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Chinese Chemical Letters 2022年第9期33卷 4293-4297页

作者： Chunyang Hu Fangming Chen guo-ping lu Wen-Bin Yi School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Organofluorine Chemistry Shanghai Institute Organic ChemistryChinese Academy of SciencesShanghai 200032China

A new,stable and scalable reagent for deuteriodifluoromethylthiolation(deuterated N-difluoromethylthiophthalimide,PhthSCF_(2)D)has been developed.This reagent can be applied for the photocatalytic radical deuteriodifluoromethylthiolation of various olefins and aldehydes(30 examples).Meanwhile,it can achieve the electrophilic deuteriodifluoromethylthiolation of a series of electrophilic substrates including electron-rich arenes,aryl/vinylboronicacids,alkynes,amines,thiols andβ-ketoesters(22 examples).Some complex molecules can also be applied in both radical and electrophilic deuteriodifluoromethylthiolation using PhthSCF_(2)D as the reagent.

关键词： Deuteration Deuteriodifluoromethylthiolation Photocatalytic Electrophilic Radical

Lignin-derived Zn single atom/N-codoped porous carbon forα-alkylation of aromatic ketones with alcohols via borrowing hydrogen strategy

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Nano Research 2022年第3期15卷 1874-1881页

作者： Xueping Zhang guo-ping lu Kun Wang Yamei Lin Pengcheng Wang Wenbin Yi School of Chemistry and Chemical Engineering Nanjing University of Science&TechnologyXiaolingwei 200Nanjing 210094China School of Pharmaceutical Sciences Wenzhou Medical CollegeUniversity TownChashanWenzhou 325035China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityWenyuanstreet 200Nanjing 210032China

A green and scalable strategy has been developed for the synthesis of lignin-derived Zn single atom/N-codoped porous carbon(LCN@Zn-SAC)containing similar ZnNx sites with carbonic anhydrases.This catalyst exhibits superior activity on theα-alkylation of ketones with alcohols via borrowing hydrogen strategy(TON up to 15 h^(−1))than most of previously reported works.The dehydrogenation of benzyl alcohol is the rate-determining step based on kinetic experiment results.According to experimental and theoretical calculation results,Zn electron density is inversely proportional to reaction energy barriers,because Zn sites with less positive charge(ZnN_(4) and ZnN_(3)C)in Zn-SACs display better borrowing hydrogen ability than other Zn sites.Furthermore,this catalyst can be recycled by simple centrifugation,which can be reused at least 8 runs with no obvious lose in activity.To the best of our knowledge,this is the first example of non-noble metal-SAC-catalyzedα-alkylation via borrowing hydrogen strategy.

关键词： lignin zinc single atom catalyst N-doped porous carbon α-alkylation borrowing hydrogen

Carbohydrate-derived porous carbon materials:An ideal platform for green organic synthesis

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Chinese Chemical Letters 2022年第1期33卷 186-196页

作者： Yamei Lin Jie Yu Xing Zhang Jingkun Fang guo-ping lu He Huang School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210023China School of Pharmaceutical Sciences Nanjing Tech UniversityNanjing 210009China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

Porous carbon materials have attracted much attention in the field of organic synthesis in recent years,due to their tunable properties,excellent catalytic activity and stability.Biomass-based carbohydrates emerge as an ideal precursor for the generation of these materials owing to their renewability,low cost,non-toxicity and high content of functional groups.Thus,carbon materials prepared from carbohydrates is of considerable importance for the sustainable development of organic chemistry.The present review not only summarizes recent examples of carbohydrate-derived porous carbon material-catalyzed organic reactions including the oxidation,hydrogenation,cross-coupling,esterification and condensation reactions,but also introduces the preparation and functionalization strategies of these materials.Furthermore,the challenges and opportunities of organic synthesis over these sustainable materials have also been addressed.This review will stimulate further research on exploring novel carbohydrate-derived porous carbon materials and new sustainable organic synthetic processes over these materials.

