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Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang Pan-quan Luo Zhi-Jian Wei A-Man Xu tao guo Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laboratory of Digestive Disease Hefei 230031Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230000Anhui ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor,long non-coding RNA and microRNA(miRNA)are important regulators that affect tumor proliferation,metastasis and chemotherapy resistance,and thus participate in tumor ***19 is a new bio-marker which can promote tumor invasion and ***,the mechanism by which CASC19 affects the progression of GC through miRNA is not *** To explore the role of the CASC19/miR-491-5p/HMGA2 regulatory axis in *** To explore the expression and prognosis of CASC19 in GC through clinical samples,and investigate the effects of inhibiting CASC19 on the proliferation,migration,invasion and other functions of GC cells through cell counting Kit-8(CCK-8),ethynyldeoxyuridine,Wound healing assay,Transwell,Western blot and flow cytometry *** effect of miR-491-5p and HMGA2 in GC were also *** regulatory relationship between CASC19 and miR-491-5p,miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transcription *** CCK-8,Transwell,Wound healing assay,flow cytometry and animal experiments verify the role of CASC19/miR-491-5p/HMGA2 regulatory *** The expression level of CASC19 is related to the T stage,N stage,and tumor size of *** of the expression of CASC19 can inhibit the ability of proliferation,migration,invasion and EMT conversion of GC cells,and knocking down the expression of CASC19 can promote the apoptosis of GC *** the expression of miR-491-5p can inhibit the proliferation of GC cells,miR-491-5p mimics can inhibit EMT conversion,and promote the apoptosis of GC cells,while decreasing the expression of miR-491-5p can promote the proliferation and EMT conversion and inhibit the apoptosis of GC *** expression of HMGA2 in GC tissues is higher than that in adjacent *** the same time,the expression level of HMGA2 is related to the N and T stages of the *** the level of HMGA2 can pr

关键词： Gastric cancer Long non-coding RNA CASC19 miR-491-5p HMGA2 Prognosis

Mechanism analysis of foam penetration in EPB shield tunnelling with a focus on FER and soil particle size

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Underground Space 2024年第4期17卷 170-187页

作者： He Huang quan Sun tao Xu Wanhuan Zhou State Key Laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of MacaoMacao 999078China Department of Civil and Environmental Engineering University of MacaoMacao 999078China School of Transportation Southeast UniversityNanjing 210000China

Parameters of foam penetration in earth pressure balance(EPB)shield tunnelling,such as permeability coefficients and penetration distances,significantly impact tunnel face ***,existing studies have faced inaccuracies in analysing these parameters due to imitations in experimental *** study addresses this issue by employing enhanced methods for a more precise analysis of foam *** involving three distinct sand types(coarse,medium,and fine)and three foam expansion ratios(FER)(10,15,and 20)are conducted using a modified model test *** from a novel computer vision-based method,the model test outcomes unveil two distinct foam penetration paths:liquid migration(L_(w))and bubble migration(L_(f)).Three penetration phases-namely,injection,blockage&drainage,and breakage—are identified based on L_(w)and L_(f)*** initial"injection"phase conforms to Darcy’s law and is amenable to mathematical *** foam with FER of 15 has the maximum viscosity and,hence the L_(f)and permeability in the penetration tests with FER of 15 are the lowest in the same *** bubble size distribution of foam with different FER shows minor ***,the characteristics of foam penetration vary due to the distinct particle size distribution(PSD)of different *** penetration creates low-permeability layers in both medium and fine sands due to the larger bubble size of the foam compared to the estimated pore sizes of medium and fine *** the coarse sand results in a different situation due to its large pore *** distinctive characteristics of foam penetration in different sand strata are notably shaped by FER,PSD,and pore size *** insights shed light on the complex interactions during foam penetration at the tunnel face,contributing valuable knowledge to EPB shield tunnelling practices.

关键词： EPB Soil conditioning Foam penetration Permeability Tunnel face

Revealing the role of calcium ion intercalation of hydrated vanadium oxides for aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 9-19,I0001页

作者： tao Zhou Xuan Du guo Gao Key Laboratory for Thin Film and Micro Fabrication of the Ministry of Education School of Sensing Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Exploring suitable high-capacity V_(2)O_(5)-based cathode materials is essential for the rapid advancement of aqueous zinc ion batteries(ZIBs).However,the typical problem of slow Zn^(2+)diffusion kinetics has severely limited the feasibility of such *** this work,unique hydrated vanadates(CaVO,BaVO)were obtained by intercalation of Ca^(2+)or Ba^(2+)into hydrated vanadium *** the CaVO//Zn and BaVO//Zn batteries systems,the former delivered up to a 489.8 mAh g^(-1)discharge specific capacity at 0.1 A g^(-1).Moreover,the remarkable energy density of 370.07 Wh kg^(-1)and favorable cycling stability yard outperform BaVO,pure V_(2)O_(5),and many reported cathodes of similar ionic intercalation *** addition,pseudocapacitance analysis,galvanostatic intermittent titration(GITT)tests,and Trasatti analysis revealed the high capacitance contribution and Zn^(2+)diffusion coefficient of CaVO,while an in-depth investigation based on EIS elucidated the reasons for the better electrochemical performance of ***,ex-situ XRD,XPS,and TEM tests further demonstrated the Zn^(2+)insertion/extraction and Zn-storage mechanism that occurred during the cycle in the CaVO//Zn battery *** work provides new insights into the intercalation of similar divalent cations in vanadium oxides and offers new solutions for designing cathodes for high-capacity aqueous ZIBs.

