *** deposition process was demonstrated by means of tailoring TiN/TiAlN multilayers with different modulation periods（M1：26.5 nm,M2：80.0 nm,M3：6.0 nm,M4：4.0 nm）.The microstructure and hardness of the multilayer coatings were comparatively studied with TiN and TiAlN singlelayer *** columnar structure of the coatings（TiN,TiAlN,M1,M2）is replaced by a glassy-like microstructure when the modulation period decreases to less than 10 nm（M3,M4）.Simultaneously,superlattice growth *** the decrease of modulation period,both the hardness and the plastic deformation resistance（H^3/E^2,H-hardness and E-elastic modulus）increase.M4coating exhibits the maximum hardness of（49.6±2.7）GPa and the maximum plastic deformation resistance of^0.74 GPa.

关键词： Nano-multilayer coatings Superlattice Plasmaactivation TiN/TiAlN EB-PVD Hardness

Therapeutic application of exosomes in ischaemic stroke

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Stroke & Vascular Neurology 2021年第3期6卷 483-495页

作者： Yongfang Li Yaohui Tang guo-yuan yang Department of Neurology Ruijin HospitalSchool of medcineShanghai Jiao Tong UniversityShanghaiChina Neuroscience and Neuroengineering Center Medx Research InstituteShanghai Jiao Tong University School of Biomedical EngineeringShanghaiChina

Ischaemic stroke is a leading cause of long-term disability in the world,with limited effective *** evidence demonstrates that exosomes are involved in ischaemic pathology and exhibit restorative therapeutic effects by mediating cell–cell *** potential of exosome therapy for ischaemic stroke has been actively investigated in the past *** this review,we mainly discuss the current knowledge of therapeutic applications of exosomes from different cell types,different exosomal administration routes,and current advances of exosome tracking and targeting in ischaemic *** also briefly summarised the pathology of ischaemic stroke,exosome biogenesis,exosome profile changes after stroke as well as registered clinical trials of exosome-based therapy.

关键词： ischaemic pathology Therapeutic

Arterial stiffness and stroke:de-stiffening strategy,a therapeutic target for stroke

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Stroke & Vascular Neurology 2017年第2期2卷 65-72页

作者： Yajing Chen Fanxia Shen Jianrong Liu guo-yuan yang Department of Neurology Ruijin Hospital and Ruijin Hospital NorthShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Neuroscience and Neuroengineering Center Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

Stroke is the second leading cause of mortality and morbidity *** intervention is of great importance in reducing disease *** the conventional risk factors cannot fully account for the pathogenesis of stroke,it is extremely important to detect useful biomarkers of the vascular disorder for appropriate *** stiffness,a newly recognised reliable feature of arterial structure and function,is demonstrated to be associated with stroke onset and serve as an independent predictor of stroke incidence and poststroke functional *** this review article,different measurements of arterial stiffness,especially pressure wave velocity,were *** explained the association between arterial stiffness and stroke occurrence by discussing the secondary haemodynamic *** reviewed clinical data that support the prediction role of arterial stiffness on *** the lack of long-term randomised double-blind controlled therapeutic trials,it is high potential to reduce stroke prevalence through a significant reduction of arterial stiffness(which is called de-stiffening therapy).Pharmacological interventions or lifestyle modification that can influence blood pressure,arterial function or structure in either the short or long term are promising de-stiffening ***,we summarised different de-stiffening strategies including antihypertension drugs,antihyperlipidaemic agents,chemicals that target arterial remodelling and exercise *** and well-designed clinical trials on de-stiffening strategy are needed to testify the prevention effect for *** techniques such as modern microscopic imaging and reliable animal models would facilitate the mechanistic analyses in pathophysiology,pharmacology and therapeutics.

