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Technetium-99m-sestamibi SPECT for the diagnosis andfollow-up of nasopharyngeal carcinoma

Frontiers of Medicine 2010年第1期4卷 96-100页

作者： Jing CHEN Guang-Yuan hu guo-qing hu hua WU Department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Nuclear Medicine Xiamen First HospitalFujian Medical UniversityXiamen 361003China

This study was to investigate a better way to detect and differentiate primary,residual,recurrent naso-pharyngeal carcinoma(NPC)lesions post-radiotherapy in patients with NPC by means of routine computed tomography(CT)in combination with 99Tcm-sestamibi single photon emission computed tomography(99Tcm-MIBI SPECT).Forty-eight patients with histologically conﬁrmed primary NPC underwent 99Tcm-MIBI SPECT at the 3rd month before and after radiotherapy,and at the 6th month after *** patients had contempora-neous CT *** results and/or clinical follow-up data(over 18 months)were used as the golden standard for evaluating residual/recurrent *** radioactive count ratio of nasopharynx to scalp was obtained as the MIBI uptake index(MUI).Receiver operating characteristic analysis was employed to deﬁne the cut-off value of MUI for *** MUI 2.15 as the cut-off point,the accuracy for detecting primary NPC was 94.12%.The mean MUI in the local-regional of the nasopharynx in such negative cases was 1.21�0.12 at the 3rd month,while the mean MUI was higher in the other 15 patients with histologically conﬁrmed recurrent/residual lesions(MUI=1.40�0.16,t=4.71,P<0.001).The optimal cut-off point of 1.33 of MUI was deﬁned with 89.58%accuracy for differentiating residual/recurrent lesions from the benign process post radiotherapy,while CT evaluations showed an accuracy of 81.25%.A combination of CT and 99Tcm-MIBI SPECT for 37 NPC patients with congruent results showed an accuracy of 97.30%for differentiating residual/recurrent NPC from benign lesions.99Tcm-MIBI SPECT plays a role in evaluating residual/recurrent lesions *** combination of CT and 99Tcm-MIBI SPECT can give more accurate diagnosis in the follow-up of NPC.

关键词： nasopharyngeal carcinoma diagnosis follow-up

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Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi guo Bin hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

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A novel chromatic dispersion 16/64-QAM system based on histogram monitoring technique for asynchronous amplitudehistogram

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Optoelectronics Letters 2013年第3期9卷 229-232页

作者： YAN Li-juan Zhu Bo LIU guo-qing hu Fang-ren Department of Optical Information Technology Nanjing University of Posts and Telecommunications Nanjing210046 China

A novel chromatic dispersion （CD） monitoring technique based on asynchronous amplitude histogram （AAH） for higher order modulation formats is proposed in this paper. Without demodulating the signal, in the monitoring scheme, the received signal is sampled asynchronously, and thus clock information and high-speed sampling units are unnecessary, resulting in low cost and high reliability. Simulations of CD monitoring technique for non-return-to-zero/return-to-zero （NRZ/RZ） 16- and 64-quadrature amplitude modulation （QAM） systems with different optical signal-to- noise ratios （OSNRs） and duty cycles are investigated, and the tolerance of the scheme is also discussed. Simulation results show that the presented CD monitoring technique with high sensitivity can be applied to monitor the residual CD of a transmission link in the next-generation optical networks.

关键词： QAM系统监测技术异步采样直方图色散正交幅度调制信号噪声比下一代光网络

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Global road traffic injury statistics:Challenges,mechanisms and solutions

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Chinese Journal of Traumatology 2020年第4期23卷 216-218页

作者： Fang-Rong Chang He-Lai huang David CSchwebel Alan HSChan guo-qing hu School of Traffic&Transportation Engineering Central South University ChangshaChina Department of System Engineering and Engineering Management The City University of Hong KongHong KongChina Department of Psychology College of Arts and SciencesUniversity of Alabama at BirminghamBirminghamALUSA Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha410078China

High-quality data are the foundation to monitor the progress and evaluate the effects of road traffic injury prevention ***,official road traffic injury statistics delivered by governments worldwide,are often believed somewhat unreliable and *** summarized the reported problems concerning the road traffic injury statistics through systematically searching and reviewing the *** problems include absence of regular data,under-reporting,low specificity,distorted cause spectrum of road traffic injury,inconsistency,inaccessibility,and delay of data *** also explored the mechanisms behind the problematic data and proposed the solutions to the addressed challenges for road traffic statistics.