关键词： Carbohydrates Carbon materials Green chemistry Catalysis Organic synthesis

Establishment of a Rat Model of Capillary Leakage Syndrome Induced by Cardiopulmonary Resuscitation After Cardiac Arrest

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当代医学科学(英文) 2023年第4期43卷 708-715页

作者： Xiao-lei ZHANG Ye CHENG Chun-lin XING Jia-yun YING Xue YANG Xiao-di CAI guo-ping lu Department of Pediatric Emergency Medicine and Critical Care Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Critical Care Medicine Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Objective:Cardiopulmonary resuscitation(CPR)after cardiac arrest(CA)is one of the main causes of capillary leakage syndrome(CLS).This study aimed to establish a stable CLS model following the CA and cardiopulmonary resuscitation(CA-CPR)model in Sprague-Dawley(SD)rats.Methods:We conducted a prospective,randomized,animal model study.All adult male SD rats were randomly divided into a normal group(group N),a sham operation group(group S),and a cardiopulmonary resuscitation group(group T).The SD rats of the three groups were all inserted with 24-G needles through their left femoral arteries and right femoral veins.In group S and group T,the endotracheal tube was intubated.In group T,CA induced by asphyxia(AACA)was caused by vecuronium bromide with the endotracheal tube obstructed for 8 min,and the rats were resuscitated with manual chest compression and mechanical ventilation.Preresuscitation and postresuscitation measurements,including basic vital signs(BVS),blood gas analysis(BG),routine complete blood count(CBC),wet-to-dry ratio of tissues(W/D),and the HE staining results after 6 h were evaluated.Results:In group T,the success rate of the CA-CPR model was 60%(18/30),and CLS occurred in 26.6%(8/30)of the rats.There were no significant differences in the baseline characteristics,including BVS,BG,and CBC,among the three groups(P>0.05).Compared with pre-asphyxia,there were significant differences in BVS,CBC,and BG,including temperature,oxygen saturation(SpO_(2)),mean arterial pressure(MAP),central venous pressure(CVP),white blood cell count(WBC),hemoglobin,hematocrit,pH,pCO_(2),pO_(2),SO_(2),lactate(Lac),base excess(BE),and Na+(P<0.05)after the return of spontaneous circulation(ROSC)in group T.At 6 h after ROSC in group T and at 6 h after surgery in groups N and S,there were significant differences in temperature,heart rate(HR),respiratory rate(RR),SpO_(2),MAP,CVP,WBC,pH,pCO_(2),Na+,and K+among the three groups(P<0.05).Compared with the other two groups,the rats in group T showed a significantly increased W/D weight r

关键词： cardiac arrest cardiopulmonary resuscitation capillary leakage model

2023 China Guidelines for Lipid Management

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老年心脏病学杂志:英文版 2023年第9期20卷 621-663页

作者： Jian-Jun LI Shui-ping ZHAO Dong ZHAO guo-ping lu Dao-Quan PENG Jing LIU Zhen-Yue CHEN Yuan-Lin guo Na-Qiong WU Sheng-Kai YAN Zeng-Wu WANG Run-Lin GAO National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical SciencesBeijingChina The Second Xiangya Hospital of Central South University ChangshaHunanChina Beijing Anzhen Hospital Capital Medical UniversityBeijingChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina Affiliated Hospital of Zunyi Medical University School of Laboratory Medicine of Zunyi Medical UniversityZunyiGuizhouChina

Atherosclerotic cardiovascular disease(ASCVD)is the leading cause of death among urban and rural residents in China,and elevated low-density lipoprotein cholesterol(LDL-C)is a risk factor for ASCVD.Considering the increasing burden of ASCVD,lipid management is of the utmost importance.In recent years,research on blood lipids has made breakthroughs around the world,hence a revision of China guidelines for lipid management is imperative,especially since the target lipid levels in the general population vary in respect to the risk of ASCVD.The level of LDL-C,which can be regarded as appropriate in a population without frisk factors,can be considered abnormal in people at high risk of developing ASCVD.As a result,the“Guidelines for the prevention and treatment of dyslipidemia”were adapted into the“China Guidelines for Lipid Management”(henceforth referred to as the new guidelines)by an Experts’committee after careful deliberation.The new guidelines still recommend LDL-C as the primary target for lipid control,with CVD risk stratification to determine its target value.These guidelines recommend that moderate intensity statin therapy in adjunct with a heart-healthy lifestyle,be used as an initial line of treatment,followed by cholesterol absorption inhibitors or/and proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors,as necessary.The new guidelines provide guidance for lipid management across various age groups,from children to the elderly.The aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by guiding clinical practice.