关键词： therapeutic prevention stiffness

Effect of ischaemic brain injury on sexual function in adult mice

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Stroke & Vascular Neurology 2016年第3期1卷 127-132页

作者： Yaohui Tang Falei yuan Beibei Cai Weiliang Xia Yongting Wang guo-yuan yang Neuroscience and Neuroengineering Center Med-X Research Institute Shanghai Jiao Tong UniversityShanghaiChina Shanghai Ruijin Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Objective:Priapism refers to a condition with persistent abnormal erection of the penis,which is usually caused by disease or injury in the brain or spinal cord,or obstruction to the outflow of blood through the dorsal vein at the root of the penis,without sexual *** effect of cerebral ischaemia on sexual function is *** aim of this study is to explore whether priapism occurs in adult ***,we examined the relationship between priapism and the region of infarct in the ***:Adult male CD-1 mice who underwent permanent middle cerebral artery occlusion(pMCAO)were closely examined from 2 hours to 14 days ***:We found that priapism occurs in∼80%of the mice with pMCAO,which could persist up to 14 *** study has demonstrated that the occurrence of priapism is related to the infarct region:priapism is found only in mice with ischaemic injury extending to the hypothalamus and the hippocampus ***:Our result suggested priapism may be used as a deep brain injury marker for evaluating brain injury in mice after pMCAO.

关键词： cerebral injury function

Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia

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Neuroscience Bulletin 2015年第5期31卷 550-560页

作者： Hongxia Cai Zhihao Mu Zhen Jiang Yongting Wang guo-yuan yang Zhijun Zhang Department of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Neuroscience and Neuroengineering Center Med-X Research Institute Shanghai Jiao Tong University

Matrix metalloproteinase-9（MMP-9） plays a beneficial role in the sub-acute phase after ischemic ***,unrestrained MMP-9 may disrupt the blood-brain barrier（BBB）,which has limited its use for the treatment of brain *** the present study,we constructed lentivirus mediated hypoxiacontrolled MMP-9 expression and explored its role after *** response element（HRE）was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery *** were injected into the peri-infarct area on day 7 after transient *** found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia,and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV ***,mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline,GFP,and SB-3CT ***,hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke.

关键词： blood-brain barrier hypoxia response element matrix metalloproteinase 9 stroke

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

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Frontiers of Medicine 2011年第1期5卷 86-93页

作者： Haiyan LU Yongting WANG Falei yuan Jianrong LIU Lili ZENG guo-yuan yang Neuroscience and Neuroengineering Research Center Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China Departments of Neurology Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China

Netrin-1(NT-1)is one of the axon-guiding molecules that are critical for neuronal *** of its structural homology to the endothelial mitogens,NT-1 may have similar effects on vascular network ***-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in *** the present study,we reported the delivery of NT-1 using an adeno-associated virus(AAV)vector(AAV-NT-1)into mouse brain followed by transient middle cerebral artery occlusion(tMCAO).We found that AAV vectors did not elicit a detectable inflammatory response,cell loss or neuronal damage after brain *** level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control ***,the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals(P<0.05)7 days after *** data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.

关键词： adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1

Surgical treatment and pathologic analysis of posterior lentiglobus with cataract

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International Journal of Ophthalmology(English edition) 2011年第5期4卷 572-574页

作者： guo-yuan yang Long-Qian Liu and Chun-Ling Liu Department of Ophthalmology West China Hospital of Sichuan University. Chengdu 610041 Sichuan Province China

Hybrid concurrency control protocol for data sharing among heterogeneous blockchains

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Frontiers of Computer Science 2024年第3期18卷 1-12页

作者： Tiezheng guo Zhiwei ZHANG Ye yuan Xiaochun yang guoren WANG School of Computer Science and Technology Beijing Institute of TechnologyBeijing 100029China School of Computer Science and Engineering Northeastern UniversityShenyang 110167China

With the development of information technology and cloud computing,data sharing has become an important part of scientific *** traditional data sharing,data is stored on a third-party storage platform,which causes the owner to lose control of the *** a result,there are issues of intentional data leakage and tampering by third parties,and the private information contained in the data may lead to more significant ***,data is frequently maintained on multiple storage platforms,posing significant hurdles in terms of enlisting multiple parties to engage in data sharing while maintaining *** this work,we propose a new architecture for applying blockchains to data sharing and achieve efficient and reliable data sharing among heterogeneous *** design a new data sharing transaction mechanism based on the system architecture to protect the security of the raw data and the processing *** also design and implement a hybrid concurrency control protocol to overcome issues caused by the large differences in blockchain performance in our system and to improve the success rate of data sharing *** took Ethereum and Hyperledger Fabric as examples to conduct crossblockchain data sharing *** results show that our system achieves data sharing across heterogeneous blockchains with reasonable performance and has high scalability.

关键词： data sharing blockchain concurrency control protocol crosschain