关键词： Aqueous zinc ion batteries Cathode materials Ion pre-intercalation Vanadium oxides Energy storage mechanism

The electroweak monopole–antimonopole pair in the standard model

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Communications in Theoretical Physics 2024年第3期76卷 113-119页

作者： Dan Zhu Khai-Ming Wong guo-quan Wong School of Physics Universiti Sains Malaysia11800 USMPenangMalaysia

We present the first numerical solution that corresponds to a pair of Cho–Maison monopoles and antimonopoles(MAPs) in the SU(2) × U(1) Weinberg–Salam(WS) *** monopoles are finitely separated,while each pole carries a magnetic charge ±4π/*** positive pole is situated in the upper hemisphere,whereas the negative pole is in the lower *** Cho–Maison MAP is investigated for a range of Weinberg angles,0.4675≤ tan θ_(W)≤10,and Higgs self-coupling,0 ≤ β ≤ *** magnetic dipole moment(μm) and pole separation(d_(z)) of the numerical solutions are calculated and *** total energy of the system,however,is infinite due to point singularities at the locations of monopoles.

关键词： magnetic monopole Cho-Maison monopole Weinberg-Salam model

The nitrogen transformation behavior based on the pyrolysis products of wheat straw

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Chinese Journal of Chemical Engineering 2024年第7期71卷 58-65页

作者： Shun guo Yunfei Li Shengwei Tang tao Zhang School of Chemical Engineering Sichuan UniversityChengdu 610065China

In order to provide basic design parameters for the industrial pyrolysis process,the transformation behavior of nitrogen was investigated using wheat straw as raw *** distributions of nitrogen in pyrolysis char,oil,and gas were obtained and the nitrogenous components in the products were analyzed systematically by X-ray photoelectron spectroscopy(XPS),pyrolysis-gas chromatography/mass spectrometry(Py-GC/MS)and thermogravimetric-Fourier transform infrared spectrometry(TG-FTIR).The nitrogen distribution ranges of the pyrolysis char,oil,and gas were 37.34%–54.82%,32.87%–40.94%and 10.20%–28.83%,*** nitrogen was retained in char at lower pyrolysis temperature and the nitrogen distribution of oil was from rise to decline with increasing *** most abundant N-containing compounds in three-phase products were pyrrole-N,amines,and HCN,*** addition,the transformation mechanism of nitrogen from wheat straw to pyrolysis products was concluded.

关键词： Pyrolysis Nitrogen transformation Wheat straw Py-GC/MS TG-FTIR

Improving benzene catalytic oxidation on Ag/Co_(3)O_(4) by regulating the chemical states of Co and Ag

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Journal of Environmental Sciences 2024年第9期143卷 201-212页

作者： Hao guo tao guo Mengqi Zhao Yaxin Zhang Wenfeng Shangguan Yinnian Liao State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources Xinjiang UniversityXinjiang 830017China Xinjiang Key Laboratory of Coal Clean Conversion&Chemical Engineering Process Xinjiang UniversityXinjiang 830017China School of Chemical Engineering and Technology Xinjiang UniversityXinjiang 830017China Research Center for Combustion and Environmental Technology Shanghai Jiao Tong UniversityShanghai 200240China School of Applied Chemistry and Materials Zhuhai College of Science and TechnologyGuangdong 519041China

Silver(9 wt.%)was loaded on Co_(3)O_(4)-nanofiber using reduction and impregnation methods,*** to the stronger electronegativity of silver,the ratios of surface Co^(3+)/Co^(2+) on Ag/Co_(3)O_(4) were higher than on Co_(3)O_(4),which further led to more adsorbed oxygen species as a result of the charge ***,the introducing of silver also obviously improved the reducibility of Co_(3)O_(4).Hence the Ag/Co_(3)O_(4) showed better catalytic performance than Co_(3)O_(4) in benzene *** with the Ag/Co_(3)O_(4) synthesized via impregnation method,the one prepared using reduction method(named as Ag Co-R)exhibited higher contents of surface Co^(3+) and adsorbed oxygen species,stronger reducibility,as well as more active surface lattice oxygen ***,Ag Co-R showed lowest T_(90) value of 183℃,admirable catalytic stability,largest normalized reaction rate of1.36×10^(-4)mol/(h·m^(2))(150℃),and lowest apparent activation energy(E_(a))of 63.2 kJ/*** analyzing of in-situ DRIFTS indicated benzene molecules were successively oxidized to phenol,o-benzoquinone,small molecular intermediates,and finally to CO_(2) and water on the surface of Ag *** last,potential reaction pathways including five detailed steps were proposed.

