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World Journal of Clinical Cases 2023年第2期11卷 441-448页

作者： guo-chun ou Wen Luo Wei-Shan Zhang Shu-Hong Wang Jie Zhao Hong-Mei Zhao Rong Qiu Department of Respiratory and Critical Care Medicine Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Pathology Suining Central HospitalSuining 629000Sichuan ProvinceChina

BACKGRouND Lung invasive mucinous adenocarcinoma(LIMA),formerly referred to as mucinous bronchioloalveolar carcinoma,is a rare disease that usually presents as bilateral lung infiltration,is unsuitable for surgery and radiotherapy,and shows poor response to conventional *** SUMMARY We report a 56-year-old Chinese man with a history of smoking and epidermal growth factor receptor mutation-positivity who was initially misdiagnosed as severe pneumonia,but was ultimately diagnosed as a case of invasive mucinous adenocarcinoma of the lung by computed tomography-guided percutaneous lung *** and dyspnea were improved within 24 h after initiation of gefitinib therapy and the radiographic signs of bilateral lung consolidation showed visible improvement within 30 *** more than 11 months of treatment,there is no evidence of recurrence or severe adverse *** Although the precise mechanism of the antitumor effects of gefitinib are not clear,our experience indicates an important role of the drug in LIMA and provides a reference for the diagnosis and treatment of this disease.

关键词： Gefitinib Epidermal growth factor receptor Lung cancer Bronchorrhea Lung invasive mucinous adenocarcinoma Case report

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang chun-Lin ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

The controllable preparation of electrospun carbon fibers supported Pd nanoparticles catalyst and its application in Suzuki and Heck reactions

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Chinese Chemical Letters 2016年第3期27卷 459-463页

作者： Shou-Jun guo Jie Bai Hai-ou Liang chun-Ping Li Chemical Engineering College Inner Mongolia University of Technology

The palladium nanoparticles/carbon nanofibers（Pd NPs/CNFs） catalyst was prepared by the electrospinning method, the hydrazine hydrate solution reduction in an ice bath environment, the high temperature carbonization. The catalyst was characterized by X-ray diffraction（XRD）, fieldemission scanning electron microscope（FE-SEM）, and transmission electron microscopy（TEM）. The nanofibers are not cross-linked and arranged in order. The surface of Pd NPs/CNFs is smooth, and it can be observed that a large number of particles were loaded and well-dispersed in carbon fiber matrix, and the particle distribution is uniform. The activity center of catalyst is Pd^（0）. The Pd NPs/CNFs exhibited a high efficiency, good reusability and stability in the Suzuki and Heck reactions. It can be used for at least five consecutive runs without significant loss of its catalytic activity. The good recyclability of Pd NPs/CNFs provides a way to greatly reduce the cost of the catalyst.

关键词： Pd NPs/CNFs Electrospinning Carbonization Catalysts

APPLYING PROCESS MINING APPROACH TO SUPPORT THE VERIFICATION OF A MULTI-AGENT SYSTEM

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Journal of Systems Science and Systems Engineering 2010年第2期19卷 131-149页

作者： C.ou-YANG Yeh-chun JUAN Depart.of Industrial Management National Taiwan University of Science and Technology Depart.of Industrial Engineering and Management Ming Chi University of Technology

Using agent development tools to construct an agent-based system is a well applied approach. However, the development tools usually do not have the function to check the feasibility about the workflow of the agent system during it implementation stage. Therefore, to develop an evaluation approach to analyze the feasibility of a developing agent system such that the improper workflow of an agent system can be found in the early design stage is a necessary task to reduce the risk of implementation. In this research, a Petri Net （PN） based three-stage evaluation approach was developed. In the conceptual stage, the pitfall of the current agent system developing process was examined and an improvement analysis process was specified. Then, in the system design stage, an evaluation approach which extracted the process log file from a developing agent system into a PN model in terms of a process mining approach-or algorithm was proposed. This model was simulated in a PN simulation package. The agent system performance was evaluated in terms of analyzing the deadlock phenomena of the PN model. Finally, in the implementation stage, the proposed concept was implemented by using an agent developing tool JADE and a PN simulation tool CPN. An agent-based robotic assembly system was used to examine the possible deadlock of the agent system.