关键词： Lipid prevention hence

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World Journal of Clinical Cases 2021年第13期9卷 3070-3078页

作者： Qiao-Feng Ye Guang-Fei Wang Yi-Xue Wang guo-ping lu Zhi-ping Li Department of Clinical Pharmacy National Children's Medical CenterChildren's Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Intensive Care Unit National Children's Medical CenterChildren's Hospital of Fudan UniversityShanghai 201102China

BACKGROUND Vancomycin is often used as an anti-infective drug in patients receiving antitumor chemotherapy.There are concerns about its adverse drug reactions during treatment,such as nephrotoxicity,ototoxicity,hypersensitivity reactions,etc.However,potential convulsion related to high plasma concentrations of vancomycin in children receiving chemotherapy has not been reported.CASE SUMMARY A 3.9-year-old pediatric patient with neuroblastoma receiving vancomycin to treat post-chemotherapy infection developed an unexpected convulsion.No other potential disease conditions could explain the occurrence of the convulsion.The subsequently measured overly high plasma concentrations of vancomycin could possibly provide a clue to the occurrence of this convulsion.The peak and trough plasma concentrations of vancomycin were 59.5 mg/L and 38.6 mg/L,respectively,which were much higher than the safe range.Simulation with the Bayesian approach using MwPharm software showed that the area under the concentration-time curve over 24 h was 1086.6 mg·h/L.Therefore,vancomycin was immediately stopped and teicoplanin was administered instead combined with meropenem and fluconazole as the anti-infective treatment strategy.CONCluSION Unexpected convulsion occurring in a patient after chemotherapy is probably due to toxicity caused by abnormal pharmacokinetics of vancomycin.Overall evaluation and close therapeutic drug monitoring should be conducted to determine the underlying etiology and to take the necessary action as soon as possible.

关键词： Vancomycin Neuroblastoma Convulsion Children Adverse drug reaction Case report

The synergistic catalysis on Co nanoparticles and CoNx sites of aniline-modified ZIF derived Co@NCs for oxidative esterification of HMF

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Chinese Chemical Letters 2021年第2期32卷 685-690页

作者： Tao Rui guo-ping lu Xin Zhao Xun Cao Zhong Chen School of Chemical Engineering Nanjing University of Science&TechnologyNanjing 210094China School of Materials Science&Engineering Nanyang Technological UniversitySingapore 639798Singapore

An efficient sustainable and scalable strategy for the synthesis of porous cobalt/nitrogen co-doped carbons(Co@NCs) via pyrolysis of aniline-modified ZIFs,has been demonstrated.Aniline can coordinate and absorb on the surface of ZIF(ZIF-CoZn3-PhA),accelerate the precipitation of ZIFs,thus resulting in smaller ZIF particle size.Meanwhile,the aniline on the surface of ZIF-CoZn3-PhA promotes the formation of the protective carbon shell and smaller Co nanoparticles,and increases nitrogen content of the catalyst.Because of these prope rties of Co@NC-PhA-3,the oxidative esterification of 5-hydroxymethylfurfural can be carried out under ambient conditions.According to our experimental and computational results,a synergistic catalytic effect between CoNx sites and Co nanoparticles has been established,in which both Co nanoparticles and CoNx can activate O2 while Co nanoparticles bind and oxidize HMF.Moreover,the formation and release of active oxygen species in CoNx sites are reinfo rced by the electronic interaction between Co nanoparticles and CoNx.

关键词： Aniline-modified ZIF Porous cobalt/nitrogen co-doped carbon Synergistic catalysis on CoNx sites and Co nanoparticles Oxidative esterification 5-Hydroxymethylfurfural

Clinical experiences in the management of critically ill patients with COVID‑19 in a designated children’s hospital in China

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World Journal of Pediatrics 2023年第6期19卷 605-608页

作者： Gong-Bao Liu Ying Gu Ying-Wen Wang Chuan-Qing Wang Jian Ma Mei Zeng guo-ping lu Zhong-Lin Wang Ai-Mei Xia Jin-Hao Tao Xiao-Wen Zhai Wen-Hao Zhou Hong Xu Yong-Hao Gui guo-Ying Huang Xiao-Bo Zhang Department of Medical Affairs Children’s Hospital of Fudan UniversityShanghaiChina Department of Nursing Children’s Hospital of Fudan UniversityShanghaiChina Department of Nosocomial Infection Prevention and Control Children’s Hospital of Fudan UniversityShanghaiChina Department of Infectious Disease Children’s Hospital of Fudan UniversityShanghaiChina Department of Critical Medicine Children’s Hospital of Fudan UniversityShanghaiChina Department of Hematology Children’s Hospital of Fudan UniversityShanghaiChina Department of Neonate Children’s Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children’s Hospital of Fudan UniversityShanghaiChina Department of Key Laboratory of Ministry of Health for Neonatal Disease Children’s Hospital of Fudan UniversityShanghaiChina Department of Cardiology Children’s Hospital of Fudan UniversityWanyuan RdNo.399ShanghaiChina Department of Respiratory Children’s Hospital of Fudan UniversityWanyuan RdNo.399ShanghaiChina