关键词： Traffic injury data Reported problems Mechanisms behind the data

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Left-turning vehicle-pedestrian conflicts at signalized intersections with traffic lights: Benefit or harm? A two-stage study

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Chinese Journal of Traumatology 2019年第2期22卷 63-68页

作者： Yi-Ling He Ruo-Tong Li Li Li David C. Schwebel He-Lai huang qing-Yi Yin guo-qing hu School of Public Health Sun Yat-sen University Guangzhou 510080 China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South University Changsha 410078 China Department of Psychology College of Arts and Sciences. University of Alabama at Birmingham 1720 2nd Avenue South. HHB 560 Birmingham. AL. 35294 USA Urban Transport Research Center School of Traffic and Transportation Engineering Central South University Changsha 410075 China

Purpose: Vehicle-pedestrian conflicts are com mon at road intersections when traffic lights change. However, the impact of traffic light on transportation safety and efficiency remains poorly understood. Methods: A two-stage study was used to survey the proportion of intersections with conflicting traffic lights and the related transpoilation efficiency and safety were evaluated as well. First, a cross-sectional study estimated the proportion of signalized intersections with conflicting left-turning vehicle-pedestrian traffic lights in Changsha city, China. Second, a natural experiment compared transportation efficiency and safety between intersections w让h and without conflicting left-turning vehicle-pedestrian traffic lights. Risky conflicts, where motor vehicles violated laws and failed to yield to pedestrians in crosswalk were used as a surrogate for transpoilation safety. The number of motor vehicles and pedestrians passing through the intersections per second and per meter were used to estimate transportation efficiency. Data were collected and analyzed in 2015 (from March to December). A search of on line news from domestic media sources was also conducted to collect pedestrian injury data occurri ng at the intersections. Results: About one-fourth (57/216) intersections had conflicting left-turning traffic lights (95% Cl: 20.5%, 32.3%). Risky vehicle-pedestria n con flicts were more frequently observed at in tersections with conflicti ng lights compared to those without (incidenee rate ratio (IRR) 3.13;pedestrians: IRR = 4.02), after adjusting for type of day (weekday vs. weekend), the time period of observation, and motor vehicles traffic flow. Intersections without conflicting vehicle-pedestrian traffic lights had similar transportation efficiency to those with conflicting lights after controlling for covariates (p > 0.05). The systematic review of news media reports yielded 10 left-turning vehicle-pedestrian crash events between 2011 and 2017, involving 11

关键词： Traffic light Transportation efficiency Conflict Road safety Pedestrian

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结直肠癌干细胞的研究进展

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世界华人消化杂志 2016年第28期24卷 3953-3962页

作者：彭珊胡国清华中科技大学同济医学院附属同济医院肿瘤科湖北省武汉市430030

结直肠癌(colorectal cancer,CRC)是常见的消化系恶性肿瘤之一,其发生、发展及预后与肿瘤干细胞(cancer stem cells,CSCs)有着密切联系.CSCs是肿瘤中极小一部分具有无限自我更新、多向分化潜能和高度恶性的肿瘤细胞亚群,其已被证实存在... 详细信息

结直肠癌(colorectal cancer,CRC)是常见的消化系恶性肿瘤之一,其发生、发展及预后与肿瘤干细胞(cancer stem cells,CSCs)有着密切联系.CSCs是肿瘤中极小一部分具有无限自我更新、多向分化潜能和高度恶性的肿瘤细胞亚群,其已被证实存在于包括结肠癌在内的多种类型肿瘤中.CSCs赋予肿瘤转移、化学耐药和对微环境的持续适应能力.本文基于近年来国内外发表的CRC干细胞相关论文,就其表面标志物、生物学特性、信号通路及临床意义等方面进行综述.

关键词：结直肠癌结直肠癌干细胞肿瘤干细胞表面标志物生物学特性信号通路肿瘤转移靶向治疗

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异环磷酰胺氮芥卟啉二聚体的合成及生物活性

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高等学校化学学报 2011年第8期32卷 1761-1767页

作者：王志伟郭灿城田蜜郭琳孙腾飞郭清虎湖南大学化学化工学院长沙410082

以羟基取代卟啉为原料,通过控制反应过程中双卟啉磷酰氯的合成条件,采用一锅法合成了5个异环磷酰胺氮芥卟啉二聚体.所有化合物均经过MS、1H NMR、31P NMR和元素分析确定结构.细胞吸附实验和细胞毒性实验结果表明,异环磷酰胺氮芥卟啉二... 详细信息

以羟基取代卟啉为原料,通过控制反应过程中双卟啉磷酰氯的合成条件,采用一锅法合成了5个异环磷酰胺氮芥卟啉二聚体.所有化合物均经过MS、1H NMR、31P NMR和元素分析确定结构.细胞吸附实验和细胞毒性实验结果表明,异环磷酰胺氮芥卟啉二聚体可以选择性富集和杀死肿瘤细胞.利用荧光光谱研究了异环磷酰胺氮芥卟啉二聚体与牛血清白蛋白(BSA)的相互作用,结果表明卟啉二聚体对BSA的荧光有较强的静态猝灭作用,可以生成稳定的卟啉二聚体-BSA复合物.