关键词： Agent-based systems workflow feasibility process mining Petri Nets

Improved preparation of(1S,3',4'S,5'S,6'R)-5-chloro-6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-spiro[isobenzofuran-l(3H),2'-[2H]pyran]-3',4',5'-triol

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Chinese Chemical Letters 2013年第2期24卷 131-133页

作者： Yong-Hai Liu Ting-Ming Fu chun-Yan ou Wen-Ling Fan guo-Ping Peng School of Pharmacy Nanjing University of Chinese Medicine

Received 9 November 2012 Received in revised form 23 November 2012 Accepted 3 December 2012 Available online 29 January 2013

关键词： Type 2 diabetesSodiurn glucose co-transporter 2InhibitorPreparation

Association between inflammatory bowel disease and all-cause dementia:A two-sample Mendelian randomization study

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World Journal of Psychiatry 2024年第1期14卷 15-25页

作者： ou-Lan Liao Si-Yuan Xie Jun Ye Qin Du guo-chun Lou Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Gastroenterology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGRouND Numerous observational studies have documented a correlation between inflammatory bowel disease(IBD)and an increased risk of ***,the causality of their associations remains *** To assess the causal relationship between IBD and the occurrence of all-cause dementia using the two-sample Mendelian randomization(MR)*** Genetic variants extracted from the large genome-wide association study(GWAS)for IBD(the International IBD Genetics Consortium,n=34652)were used to identify the causal link between IBD and dementia(FinnGen,n=306102).The results of the study were validated via another IBD GWAS(United Kingdom Biobank,n=463372).Moreover,MR egger intercept,MR pleiotropy residual sum and outlier,and Cochran's Q test were employed to evaluate pleiotropy and ***,multiple MR methods were performed to estimate the effects of genetically predicted IBD on dementia,with the inverse variance weighted approach adopted as the primary *** The results of the pleiotropy and heterogeneity tests revealed an absence of significant pleiotropic effects or heterogeneity across all genetic variants in outcome *** evidence of a causal effect between IBD and the risk of dementia was identified in the inverse variance weighted[odds ratio(OR)=0.980,95%CI:0.942-1.020,P value=0.325],weighted median(OR=0.964,95%CI:0.914-1.017,P value=0.180),and MR-Egger(OR=0.963,95%CI:0.867-1.070,P value=0.492)*** results were observed in validation *** MR analysis also showed no effect of dementia on the development of ***,MR analysis suggested that IBD and its subtypes did not causally affect allcause dementia and its four subtypes,including dementia in Alzheimer's disease,vascular dementia,dementia in other diseases classified elsewhere,and unspecified *** Taken together,our MR study signaled that IBD and its subentities were not genetically associated with all-cause dementia or its

Traveling wave for a time-periodic Lotka-Volterra model with bistable nonlinearity

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Applied Mathematics(A Journal of Chinese Universities) 2022年第3期37卷 396-403页

作者： YUE Jia-jun MA Man-jun ou chun-hua Department of Mathematics School of ScienceZhejiang Sci-Tech UniversityHangzhou 310018China Department of Mathematics and Statistics Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada

This paper studies bistable wavefronts of a diffusive time-periodic Lotka-Volterra *** obtain a new condition for the existence,uniqueness and stability of bistable timeperiodic traveling *** condition is sharp and greatly improves the result established in the reference(*** and ***,Journal of Differential Equations,255(2013)2402-2435).An example is given to demonstrate our consequence.

关键词： existence and uniqueness stability bistable traveling wave Lotka-Volterra model

Corrosion risk analysis of tube-and-shell heat exchangers and design of outlet temperature control system

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Petroleum Science 2021年第4期18卷 1219-1229页

作者： Hao-Zhe Jin Yong Gu guo-Fu ou The Institute of Flow-Induced Corrosion Zhejiang Sci-tech UniversityHangzhou310000ZhejiangChina Institute of Flow Induced Corrosion and Intelligent Prevention and Control Changzhou UniversityChangzhou213000JiangsuChina

This study deals with the high-risk shell-and-tube heat exchangers in the effluent system of hydrogenation reaction of the petrochemical *** process of hydroprocessing reactor effluent system is simulated in Aspen Plus to study the distribution of corrosive medium in the three phases of oil,gas and *** least-squares method is utilized to calculate the ammonium salt crystallization ***,the heat exchanger with risk of ammonium salt crystal corrosion is *** mathematical modeling of the heat exchanger is established to determine the transfer function.A temperature control system with proportional integral derivative(PID)control of the heat exchanger outlet is designed,and fuzzy logic is used to implement self-tuning of PID *** MATLAB simulation,the results show the control system can achieve rapid control of the heat exchanger outlet temperature.

关键词： Shell-and-tube heat exchanger Corrosion risk Dynamic model Fuzzy logic control PID control