Technetium-99m-sestamibi SPECT for the diagnosis andfollow-up of nasopharyngeal carcinoma

作     者：Jing CHEN Guang-Yuan HU Guo-Qing HU Hua WU 

作者机构：Department of Nuclear MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of OncologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Nuclear MedicineXiamen First HospitalFujian Medical UniversityXiamen 361003China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2010年第4卷第1期

页      面：96-100页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：nasopharyngeal carcinoma diagnosis follow-up 

摘      要：This study was to investigate a better way to detect and differentiate primary,residual,recurrent naso-pharyngeal carcinoma(NPC)lesions post-radiotherapy in patients with NPC by means of routine computed tomography(CT)in combination with 99Tcm-sestamibi single photon emission computed tomography(99Tcm-MIBI SPECT).Forty-eight patients with histologically confirmed primary NPC underwent 99Tcm-MIBI SPECT at the 3rd month before and after radiotherapy,and at the 6th month after *** patients had contempora-neous CT *** results and/or clinical follow-up data(over 18 months)were used as the golden standard for evaluating residual/recurrent *** radioactive count ratio of nasopharynx to scalp was obtained as the MIBI uptake index(MUI).Receiver operating characteristic analysis was employed to define the cut-off value of MUI for *** MUI 2.15 as the cut-off point,the accuracy for detecting primary NPC was 94.12%.The mean MUI in the local-regional of the nasopharynx in such negative cases was 1.21�0.12 at the 3rd month,while the mean MUI was higher in the other 15 patients with histologically confirmed recurrent/residual lesions(MUI=1.40�0.16,t=4.71,P0.001).The optimal cut-off point of 1.33 of MUI was defined with 89.58%accuracy for differentiating residual/recurrent lesions from the benign process post radiotherapy,while CT evaluations showed an accuracy of 81.25%.A combination of CT and 99Tcm-MIBI SPECT for 37 NPC patients with congruent results showed an accuracy of 97.30%for differentiating residual/recurrent NPC from benign lesions.99Tcm-MIBI SPECT plays a role in evaluating residual/recurrent lesions *** combination of CT and 99Tcm-MIBI SPECT can give more accurate diagnosis in the follow-up of NPC.