关键词： Reduction method Co_(3)O_(4)-supported Ag catalyst,VOCs Benzene oxidation Reaction mechanism

Molecular investigation into the transformation of recalcitrant dissolved organic sulfur in refinery sour water during stripping process

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Petroleum Science 2024年第3期21卷 2112-2119页

作者： Yu-guo Li Chen He Chun-Mao Chen Fan Liu quan Shi State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China State Key Laboratory of Coal Mining and Clean Utilization Beijing 100013China PetroChina Ningxia Petrochemical Company Yinchuan 750021NingxiaChina

Refinery sour water primarily originates from the tops of towers in various units and coker condensate,and cannot be discharged directly to a wastewater treatment plant due to high levels of chemical oxygen demand(COD)and organic sulfur *** after the recovery of H_(2)S from the sour water by the stripping process,the effluent still contains a high concentration of dissolved organic sulfur(DOS),which can have a huge bad *** chemical composition of dissolved organic matter(DOM)in refinery wastewater has been extensively studied,the investigation of recalcitrant DOS from sour waters remains *** the present study,chemical composition of sour water DOMs(especially DOS)was investigated using fluorescence spectroscopy(excitation-emission matrix,EEM)and mass spectrometry,including gas chromatography-mass spectrometry(GC-MS)and high-resolution Orbitrap *** GC-MS and EEM results showed that volatile and low-aromaticity compounds were effectively removed during the stripping process,while compounds with high hydrophilicity and humification degree were found to be more *** Orbitrap MS results showed that weak-polar oxygenated sulfur compounds were easier to be removed than oxygenated ***,the effluent still contained significant amounts of sulfur-containing compounds with multiple sulfur atoms,particularly in the form of highly unsaturated and aromatic *** Orbitrap MS/MS results of CHOS-containing compounds from the effluent indicate that the sulfur atoms may exist as sulfonates,disulfide bonds,*** the composition and structure of sour water DOS is crucial for the development of effective treatment processes that can target polysulfide compounds and minimize their impact on the environment.

关键词： Molecular transformation Dissolved organic sulfur Stripping process Refinery sourwater Orbitrap MS

Excavation compensation and bolt support for a deep mine drift

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3206-3220页

作者： Longji guo Zhigang tao Manchao He Massimo Coli State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing100083China School of Mechanics&Civil Engineering China University of Mining and Technology(Beijing)Beijing100083China Department of Earth Sciences University of FlorenceFirenze50121Italy

To overcome large deformation of deep phosphate rock roadways and pillar damage,a new type of constant-resistance large-deformation negative Poisson’s ratio(NPR)bolt that can withstand a high prestress of at least 130 KN was *** the conducted tests,the amount of deformation was 200-2000 mm,the breaking force reached 350 KN,and a high constant-resistance pre-stress was maintained during the deformation process.A stress compensation theory of phosphate rock excavation based on NPR bolts is proposed together with a balance system for bolt compensation of the time-space effect and high NPR *** split-set rock bolts are unable to maintain the stability of roadway roofs and *** verify the support effect of the proposed bolt,field tests were conducted using both the proposed NPR bolts and split-set rock bolts as support systems on the same mining *** addition,the stress compensation mechanism of roadway mining was simulated using the particle flow code in three dimensions(PFC^(3D))-fast Lagrangian analysis of continua(FLAC^(3D))particle-flow coupling numerical ***-site monitoring and numerical simulations showed that the NPR excavation compensation support scheme effectively improves the stress state of the bolts and reduces the deformation of the surrounding *** to the original support scheme,the final deformation of the surrounding rock was reduced by approximately 70%.These results significantly contribute to domestic and foreign research on phosphate-rock NPR compensation support technology,theoretical systems,and engineering practices,and further promote technological innovation in the phosphate rock mining industry.

关键词： Deep phosphate rock NPR bolt Split-set rock bolt PFC3D-FLAC3D Compensation support

Food poisoning due to money tree seeds:a case report of toxic encephalopathy

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Emergency and Critical Care Medicine 2024年第3期4卷 126-129页

作者： Yue Zhao Xiaojiao quan tao Wang Department of Emergency Medicine Hainan Hospital of Chinese PLA General HospitalSanyaHainanChina The Center of Heat Stroke Prevention and Treatment of Peoples’Liberation Army SanyaHainanChina

Background:The money tree is a favored indoor potted plant in *** seeds resemble chestnuts in both shape and flavor when cooked,which are generally considered non-toxic and safe for *** presentation:This report presents the first published case of food poisoning due to the ingestion of large amounts of money tree seeds.A 67-year-old man exhibited toxic encephalopathy symptoms and dyspnea after consuming the seeds for approximately 6 *** empirical mechanical ventilation,therapeutic plasma exchange,and other medical interventions,the patient’s clinical status improved *** was subsequently discharged from the ***:Consuming a substantial quantity of money tree seeds within a limited timeframe can lead to poisoning,resulting in adverse outcomes,particularly toxic ***,plasma exchange may have some therapeutic effect.

关键词： Case report Money tree Pachira macrocarpa Respiratory failure Toxic encephalopathy