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The role of cholesterol metabolism in lung cancer

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Oncology Research 2024年第10期32卷 1613-1621页

作者： WEIGANG xiu XINGYU LIU KAIXIN HU QIN zhang HUASHAN SHI Department of Thoracic Oncology and State Key Laboratory of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengdu610041China West China School of Medicine Sichuan UniversityChengdu610041China Department of Postgraduate Students West China School of MedicineChengdu610041China Department of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengdu610041China

Elevated serum cholesterol metabolism is associated with a reduced risk of lung *** cholesterol metabolism is evident in both lung cancer patients and tumor *** tumor cell cholesterol uptake or biosynthesis pathways,through the modulation of receptors and enzymes such as liver X receptor and sterolregulatory element binding protein 2,effectively restrains lung tumor ***,promoting cholesterol excretion yields comparable *** metabolites,including oxysterols and isoprenoids,play a crucial role in regulating cholesterol metabolism within tumor cells,consequently impacting cancer *** lung cancer patients,both the cholesterol levels in the tumor microenvironment and within tumor cells significantly influence cell growth,proliferation,and *** effects of cholesterol metabolism are further mediated by the reprogramming of immune cells such as T cells,B cells,macrophages,myeloid-derived suppressor cells,among *** research is investigating drugs targeting cholesterol metabolism for clinical ***,targeting the cholesterol biosynthesis pathway,are widely employed in lung cancer treatment,either as standalone agents or in combination with other ***,drugs focusing on cholesterol transportation have shown promise as effective therapies for lung *** this review,we summarized current research regarding the rule of cholesterol metabolism and therapeutic advances in lung cancer.

关键词： Cholesterol metabolism Lung cancer Immune cells Targeted strategies

Energy Efficiency Maximization in Mobile Edge Computing Networks via IRS assisted UAV Communications

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1865-1884页

作者： Ying zhang Weiming Niu Supu xiu Guangchen Mu School of Electronic Information Engineering Henan Institute of TechnologyXinxiang453003China Houde College Henan Institute of TechnologyXinxiang453003China Department of Science Henan Institute of TechnologyXinxiang453003China

In this paper,we investigate the energy efficiency maximization for mobile edge computing(MEC)in intelligent reflecting surface(IRS)assisted unmanned aerial vehicle(UAV)*** particular,UAVcan collect the computing tasks of the terrestrial users and transmit the results back to them after *** jointly optimize the users’transmitted beamforming and uploading ratios,the phase shift matrix of IRS,and the UAV trajectory to improve the energy *** formulated optimization problem is highly non-convex and difficult to be solved ***,we decompose the original problem into three *** first propose the successive convex approximation(SCA)based method to design the beamforming of the users and the phase shift matrix of IRS,and apply the Lagrange dual method to obtain a closed-form expression of the uploading *** the trajectory optimization,we propose a block coordinate descent(BCD)based method to obtain a local optimal ***,we propose the alternating optimization(AO)based overall algorithmand analyzed its complexity to be equivalent or lower than existing *** results show the superiority of the proposedmethod compared with existing schemes in energy efficiency.

关键词： Mobile edge computing(MEC) unmanned aerial vehicle(UAV) intelligent reflecting surface(IRS) energy efficiency

Spherical Polyelectrolyte Brush Nanoreactor:Preparation of Hollow TiO_(2) Nanospheres and Characterization by Small Angle X-Ray Scattering

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Chinese Journal of Polymer Science 2024年第9期42卷 1393-1400,I0009页

作者： Yu-Hua zhang Zi-Yu zhang Xin Liu En-Guang Ma Jiang-Tao guo Li Li Xu-Hong guo State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai200237China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou253023China Institute of Bast Fiber Crops&Center of Southern Economic Crops Chinese Academy of Agricultural SciencesChangsha410205China

Titanium dioxide(TiO_(2))hollow nanoparticles present significant potential for photocatalytic applications while their straightforward preparation with precise structure control is still *** work reports the approach to preparing tunable hollow TiO_(2) nanospheres by utilization of spherical polyelectrolyte brushes(SPB)as nanoreactors and *** the preparation,the evolution of the structure was characterized by small angle X-ray scattering(SAXS),and in combination with dynamic light scattering and transmission electron *** formation of TiO_(2) shell within the brush(SPB@TiO_(2))is confirmed by the significant increase of the electron density,and its internal structure has been analyzed by fitting SAXS data,which can be influenced by Titanium precursors and ammonia *** calcining SPB@TiO_(2) in a muffle furnace,hollow TiO_(2) nanospheres are produced,and their transition to the anatase crystal form is triggered,as confirmed by X-ray diffraction *** the advantages of their hollow structure,these TiO_(2) nanospheres exhibit exceptional catalytic degradation efficiency of methylene blue(MB),tetracycline(TC),and 2,4-dichlorophenoxyacetic acid(2,4-D),and also demonstrate excellent recyclability.