关键词：卟啉二聚体异环磷酰胺氮芥细胞吸附牛血清白蛋白

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Road traffic injury mortality and morbidity by country development status, 2011- 2017

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Chinese Journal of Traumatology 2021年第2期24卷 88-93页

作者： Jie-Yi He Wang-Xin Xiao David CSchwebel Mo-Tao Zhu Pei-Shan Ning Li Li Xun-Jie Cheng Jun-Jie hua guo-qing hu Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha410078China Department of Psychology University of Alabama at BirminghamBirminghamAL35294USA Center for Injury Research and Policy Abigail Wexner Research Institute at Nationwide Children’s HospitalDepartment of PediatricsThe Ohio State UniversityColumbusOH43205USA Division of Epidemiology College of Public HealthThe Ohio State UniversityColumbusOH43210USA

Purpose:This research examined road traffic injury mortality and morbidity disparities across of country development status,and discussed the possibility of reducing country disparities by various actions to accelerate the pace of achieving Sustainable Development Goals target 3.6 e to halve the number of global deaths and injuries from road traffic accidents by ***:Data for road traffic mortality,morbidity,and socio-demographic index(SDI)were extracted by country from the estimates of the Global Burden of Disease study,and the implementation of the three types of national actions(legislation,prioritized vehicle safety standards,and trauma-related post-crash care service)were extracted from the Global Status Report on Road Safety byWorld Health *** fitted joinpoint regression analysis to identify and quantify the significant rate changes from 2011 to ***:Age-adjusted road traffic mortality decreased substantially for all the five SDI categories from 2011 to 2017(by 7.52%e16.08%).Age-adjusted road traffic mortality decreased significantly as SDI increased in the study time period,while age-adjusted morbidity generally increased as SDI *** analysis by road user yielded similar results,but with two major differences during the study period of 2011 to 2017:(1)pedestrians in the high SDI countries experienced the lowest mortality(1.68e1.90 per 100,000 population)and morbidity(110.45e112.72 per 100,000 population for incidence and 487.48e491.24 per 100,000 population for prevalence),and(2)motor vehicle occupants in the high SDI countries had the lowest mortality(4.07e4.50 per 100,000 population)but the highest morbidity(428.74e467.78 per 100,000 population for incidence and 1025.70e1116.60 per 100,000 population for prevalence).Implementation of the three types of national actions remained nearly unchanged in all five SDI categories from 2011 to 2017 and was consistently stronger in the higher SDI countries than in the lower SD

关键词： Road traffic injury Mortality Morbidity Socioeconomic disparity Sustainable development goals

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao guo hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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中晚期胃癌术后序贯放化疗36例

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世界华人消化杂志 2007年第36期15卷 3856-3859页

作者：袁响林付强胡国清陈元张莉红胡广原于世英华中科技大学同济医学院附属同济医院肿瘤中心湖北省武汉市430030

目的:评价术后序贯放化疗对中晚期胃癌的生存影响和不良反应.方法:收集我院2003-01/2005-12胃癌根治术后行序贯放化疗患者36例及对照单纯化疗患者32例,分析两组的1年和3年生存率,同时评价放化疗期间出现的血液学,肝肾功能及胃肠道等不... 详细信息

目的:评价术后序贯放化疗对中晚期胃癌的生存影响和不良反应.方法:收集我院2003-01/2005-12胃癌根治术后行序贯放化疗患者36例及对照单纯化疗患者32例,分析两组的1年和3年生存率,同时评价放化疗期间出现的血液学,肝肾功能及胃肠道等不良反应.结果:术后序贯放化疗组和单纯化疗组1年生存率分别为77%和61%,3年生存率分别为47%和25%(P=0.041),中位生存时间分别为40.0 mo和24.5 mo(P=0.038),治疗期间两组出现Ⅲ-Ⅳ级白细胞减少分别为11.1%和6.3%,Ⅲ-Ⅳ级恶心呕吐分别为8.3%和3.1%,但差异无统计学意义.结论:胃癌患者术后序贯放化疗较单纯化疗可提高1年和3年生存率,延长中位生存时间,不良反应可耐受.

关键词：中晚期胃癌序贯放化疗 OLF方案生存率

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