Clinicopathologic significance of HER-2/neu protein expression and gene amplification in gastric carcinoma
Clinicopathologic significance of HER-2/neu protein expression and gene amplification in gastric carcinoma作者机构：Department of Gastroenterology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 China Department of General Surgery Huaian No.1 People's Hospital affiliated to Nanjing Medical University Huaian 223300 Jiangsu Province China Department of Pathology Cancer Hospital Fudan University Shanghai 200032 China Department of Pathology Institute of Traditional Chinese Medicine Nanjing 210029 Jiangsu Province China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2011年第17卷第11期
页 面：1501-1506页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：Supported by National Natural Science Foundation of China No.81071888
主 题：基因扩增 蛋白表达 胃癌 临床意义 荧光原位杂交 免疫组织化学 HER 肿瘤组织
摘 要：AIM:To study the HER-2/neu protein expression and gene amplification in gastric carcinoma and their ***:One hundred and forty-five formalin-fixed and paraffin-embedded tumor tissue samples from Chinese gastric carcinoma patients were studied with immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH)*** data about all patients were ***:The levels of HER-2 3+,HER-2 2+and HER21+were measurable in 6.9%,8.3%and 17.2%of the samples,*** HER-2 was stained in 67.6% of the *** showed that HER-2 gene was amplified in 18 samples,10 HER-2 3+samples,5 HER-2 2+samples,and 3 HER-2 1+samples with IHC ***-2 status was not correlated with the sex and age of patients,and tumor size,location or differentiation,but with the depth of invasion,TNM stage,lymph node and distant metastasis as well as histopathological classification of gastric cancer(P0.05).CONCLUSION:All samples with IHC as HER-2 expression should be analyzed with *** of HER-2 gene amplification can assess the malignant biological behaviors and prognosis of gastric cancer.
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