关键词： Spherical polyelectrolyte brush Nanoreactor Hollow titanium dioxide X-ray scattering

Model moisture transport in oil-paper insulation of transformer:Theory and experiment

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High Voltage 2024年第4期9卷 879-887页

作者： Junjie Zhou Zhicheng Wu Yiran guo Rui zhang Wenbing Zhu Qiaogen zhang State Key Laboratory of Electric Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina State Grid Shandong Electric Power Research Institute JinanChina

The insulation performance of oil paper insulation is significantly affected by moisture such that monitoring moisture content is ***,it is difficult to obtain the moisture content accurately due to its dynamic change under multi physical *** the moisture transportation in oil paper insulation under multi physical fields becomes a vital method in solving the problem.A multi physical model describing moisture migration was proposed,which considered the effects of temperature on moisture in different existing states in oil-immersed paper(OIP).The temperature distribution formed a vapour pressure gradient to drive moisture migration and affected migration ***,experiments and simulations of moisture migration were performed,which showed that the experiments were in good agreement with *** results revealed that the temperature gradient caused uneven moisture distribution and the increased temperature reduced OIP moisture *** established model could fully characterise moisture migration under temperature gradient,which provided a theoretical reference for predicting the risk of partial dampness and evaluating insulation performance.

关键词： moisture insulation distribution

Conversion of a single-layer ANN to photonic SNN for pattern recognition

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Science China(Information Sciences) 2024年第1期67卷 261-270页

作者： Yanan HAN Shuiying XIANG Tianrui zhang Yahui zhang Xingxing guo Yuechun SHI State Key Laboratory of Integrated Service Networks State Key Discipline Laboratory of Wide Bandgap Semiconductor TechnologyXidian University Yongjiang Laboratory

This work presents a complete conversion scheme for photonic spiking neural networks(SNNs).We verified that the output of an artificial neural network(ANN) trained with the simulated optical activation function can be directly converted into the spike rate of a photonic spiking neuron *** reveal the feasibility of hardware implementation,we considered the effects of different bit precisions of data and weight,noise level,and bias current mismatch on the converted *** proposed scheme was evaluated using the Deterding vowel,IRIS,TIDIGITS,and MNIST datasets for pattern recognition,and achieved mean accuracies of 95.80%,98.67%,96.19%,and 92.33%,*** proposed scheme can convert an ANN into a photonic SNN with almost no precision loss,and the performance was comparable to that of an ANN trained with the rectified linear unit *** proposed scheme can enable the high-performance implementation of photonic SNNs.

关键词： photonic SNN conversion optical computing pattern recognition artificial neural network

Regulation of Ti(C,N)deposition on hot surface of refractory in blast furnace hearth

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Journal of Iron and Steel Research International 2024年第6期31卷 1423-1435页

作者： Jian Cao Cui Wang Jjan-liang zhang Ke-xin Jiao guo-hua zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Ti(C,N)concentration was found to be lower on the hearth sidewall of a blast furnace and increased gradually toward the bottom of the blast *** Ti(C,N)protective layer in a blast furnace is ***,the formation of a Ti(C,N)protective layer was promoted by studying the heterogeneous nucleation principle of titanium compounds on different substances and regulation measures for the deposition process of titanium compounds on refractories or *** lattice disregistry between the titanium compounds and the main components in the refractory or the main impurities in the protective layer was calculated using a two-dimensional disregistry equation to study the heterogeneous nucleation principle of titanium *** results revealed that in refractory materials,the heterogeneous nucleation of carbonitride is weak when C,SiO_(2),and Al_(2)O_(3) are used as heterogeneous nucleation substrates,and the heterogeneous nucleation of carbonitride is strong when TiO_(2) and SiC are used as heterogeneous nucleation *** nucleation phases,TiC,TiN,Ti(C_(0.3),N_(0.7)),and Ti(C_(0.5),N_(0.5))have similar heterogeneous nucleation ability in single component refractory,and the type of carbonitride has little effect on the lattice *** impurities in the protective layer as the substrate phases are not conducive to the heterogeneous nucleation of *** CaS was used as the substrate phase,the heterogeneous nucleation ability of carbonitride was the *** carbon and alumina were not conducive to the heterogeneous nucleation of carbonitride,but carbon was more unfavourable than alumina.