Omicron variant has been the dominant epidemic variant of novel coronavirus in the world since 2021.Studies have shown that the incidence of severe or critical cases with coronavirus disease 2019(COVID-19)is much lower than that of the previous novel coronavirus variants[1,2];however,it is still a major challenge to treat critical pediatric patients with COVID-19,especially for those with underlying diseases.

关键词： patients Clinical cases

2016 Chinese guidelines for the management of dyslipidemia in adults

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Journal of Geriatric Cardiology 2018年第1期15卷 1-29页

作者： Jun-Ren ZHU Run-Lin GAO Shui-ping ZHAO guo-ping lu Dong ZHAO Jian-Jun LI Joint committee for guideline revision

Over the last 30 years, the blood lipid level in the Chinese population has gradually increased, and the incidence of dyslipidemia has significantly increased. A nationwide survey in 2012 showed that the average serum total cholesterol (TC) value in adults was 4.50 mmol/L and that the prevalence of hypercholesterolemia was 4.9%; the average value of triglyceride (TG) was 1.38 mmol/L, and the prevalence of hypertriglyceridemia was 13.1%; the average value of high-density lipoprotein cholesterol (HDL-C) was 1.19 mmol/L, and the prevalence of HDL-C hypolipidemia was 33.9%. The overall prevalence of dyslipidemia among Chinese adults reached 40.4%, which has substantially increased since 2002. The increase of serum cholesterol level in the population will increase by approximately 9.2 million cases of cardiovascular events in China between 2010 and 2030. The prevalence of hypercholesterolemia among Chinese children and adolescents is also significantly increasing, suggesting that the development of dyslipidemia and the relevant disease burdens in Chinese adults will continue to increase.

关键词：成年人管理指南中国动脉粥样硬化生产厂商丙氨酸症候群

Continuous tracheal gas insufflation during protective mechanical ventilation in juvenile piglets with acute lung injury induced by endotoxin

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World Journal of Emergency Medicine 2010年第1期1卷 59-64页

作者： Zhong-liang guo Tao Ren Ying-yun Cai guo-ping lu Jing-yu Gong Yong-jic Liang Department of Respiratory Medicine East Hospital Tongji University School of Medicine Shanghai 200120 China Pediatric Department Zhongshan Hospital Fudan University Shanghai 200032 China Pediatric ICU Pediatrics Hospital Fudan University Shanghai 200032 China

BACKGROUND:Low tidal volume mechanical ventilation is difficult to correct hypoxemia, and prolonged inhalation of pure oxygen can lead to oxygen poisoning. We suggest that continuous tracheal gas insufflation (TGI) during protective mechanical ventilation could improve cardiopulmonary function in acute lung injury.;METHODS:Totally 12 healthy juvenile piglets were anesthetized and mechanically ventilated at PEEP of 2 cmH2O with a peak inspiratory pressure of 10 cmH2O. The piglets were challenged with lipopolysaccharide and randomly assigned into two groups (n=6 each group): mechanical ventilation (MV) alone and TGI with continuous airway flow 2 l/min. FIO2 was set at 0.4 to avoid oxygen toxicity and continuously monitored with an oxygen analyzer.;RESULTS:Tidal volume, ventilation efficacy index and mean airway resistant pressure were significantly improved in the TGI group (Plung compliance and mean resistance of airway between the two groups. lung histological examination showed reduced inflammation, reduced intra-alveolar and interstitial patchy hemorrhage, and homogenously expanded lungs in the TGI group.;CONCluSIONS:Continuous TGI during MV can significantly improve gas exchange and ventilation efficacy and may provide a better treatment for acute lung injury.

关键词： Acute lung injury lung protective strategy Mechanical ventilation Tracheal gas insufflation