关键词： Ti(C,N) Lattice disregistry Lattice constant Heterogeneous nucleation Regulation measure

Hypoxic tumor microenvironment:Destroyer of natural killer cell function

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Chinese Journal of Cancer Research 2024年第2期36卷 138-150页

作者： Yongfei zhang Feifei guo Yufeng Wang Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

In recent years, immunotherapy has made remarkable progress in treating certain tumors and hematological malignancies. However, the efficacy of natural killer(NK) cells, which are an important subset of innate lymphocytes used in anticancer immunotherapy, remains limited. Hypoxia, a critical characteristic of the tumor microenvironment(TME), is involved in tumor development and resistance to radiotherapy, chemotherapy, and immunotherapy. Moreover, hypoxia contributes to the impairment of NK cell function and may be a significant factor that limits their therapeutic effects. Targeted hypoxia therapy has emerged as a promising research area for enhancing the efficacy of NK cell therapy. Therefore, understanding how the hypoxic TME influences NK cell function is crucial for improving antitumor treatment outcomes.

关键词： Hypoxia immunotherapy NK cell tumor microenvironment

Double-branch forgery image detection based on multi-scale feature fusion

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Optoelectronics Letters 2024年第5期20卷 307-312页

作者： zhang Hongying guo Chunxing WANG Xuyong College of Electronic Information and Automation Civil Aviation University of ChinaTianjin 300300China

Most of existing methods exhibit poor performance in detecting forged images due to the small size of tampered areas and the limited pixel difference between untampered and tampered regions. To alleviate the above problem, a double-branch tampered image detection based on multi-scale features is proposed. Firstly, we introduce a fusion module based on attention mechanism in the first branch to enhance the network's sensitivity towards tampered regions. Secondly, we construct a second branch specifically designed for detection, aiming to identify subtle differences between tampered and untampered areas by utilizing rich edge information from shallow features as guidance. Compared to the existing methods on the public benchmark datasets CASIA1.0, Columbia and NIST16, the values of F-score reached 0.766, 0.900 and 0.930 on those datasets, respectively. The experimental results show that our method could significantly improve the accuracy on detecting the tampered area.

关键词： branch image utilizing

Numerical Simulation of the Seismic Response of a Horizontal Storage Tank Based on a SPH-FEM Coupling Method

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1655-1678页

作者： Peilei Yan Endong guo HouliWu Liangchao zhang Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin150080China

A coupled numerical calculation method combining smooth particle hydrodynamics(SPH)and the finite element method(FEM)was implemented to investigate the seismic response of horizontal storage *** of a horizontal storage tank featuring a free liquid surface under seismic action was constructed using the SPH–FEM coupling *** stored liquid was discretized using SPH particles,while the tank and supports were discretized using the *** interaction between the stored liquid and the tank was simulated by using the meshless particle contact ***,the numerical simulation results were compared and analyzed against seismic simulation shaking table test data to validate the ***,a series of numerical models,considering different liquid storage volumes and seismic effects,were constructed to obtain time history data of base shear and top center displacement,which revealed the seismic performance of horizontal storage *** simulation results and experimental data showed good agreement,with an error rate of less than 18.85%.And this conformity signifies the rationality of the SPH-FEM coupling *** base shear and top center displacement values obtained by the coupled SPH-FEM method were only 53.3% to 69.1% of those calculated by the equivalent mass method employed in the current *** the stored liquid volume increased,the seismic response of the horizontal storage tank exhibited a gradual upward trend,with the seismic response increasing from 73% to 388% for every 35% increase in stored liquid *** maximum von Mises stress of the tank and the supports remained below the steel yield strength during the *** coupled SPH-FEM method holds certain advantages in studying the seismic problems of tanks with complex structural forms,particularly due to the representation of the flow field distribution during earthquakes by involving reservoir fluid participation.

关键词： SPH-FEM coupling method horizontal storage tank seismic response sloshing